Published in Biochem Biophys Res Commun on September 15, 1993
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J (1998) 3.94
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest (2000) 3.79
1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc Natl Acad Sci U S A (1994) 3.37
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol (1996) 3.08
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest (1995) 2.66
Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5. Proc Natl Acad Sci U S A (1995) 2.58
Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem J (1994) 2.30
Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem J (1994) 2.27
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes. Proc Natl Acad Sci U S A (1994) 2.07
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1997) 1.73
Phosphatidylinositol 3-kinase activity is required for early endosome fusion. Biochem J (1995) 1.47
Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. Mol Biol Cell (1998) 1.43
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Mol Cell Biol (1995) 1.42
The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem J (1995) 1.31
Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci U S A (1994) 1.29
Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells. Biochem J (1996) 1.19
Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation. Biochem J (2001) 1.16
PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma. Cancer Res (2008) 1.13
Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in Fc epsilon RI-mediated signal transduction. Biochem J (1995) 1.06
G(alpha)11 signaling through ARF6 regulates F-actin mobilization and GLUT4 glucose transporter translocation to the plasma membrane. Mol Cell Biol (2001) 1.04
Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin. Biochem J (1996) 1.00
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol (2002) 0.98
Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane. Mol Cell Biol (2006) 0.97
Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor. Proc Natl Acad Sci U S A (1995) 0.97
Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with insulin action. Biochem J (1995) 0.96
Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1996) 0.93
The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin. Biochem J (2000) 0.92
The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes. Biochem J (1996) 0.91
Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with phosphatidylinositol 3-kinase in rat heart. Biochem J (1995) 0.91
Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and beta gamma-subunits of GTP-binding proteins. Biochem J (1996) 0.89
Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats. Cardiovasc Diabetol (2008) 0.87
Function-based discovery of significant transcriptional temporal patterns in insulin stimulated muscle cells. PLoS One (2012) 0.86
Elastin-derived peptides are new regulators of insulin resistance development in mice. Diabetes (2013) 0.86
Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin. Biochem J (1995) 0.86
Roles of insulin, guanosine 5'-[gamma-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation. Biochem J (1996) 0.86
Insulin and insulin-like growth factor I (IGF-I) stimulate GLUT4 glucose transporter translocation in Xenopus oocytes. Biochem J (1995) 0.85
Dissection of stress-activated glucose transport from insulin-induced glucose transport in mammalian cells using wortmannin and ML-9. Biochem J (1995) 0.82
Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3'-kinase with distinct properties. Biochem J (1996) 0.81
Polyphosphoinositide inclusion in artificial lipid bilayer vesicles promotes divalent cation-dependent membrane fusion. Biophys J (1996) 0.81
Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes. J Biol Chem (2010) 0.80
Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism (2008) 0.79
Insulin and secretagogues differentially regulate fluid-phase pinocytosis in insulin-secreting beta-cells. Biochem J (1996) 0.79
Phosphoinositides: Key modulators of energy metabolism. Biochim Biophys Acta (2014) 0.79
Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase. Biochem J (2000) 0.79
Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: a novel mechanism of growth hormone receptor regulation. Proc Natl Acad Sci U S A (1997) 0.78
Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis. Front Endocrinol (Lausanne) (2016) 0.78
An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles. BMC Cell Biol (2008) 0.77
Cortactin, an actin binding protein, regulates GLUT4 translocation via actin filament remodeling. Biochemistry (Mosc) (2011) 0.76
