Published in Mol Microbiol on April 01, 2000
Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol (2011) 17.11
CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats. Nucleic Acids Res (2007) 15.56
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature (2010) 14.21
Development and applications of CRISPR-Cas9 for genome engineering. Cell (2014) 13.50
A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. PLoS Comput Biol (2005) 11.82
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol Direct (2006) 11.31
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J Mol Evol (2005) 11.05
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nat Rev Genet (2010) 7.47
The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats. BMC Bioinformatics (2007) 7.34
Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus. Proc Natl Acad Sci U S A (2002) 7.04
Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence. Proc Natl Acad Sci U S A (2011) 6.89
CRISPR recognition tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats. BMC Bioinformatics (2007) 5.84
Evolutionary conservation of sequence and secondary structures in CRISPR repeats. Genome Biol (2007) 5.40
The repetitive DNA elements called CRISPRs and their associated genes: evidence of horizontal transfer among prokaryotes. J Mol Evol (2006) 5.37
The CRISPR system: small RNA-guided defense in bacteria and archaea. Mol Cell (2010) 4.60
PILER-CR: fast and accurate identification of CRISPR repeats. BMC Bioinformatics (2007) 4.28
Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum. Microbiol Mol Biol Rev (2007) 4.13
Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system. Nat Commun (2012) 4.04
Genus-specific protein binding to the large clusters of DNA repeats (short regularly spaced repeats) present in Sulfolobus genomes. J Bacteriol (2003) 3.07
Transcription, processing and function of CRISPR cassettes in Escherichia coli. Mol Microbiol (2010) 3.05
The rise of regulatory RNA. Nat Rev Genet (2014) 3.02
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. J Biol Chem (2008) 3.00
Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901. PLoS Genet (2005) 2.21
Germ warfare in a microbial mat community: CRISPRs provide insights into the co-evolution of host and viral genomes. PLoS One (2009) 2.02
Insight into microevolution of Yersinia pestis by clustered regularly interspaced short palindromic repeats. PLoS One (2008) 1.86
CRISPR-Cas immunity in prokaryotes. Nature (2015) 1.75
The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity. PLoS Genet (2009) 1.64
Pyrococcus genome comparison evidences chromosome shuffling-driven evolution. Nucleic Acids Res (2002) 1.58
Deinococcus geothermalis: the pool of extreme radiation resistance genes shrinks. PLoS One (2007) 1.52
CRISPR Content Correlates with the Pathogenic Potential of Escherichia coli. PLoS One (2015) 1.50
CRISPR interference: a structural perspective. Biochem J (2013) 1.48
CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli. RNA Biol (2013) 1.45
High-throughput analysis of type I-E CRISPR/Cas spacer acquisition in E. coli. RNA Biol (2013) 1.43
Function and regulation of clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR associated (Cas) systems. Viruses (2012) 1.27
Insights from 20 years of bacterial genome sequencing. Funct Integr Genomics (2015) 1.27
Interference with histidyl-tRNA synthetase by a CRISPR spacer sequence as a factor in the evolution of Pelobacter carbinolicus. BMC Evol Biol (2010) 1.23
High-resolution DNA melt curve analysis of the clustered, regularly interspaced short-palindromic-repeat locus of Campylobacter jejuni. Appl Environ Microbiol (2007) 1.22
Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus. Proc Natl Acad Sci U S A (2006) 1.21
The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae. MBio (2013) 1.18
Transcription activation mediated by a cyclic AMP receptor protein from Thermus thermophilus HB8. J Bacteriol (2007) 1.17
Pervasive generation of oppositely oriented spacers during CRISPR adaptation. Nucleic Acids Res (2014) 1.14
The role of CRISPR-Cas systems in virulence of pathogenic bacteria. Microbiol Mol Biol Rev (2014) 1.12
Target motifs affecting natural immunity by a constitutive CRISPR-Cas system in Escherichia coli. PLoS One (2012) 1.12
