Published in Immunology on April 01, 2000
Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Infect Immun (2002) 1.45
Clinical and experimental advances in treatment of visceral leishmaniasis. Antimicrob Agents Chemother (2001) 1.39
Testing the efficacy of a multi-component DNA-prime/DNA-boost vaccine against Trypanosoma cruzi infection in dogs. PLoS Negl Trop Dis (2011) 1.06
Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect Immun (2006) 1.02
Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy. Infect Immun (2002) 0.99
Does T Helper Differentiation Correlate with Resistance or Susceptibility to Infection with L. major? Some Insights From the Murine Model. Front Immunol (2012) 0.98
Leishmania mexicana Gp63 cDNA Using Gene Gun Induced Higher Immunity to L. mexicana Infection Compared to Soluble Leishmania Antigen in BALB/C. Iran J Parasitol (2011) 0.86
Ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein. Immunology (2004) 0.84
Natural killer cells in experimental and human leishmaniasis. Front Cell Infect Microbiol (2012) 0.82
Granule-dependent killing of Toxoplasma gondii by CD8+ T cells. Immunology (2001) 0.79
Concepts of immunostimulation to increase antiparasitic drug action. Parasitol Res (2003) 0.75
Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (1991) 38.64
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med (1989) 11.36
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med (1989) 10.60
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med (1988) 7.02
Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med (1993) 5.75
Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity (1998) 5.75
Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med (1993) 5.71
DNA vaccines. Annu Rev Immunol (1997) 5.05
Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci U S A (1991) 4.95
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci U S A (1990) 4.60
DNA-based immunization by in vivo transfection of dendritic cells. Nat Med (1996) 3.62
Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature (1992) 3.50
Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol (1991) 3.40
Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. J Exp Med (1992) 3.34
Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol (1998) 3.17
Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med (1998) 2.84
Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent. Int Immunol (1993) 2.36
In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci U S A (1990) 2.21
Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect Immun (1996) 2.18
Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice. J Immunol (1991) 2.08
IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells. J Immunol (1993) 2.01
Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells. Infect Immun (1996) 1.93
Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol (1991) 1.89
Gene vaccination: plasmid DNA is more than just a blueprint. Immunol Today (1998) 1.86
Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J Exp Med (1995) 1.80
The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis. Exp Parasitol (1989) 1.79
IL-10 mediates susceptibility to Trypanosoma cruzi infection. J Immunol (1994) 1.70
Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect Immun (1993) 1.59
Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int Immunol (1996) 1.43
In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc Natl Acad Sci U S A (1993) 1.43
Xid-associated resistance to experimental Chagas' disease is IFN-gamma dependent. J Immunol (1993) 1.38
Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon. Infect Immun (1996) 1.30
Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors. Proc Natl Acad Sci U S A (1996) 1.23
Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10. J Immunol (1997) 1.21
Role of T helper/inducer cells as well as natural killer cells in resistance to Trypanosoma cruzi infection. Scand J Immunol (1988) 1.18
Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8. Immunol Lett (1995) 1.17
Interleukin-12 is indispensable for protective immunity against Leishmania major. Infect Immun (1997) 1.10
Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL. J Immunol (1994) 0.98
Cytokine gene therapy of cancer using gene gun technology: superior antitumor activity of interleukin-12. Hum Gene Ther (1997) 0.98
In vivo cytokine gene transfer by gene gun reduces tumor growth in mice. Proc Natl Acad Sci U S A (1995) 0.96
Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation. Cell Immunol (1992) 0.95
Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice. Hum Gene Ther (1998) 0.95
Injection of complementary DNA encoding interleukin-12 inhibits tumor establishment at a distant site in a murine renal carcinoma model. Cancer Res (1996) 0.90
