Paracetamol, alcohol and the liver.

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Published in Br J Clin Pharmacol on April 01, 2000

Authors

L F Prescott1

Author Affiliations

1: Clinical Pharmacology, University of Edinburgh, Edinburgh, UK.

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Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther (1973) 4.40

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Acetaminophen treatment nomogram. N Engl J Med (1994) 2.69

Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Pharmacol Ther (1974) 2.62

Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem (1996) 2.25

Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med (1981) 2.15

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Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Hepatology (1999) 1.99

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Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys (1989) 1.89

Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med (1991) 1.82

Analysis of factors responsible for continuing mortality after paracetamol overdose. Hum Toxicol (1986) 1.82

The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose. Hum Exp Toxicol (1991) 1.70

Paracetamol overdosage. Pharmacological considerations and clinical management. Drugs (1983) 1.70

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol (1993) 1.67

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Toxicol Appl Pharmacol (1998) 1.63

Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology (1995) 1.54

Chronic excessive acetaminophen use and liver damage. Ann Intern Med (1977) 1.46

Hepatotoxicity due to repeated intake of low doses of paracetamol. J Intern Med (1992) 1.46

Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut (1988) 1.39

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. Biochem Pharmacol (1993) 1.38

Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scott Med J (1973) 1.25

Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases. Am J Dis Child (1984) 1.25

Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism. Biochem Pharmacol (1979) 1.22

Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. Mol Pharmacol (1980) 1.18

Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. Ann Intern Med (1986) 1.12

Acetaminophen hepatotoxicity. Annu Rev Med (1984) 1.09

Letter: cysteamine treatment in paracetamol overdose. Lancet (1975) 1.08

The complex interaction between ethanol and acetaminophen. Clin Pharmacol Ther (1996) 1.08

Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. Chem Res Toxicol (1998) 1.05

Potentiation of acetaminophen hepatotoxicity by alcohol. JAMA (1980) 1.04

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics. Biochem Pharmacol (1994) 1.00

Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen. Biochem Biophys Res Commun (1983) 0.98

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Elevated SGOT/SGPT ratio in alcoholic patients with acetaminophen hepatotoxicity. Am J Gastroenterol (1984) 0.95

Is there a place for cimetidine or ethanol in the treatment of paracetamol poisoning? Lancet (1983) 0.94

Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity. Biochem Biophys Res Commun (1994) 0.94

Drug interactions affecting analgesic toxicity. Am J Med (1983) 0.92

Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat. Biochem Pharmacol (1987) 0.91

Concomitant alcohol and drug abuse enhancing acetaminophen toxicity. Report of a case. Am J Gastroenterol (1978) 0.90

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Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. Arch Biochem Biophys (1995) 0.90

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Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes. Alcohol Clin Exp Res (1996) 0.88

Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake. Eur J Clin Invest (1989) 0.87

Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen. Chem Res Toxicol (1992) 0.87

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Acute renal failure after analgesic drugs including paracetamol (acetaminophen). Nephron (1988) 0.86

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Ethanol induction of acetaminophen toxicity and metabolism. Life Sci (1980) 0.85

Acetaminophen, alcohol, and cytochrome P-450. Ann Intern Med (1986) 0.85

The effect of mild alcohol consumption on the metabolism of acetaminophen in man. Res Commun Chem Pathol Pharmacol (1982) 0.85

Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat. Gastroenterology (1981) 0.84

Clinical and toxicological consequences of the inductive potential of ethanol. Eur J Clin Pharmacol (1998) 0.84

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Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2. Drug Metab Dispos (1991) 0.84

Enhanced hepatotoxicity of acetaminophen in the alcoholic patient. Two case reports and a review of the literature. Medicine (Baltimore) (1997) 0.84

[Hepatic and renal toxicity of paracetamol in chronic alcoholic patient]. Presse Med (1988) 0.83

Patterns of acetaminophen use in alcoholic patients. Pharmacotherapy (1993) 0.83

Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis. Chest (1994) 0.83

Acetaminophen hepatotoxicity in the alcoholic. South Med J (1990) 0.83

Acetaminophen associated hepatic injury, Report of two cases showing unusual portal tract reactions. Hum Pathol (1980) 0.83

Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: comparison with carbon tetrachloride-induced hepatoxicity. J Pharmacol Exp Ther (1981) 0.83

Anion gap acidosis with hypoglycemia in acetaminophen toxicity. Ann Emerg Med (1984) 0.82

Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen. Arch Intern Med (1985) 0.82

Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A. Biochem Pharmacol (1998) 0.82

Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases. S Afr Med J (1977) 0.81

Alcohol-inducible cytochrome P-450 (P-450ALC). Arch Toxicol (1987) 0.81

[Pharmacokinetics and metabolism of acetaminophen in normal, alcoholic and cirrhotic subjects]. Gastroenterol Clin Biol (1983) 0.81

Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics. Arch Intern Med (1991) 0.81

Effect of chronic ethanol administration on drug metabolism in isolated hepatocytes with emphasis on paracetamol activation. Biochem Pharmacol (1980) 0.81

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Effect of a concomitant single dose of ethanol on the hepatotoxicity and metabolism of acetaminophen in mice. Toxicology (1980) 0.80

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[Acute hepato-nephritis in an alcoholic following a therapeutic dose of paracetamol]. Presse Med (1988) 0.80

Severe liver damage caused by therapeutic doses of acetaminophen. Acta Med Scand (1987) 0.79

Late presentation of acetaminophen hepatotoxicity. Dig Dis Sci (1982) 0.79

Increased acetaminophen-induced hepatotoxicity after chronic ethanol consumption in mice. Toxicology (1983) 0.79

Alcohol metabolism and toxicity: role of cytochrome P-450. Fundam Appl Toxicol (1984) 0.79

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Acetaminophen poisoning and liver function. N Engl J Med (1994) 0.79

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Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic. JAMA (1986) 0.78

Mechanism of the preventive effect of ethanol on acetaminophen-induced hepatoxicity. J Pharmacol Exp Ther (1981) 0.78

Interaction of ethanol with acetaminophen metabolism in the baboon. Biochem Pharmacol (1984) 0.78

Interaction of acute ethanol administration with acetaminophen metabolism and toxicity in rats fed alcohol chronically. Alcohol Clin Exp Res (1984) 0.78

Mechanism by which ethanol diminishes the hepatotoxicity of acetaminophen. J Pharmacol Exp Ther (1988) 0.78

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