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference. Nucleic Acids Res (2015) 1.10
Capsid expansion mechanism of bacteriophage T7 revealed by multistate atomic models derived from cryo-EM reconstructions. Proc Natl Acad Sci U S A (2014) 0.98
Comparative genomics of Bifidobacterium animalis subsp. lactis reveals a strict monophyletic bifidobacterial taxon. Appl Environ Microbiol (2013) 0.98
Structure and RNA-binding properties of the type III-A CRISPR-associated protein Csm3. RNA Biol (2013) 0.95
CRISPRs: molecular signatures used for pathogen subtyping. Appl Environ Microbiol (2013) 0.93
Comparative genome analysis of the high pathogenicity Salmonella Typhimurium strain UK-1. PLoS One (2012) 0.92
Heritable CRISPR/Cas9-mediated genome editing in the yellow fever mosquito, Aedes aegypti. PLoS One (2015) 0.91
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity. Mol Cell (2016) 0.91
Structure of the archaeal Cascade subunit Csa5: relating the small subunits of CRISPR effector complexes. RNA Biol (2013) 0.90
CRISPR-Cas functional module exchange in Escherichia coli. MBio (2014) 0.89
Regulation of the Type I-F CRISPR-Cas system by CRP-cAMP and GalM controls spacer acquisition and interference. Nucleic Acids Res (2015) 0.89
CRISPR transcript processing: a mechanism for generating a large number of small interfering RNAs. Biol Direct (2012) 0.88
CRISPR/Cas9-mediated efficient and heritable targeted mutagenesis in tomato plants in the first and later generations. Sci Rep (2016) 0.87
Complete genome sequence of Bifidobacterium animalis subsp. lactis BLC1. J Bacteriol (2011) 0.87
Different genome stability proteins underpin primed and naïve adaptation in E. coli CRISPR-Cas immunity. Nucleic Acids Res (2015) 0.86
Harnessing CRISPR-Cas9 immunity for genetic engineering. Curr Opin Microbiol (2014) 0.86
Patterns and architecture of genomic islands in marine bacteria. BMC Genomics (2012) 0.85
Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain. J Clin Microbiol (2004) 0.83
A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research. Arterioscler Thromb Vasc Biol (2016) 0.81
DMS3-42: the secret to CRISPR-dependent biofilm inhibition in Pseudomonas aeruginosa. J Bacteriol (2011) 0.81
CRISPR-Cas and Restriction-Modification Act Additively against Conjugative Antibiotic Resistance Plasmid Transfer in Enterococcus faecalis. mSphere (2016) 0.81
The Adaptive Immune System of Haloferax volcanii. Life (Basel) (2015) 0.80
Genome-Wide RNA Sequencing Analysis of Quorum Sensing-Controlled Regulons in the Plant-Associated Burkholderia glumae PG1 Strain. Appl Environ Microbiol (2015) 0.80
Combining CRISPR/Cas9 and rAAV Templates for Efficient Gene Editing. Nucleic Acid Ther (2015) 0.79
Correction of Monogenic and Common Retinal Disorders with Gene Therapy. Genes (Basel) (2017) 0.79
CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases. Front Mol Neurosci (2016) 0.79
Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers. Biochem J (2014) 0.78
Diversity of CRISPR-Cas immune systems and molecular machines. Genome Biol (2015) 0.78
Genetically engineered mouse models in oncology research and cancer medicine. EMBO Mol Med (2016) 0.77
A decade of discovery: CRISPR functions and applications. Nat Microbiol (2017) 0.77
The emerging patent landscape of CRISPR-Cas gene editing technology. Nat Biotechnol (2016) 0.76
Comparative Analysis of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) of Streptococcus thermophilus St-I and its Bacteriophage-Insensitive Mutants (BIM) Derivatives. Curr Microbiol (2016) 0.76
Biased and Unbiased Methods for the Detection of Off-Target Cleavage by CRISPR/Cas9: An Overview. Int J Mol Sci (2016) 0.76
ZouA, a putative relaxase, is essential for dna amplification in Streptomyces kanamyceticus. J Bacteriol (2011) 0.76
Anti-cas spacers in orphan CRISPR4 arrays prevent uptake of active CRISPR-Cas I-F systems. Nat Microbiol (2016) 0.76
CRISPR/Cas9 in zebrafish: an efficient combination for human genetic diseases modeling. Hum Genet (2016) 0.75
Clustered Regularly Interspaced Short Palindromic Repeats: Challenges in Treating Retinal Disease. Asia Pac J Ophthalmol (Phila) (2016) 0.75
To Defend or Not To Defend: That's the Question. mSphere (2016) 0.75
CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease. Int J Mol Sci (2017) 0.75
