Published in Drugs on March 01, 1983
UK legislation on analgesic packs: before and after study of long term effect on poisonings. BMJ (2004) 2.11
Paracetamol induced hepatotoxicity. Arch Dis Child (2006) 1.67
Effects of non-narcotic analgesics on the liver. Drugs (1986) 1.50
A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose. Arch Emerg Med (1990) 1.37
Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol (2008) 1.36
Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid Med Cell Longev (2010) 1.30
Adverse reactions to acetylcysteine and effects of overdose. Br Med J (Clin Res Ed) (1984) 1.26
Paracetamol poisoning in children and hepatotoxicity. Br J Clin Pharmacol (1991) 1.25
Pain management in the cirrhotic patient: the clinical challenge. Mayo Clin Proc (2010) 1.24
Paracetamol, alcohol and the liver. Br J Clin Pharmacol (2000) 1.19
New approaches in managing drug overdosage and poisoning. Br Med J (Clin Res Ed) (1983) 1.15
Paracetamol overdose: an evidence based flowchart to guide management. Emerg Med J (2002) 1.08
Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Curr Gerontol Geriatr Res (2011) 1.01
Impact of different pack sizes of paracetamol in the United Kingdom and Ireland on intentional overdoses: a comparative study. BMC Public Health (2011) 0.99
Paracetamol and phenacetin. Drugs (1986) 0.99
Paracetamol availability and recent changes in paracetamol poisoning: is the 1998 legislation limiting availability of paracetamol being followed? Postgrad Med J (2006) 0.98
Renal injury at first presentation as a predictor for poor outcome in severe paracetamol poisoning referred to a liver transplant unit. Eur J Clin Pharmacol (2008) 0.97
Acetaminophen: a practical pharmacologic overview. Can Med Assoc J (1984) 0.97
Acute poisoning: understanding 90% of cases in a nutshell. Postgrad Med J (2005) 0.94
Acetaminophen liver injury. Can Fam Physician (1985) 0.91
Antioxidant effects of pineapple vinegar in reversing of paracetamol-induced liver damage in mice. Chin Med (2015) 0.85
Inhibition of the metabolism of paracetamol by isoniazid. Br J Clin Pharmacol (1991) 0.84
Heat shock protein 70 induction and its urinary excretion in a model of acetaminophen nephrotoxicity. Pediatr Nephrol (2010) 0.81
The comparative effects of paracetamol and indomethacin on renal function in healthy female volunteers. Br J Clin Pharmacol (1990) 0.79
Drug-induced liver injury in older adults. Ther Adv Drug Saf (2010) 0.79
Paracetamol (acetaminophen) poisoning. BMJ Clin Evid (2007) 0.78
PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics (2015) 0.78
The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies. Springerplus (2016) 0.78
Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose? Open Access Emerg Med (2011) 0.75
Overexpression of Aldose Reductase Render Mouse Hepatocytes More Sensitive to Acetaminophen Induced Oxidative Stress and Cell Death. Indian J Clin Biochem (2015) 0.75
In vitro and PBPK based assessment of drug-drug interaction potential of canagliflozin. Br J Clin Pharmacol (2016) 0.75
Multiple organ transplantation after suicide by acetaminophen and gunshot wound. West J Emerg Med (2010) 0.75
Non-narcotic analgesics. Problems of overdosage. Drugs (1986) 0.75
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J (1979) 6.45
Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet (1971) 4.40
Successful treatment of severe paracetamol overdosage with cysteamine. Lancet (1974) 3.83
Mefenamic acid nephropathy. Lancet (1980) 3.80
Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. Br Med J (1973) 3.77
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. Lancet (1976) 3.41
Should methionine be added to every paracetamol tablet? BMJ (1997) 3.33
The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol (1973) 3.26
Treatment of drug overdosage with naloxone, a specific narcotic antagonist. Lancet (1973) 3.16
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet (1977) 3.00
Treatment of salicylate poisoning with repeated oral charcoal. Br Med J (Clin Res Ed) (1985) 2.90
Diuresis or urinary alkalinisation for salicylate poisoning? Br Med J (Clin Res Ed) (1982) 2.90
