Published in Biochem Pharmacol on December 01, 1997
Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products: evidence for both sp2 radical and orthoquinonemethide intermediates. J Am Chem Soc (2006) 1.12
Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm. BMC Complement Altern Med (2012) 0.96
A proposal for the mechanism-of-action of diazoparaquinone natural products. J Am Chem Soc (2005) 0.94
A phase I and pharmacokinetic study of irofulven and capecitabine administered every 2 weeks in patients with advanced solid tumors. Invest New Drugs (2007) 0.82
Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil. Invest New Drugs (2008) 0.82
Chemical and enzymatic reductive activation of acylfulvene to isomeric cytotoxic reactive intermediates. Chem Res Toxicol (2011) 0.82
Susceptibility of the antioxidant selenoenyzmes thioredoxin reductase and glutathione peroxidase to alkylation-mediated inhibition by anticancer acylfulvenes. Chem Res Toxicol (2011) 0.80
Irofulven, a novel inhibitor of DNA synthesis, in metastatic renal cell cancer. Invest New Drugs (2002) 0.77
A phase I and pharmacokinetic study of irofulven and cisplatin administered in a 30-min infusion every two weeks to patients with advanced solid tumors. Invest New Drugs (2006) 0.76
A phase 2 evaluation of irofulven as second-line treatment of recurrent or persistent intermediately platinum-sensitive ovarian or primary peritoneal cancer: a Gynecologic Oncology Group trial. Int J Gynecol Cancer (2010) 0.76
Phase II trial of irofulven (6-hydroxymethylacylfulvene) for patients with advanced renal cell carcinoma. Invest New Drugs (2001) 0.75
Enantioselective total synthesis of (-)-acylfulvene and (-)-irofulven. J Org Chem (2009) 0.75
Changes in prostate-specific antigen (PSA) level correlate with growth inhibition of prostate cancer cells treated in vitro with a novel anticancer drug, irofulven. Invest New Drugs (2001) 0.75
Phase I study of irofulven (MGI 114), an acylfulvene illudin analog, in patients with acute leukemia. Invest New Drugs (2001) 0.75
Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci (1998) 2.39
Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol (1998) 2.36
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol (2000) 2.27
Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J Neurosci (1998) 1.99
Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke (1994) 1.99
The impact of a clinic-based literacy intervention on language development in inner-city preschool children. Pediatrics (2001) 1.90
MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol (2008) 1.84
Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci (1997) 1.84
Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc Natl Acad Sci U S A (1991) 1.82
Syndrome and outbreak detection using chief-complaint data--experience of the Real-Time Outbreak and Disease Surveillance project. MMWR Morb Mortal Wkly Rep (2004) 1.78
A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve (1997) 1.78
Continuous treatment of Barrett's oesophagus patients with proton pump inhibitors up to 13 years: observations on regression and cancer incidence. Aliment Pharmacol Ther (2006) 1.74
Identification and characterization of zebrafish thrombocytes. Br J Haematol (1999) 1.70
Changes in the demographics and perioperative care of stage IA(2)/IB(1) cervical cancer over the past 16 years. Gynecol Oncol (2001) 1.61
Removing a barrier to computer-based outbreak and disease surveillance--the RODS Open Source Project. MMWR Morb Mortal Wkly Rep (2004) 1.60
Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes. Gut (1996) 1.60
Repair of a traumatically amputated penis with return of erectile function. J Urol (1991) 1.53
Effects of III-IV linker mutations on human heart Na+ channel inactivation gating. Circ Res (1994) 1.50
Sequence- and region-specificity of oxaliplatin adducts in naked and cellular DNA. Mol Pharmacol (1998) 1.50
The time course for elevated muscle protein synthesis following heavy resistance exercise. Can J Appl Physiol (1995) 1.49
Muscle performance and enzymatic adaptations to sprint interval training. J Appl Physiol (1985) (1998) 1.46
