Evaluation of antidotes for extravasation injury produced by 6-hydroxymethylacylfulvene (MGI 114), a novel cytotoxic antitumor agent, in an intradermal toxicity model in rats.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 10803923)

Published in Cancer Chemother Pharmacol on January 01, 2000

Authors

R F Marshall1, L E Arthaud, J R MacDonald

Author Affiliations

1: MGI Pharma, Inc., Bloomington, MN 55348-2318, USA.

Articles by these authors

A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve (1997) 1.78

The time course for elevated muscle protein synthesis following heavy resistance exercise. Can J Appl Physiol (1995) 1.49

Muscle performance and enzymatic adaptations to sprint interval training. J Appl Physiol (1985) (1998) 1.46

Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506. Biochem J (1998) 1.33

Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114). Biochem Pharmacol (1997) 1.07

Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc (2000) 1.02

Drug uptake and cellular targets of hydroxymethylacylfulvene (HMAF). Biochem Pharmacol (1999) 0.99

Differential cytotoxicity and induction of apoptosis in tumor and normal cells by hydroxymethylacylfulvene (HMAF). Biochem Pharmacol (2000) 0.96

Myofibrillar disruption following acute concentric and eccentric resistance exercise in strength-trained men. Can J Physiol Pharmacol (2000) 0.89

Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model. Cancer Res (1999) 0.85

Cytotoxic effects of MGI 114 are independent of tumor p53 or p21 expression. Anticancer Res (1999) 0.83

The acute effects of androstenedione supplementation in healthy young males. Can J Appl Physiol (2000) 0.83

Biochemical alterations in guinea pig adrenal cortex following administration of PD 132301-2, an inhibitor of acyl-CoA:cholesterol acyltransferase. Life Sci (1995) 0.82

Antitumor activity of MGI 114 (6-hydroxymethylacylfulvene, HMAF), a semisynthetic derivative of illudin S, against adult and pediatric human tumor colony-forming units. Anticancer Drugs (1999) 0.82

An ultrastructural and histochemical study of the prominent inflammatory response in D(+)-galactosamine hepatotoxicity. Br J Exp Pathol (1987) 0.81

5,6 Dihydro-5'-azacytidine (DHAC) restores androgen responsiveness in androgen-insensitive prostate cancer cells. Anticancer Res (1999) 0.81

Morphogenesis of a zone-specific adrenocortical cytotoxicity in guinea pigs administered PD 132301-2, an inhibitor of acyl-CoA:cholesterol acyltransferase. Toxicol Pathol (1993) 0.81

Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicol Appl Pharmacol (1985) 0.81

Prehospital endotracheal tube airway or esophageal gastric tube airway: a critical comparison. Ann Emerg Med (1985) 0.80

Cystamine modulation of galactosamine-induced hepatotoxicity. Toxicol Appl Pharmacol (1984) 0.80

Toxicological assessment of gadoversetamide injection (OptiMARK), a new contrast-enhancement agent for use in magnetic resonance imaging. Invest Radiol (2001) 0.80

In vivo antitumour efficacy of MGI-114 (6-hydroxymethylacylfulvene, HMAF) in various human tumour xenograft models including several lung and gastric tumours. Eur J Cancer (2001) 0.79

Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan. Leukemia (2000) 0.79

Phase I and pharmacokinetic study of irofulven, a novel mushroom-derived cytotoxin, administered for five consecutive days every four weeks in patients with advanced solid malignancies. J Clin Oncol (2000) 0.79

Enhanced antitumour activity of 6-hydroxymethylacylfulvene in combination with topotecan or paclitaxel in the MV522 lung carcinoma xenograft model. Eur J Cancer (2000) 0.79

Alterations in hepatocyte plasma membrane in carbon tetrachloride poisoning. Freeze-fracture analysis of gap junction and electron spin resonance analysis of lipid fluidity. Lab Invest (1986) 0.78

