Published in J Biol Chem on May 12, 2000
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A (2002) 2.37
Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem (2002) 1.86
A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA. Proc Natl Acad Sci U S A (2002) 1.78
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction. Proc Natl Acad Sci U S A (2001) 1.78
Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol Biol Cell (2006) 1.69
IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. J Clin Invest (2001) 1.60
CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners. Integr Biol (Camb) (2010) 1.32
Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis. Gastroenterology (2010) 1.27
Regulatory actions of the A-kinase anchoring protein Yotiao on a heart potassium channel downstream of PKA phosphorylation. Proc Natl Acad Sci U S A (2004) 1.26
Alveolar epithelial beta2-adrenergic receptors. Am J Respir Cell Mol Biol (2007) 1.23
Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J (2008) 1.17
Physiology of epithelial chloride and fluid secretion. Cold Spring Harb Perspect Med (2012) 1.16
Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells. J Cell Sci (2008) 1.13
CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures. Mol Biol Cell (2010) 1.07
Clara cell impact in air-side activation of CFTR in small pulmonary airways. Proc Natl Acad Sci U S A (2002) 1.04
NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem (2010) 0.98
NHERF and regulation of the renal sodium-hydrogen exchanger NHE3. Pflugers Arch (2005) 0.97
Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells. Mol Biol Cell (2009) 0.91
CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity. J Cell Sci (2012) 0.91
Therapeutic Approaches to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis. Ann Am Thorac Soc (2016) 0.87
Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3. PLoS One (2013) 0.86
Regulation of ABC transporter function via phosphorylation by protein kinases. Curr Pharm Biotechnol (2011) 0.86
Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling. Br J Pharmacol (2014) 0.84
Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling. Br J Pharmacol (2013) 0.83
Apical CFTR expression in human nasal epithelium correlates with lung disease in cystic fibrosis. PLoS One (2013) 0.81
Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR). J Proteomics (2013) 0.79
Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer). J Biol Chem (2015) 0.79
Control of epithelial ion transport by Cl- and PDZ proteins. J Membr Biol (2004) 0.78
Ezrin finds its groove in cholangiocytes. Hepatology (2015) 0.76
Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells. Eur J Oral Sci (2015) 0.75
Porosome in Cystic Fibrosis. Discoveries (Craiova) (2015) 0.75
Sodium-coupled chloride transport by epithelial tissues. Am J Physiol (1979) 4.01
Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations. Nat Med (1996) 3.82
Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell (1990) 3.70
Altered regulation of airway epithelial cell chloride channels in cystic fibrosis. Science (1986) 3.40
Role of CFTR in airway disease. Physiol Rev (1999) 3.33
Quantitative analysis of the packaging capacity of recombinant adeno-associated virus. Hum Gene Ther (1996) 3.26
Ionic conductances of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential differences. J Gen Physiol (1972) 3.19
Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes. Science (1991) 3.12
Crypts are the site of intestinal fluid and electrolyte secretion. Science (1982) 2.66
Separate Cl- conductances activated by cAMP and Ca2+ in Cl(-)-secreting epithelial cells. Proc Natl Acad Sci U S A (1990) 2.49
Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR. Science (1994) 2.24
Ion transport by rabbit colon. I. Active and passive components. J Membr Biol (1976) 2.20
Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells. Nature (1988) 2.13
CFTR biomarkers: time for promotion to surrogate end-point. Eur Respir J (2012) 2.11
Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells. J Gen Physiol (1999) 1.88
A volume-sensitive chloride conductance in human colonic cell line T84. Am J Physiol (1989) 1.84
Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol (1993) 1.80
Chloride secretion by canine tracheal epithelium: I. Role of intracellular c AMP levels. J Membr Biol (1982) 1.79