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ (2004) 1.44
A collagen-like glycoprotein of the extracellular matrix is the undegraded form of type VI collagen. Biochemistry (1984) 1.34
Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506. Biochem J (1998) 1.33
Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors. Cancer Gene Ther (2007) 1.31
How important is removal of the parametrium at surgery for carcinoma of the cervix? Gynecol Oncol (2002) 1.28
The relations of children's emotion regulation to their vicarious emotional responses and comforting behaviors. Child Dev (1994) 1.27
Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Ann Neurol (1998) 1.26
Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53. Mol Cell Biol (1997) 1.17
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol Cell Biol (1998) 1.14
Functional roles of the extracellular segments of the sodium channel alpha subunit in voltage-dependent gating and modulation by beta1 subunits. J Biol Chem (1999) 1.13
Effect of dGTP concentration on human and CHO telomerase. Biochemistry (1999) 1.12
Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase. Ann Neurol (1991) 1.08
The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers--a study of the National Cancer Institute of Canada Clinical Trials Group. Int J Gynecol Cancer (2004) 1.06
Contractile properties of cultured glomerular mesangial cells. Am J Physiol (1985) 1.06
The relations of maternal practices and characteristics to children's vicarious emotional responsiveness. Child Dev (1992) 1.06
Transplantation of pig stem cells into rat brain: proliferation during the first 8 weeks. Exp Neurol (2004) 1.06
Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice. J Neurosurg (1996) 1.04
Undulin, an extracellular matrix glycoprotein associated with collagen fibrils. J Biol Chem (1990) 1.04
Preclinical antitumor activity of 6-hydroxymethylacylfulvene, a semisynthetic derivative of the mushroom toxin illudin S. Cancer Res (1997) 1.02
Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc (2000) 1.02
Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: comparison with rat and guinea pig. Life Sci (2012) 1.01
Tumour proliferation and apoptosis in human uterine cervix carcinoma II: correlations with clinical outcome. Radiother Oncol (1999) 1.01
Serial learning by rhesus monkeys: I. Acquisition and retention of multiple four-item lists. J Exp Psychol Anim Behav Process (1991) 1.01
VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. Oncogene (1999) 1.00
Drug uptake and cellular targets of hydroxymethylacylfulvene (HMAF). Biochem Pharmacol (1999) 0.99
Differential cytotoxicity and induction of apoptosis in tumor and normal cells by hydroxymethylacylfulvene (HMAF). Biochem Pharmacol (2000) 0.96
Cutaneous metastatic adenocarcinoma of gallbladder origin. Arch Dermatol (1982) 0.96
Life span is prolonged in food-restricted autoimmune-prone (NZB x NZW)F(1) mice fed a diet enriched with (n-3) fatty acids. J Nutr (2001) 0.96
Cloning and characterization of the gene for a new epithelial beta-defensin. Genomic structure, chromosomal localization, and evidence for its constitutive expression. J Biol Chem (1999) 0.96
Cold injury in mice: a model to study mechanisms of brain edema and neuronal apoptosis. Prog Neurobiol (1999) 0.95
Altruistic living donors: evaluation for nondirected kidney or liver donation. Am J Transplant (2006) 0.95
Differential analyses of angiogenesis and expression of growth factors in micro- and macrovascular endothelial cells of type 2 diabetic rats. Life Sci (2008) 0.94
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis (2013) 0.94
Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia. Prog Brain Res (1993) 0.94
Apoptosis causes lumen formation during angiogenesis in vitro. Microvasc Res (2002) 0.94
Metastatic cancer without a detectable primary site. Am J Surg (1967) 0.93
The unidentified interstellar infrared bands: PAHs as carriers? Science (1994) 0.93
Demonstration of the extrinsic coagulation pathway in teleostei: identification of zebrafish coagulation factor VII. Proc Natl Acad Sci U S A (2001) 0.93
