Published in J Biol Chem on May 03, 2001
Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism. Mol Cell (2011) 2.50
TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol (2009) 1.87
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors. Cancer Cell (2014) 1.84
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cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes. Am J Physiol Gastrointest Liver Physiol (2009) 0.87
Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha. J Biol Chem (2002) 0.87
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Inhibition of phosphatidylinositol 3-kinase stimulates activity of the small-conductance K channel in the CCD. Am J Physiol Renal Physiol (2005) 0.85
A switch of G protein-coupled receptor binding preference from phosphoinositide 3-kinase (PI3K)-p85 to filamin A negatively controls the PI3K pathway. Mol Cell Biol (2011) 0.84
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Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression. Front Immunol (2016) 0.83
Conditional knockout of myocyte focal adhesion kinase abrogates ischemic preconditioning in adult murine hearts. J Am Heart Assoc (2013) 0.83
Phosphatidylinositol Phosphate 5-Kinase Iγ and Phosphoinositide 3-Kinase/Akt Signaling Couple to Promote Oncogenic Growth. J Biol Chem (2015) 0.83
A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survival. J Biol Chem (2014) 0.83
Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction. J Biol Chem (2017) 0.83
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside. Virology (2015) 0.82
ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. Cancer Res (2015) 0.81
Extracellular matrix protein laminin induces matrix metalloproteinase-9 in human breast cancer cell line mcf-7. Cancer Microenviron (2014) 0.79
Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation. Oncogene (2015) 0.79
The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system. Mol Biol Cell (2011) 0.79
Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways. Breast Cancer Res (2014) 0.79
Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells. Proc Natl Acad Sci U S A (2012) 0.79
Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells. J Leukoc Biol (2014) 0.79
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Early signaling dynamics of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (2016) 0.77
Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment. Pharmacogenomics (2016) 0.77
An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers. PLoS Biol (2016) 0.76
Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium. Elife (2015) 0.76
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The role of PTEN in chronic growth hormone-induced hepatic insulin resistance. PLoS One (2013) 0.76
p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration. Immunol Cell Biol (2015) 0.75
PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System. Tissue Eng Part A (2015) 0.75
Neomorphic mutations create therapeutic challenges in cancer. Oncogene (2016) 0.75
The p110α and p110β isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells. Mediators Inflamm (2010) 0.75
Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma. Oncotarget (2015) 0.75
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T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells. J Immunol (2017) 0.75
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