Nomenclature of voltage-gated calcium channels.

Voltage-gated calcium channels. Cold Spring Harb Perspect Biol (2011) 3.36

The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03

Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev (2008) 2.90

Calcium and arrhythmogenesis. Physiol Rev (2007) 2.76

Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev (2009) 2.53

The ß subunit of voltage-gated Ca2+ channels. Physiol Rev (2010) 2.30

Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO J (2004) 2.15

Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Proc Natl Acad Sci U S A (2003) 2.09

RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci (2007) 1.95

Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J Physiol (2006) 1.92

Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating. Biophys J (2003) 1.83

Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons. Proc Natl Acad Sci U S A (2002) 1.64

Synaptic targeting of N-type calcium channels in hippocampal neurons. J Neurosci (2002) 1.53

Calcium channel alpha2delta subunits: differential expression, function, and drug binding. J Bioenerg Biomembr (2003) 1.49

Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation. J Clin Invest (2001) 1.46

Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J (2001) 1.45

Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel. Hum Mol Genet (2011) 1.37

Molecular determinants of inactivation in voltage-gated Ca2+ channels. J Physiol (2000) 1.30

Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice. J Assoc Res Otolaryngol (2004) 1.29

Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice. J Physiol (2003) 1.29

Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. EMBO J (2001) 1.29

Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels. Proc Natl Acad Sci U S A (2003) 1.29

A short history of voltage-gated calcium channels. Br J Pharmacol (2006) 1.29

Increased phosphorylation of the neuronal L-type Ca(2+) channel Ca(v)1.2 during aging. Proc Natl Acad Sci U S A (2003) 1.28

Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C in human heart tissues. Pharmacogenet Genomics (2006) 1.27

Organization of Ca2+ release units in excitable smooth muscle of the guinea-pig urinary bladder. Biophys J (2004) 1.25

The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword. Prog Neurobiol (2010) 1.23

Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins. Mol Cell Biol (2009) 1.20

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels. Proc Natl Acad Sci U S A (2001) 1.20

Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. J Neurosci (2011) 1.17

Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo. J Biol Chem (2011) 1.16

Regulation of Ca(V)2 calcium channels by G protein coupled receptors. Biochim Biophys Acta (2012) 1.15

A CaVbeta SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ channels. J Gen Physiol (2005) 1.14

L-type Ca2+ channels mediate adaptation of extracellular signal-regulated kinase 1/2 phosphorylation in the ventral tegmental area after chronic amphetamine treatment. J Neurosci (2004) 1.12

Inhibition of cardiac L-type calcium channels by protein kinase C phosphorylation of two sites in the N-terminal domain. Proc Natl Acad Sci U S A (2000) 1.11

N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2. J Biol Chem (2009) 1.11

Functional interplay between NMDA receptors, SK channels and voltage-gated Ca2+ channels regulates synaptic excitability in the medial prefrontal cortex. J Physiol (2010) 1.10

Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse. J Physiol (2001) 1.10

Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation. Biophys J (2002) 1.09

Molecular determinants of inactivation within the I-II linker of alpha1E (CaV2.3) calcium channels. Biophys J (2001) 1.08

Functional modularity of the beta-subunit of voltage-gated Ca2+ channels. Biophys J (2007) 1.07

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies. Br J Pharmacol (2012) 1.07

The impact of splice isoforms on voltage-gated calcium channel alpha1 subunits. J Physiol (2003) 1.06

Low-voltage-activated ("T-Type") calcium channels in review. J Bioenerg Biomembr (2003) 1.06

Subtype-selective reconstitution of synaptic transmission in sympathetic ganglion neurons by expression of exogenous calcium channels. Proc Natl Acad Sci U S A (2003) 1.05

Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain. Pain (2008) 1.02

Calcium channel functions in pain processing. Channels (Austin) (2010) 1.02

Inactivation determinants in segment IIIS6 of Ca(v)3.1. J Physiol (2001) 1.02

Regulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha). J Gen Physiol (2006) 1.02

Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials. J Physiol (2004) 1.02

Allosteric modulation of Ca2+ channels by G proteins, voltage-dependent facilitation, protein kinase C, and Ca(v)beta subunits. Proc Natl Acad Sci U S A (2001) 1.01

Evidence for common structural determinants of activation and inactivation in T-type Ca2+ channels. Pflugers Arch (2006) 1.01

Ca2+ transport properties and determinants of anomalous mole fraction effects of single voltage-gated Ca2+ channels in hair cells from bullfrog saccule. J Physiol (2002) 1.01

Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat (2007) 1.01

Effects of permeant ion concentrations on the gating of L-type Ca2+ channels in hair cells. Biophys J (2003) 1.00