Active chloride secretion by rabbit colon: calcium-dependent stimulation by ionophore A23187. J Membr Biol (1977) 1.78
Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel. Am J Physiol (1996) 1.78
Chloride secretion by canine tracheal epithelium: II. The cellular electrical potential profile. J Membr Biol (1982) 1.74
E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells. J Biol Chem (2000) 1.73
Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR. Hum Mol Genet (1993) 1.71
A cystic fibrosis pancreatic adenocarcinoma cell line. Proc Natl Acad Sci U S A (1990) 1.62
Coupled sodium-chloride influx across the brush border of rabbit ileum. Am J Physiol (1973) 1.57
Apical membrane chloride channels in a colonic cell line activated by secretory agonists. Am J Physiol (1988) 1.53
ATP alters current fluctuations of cystic fibrosis transmembrane conductance regulator: evidence for a three-state activation mechanism. J Gen Physiol (1994) 1.53
A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells. Am J Physiol (1990) 1.50
Active sodium transport and the electrophysiology of rabbit colon. J Membr Biol (1977) 1.49
Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase. Hum Gene Ther (1995) 1.48
Expression of an abundant alternatively spliced form of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is not associated with a cAMP-activated chloride conductance. Hum Mol Genet (1993) 1.43
Anion permeation in an apical membrane chloride channel of a secretory epithelial cell. J Gen Physiol (1992) 1.43
Na+-K+-Cl- co-transport in the intestine of a marine teleost. Nature (1982) 1.39
Sodium chloride transport by rabbit gallbladder. Direct evidence for a coupled NaCl influx process. J Gen Physiol (1975) 1.37
Brush-border processes and transepithelial Na and Cl transport by rabbit ileum. Am J Physiol (1974) 1.34
Chloride secretion by canine tracheal epithelium: III. Membrane resistances and electromotive forces. J Membr Biol (1983) 1.30
Glibenclamide blockade of CFTR chloride channels. Am J Physiol (1996) 1.30
Chloride secretion by canine tracheal epithelium: IV. Basolateral membrane K permeability parallels secretion rate. J Membr Biol (1984) 1.30
Sodium-dependent chloride secretion across rabbit descending colon. Am J Physiol (1983) 1.28
Rescue of dysfunctional deltaF508-CFTR chloride channel activity by IBMX. J Membr Biol (1999) 1.27
Active K transport across rabbit distal colon: relation to Na absorption and Cl secretion. Am J Physiol (1986) 1.24
Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients. Lancet (1986) 1.23
Modulation of Cl- secretion by benzimidazolones. II. Coordinate regulation of apical GCl and basolateral GK. Am J Physiol (1996) 1.23
CaMKII mediates stimulation of chloride conductance by calcium in T84 cells. Am J Physiol (1991) 1.22
Established cell lines used in cystic fibrosis research. J Cyst Fibros (2004) 1.21
Effect of aldosterone on ion transport by rabbit colon in vitro. J Membr Biol (1978) 1.21
Regulation of CFTR Cl- channel gating by ADP and ATP analogues. J Gen Physiol (1995) 1.21
Effect of acetazolamide on sodium and chloride transport by in vitro rabbit ileum. Am J Physiol (1975) 1.19
Interaction between cell sodium and the amiloride-sensitive sodium entry step in rabbit colon. J Membr Biol (1978) 1.17
Stilbene disulfonate blockade of colonic secretory Cl- channels in planar lipid bilayers. Am J Physiol (1989) 1.17
Forskolin-induced apical membrane insertion of virally expressed, epitope-tagged CFTR in polarized MDCK cells. Am J Physiol Cell Physiol (2000) 1.15
Effects of anions on amiloride-sensitive, active sodium transport across rabbit colon, in vitro. Evidence for "trans-inhibition" of the Na entry mechanism. J Membr Biol (1977) 1.14
Hormonal control of chloride secretion by canine tracheal epithelium: an electrophysiologic analysis. Ann N Y Acad Sci (1981) 1.13
Intracellular chloride activities in rabbit gallbladder: direct evidence for the role of the sodium-gradient in energizing "uphill" chloride transport. J Membr Biol (1978) 1.13
Cell cycle dependence of chloride permeability in normal and cystic fibrosis lymphocytes. Science (1990) 1.11
An overview of intestinal absorptive and secretory processes. Gastroenterology (1972) 1.11
Syntaxin 1A inhibits regulated CFTR trafficking in xenopus oocytes. Am J Physiol (1999) 1.09