The dermal toxicity of isoamyl-2-cyanoacrylate. J Biomed Mater Res (1972) 0.78

Effects on the monkey, pig and rat pancreas of soy products with varying levels of trypsin inhibitor and comparison with the administration of cholecystokinin. J Nutr (1983) 0.78

MGI 114: augmentation of antitumor activity when combined with topotecan. J Pediatr Hematol Oncol (2000) 0.77

CNTF rescues motoneurons from ontogenetic cell death in-vivo, but not in-vitro. Neuroreport (1991) 0.77

Short-term 17-beta-estradiol administration does not affect metabolism in young males. Int J Sports Med (2001) 0.77

Recognition of cerebrovascular fibromuscular hyperplasia. Arch Surg (1969) 0.76

Ultrastructural juxtaglomerular cell changes in normotensive rats treated with quinapril, an inhibitor of angiotensin-converting enzyme. Toxicol Pathol (1990) 0.76

Targeting apoptosis by hydroxymethylacylfulvene in combination with gamma radiation in prostate tumor cells. Radiat Res (2000) 0.76

ATP depletion is associated with cytotoxicity of a novel lipid regulator in guinea pig adrenocortical cells. Toxicol Appl Pharmacol (1993) 0.76

Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues. J Org Chem (2001) 0.76

Cystamine treatment of chemically induced liver injury. Dev Toxicol Environ Sci (1983) 0.76

Amelioration of carbon tetrachloride-induced hepatic necrosis by post-toxicant treatment with cystamine. Toxicology (1986) 0.76

Acetone potentiation of 1,1,2-trichloroethane hepatotoxicity. Toxicol Lett (1982) 0.76

Covalent binding of 14C-1,1,2-trichloroethane to hepatic proteins following acetone pretreatment. Drug Chem Toxicol (1982) 0.76

Early hypomethylation of 2'-O-ribose moieties in hepatocyte cytoplasmic ribosomal RNA underlies the protein synthetic defect produced by CCl4. J Cell Biol (1987) 0.75

Pilocarpine, a salivary gland radioprotectant, does not inhibit cytotoxic effect of gamma-radiation on squamous cell carcinoma in vitro. Int J Radiat Oncol Biol Phys (1997) 0.75

Methoxyflurane-induced nephrotoxicity: influence of food intake on some biochemical indicators of renal function in Fischer 344 rats. Toxicol Appl Pharmacol (1978) 0.75

Determination of hepatic tissue calcium levels by flame emission spectrophotometry. J Anal Toxicol (1984) 0.75

Comparative inhibition of trypsins from several species by soybean trypsin inhibitors. J Nutr (1983) 0.75

Inhibition of galactosamine cytotoxicity in an in vivo/in vitro hepatocellular toxicity model. Toxicol Appl Pharmacol (1987) 0.75

Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells. Anticancer Res (2001) 0.75

Preclinical safety evaluation of the benzodiazepine quazepam. Arzneimittelforschung (1987) 0.75

Influence of several plant and animal proteins on rat pancreas. J Nutr (1983) 0.75

Validity of predicting mean arterial blood pressure during exercise. Med Sci Sports Exerc (1999) 0.75

Isolation and maintenance of monolayer hepatocytes from the livers of toxin-treated rats. Exp Mol Pathol (1987) 0.75

5,6-Dihydro-5'-azacytidine (DHAC) affects estrogen sensitivity in estrogen-refractory human breast carcinoma cell lines. Anticancer Res (1999) 0.75

Toxicity of the anticancer folate antagonist trimetrexate in rats. Fundam Appl Toxicol (1992) 0.75

A Parkinson-like neurologic deficit in primates is caused by a novel 4-substituted piperidine. Brain Res (1986) 0.75

Hepatic cysteamine and non-protein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats. Drug Chem Toxicol (1985) 0.75

Alterations in lipid metabolism and cellular morphology in the liver of female rats treated with ethmozine. Toxicol Appl Pharmacol (1988) 0.75