Visualization analysis of CRISPR/Cas9 gene editing technology studies. J Zhejiang Univ Sci B (2016) 0.75
CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells. Korean J Intern Med (2017) 0.75
Survival and Evolution of CRISPR-Cas System in Prokaryotes and Its Applications. Front Immunol (2016) 0.75
The big bang of genome editing technology: development and application of the CRISPR/Cas9 system in disease animal models. Dongwuxue Yanjiu (2016) 0.75
CRISPR-Cas and Contact-Dependent Secretion Systems Present on Excisable Pathogenicity Islands with Conserved Recombination Modules. J Bacteriol (2017) 0.75
Gene editing using CRISPR-Cas9 for the treatment of lung cancer. Colomb Med (Cali) (2016) 0.75
Priming In A Permissive Type I-C CRISPR-Cas System Reveals Distinct Dynamics Of Spacer Acquisition And Loss. RNA (2017) 0.75
A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes. Anal Biochem (2017) 0.75
Legionella Pneumophila and Dendrimers-Mediated Antisense Therapy. Adv Pharm Bull (2017) 0.75
New variants of CRISPR RNA guided genome editing enzymes. Plant Biotechnol J (2017) 0.75
Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology (2009) 10.67
Long stretches of short tandem repeats are present in the largest replicons of the Archaea Haloferax mediterranei and Haloferax volcanii and could be involved in replicon partitioning. Mol Microbiol (1995) 3.92
Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. Circ Res (2000) 2.42
Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma. Ann Oncol (2010) 1.55
Variation of environmental features and microbial populations with salt concentrations in a multi-pond saltern. Microb Ecol (1985) 1.27
Transcription at different salinities of Haloferax mediterranei sequences adjacent to partially modified PstI sites. Mol Microbiol (1993) 1.21
The neurophysiological profile of vitamin B12 deficiency. Muscle Nerve (1990) 1.05
Halobacterium mediterranei spec, nov., a New Carbohydrate-Utilizing Extreme Halophile. Syst Appl Microbiol (1983) 0.98
Differentially transcribed regions of Haloferax volcanii genome depending on the medium salinity. J Bacteriol (1996) 0.91
Effects of salt and temperature on plasmid topology in the halophilic archaeon Haloferax volcanii. J Bacteriol (1994) 0.91
Idiotype vaccines for human B-cell malignancies. Curr Pharm Des (2010) 0.86
Osmotically induced response in representatives of halophilic prokaryotes: the bacterium Halomonas elongata and the archaeon Haloferax volcanii. J Bacteriol (1997) 0.85
Fertility regulation in nursing women: IV. Long-term influence of a low-dose combined oral contraceptive initiated at day 30 postpartum upon lactation and infant growth. Contraception (1983) 0.84
Fertility regulation in nursing women: III. Short-term influence of a low-dose combined oral contraceptive upon lactation and infant growth. Contraception (1983) 0.83
Opposite effects of myocardial stretch and verapamil on the complexity of the ventricular fibrillatory pattern: an experimental study. Pacing Clin Electrophysiol (2000) 0.79
Purification and characterization of guanine nucleotide-exchange factor, eIF-2B, and p37 calmodulin-binding protein from calf brain. J Neurochem (1995) 0.79
Evidence for salt-associated restriction pattern modifications in the archaeobacterium Haloferax mediterranei. J Bacteriol (1990) 0.78
[Effect of a combined oral contraceptive on lactation and growth of the infant]. Rev Chil Obstet Ginecol (1983) 0.78
[Intrauterine growth in Chilean middle class newborn infants]. Rev Chil Pediatr (1990) 0.77
Auditory and somatosensory evoked potentials in a case of "locked-in" syndrome: a clinical and pathological study. Electromyogr Clin Neurophysiol (1989) 0.77
[Intrauterine growth curve for the appropriate diagnosis of intrauterine growth retardation]. Rev Med Chil (1989) 0.77
Fertility regulation in nursing women. VI. Contraceptive effectiveness of a subdermal progesterone implant. Contraception (1984) 0.76
Quantitative detection of Helicobacter pylori in water samples by real-time PCR amplification of the cag pathogenicity island gene, cagE. J Appl Microbiol (2009) 0.76
PTEN protein expression correlates with PTEN gene molecular changes but not with VEGF expression in astrocytomas. Diagn Mol Pathol (2003) 0.76