The beta1a subunit regulates the functional properties of adult frog and mouse L-type Ca2+ channels of skeletal muscle. J Physiol (2002) 1.00

Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther (2008) 1.00

Ion interactions in the high-affinity binding locus of a voltage-gated Ca(2+) channel. J Gen Physiol (2000) 0.99

Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. J Neurophysiol (2008) 0.99

Ca(v)1.2 splice variant with exon 9* is critical for regulation of cerebral artery diameter. Am J Physiol Heart Circ Physiol (2009) 0.98

Expression and roles of Cav1.3 (α1D) L-type Ca²+ channel in atrioventricular node automaticity. J Mol Cell Cardiol (2010) 0.98

Calcium channels and short-term synaptic plasticity. J Biol Chem (2013) 0.97

Molecular pharmacology of high voltage-activated calcium channels. J Bioenerg Biomembr (2003) 0.97

Charge movement and transcription regulation of L-type calcium channel alpha(1S) in skeletal muscle cells. J Physiol (2002) 0.97

Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels. J Biol Chem (2010) 0.96

Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice. J Physiol (2010) 0.96

Disturbed atrio-ventricular conduction and normal contractile function in isolated hearts from Cav1.3-knockout mice. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.96

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci (2011) 0.96

Calcium influx pathways in breast cancer: opportunities for pharmacological intervention. Br J Pharmacol (2014) 0.96

Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture. J Biol Chem (2009) 0.95

The Ca(V)2.3 Ca(2+) channel subunit contributes to R-type Ca(2+) currents in murine hippocampal and neocortical neurones. J Physiol (2002) 0.94

Targeting voltage-gated calcium channels for neuropathic pain management. Neurotherapeutics (2009) 0.94

Slow calcium signals after tetanic electrical stimulation in skeletal myotubes. Biophys J (2004) 0.93

Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels. Cell Mol Neurobiol (2002) 0.92

Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation. Am J Physiol Heart Circ Physiol (2008) 0.92

The fourth-generation Calcium channel blocker: cilnidipine. Indian Heart J (2013) 0.91

Antioxidant effects and the therapeutic mode of action of calcium channel blockers in hypertension and atherosclerosis. Philos Trans R Soc Lond B Biol Sci (2005) 0.91

Psychostimulants, L-type calcium channels, kinases, and phosphatases. Neuroscientist (2005) 0.91

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution. Nature (2016) 0.91

Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells. J Physiol (2009) 0.91

The role of MAP1A light chain 2 in synaptic surface retention of Cav2.2 channels in hippocampal neurons. J Neurosci (2008) 0.91

Negatively charged residues in the N-terminal of the AID helix confer slow voltage dependent inactivation gating to CaV1.2. Biophys J (2004) 0.89

Calcium currents are enhanced by α2δ-1 lacking its membrane anchor. J Biol Chem (2012) 0.88

New Generation Calcium Channel Blockers in Hypertensive Treatment. Curr Hypertens Rev (2006) 0.88

Molecular interaction of dihydropyridine receptors with type-1 ryanodine receptors in rat brain. Biochem J (2001) 0.88

Zn2+ sensitivity of high- and low-voltage activated calcium channels. Biophys J (2007) 0.87

Use of a purified and functional recombinant calcium-channel beta4 subunit in surface-plasmon resonance studies. Biochem J (2002) 0.87

In vivo analysis of voltage-dependent calcium channels. J Bioenerg Biomembr (2003) 0.87

Identification of calcium channel alpha1 subunit mRNA expressed in retinal bipolar neurons. Mol Vis (2006) 0.87

Developmental alterations in the biophysical properties of Ca(v) 1.3 Ca(2+) channels in mouse inner hair cells. Channels (Austin) (2013) 0.87

Voltage-gated divalent currents in descending vasa recta pericytes. Am J Physiol Renal Physiol (2010) 0.86

Calcium channels: unanswered questions. J Bioenerg Biomembr (2003) 0.86

Mathematical modeling of calcium signaling during sperm hyperactivation. Mol Hum Reprod (2011) 0.86

Calcium homeostasis in aging neurons. Front Genet (2012) 0.86

Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory. J Biol Chem (2008) 0.86

Electro-magnetic field promotes osteogenic differentiation of BM-hMSCs through a selective action on Ca(2+)-related mechanisms. Sci Rep (2015) 0.85

Tumour necrosis factor alpha activates nuclear factor kappaB signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons. J Physiol (2009) 0.85

Voltage-gated calcium channels in chronic pain: emerging role of alternative splicing. Pflugers Arch (2008) 0.85

Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac voltage-dependent L-type calcium channel. Circ Res (2011) 0.84

Targeting of voltage-gated calcium channel α2δ-1 subunit to lipid rafts is independent from a GPI-anchoring motif. PLoS One (2011) 0.84