Anti-Diabetic Effects of Jiang Tang Xiao Ke Granule via PI3K/Akt Signalling Pathway in Type 2 Diabetes KKAy Mice. PLoS One (2017) 0.75
Crystal structure of rhodopsin: A G protein-coupled receptor. Science (2000) 28.60
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet (2001) 18.55
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res (2001) 15.22
The DNA sequence of human chromosome 21. Nature (2000) 10.66
Protein localization in E. coli: is there a common step in the secretion of periplasmic and outer-membrane proteins? Cell (1981) 8.24
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell (1985) 7.45
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol (2000) 5.73
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc Natl Acad Sci U S A (1982) 5.68
Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. Biochemistry (1982) 5.33
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res (2001) 5.04
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem (1994) 4.90
Universal spelling. Nature (1996) 4.59
A new micromethod for the colorimetric determination of inorganic phosphate. Clin Chim Acta (1966) 4.39
Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature. J Bacteriol (1978) 4.38
Biological and chemical detection of trichothecene mycotoxins of Fusarium species. Appl Microbiol (1973) 4.37
Synthesis and assembly of the membrane proteins in E. coli. Cell (1977) 4.18
Benzodiazepine receptor: demonstration in the central nervous system. Science (1977) 3.92
Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage (2002) 3.88
Complete nucleotide sequence of the metapyrocatechase gene on the TOI plasmid of Pseudomonas putida mt-2. J Biol Chem (1983) 3.81
Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference. Development (2000) 3.70
Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science (1998) 3.68
Clinical features and management of hepatic portal venous gas: four case reports and cumulative review of the literature. Arch Surg (2001) 3.66
Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry (2001) 3.62
Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. J Mol Evol (1982) 3.45
BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med (2001) 3.40
SecA protein hydrolyzes ATP and is an essential component of the protein translocation ATPase of Escherichia coli. EMBO J (1989) 3.33
Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci U S A (1987) 3.32
A temperature-sensitive mutant of E. coli exhibiting slow processing of exported proteins. Cell (1983) 3.26
Prospective randomized pilot trial of selective biliary cannulation using pancreatic guide-wire placement. Endoscopy (2003) 3.24
Topology analysis of the SecY protein, an integral membrane protein involved in protein export in Escherichia coli. EMBO J (1987) 3.24
Toxicological approaches to the metabolites of Fusaria. IV. Microbial survey on "bean-hulls poisoning of horses" with the isolation of toxic trichothecenes, neosolaniol and T-2 toxin of Fusarium solani M-1-1. Jpn J Exp Med (1972) 3.15
Biosynthesis of RNA polymerase in Escherichia coli. I. Control of RNA polymerase content at various growth rates. Mol Gen Genet (1974) 3.15
Synthesis, assembly into the cytoplasmic membrane, and proteolytic processing of the precursor of coliphage M13 coat protein. J Biol Chem (1980) 3.09
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem Sci (1995) 3.08
Identification and characterization of an Escherichia coli gene required for the formation of correctly folded alkaline phosphatase, a periplasmic enzyme. EMBO J (1992) 3.08
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity. J Biol Chem (1982) 3.04
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J Biol Chem (1997) 3.03
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet (1998) 3.01
Isolation of TOL and RP4 recombinants by integrative suppression. J Bacteriol (1978) 3.00
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A (1987) 2.99
Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J (1994) 2.94
An in vitro investigation of the acetabular labral seal in hip joint mechanics. J Biomech (2003) 2.92
Nucleotide sequence surrounding transcription initiation site of xylABC operon on TOL plasmid of Pseudomonas putida. Proc Natl Acad Sci U S A (1984) 2.91
Heat shock regulatory gene (htpR) of Escherichia coli is required for growth at high temperature but is dispensable at low temperature. Proc Natl Acad Sci U S A (1984) 2.89
Intestinal intraepithelial lymphocytes are a distinct set of gamma delta T cells. Nature (1988) 2.89
Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A (1986) 2.83
Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma. Am J Clin Pathol (1999) 2.81
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. J Gen Virol (1992) 2.74
Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development (2000) 2.73
A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cells. J Biol Chem (1983) 2.65
The acetabular labrum seal: a poroelastic finite element model. Clin Biomech (Bristol, Avon) (2000) 2.64
Calcium and potassium currents of the membrane of a barnacle muscle fibre in relation to the calcium spike. J Physiol (1969) 2.63
The influence of the acetabular labrum on hip joint cartilage consolidation: a poroelastic finite element model. J Biomech (2000) 2.62
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med (1998) 2.56
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet (1999) 2.54
Ultrasound-guided infraclavicular brachial plexus block: an alternative technique to anatomical landmark-guided approaches. Reg Anesth Pain Med (2001) 2.53
Effects of mutations in heat-shock genes groES and groEL on protein export in Escherichia coli. EMBO J (1989) 2.53
De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. Neurology (2009) 2.53
An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue. Biochem Med (1977) 2.52
Production of trichothecene mycotoxins by Fusarium species in shake culture. Appl Microbiol (1975) 2.51
Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase. J Biol Chem (1987) 2.51
The Sec protein-translocation pathway. Trends Microbiol (2001) 2.48
Changes in anterior chamber angle width and depth after intraocular lens implantation in eyes with glaucoma. Ophthalmology (2000) 2.48
Fragmin: a calcium ion sensitive regulatory factor on the formation of actin filaments. Biochemistry (1980) 2.48
Linkage disequilibrium in natural populations of Drosophila melanogaster Seasonal variation. Genetics (1977) 2.47
Respiratory hospital admissions and summertime haze air pollution in Toronto, Ontario: consideration of the role of acid aerosols. Environ Res (1994) 2.47
High prevalence of anti-hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan. Gut (1999) 2.46
Fractures of the coracoid process. J Bone Joint Surg Br (1997) 2.45
Comparative toxicology of trichothec mycotoxins: inhibition of protein synthesis in animal cells. J Biochem (1973) 2.45
CSF spaces in idiopathic normal pressure hydrocephalus: morphology and volumetry. AJNR Am J Neuroradiol (1998) 2.45
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. Mol Cell Biol (2001) 2.44
Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Nat Genet (1998) 2.44
Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak. DNA Res (1998) 2.43
Effect of temporal fluctuation of selection coefficient on gene frequency in a population. Proc Natl Acad Sci U S A (1975) 2.41
Toxicological approaches to the metabolites of Fusaria. V. Neosolaniol, T-2 toxin and butenolide, toxic metabolites of Fusarium sporotrichioides NRRL 3510 and Fusarium poae 3287. Jpn J Exp Med (1972) 2.37
Anterior capsule contraction and intraocular lens dislocation after implant surgery in eyes with retinitis pigmentosa. Ophthalmology (1998) 2.37
Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J (2005) 2.37
Daily walking combined with diet therapy is a useful means for obese NIDDM patients not only to reduce body weight but also to improve insulin sensitivity. Diabetes Care (1995) 2.33
New cephalosporin derivatives with high antibacterial activities. Chem Pharm Bull (Tokyo) (1977) 2.33
The human amygdala plays an important role in gaze monitoring. A PET study. Brain (1999) 2.33
A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A (2000) 2.31
Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J Biol Chem (1994) 2.31
Respiratory chain is required to maintain oxidized states of the DsbA-DsbB disulfide bond formation system in aerobically growing Escherichia coli cells. Proc Natl Acad Sci U S A (1997) 2.31
Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment. J Nucl Med (1992) 2.30
Epidemiological studies of acute ozone exposures and mortality. J Expo Anal Environ Epidemiol (2001) 2.30
Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature (1991) 2.28
Isolation and physical mapping of temperature-sensitive mutants defective in heat-shock induction of proteins in Escherichia coli. Mol Gen Genet (1984) 2.27
Islets-activating protein (IAP) in Bordetella pertussis that potentiates insulin secretory responses of rats. Purification and characterization. J Biochem (1978) 2.26
Tryptophanyl transfer RNA synthetase and expression of the tryptophan operon in the trpS mutants of Escherichia coli. Genetics (1969) 2.26