Published in Cell on March 17, 2000
Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils. Biophys J (2002) 3.93
Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J Cell Biol (2001) 3.70
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol (2000) 3.63
Spatial sensing in fibroblasts mediated by 3' phosphoinositides. J Cell Biol (2000) 3.21
Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A (2000) 2.59
Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place. J Membr Biol (2003) 2.43
Cross-talk unfolded: MARCKS proteins. Biochem J (2002) 2.41
The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate. Mol Biol Cell (2002) 2.39
Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2. Nat Cell Biol (2006) 2.11
Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding. J Virol (2007) 2.08
Crystal structure of CapZ: structural basis for actin filament barbed end capping. EMBO J (2003) 1.98
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J (2002) 1.94
Structural determinants for partitioning of lipids and proteins between coexisting fluid phases in giant plasma membrane vesicles. Biochim Biophys Acta (2007) 1.84
Kinetic analysis of receptor-activated phosphoinositide turnover. J Cell Biol (2003) 1.81
Cytoskeleton-membrane interactions in membrane raft structure. Cell Mol Life Sci (2009) 1.59
PIP2 signaling in lipid domains: a critical re-evaluation. EMBO J (2005) 1.59
How are the cellular functions of myosin VI regulated within the cell? Biochem Biophys Res Commun (2007) 1.58
Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization. J Mol Biol (2010) 1.53
GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid. Biochemistry (2004) 1.48
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. J Cell Biol (2001) 1.46
Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn (2010) 1.45
Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J Cell Biol (2002) 1.40
Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum. Trends Cell Biol (2009) 1.37
Determinants of molecular specificity in phosphoinositide regulation. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the endogenous lipid regulating TRPV1. J Biol Chem (2008) 1.37
Translocation and endocytosis for cell-penetrating peptide internalization. J Biol Chem (2009) 1.36
Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes. Mol Cell Biol (2004) 1.32
A computational model for the electrostatic sequestration of PI(4,5)P2 by membrane-adsorbed basic peptides. Biophys J (2004) 1.32
The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem J (2001) 1.31
Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis. Dev Biol (2003) 1.24
Regulation of voltage-gated potassium channels by PI(4,5)P2. J Gen Physiol (2012) 1.22
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22
Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (PIP2)- and cholesterol-containing monolayers. Biochemistry (2009) 1.21
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc Natl Acad Sci U S A (2003) 1.19
Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor. J Cell Biol (2001) 1.17
Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A (2001) 1.16
Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit? Neurobiol Aging (2007) 1.16
Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts. J Cell Biol (2001) 1.15
Increased concentration of polyvalent phospholipids in the adsorption domain of a charged protein. Biophys J (2004) 1.14
Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway. Pflugers Arch (2005) 1.13
A molecular dynamics investigation of lipid bilayer perturbation by PIP2. Biophys J (2010) 1.12
Patellin1, a novel Sec14-like protein, localizes to the cell plate and binds phosphoinositides. Plant Physiol (2004) 1.11
Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway. Plant Physiol (2005) 1.11
Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. J Exp Med (2013) 1.09
Molecular mechanism of membrane targeting by the GRP1 PH domain. J Lipid Res (2008) 1.09
Discovery of a novel class of AKT pleckstrin homology domain inhibitors. Mol Cancer Ther (2008) 1.09
PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. Nat Chem Biol (2014) 1.07
p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression. Nat Commun (2014) 1.06
Regulation of the transient receptor potential channel TRPM3 by phosphoinositides. J Gen Physiol (2015) 1.06
Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflugers Arch (2010) 1.04
Molecular characterization of an Arabidopsis gene encoding a phospholipid-specific inositol polyphosphate 5-phosphatase. Plant Physiol (2004) 1.01
Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction. BMC Syst Biol (2008) 1.01
Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions. Mol Biol Cell (2007) 1.00
Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity. Proc Natl Acad Sci U S A (2001) 1.00
The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells. Proc Natl Acad Sci U S A (2002) 1.00
Regulation of the epithelial sodium channel (ENaC) by membrane trafficking. Biochim Biophys Acta (2010) 0.99
Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones. EMBO J (2004) 0.98
IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. EMBO J (2013) 0.96
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96
Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum. Proc Natl Acad Sci U S A (2010) 0.95
Up-regulation of phosphoinositide metabolism in tobacco cells constitutively expressing the human type I inositol polyphosphate 5-phosphatase. Plant Physiol (2002) 0.95
Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus. Cardiovasc Diabetol (2008) 0.95
Reorganization of actin cytoskeleton by the phosphoinositide metabolite glycerophosphoinositol 4-phosphate. Mol Biol Cell (2003) 0.94
The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Biochemistry (2011) 0.93
High-resolution 1H MAS RFDR NMR of biological membranes. J Magn Reson (2008) 0.92
Assembly of membrane-bound protein complexes: detection and analysis by single molecule diffusion. Biochemistry (2012) 0.90
Chemical modulation of glycerolipid signaling and metabolic pathways. Biochim Biophys Acta (2014) 0.89
Amphiphysin 1 is important for actin polymerization during phagocytosis. Mol Biol Cell (2007) 0.89
Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation. J Biol Chem (2013) 0.89
Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol (2008) 0.88
High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate. Biochem J (2005) 0.88
Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function. Nat Struct Mol Biol (2016) 0.87
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes. Biochem J (2003) 0.87
Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin. Mol Biol Cell (2003) 0.87
Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization. J Hematol Oncol (2014) 0.87
Molecular mechanism of membrane binding of the GRP1 PH domain. J Mol Biol (2013) 0.87
Cell content of phosphatidylinositol (4,5)bisphosphate in Ehrlich mouse ascites tumour cells in response to cell volume perturbations in anisotonic and in isosmotic media. J Physiol (2007) 0.87
Neuronal survival induced by neurotrophins requires calmodulin. J Cell Biol (2001) 0.86
Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data. Theor Biol Med Model (2006) 0.86
Calmodulin potentiates G beta gamma activation of phospholipase C-beta3. Biochem Pharmacol (2006) 0.85
KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. J Cell Biol (2014) 0.85
Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta. Am J Hum Genet (2016) 0.85
Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study. PLoS One (2012) 0.84
Side-chain oxysterols: from cells to membranes to molecules. Biochim Biophys Acta (2011) 0.83
Lipid agonism: The PIP2 paradigm of ligand-gated ion channels. Biochim Biophys Acta (2015) 0.83
Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator. J Biol Chem (2012) 0.83
Ceramide signals for initiation of yeast mating-specific cell cycle arrest. Cell Cycle (2016) 0.83
Membrane position of a basic aromatic peptide that sequesters phosphatidylinositol 4,5 bisphosphate determined by site-directed spin labeling and high-resolution NMR. Biophys J (2004) 0.83
A novel gene expression pathway regulated by nuclear phosphoinositides. Adv Enzyme Regul (2009) 0.82
Amelogenesis Imperfecta; Genes, Proteins, and Pathways. Front Physiol (2017) 0.82
Phosphatidylinositol 4,5-bisphosphate is an HCV NS5A ligand and mediates replication of the viral genome. Gastroenterology (2014) 0.81
Role and regulation of EGFR in actin remodeling in sperm capacitation and the acrosome reaction. Asian J Androl (2010) 0.81
Exposure to host ligands correlates with colocalization of Gal/GalNAc lectin subunits in lipid rafts and phosphatidylinositol (4,5)-bisphosphate signaling in Entamoeba histolytica. Eukaryot Cell (2012) 0.81
Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors. Biochemistry (2010) 0.81
Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells. J Physiol (2008) 0.80
Ezrin is a Major Regulator of Membrane Tension in Epithelial Cells. Sci Rep (2015) 0.80
Cell-surface sensors: lighting the cellular environment. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2012) 0.79
Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis. Biomol Ther (Seoul) (2017) 0.79
Negative regulation of chemokine receptor signaling and B-cell chemotaxis by p66Shc. Cell Death Dis (2014) 0.79
Genomic analysis of PIS1 gene expression. Eukaryot Cell (2005) 0.78