[The maternal-neonatal characteristics of intrauterine growth retardation]. Rev Chil Obstet Ginecol (1992) 0.75
Use of self-organizing maps for analyzing the behavior of canines displaced towards midline under interceptive treatment. Med Oral Patol Oral Cir Bucal (2017) 0.75
Fertility regulation in nursing women: I. The probability of conception in full nursing women living in an urban setting. J Biosoc Sci (1982) 0.75
[Feeding in the 1st year of life]. Rev Chil Pediatr (1989) 0.75
[Influence of Norplant contraceptive implants on lactation and infant growth]. Rev Chil Obstet Ginecol (1985) 0.75
Fertility regulation in nursing women: VII. Influence of NORPLANT levonorgestrel implants upon lactation and infant growth. Contraception (1985) 0.75
[Umbilical artery catheterization. A 6-year experience]. Rev Chil Pediatr (1987) 0.75
Normal pressure hydrocephalus; associated with Guillain-Barré syndrome. N Y State J Med (1981) 0.75
[Contraception with progesterone pellets during lactation]. Rev Chil Obstet Ginecol (1984) 0.75
[Intrauterine growth in a selected group of Chilean newborn infants. Subdiagnosis of intrauterine growth retardation in Chile?]. Rev Med Chil (1984) 0.75
Detection of a thermostable brain antigen in the circulation of patients after cerebrovascular accident. Int Arch Allergy Appl Immunol (1985) 0.75
Fertility regulation in nursing women. II. Comparative performance of progesterone implants versus placebo and copper T. Am J Obstet Gynecol (1982) 0.75
[A computer system for the management of neonatal data. Hospital Clínico, Universidad Católica de Chile]. Rev Chil Pediatr (1988) 0.75
[Effect of progesterone on lactation and post-partum infertility]. Rev Chil Obstet Ginecol (1980) 0.75
Pulmonary lymphoid lesions in an experimental model of collapsing glomerulopathy in rats. Histol Histopathol (2004) 0.75
[Congenital pulmonary lymphangiectasis]. Rev Chil Pediatr (1990) 0.75
[Amenorrhea, anovulation and infertility associated with breast feeding in a selected group of urban women]. Rev Chil Obstet Ginecol (1987) 0.75
[The experience of the search for Lyme disease in the eastern Canary Islands]. Enferm Infecc Microbiol Clin (1998) 0.75
William P. Letchworth: philanthropist and pioneer epileptologist. Arch Neurol (1993) 0.75
[Coronary arteriosclerosis, ischemic cardiopathy and lipoproteins: their relationship]. Rev Clin Esp (1983) 0.75
[Neonatal polycythemia. Review of 110 cases]. Rev Chil Pediatr (1989) 0.75
The history of the blink reflex. Neurology (1992) 0.75
Growth pattern of selected urban Chilean infants during exclusive breast-feeding. Am J Clin Nutr (1983) 0.75
Fertility regulation in nursing women: VIII. Progesterone plasma levels and contraceptive efficacy of a progesterone-releasing vaginal ring. Contraception (1985) 0.75
[Relation of the brachial perimeter and some indicators of intrauterine growth]. Rev Chil Pediatr (1990) 0.75
[Acute renal failure caused by indomethacin overdose in a premature infant with patent ductus arteriosus]. Rev Chil Pediatr (1987) 0.75
[Usefulness of determining low-avidity IgG antibodies in the diagnosis of primary rubella infection in pregnant women]. Enferm Infecc Microbiol Clin (1998) 0.75
Thermography as a predictor of the more involved side in bilateral carotid disease: case history. Angiology (1987) 0.75
Fertility regulation in nursing women: V. Long-term influence of a low-dose combined oral contraceptive initiated at day 90 postpartum upon lactation and infant growth. Contraception (1983) 0.75
[Exclusive breast feeding: growth of the infant in a selected group of Chilean infants]. Rev Chil Pediatr (1985) 0.75
[Intrauterine growth according to fetal sex and maternal parity]. Rev Chil Pediatr (1990) 0.75
Impact of neonatal intensive care on neonatal mortality in Chile. Pediatrics (1980) 0.75
[Idiotype vaccines in the treatment of follicular lymphoma: current status and future perspectives]. An Sist Sanit Navar (2009) 0.75
[Intrauterine growth in full-term twins without risk factors]. Rev Chil Obstet Ginecol (1994) 0.75
[A computer surveillance system of the critically ill newborn infant patient]. Rev Chil Pediatr (1989) 0.75
[Intrauterine malnutrition: identification of a new high-risk population with a Chilean weight curve]. Rev Med Chil (1986) 0.75