Liver damage and impaired glucose tolerance after paracetamol overdosage. Br Med J (1966) 2.68
Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther (1978) 2.41
Rapid gas-liquid chromatographic estimation of antipyrine in plasma. J Pharm Pharmacol (1973) 2.31
Narcotic analgesics and delayed gastric emptying during labour. Lancet (1975) 2.24
Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol (1975) 2.18
Gas-liquid chromatographic estimation of paracetamol. J Pharm Pharmacol (1971) 2.16
Pharmacokinetic drug interactions. Lancet (1969) 2.07
Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet (1979) 2.06
Treatment of ventricular arrhythmias with mexiletine (Kö 1173). Lancet (1973) 2.04
Henry Matthew: the father of modern clinical toxicology. J R Coll Physicians Edinb (2009) 2.04
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage. Health Bull (Edinb) (1978) 2.03
Paracetamol metabolism following overdosage: application of high performance liquid chromatography. J Pharm Pharmacol (1977) 2.01
Acute haemolysis and renal failure after nomifensine overdosage. Br Med J (1980) 2.00
Kinetics and metabolism of paracetamol and phenacetin. Br J Clin Pharmacol (1980) 1.87
Opioid-induced delay in gastric emptying: a peripheral mechanism in humans. Anesthesiology (1997) 1.87
High performance liquid chromatographic estimation of paracetamol metabolites in plasma. Br J Clin Pharmacol (1978) 1.78
Absorption, distribution and elimination of mexiletine. Postgrad Med J (1977) 1.74
Pharmacokinetics and clinical toxicity of quinine overdosage: lack of efficacy of techniques intended to enhance elimination. Q J Med (1985) 1.65
Paracetamol (acetaminophen) poisoning. No need to change current guidelines to accident departments. BMJ (1998) 1.57
Generic inequivalence--clinical observations. Acta Pharmacol Toxicol (Copenh) (1971) 1.55
Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet (1982) 1.54
Effects of non-narcotic analgesics on the liver. Drugs (1986) 1.50
Gastrointestinal absorption of drugs. Med Clin North Am (1974) 1.49
Inter-subject and ethnic differences in paracetamol metabolism. Br J Clin Pharmacol (1986) 1.48
Drugs prescribed for self poisoners. Br Med J (Clin Res Ed) (1985) 1.44
Analgesic abuse and renal disease in North-East Scotland. Lancet (1966) 1.40
Paracetamol and aspirin absorption from Safapryn and Safapryn-Co. Br J Clin Pharmacol (1979) 1.39
Renal papillary necrosis and aspirin. Scott Med J (1969) 1.38
Spectrophotofluorometric and gas-liquid chromatographic methods for the estimation of mexiletine (Kö 1173) in plasma and urine. J Pharm Pharmacol (1973) 1.36
Long-term treatment of ventricular arrhythmias with oral mexiletine. Am Heart J (1976) 1.36
The gas-liquid chromatographic estimation of phenacetin and paracetamol in plasma and urine. J Pharm Pharmacol (1971) 1.29
Treatment of phenobarbitone poisoning with repeated oral administration of activated charcoal. Q J Med (1986) 1.26
Death and blindness due to overdose of quinine. Br Med J (Clin Res Ed) (1985) 1.25
Why do patients still die from paracetamol poisoning? Br Med J (Clin Res Ed) (1986) 1.25
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scott Med J (1973) 1.25
Comparison of procainamide and mexiletine in prevention of ventricular arrhythmias after acute myocardial infarction. Lancet (1975) 1.25
The treatment of acetaminophen poisoning. Annu Rev Pharmacol Toxicol (1983) 1.24
Fatal pulmonary aspiration of oral activated charcoal. BMJ (1988) 1.24
A pharmacokinetic study of doxapram in patients and volunteers. Br J Clin Pharmacol (1979) 1.22
Impaired Lignocaine metabolism in patients with myocardial infarction and cardiac failure. Br Med J (1976) 1.20
Treatment of severe 2,4-D and mecoprop intoxication with alkaline diuresis. Br J Clin Pharmacol (1979) 1.19
New approaches in managing drug overdosage and poisoning. Br Med J (Clin Res Ed) (1983) 1.15
Fulminant hyperkalaemia and multiple complications following ibuprofen overdose. Med Toxicol Adverse Drug Exp (1990) 1.15
The role of sulphate conjugation in the metabolism and disposition of oral and intravenous paracetamol in man. Br J Clin Pharmacol (1984) 1.14
Rapid gas--liquid chromatographic estimation of doxapram in plasma. J Chromatogr (1977) 1.14
