Published in Cell on June 05, 2014
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell (2015) 7.80
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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat Biotechnol (2014) 5.69
In vivo genome editing using Staphylococcus aureus Cas9. Nature (2015) 5.26
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Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature (2015) 3.64
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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat Biotechnol (2015) 3.56
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature (2016) 3.54
Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy. Science (2015) 2.97
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science (2014) 2.93
A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell (2015) 2.65
Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs. Cell Stem Cell (2014) 2.57
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9. Nat Biotechnol (2014) 2.51
Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display. Nat Methods (2015) 2.42
Therapeutic genome editing: prospects and challenges. Nat Med (2015) 2.42
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Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet (2014) 2.17
Correction of a pathogenic gene mutation in human embryos. Nature (2017) 2.09
Rapid reverse genetic screening using CRISPR in zebrafish. Nat Methods (2015) 2.04
The selection and function of cell type-specific enhancers. Nat Rev Mol Cell Biol (2015) 1.93
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Highly efficient Cas9-mediated transcriptional programming. Nat Methods (2015) 1.81
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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells. Nat Biotechnol (2015) 1.71
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Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing. J Assist Reprod Genet (2016) 1.64
The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription. Mol Cell (2015) 1.59
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Hum Mol Genet (2015) 1.56
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Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design. Genetics (2015) 1.52
Precise Editing of the Zebrafish Genome Made Simple and Efficient. Dev Cell (2016) 1.50
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proc Natl Acad Sci U S A (2015) 1.49
Massively parallel high-order combinatorial genetics in human cells. Nat Biotechnol (2015) 1.43
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Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition. Nat Biotechnol (2015) 1.41
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High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome Res (2015) 1.41
Anemia: progress in molecular mechanisms and therapies. Nat Med (2015) 1.41
Genome-editing Technologies for Gene and Cell Therapy. Mol Ther (2016) 1.41
CRISPR-directed mitotic recombination enables genetic mapping without crosses. Science (2016) 1.41
A CRISPR view of development. Genes Dev (2014) 1.41
Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat. PLoS One (2015) 1.40
Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA. Plant Physiol (2015) 1.39
DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science (2015) 1.38
The crystal structure of Cpf1 in complex with CRISPR RNA. Nature (2016) 1.35
Conformational control of DNA target cleavage by CRISPR-Cas9. Nature (2015) 1.35
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HUMAN MICROBIOTA. Small molecules from the human microbiota. Science (2015) 1.34
Targeting Hepatitis B Virus With CRISPR/Cas9. Mol Ther Nucleic Acids (2014) 1.33
Applications of the CRISPR-Cas9 system in cancer biology. Nat Rev Cancer (2015) 1.32
Rational design of a split-Cas9 enzyme complex. Proc Natl Acad Sci U S A (2015) 1.30
Precise in-frame integration of exogenous DNA mediated by CRISPR/Cas9 system in zebrafish. Sci Rep (2015) 1.30
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease. Virology (2014) 1.29
A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. Mol Cell (2015) 1.27
Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease. J Virol (2014) 1.26
CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae. FEMS Yeast Res (2015) 1.25
Target specificity of the CRISPR-Cas9 system. Quant Biol (2014) 1.23
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High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes. Genetics (2015) 1.22
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat Rev Mol Cell Biol (2015) 1.20
Successful transient expression of Cas9 and single guide RNA genes in Chlamydomonas reinhardtii. Eukaryot Cell (2014) 1.19
Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol Cell (2016) 1.19
Cas9-Guide RNA Directed Genome Editing in Soybean. Plant Physiol (2015) 1.18
Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci. Nucleic Acids Res (2016) 1.14
The molecular era of the mitochondrial calcium uniporter. Nat Rev Mol Cell Biol (2015) 1.14
Induced pluripotent stem cells: at the heart of cardiovascular precision medicine. Nat Rev Cardiol (2016) 1.13
Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression. Nucleic Acids Res (2014) 1.13
Two distinct DNA binding modes guide dual roles of a CRISPR-Cas protein complex. Mol Cell (2015) 1.13
Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation. Genome Biol (2015) 1.12
Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans. Sci Rep (2014) 1.12
Origins, genetic landscape, and emerging therapies of small cell lung cancer. Genes Dev (2015) 1.11
RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection. Proc Natl Acad Sci U S A (2014) 1.10
A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice. Nat Biotechnol (2016) 1.10
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference. Nucleic Acids Res (2015) 1.10
CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering. Genetics (2016) 1.10
Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR. Mol Cell (2015) 1.09
Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow. Nat Biotechnol (2016) 1.08
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell (2016) 1.08
Genome-editing revolution: My whirlwind year with CRISPR. Nature (2015) 1.08
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. Cancer Discov (2016) 1.08
Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J Mol Cell Biol (2015) 1.07
Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure. EMBO Rep (2015) 1.07
The structural biology of CRISPR-Cas systems. Curr Opin Struct Biol (2015) 1.07
Induced Pluripotent Stem Cells Meet Genome Editing. Cell Stem Cell (2016) 1.06
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells. Nature (2016) 1.06
Long noncoding RNAs in cancer: from function to translation. Trends Cancer (2015) 1.06
Efficient, complete deletion of synaptic proteins using CRISPR. Neuron (2014) 1.06
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells. Nat Biotechnol (2016) 1.06
CRISPR-Cas9 Can Inhibit HIV-1 Replication but NHEJ Repair Facilitates Virus Escape. Mol Ther (2016) 1.06
Induction of targeted, heritable mutations in barley and Brassica oleracea using RNA-guided Cas9 nuclease. Genome Biol (2015) 1.06
Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04
Cas9 gRNA engineering for genome editing, activation and repression. Nat Methods (2015) 1.04
Gene therapies that restore dystrophin expression for the treatment of Duchenne muscular dystrophy. Hum Genet (2016) 1.04
Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing. Hum Gene Ther (2015) 1.04
One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res (2014) 1.03
Cas9-mediated targeting of viral RNA in eukaryotic cells. Proc Natl Acad Sci U S A (2015) 1.03
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) 48.17
CRISPR provides acquired resistance against viruses in prokaryotes. Science (2007) 29.74
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol (2013) 19.99
A simple cipher governs DNA recognition by TAL effectors. Science (2009) 19.99
Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature (2005) 19.15
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol (2013) 18.01
An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol (2007) 17.80
Small CRISPR RNAs guide antiviral defense in prokaryotes. Science (2008) 17.79
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RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol (2013) 15.51
RNA-programmed genome editing in human cells. Elife (2013) 14.82
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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol (2013) 14.28
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature (2010) 14.21
Phage response to CRISPR-encoded resistance in Streptococcus thermophilus. J Bacteriol (2007) 13.67
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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37
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Genome-scale CRISPR-Cas9 knockout screening in human cells. Science (2013) 12.36
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CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science (2008) 11.82
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Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
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The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli. Nucleic Acids Res (2011) 10.43
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CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology (2005) 9.83
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Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol (2007) 9.23
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