The naming of voltage-gated calcium channels. Neuron (1994) 4.31

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature (1984) 10.27

Mechanism of ion permeation through calcium channels. Nature (1984) 9.82

Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature (1985) 9.68

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature (1984) 8.02

The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres. J Physiol (1968) 7.88

Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. J Gen Physiol (1986) 6.76

Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol (1987) 6.72

Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature (1987) 6.66

Membrane organization of the dystrophin-glycoprotein complex. Cell (1991) 6.64

Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J Physiol (1969) 6.59

Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature (1992) 6.37

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature (1988) 6.35

Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle. J Cell Biol (1988) 6.30

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature (1987) 5.94

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature (2003) 5.84

Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science (1998) 5.83

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature (1983) 5.80

A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin. J Cell Biol (1993) 5.73

Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science (1994) 5.62

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A (1992) 5.60

Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore. J Gen Physiol (1986) 5.38

Calcium channels in excitable cell membranes. Annu Rev Physiol (1983) 5.37

Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature (1999) 5.36

A novel type of cardiac calcium channel in ventricular cells. Nature (1985) 5.33

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature (1993) 5.31

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Nature (1986) 5.28

Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu Rev Pharmacol Toxicol (1980) 5.27

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature (1989) 5.21

Lidocaine block of cardiac sodium channels. J Gen Physiol (1983) 5.13

Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci (1988) 5.12

Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science (2000) 5.04

The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res (2001) 5.04

A family of hyperpolarization-activated mammalian cation channels. Nature (1998) 4.97

Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. J Physiol (1978) 4.72

Structural homology of Torpedo californica acetylcholine receptor subunits. Nature (1983) 4.70

Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. J Physiol (1985) 4.69

Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum. J Gen Physiol (1988) 4.56

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature (1989) 4.55

Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science (1989) 4.48

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science (1992) 4.44

Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science (1994) 4.38

Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit. Nature (1994) 4.34

The naming of voltage-gated calcium channels. Neuron (1994) 4.31

Reconstruction of the electrical activity of cardiac Purkinje fibres. J Physiol (1975) 4.31

Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle. Nature (1990) 4.23

CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell (1996) 4.08

Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature (1990) 4.05

Modulation of Ca2+ channels by G-protein beta gamma subunits. Nature (1996) 3.79

Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature (1991) 3.77

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76

Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science (1988) 3.75

Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci (1999) 3.73

Calcium channels: mechanisms of selectivity, permeation, and block. Annu Rev Biophys Biophys Chem (1987) 3.72

Single-channel recordings of three types of calcium channels in chick sensory neurones. J Physiol (1987) 3.69

Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature (1982) 3.69

Molecular properties of voltage-sensitive sodium channels. Annu Rev Biochem (1986) 3.69

Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature (1998) 3.68

Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell (1979) 3.67

Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits. J Cell Biol (1993) 3.54

The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. I. Properties. J Biol Chem (1971) 3.52

The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action. J Biol Chem (1971) 3.52

The sodium-potassium adenosine triphosphatase: pharmacological, physiological and biochemical aspects. Pharmacol Rev (1975) 3.51

Single synaptic vesicles fusing transiently and successively without loss of identity. Nature (2003) 3.51

Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J Exp Med (2000) 3.50

Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation (2001) 3.50

The kinetics of synaptic vesicle recycling measured at single presynaptic boutons. Neuron (1993) 3.49

A rat brain Na+ channel alpha subunit with novel gating properties. Neuron (1988) 3.48

Construction and identification by positive hybridization-translation of a bacterial plasmid containing a rat growth hormone structural gene sequence. Nucleic Acids Res (1978) 3.46

Reversal of current through calcium channels in dialysed single heart cells. Nature (1982) 3.43

Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions. Neuron (1995) 3.39

Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. Science (1988) 3.38

Animal models for muscular dystrophy show different patterns of sarcolemmal disruption. J Cell Biol (1997) 3.32

Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol (1986) 3.31

The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit. Nat Genet (1998) 3.31

Properties of single calcium channels in cardiac cell culture. Nature (1982) 3.30

Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet (1995) 3.29

Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron (1999) 3.29

Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature (1985) 3.28

Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+-permeable pore of the calcium release channel. J Biol Chem (1987) 3.25

Ca2+/calmodulin binds to and modulates P/Q-type calcium channels. Nature (1999) 3.24

Beta-adrenergic modulation of calcium channels in frog ventricular heart cells. Nature (1984) 3.24

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature (1999) 3.21

Intramembrane charge movement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor cDNAs. Nature (1990) 3.16

Auxiliary subunits of voltage-gated ion channels. Neuron (1994) 3.16

trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell (1996) 3.14

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature (1998) 3.13