Modulation of virus-induced delayed-type hypersensitivity by plasmid DNA encoding the cytokine interleukin-10. Immunology (1998) 0.79
Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (1991) 38.64
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet (2000) 21.52
On a simple form of stromuhr. J Physiol (1912) 16.95
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res (2001) 15.22
Formation of arrowhead complexes with heavy meromyosin in a variety of cell types. J Cell Biol (1969) 13.82
Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS. Nature (2000) 11.64
The DNA sequence of human chromosome 21. Nature (2000) 10.66
Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome. Proc Natl Acad Sci U S A (1982) 6.09
Mitosis and intermediate-sized filaments in developing skeletal muscle. J Cell Biol (1968) 5.78
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood (2001) 5.17
The polymerization of actin: its role in the generation of the acrosomal process of certain echinoderm sperm. J Cell Biol (1973) 4.69
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A (1999) 4.62
Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology (1990) 4.43
Biological and chemical detection of trichothecene mycotoxins of Fusarium species. Appl Microbiol (1973) 4.37
Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc Natl Acad Sci U S A (1995) 4.28
Hepatitis C in hospital employees with needlestick injuries. Ann Intern Med (1991) 4.24
IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03
A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination. FEBS Lett (2000) 4.03
Gene transfer into muscle by electroporation in vivo. Nat Biotechnol (1998) 3.89
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood (1999) 3.46
Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. J Mol Evol (1982) 3.45
Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci U S A (1987) 3.32
Toxicological approaches to the metabolites of Fusaria. IV. Microbial survey on "bean-hulls poisoning of horses" with the isolation of toxic trichothecenes, neosolaniol and T-2 toxin of Fusarium solani M-1-1. Jpn J Exp Med (1972) 3.15
Natural history of branch duct intraductal papillary-mucinous neoplasms of the pancreas without mural nodules: long-term follow-up results. Gut (2007) 3.11
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc Natl Acad Sci U S A (1998) 3.11
The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organelles. J Cell Biol (1980) 3.08
Role of cytosolic phospholipase A2 in allergic response and parturition. Nature (1997) 2.88
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus. Lancet (1992) 2.71
Clonal diversity and host distribution in Bordetella bronchiseptica. J Bacteriol (1987) 2.59
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med (1998) 2.56
Plasma and pituitary concentrations of gonadotropins (FSH and LH) in minke whales (Balaenoptera acutorostrata) during the feeding season. Theriogenology (2001) 2.55
Production of trichothecene mycotoxins by Fusarium species in shake culture. Appl Microbiol (1975) 2.51
Comparative toxicology of trichothec mycotoxins: inhibition of protein synthesis in animal cells. J Biochem (1973) 2.45
CSF spaces in idiopathic normal pressure hydrocephalus: morphology and volumetry. AJNR Am J Neuroradiol (1998) 2.45
Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak. DNA Res (1998) 2.43
Effect of temporal fluctuation of selection coefficient on gene frequency in a population. Proc Natl Acad Sci U S A (1975) 2.41
Complexity of terminal airspace geometry assessed by lung computed tomography in normal subjects and patients with chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A (1999) 2.38
Toxicological approaches to the metabolites of Fusaria. V. Neosolaniol, T-2 toxin and butenolide, toxic metabolites of Fusarium sporotrichioides NRRL 3510 and Fusarium poae 3287. Jpn J Exp Med (1972) 2.37
Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science (1998) 2.32
Formation of elaborate networks of T-system tubules in cultured skeletal muscle with special reference to the T-system formation. J Cell Biol (1968) 2.30
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A (1999) 2.29
Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis. Eur Respir J (2004) 2.27
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science (1992) 2.25
Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol (1997) 2.23
Factors affecting image acquisition during scanning laser polarimetry. Ophthalmic Surg Lasers (1998) 2.23
Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA. Nucleic Acids Res (2000) 2.16
Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest (1995) 2.16
Characterization of pseudotype VSV possessing HCV envelope proteins. Virology (2001) 2.15
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol (1999) 2.14
PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes Cells (2001) 2.13