Taurodeoxycholate activates potassium and chloride conductances via an IP3-mediated release of calcium from intracellular stores in a colonic cell line (T84) J Clin Invest (1993) 1.09
Inhibition of intestinal Cl- secretion by clotrimazole: direct effect on basolateral membrane K+ channels. Am J Physiol (1997) 1.08
cAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA. Am J Physiol (1992) 1.08
Coupled sodium-chloride influx across brush border of flounder intestine. J Membr Biol (1979) 1.07
Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector. Hum Gene Ther (1996) 1.07
The carboxyl terminus of the cystic fibrosis transmembrane conductance regulator binds to AP-2 clathrin adaptors. J Biol Chem (2000) 1.05
Mu 2 binding directs the cystic fibrosis transmembrane conductance regulator to the clathrin-mediated endocytic pathway. J Biol Chem (2001) 1.04
The small conductance K+ channel, KCNQ1: expression, function, and subunit composition in murine trachea. J Biol Chem (2001) 1.04
Cellular differentiation is required for cAMP but not Ca(2+)-dependent Cl- secretion in colonic epithelial cells expressing high levels of cystic fibrosis transmembrane conductance regulator. J Biol Chem (1992) 1.04
Effects of monovalent cations on the sodium-alanine interaction in rabbit ileum. Implication of anionic groups in sodium binding. J Gen Physiol (1970) 1.03
A novel effect of amiloride on H+-dependent Na+ transport. Am J Physiol (1983) 1.02
Activation of T84 cell chloride channels by carbachol involves a phosphoinositide-coupled muscarinic M3 receptor. Eur J Pharmacol (1992) 1.02
CFTR-dependent membrane insertion is linked to stimulation of the CFTR chloride conductance. Am J Physiol (1996) 1.02
Chloride channel regulation in secretory epithelia. Fed Proc (1986) 1.00
Role of snare proteins in CFTR and ENaC trafficking. Pflugers Arch (2001) 0.99
Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene. J Immunol (1997) 0.99
Simultaneous analysis of cell Ca2+ and Ca2(+)-stimulated chloride conductance in colonic epithelial cells (HT-29). Cell Regul (1990) 0.99
Lack of conventional ATPase properties in CFTR chloride channel gating. J Membr Biol (1996) 0.98
Single chloride channel currents from canine tracheal epithelial cells. Biochim Biophys Acta (1986) 0.98
cAMP-activated Cl channels in CFTR-transfected cystic fibrosis pancreatic epithelial cells. Am J Physiol (1992) 0.98
Intracellular chloride activities and active chloride absorption in the intestinal epithelium of the winter flounder. J Membr Biol (1979) 0.98
Regulation of the amiloride-sensitive epithelial sodium channel by syntaxin 1A. J Biol Chem (1999) 0.98
Effect of bile salts on transport across brush border of rabbit ileum. Biochim Biophys Acta (1970) 0.97
Epitope tagging permits cell surface detection of functional CFTR. Am J Physiol (1995) 0.95
Ion transport by rabbit colon: II. Unidirectional sodium influx and the effects of amphotericin B and amiloride. J Membr Biol (1978) 0.95
PKA-dependent ENaC trafficking requires the SNARE-binding protein complexin. Am J Physiol Renal Physiol (2005) 0.95
Chloride channels in the luminal membrane of rat pancreatic acini. Pflugers Arch (1997) 0.94
Chloride activities in epithelia. Fed Proc (1980) 0.94
Ca(2+)-dependent Cl- channels in undifferentiated human colonic cells (HT-29). II. Regulation and rundown. Am J Physiol (1993) 0.94
Modulation of K+ channels by arachidonic acid in T84 cells. I. Inhibition of the Ca(2+)-dependent K+ channel. Am J Physiol (1998) 0.93
Estrogen inhibition of cystic fibrosis transmembrane conductance regulator-mediated chloride secretion. J Pharmacol Exp Ther (2000) 0.93
Active potassium transport across guinea-pig distal colon: action of secretagogues. J Physiol (1996) 0.93
Calcium-mediated agonists activate an inwardly rectified K+ channel in colonic secretory cells. Am J Physiol (1993) 0.93
Inhibition of colonic Na+ transport by amiloride analogues. Am J Physiol (1989) 0.92
ION transport by mammalian small intestine. Annu Rev Physiol (1974) 0.92
Ion transport processes in apical membranes of epithelia. Fed Proc (1984) 0.92
Potassium transport by flounder intestinal mucosa. Am J Physiol (1984) 0.92
Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells. Am J Physiol (1994) 0.92
Intracellular Cl concentrations and influxes across the brush border of rabbit ileum. Am J Physiol (1973) 0.90
Psoralens: novel modulators of Cl- secretion. Am J Physiol (1997) 0.90