Analgesic nephropathy: a reassessment of the role of phenacetin and other analgesics. Drugs (1982) 1.14
Effects of microsomal enzyme induction on paracetamol metabolism in man. Br J Clin Pharmacol (1981) 1.12
Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med (1981) 1.11
SI, moles, and drugs. Br Med J (1978) 1.09
Mefenamic acid overdosage. Lancet (1981) 1.09
The effects of repeated administration of mercuric chloride on exfoliation of renal tubular cells and urinary glutamic-oxaloacetic transaminase activity in the rat. Toxicol Appl Pharmacol (1969) 1.09
Who needs molar units for drugs? Lancet (1987) 1.07
The ventilatory effects of doxapram in normal man. Clin Sci (Lond) (1983) 1.07
Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease. Br Med J (1977) 1.06
Inadequate information about drug overdosage in manufacturers' data sheets. Br Med J (1980) 1.05
The effects of particle size on the absorption of phenacetin in man. A correlation between plasma concentration of phenacetin and effects on the central nervous system. Clin Pharmacol Ther (1970) 1.05
The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br J Pharmacol (1973) 1.04
Changes in cardiorespiratory function during gastric lavage for drug overdose. Hum Toxicol (1987) 1.03
Inappropriate methods for the emergency determination of plasma paracetamol. Ann Clin Biochem (1979) 1.02
Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man. J Pharm Pharmacol (1976) 1.01
Paracetamol metabolism in chronic liver disease. Eur J Clin Pharmacol (1979) 0.99
Clinically important drug interactions. Drugs (1973) 0.99
Americans retreat on SI units. BMJ (1992) 0.98
The nephrotoxicity of analgesics. J Pharm Pharmacol (1966) 0.97
Gastric emptying and drug absorption. Br J Clin Pharmacol (1974) 0.97
Impaired absorption and metabolism of oral lignocaine in patients undergoing laparoscopy. Br J Anaesth (1973) 0.96
Paracetamol metabolites in the neonate following maternal overdose. Br J Clin Pharmacol (1984) 0.95
Gas-liquid chromatographic estimation of tolbutamide and chlorpropamide in plasma. J Pharm Pharmacol (1972) 0.94
Is there a place for cimetidine or ethanol in the treatment of paracetamol poisoning? Lancet (1983) 0.94
Panel discussion. Management of acetaminophen overdose. Arch Intern Med (1981) 0.94
Experimental paracetamol-induced hepatic necrosis: a histopathological study. J Pathol (1971) 0.94
Premedication for upper gastrointestinal endoscopy: a comparative study of flunitrazepam, diazepam and neuroleptanalgesia. Endoscopy (1978) 0.93
The absorption of aspirin and paracetamol in patients with achlorhydria. J Pharm Pharmacol (1974) 0.92
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning. Br Med J (1980) 0.92
Drug interactions affecting analgesic toxicity. Am J Med (1983) 0.92
Gross impairment of hepatic drug metabolism in a patient with chronic liver disease. Br Med J (1974) 0.91
Combined clinical and metabolic study of the effects of alpha-methyldopa on hypertensive patients. Circulation (1966) 0.91
Hepatotoxicity of mild analgesics. Br J Clin Pharmacol (1980) 0.90
The disposition of intravenous doxapram in man. Eur J Clin Pharmacol (1979) 0.90
Gas-liquid chromatographic estimation of lignocaine, ethylglycylxylidide, glycylxylidide and 4-hydroxyxylidine in plasma and urine. J Pharm Pharmacol (1974) 0.89
The comparative metabolism of phenacetin and N-acetyl-p-aminophenol in man, with particular reference to effects on the kidney. Clin Pharmacol Ther (1968) 0.89
Dose-dependent absorption and elimination of cefadroxil in man. Eur J Clin Pharmacol (1991) 0.88
Abnormal drug metabolism after barbiturate and paracetamol overdose. Br Med J (1974) 0.88
Paracetamol-induced acute renal failure in the absence of fulminant liver damage. Br Med J (Clin Res Ed) (1982) 0.88
Paracetamol pharmacokinetics in thyroid disease. Eur J Clin Pharmacol (1980) 0.88
Acetaminophen absorption and metabolism in celiac disease and Crohn's disease. Clin Pharmacol Ther (1981) 0.87
Long term treatment of ventricular arrhythmias with oral mexiletine. Postgrad Med J (1977) 0.87
Effect of food on the absorption of frusemide and bumetanide in man. Br J Clin Pharmacol (1996) 0.87