Body mass index in male patients with COPD: correlation with low attenuation areas on CT. Thorax (2008) 2.12
Expression and replication of hepatitis B virus genome in transgenic mice. Proc Natl Acad Sci U S A (1989) 2.10
Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop. J Exp Med (1996) 2.06
Pandemic of new type of conjunctivitis. Lancet (1972) 2.05
Improved methodology for the simultaneous detection of the trichothecene mycotoxins deoxynivalenol and nivalenol in cereals. Food Addit Contam (1985) 2.05
Role of the Drosophila patched gene in positional signalling. Nature (1991) 2.03
NMR studies of a DNA containing 8-hydroxydeoxyguanosine. Nucleic Acids Res (1991) 2.03
Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase. Biochem Biophys Res Commun (1993) 2.03
Relation of interferon therapy and hepatocellular carcinoma in patients with chronic hepatitis C. Osaka Hepatocellular Carcinoma Prevention Study Group. Ann Intern Med (1998) 2.01
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1992) 2.01
Very fast flagellar rotation. Nature (1994) 2.01
Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. J Biochem (1988) 2.00
Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J Exp Med (1998) 1.98
Retinal nerve fibre layer thickness measurement reproducibility improved with spectral domain optical coherence tomography. Br J Ophthalmol (2009) 1.97
Toxicological approaches to the metabolites of Fusaria. VI. Vomiting factor from moldy corn infected with Fusarium spp. Jpn J Exp Med (1974) 1.95
Solaniol, a toxic metabolite of Fusarium solani. Appl Microbiol (1971) 1.93
Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells. Proc Natl Acad Sci U S A (1986) 1.90
Involvement of IL-6 in mesangial proliferative glomerulonephritis. J Immunol (1989) 1.89
Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. Am J Respir Crit Care Med (2000) 1.88
High Fas ligand expression on lymphocytes in lesions of ulcerative colitis. Gut (1998) 1.88
Effects of cytochaslasin B and colcemide on myogenic cultures. Proc Natl Acad Sci U S A (1975) 1.86
Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. J Gen Virol (1997) 1.82
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Crit Care Med (2001) 1.82
Biological function of the dTDP-rhamnose synthesis pathway in Streptococcus mutans. J Bacteriol (1997) 1.80
Distribution and evolution of bacteriophage WO in Wolbachia, the endosymbiont causing sexual alterations in arthropods. J Mol Evol (2000) 1.80
Estimation of lung growth using computed tomography. Eur Respir J (2003) 1.78
Interferons increase transcription of a major histocompatibility class I gene via a 5' interferon consensus sequence. Mol Cell Biol (1987) 1.78
A new quality assessment parameter for optical coherence tomography. Br J Ophthalmol (2006) 1.78
Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells. Jpn J Cancer Res (1989) 1.77
Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug. Clin Cancer Res (1999) 1.76
The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J (2003) 1.75
Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membrane. Arthritis Rheum (1976) 1.75
Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT. Eur Respir J (2004) 1.74
Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I. Proc Natl Acad Sci U S A (1987) 1.72
Analysis of changes in relative elemental growth rate patterns in the elongation zone of Arabidopsis roots upon gravistimulation. Planta (1998) 1.71
Lateral supraorbital approach as an alternative to the classical pterional approach. Acta Neurochir Suppl (2005) 1.71
Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol (1999) 1.71
Complete nucleotide sequence of the prophage VT2-Sakai carrying the verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7 derived from the Sakai outbreak. Genes Genet Syst (1999) 1.70
Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB. Mol Cell Biol (1993) 1.70
Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. J Biol Chem (1994) 1.68
Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol (1996) 1.66
Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing alpha 1(IX) collagen chains with a central deletion. Proc Natl Acad Sci U S A (1993) 1.66
Hypoxic brain damage: cortical laminar necrosis and delayed changes in white matter at sequential MR imaging. Radiology (1993) 1.65
Toxicological approaches to the metabolites of Fusaria. I. Screening of toxic strains. Jpn J Exp Med (1971) 1.64
Intracellular bacterial symbionts of aphids possess many genomic copies per bacterium. J Mol Evol (1999) 1.63
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr Biol (2000) 1.61
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice. Nature (1990) 1.61
Primary sclerosing cholangitis with marked eosinophilic infiltration in the liver. J Gastroenterol (1995) 1.61