Four cases of traumatic optic nerve blindness in the horse. Equine Vet J (1986) 0.92
Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats. Brain Res (1994) 0.92
Adult Pseudomonas aeruginosa meningitis: high incidence of underlying medical and/or postneurosurgical conditions and high mortality rate. Jpn J Infect Dis (2007) 0.90
Attenuation and activation characteristics of steel and tungsten and the suitability of these materials for use in a fast neutron multileaf collimator. Med Phys (2001) 0.90
Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother (1999) 0.90
Splenic infarction and spontaneous rupture of the spleen after therapeutic embolization. Cardiovasc Radiol (1978) 0.89
Myofibrillar disruption following acute concentric and eccentric resistance exercise in strength-trained men. Can J Physiol Pharmacol (2000) 0.89
A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell Death Differ (2002) 0.89
Differential regulation of cell cycle characteristics and apoptosis in MMTV-myc and MMTV-ras mouse mammary tumors. Cancer Res (1997) 0.88
Changes in nucleoside transport of HL-60 human promyelocytic cells during N,N-dimethylformamide induced differentiation. Cancer Res (1986) 0.88
Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons. Brain Res (1998) 0.88
Immunological abnormality in C3H/HeJ mice with heritable inflammatory bowel disease. Cell Immunol (1996) 0.88
Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid. J Cereb Blood Flow Metab (2000) 0.88
Induction of intracellular superoxide radical formation by arachidonic acid and by polyunsaturated fatty acids in primary astrocytic cultures. J Neurochem (1988) 0.88
Chunking during serial learning by a pigeon: II. Integrity of a chunk on a new list. J Exp Psychol Anim Behav Process (1991) 0.87
Intraoperative near-infrared indocyanine green-videoangiography (ICG-VA) and graphic analysis of fluorescence intensity in cerebral aneurysm surgery. J Clin Neurosci (2011) 0.87
p53 mutations in epithelial ovarian cancers: possible role in predicting chemoresistance. Cancer J (2001) 0.87
Chunking during serial learning by a pigeon: III. What are the necessary conditions for establishing a chunk? J Exp Psychol Anim Behav Process (1991) 0.86
Characterization of virus-specific T-cell immunity in liver allograft recipients with HCV-induced cirrhosis. Am J Transplant (2008) 0.85
Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model. Cancer Res (1999) 0.85
SOD-1 transgenic mice as a model for studies of neuroprotection in stroke and brain trauma. Ann N Y Acad Sci (1994) 0.85
Discrimination of late apoptotic/necrotic cells (type III) by flow cytometry in solid tumors. Cytometry (1997) 0.85
Neuroprotective role of CuZn-superoxide dismutase in ischemic brain damage. Adv Neurol (1996) 0.84
Edema, cation content, and ATPase activity after middle cerebral artery occlusion in rats. Stroke (1992) 0.84
A multicentred phase III comparative clinical trial of Mesigyna, Cyclofem and Injectable No. 1 given monthly by intramuscular injection to Chinese women. I. Contraceptive efficacy and sid effects. Contraception (1995) 0.84
Cytotoxic effects of MGI 114 are independent of tumor p53 or p21 expression. Anticancer Res (1999) 0.83
Agents that target telomerase and telomeres. Curr Opin Biotechnol (1996) 0.83
Chemotherapy of mammary carcinomas arising in ras transgenic mice. Invest New Drugs (1994) 0.83
The acute effects of androstenedione supplementation in healthy young males. Can J Appl Physiol (2000) 0.83
Phospholipase C inhibitors: a new class of cytotoxic agents. J Med Chem (1994) 0.83
Evaluation of creatine analogues as a new class of anticancer agents using freshly explanted human tumor cells. J Natl Cancer Inst (1994) 0.83
The relations of empathy-related emotions and maternal practices to children's comforting behavior. J Exp Child Psychol (1993) 0.83
Retracted Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells. Mol Pharmacol (1996) 0.83
Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture. Atherosclerosis (2000) 0.83
Assessment of tumor cell repopulation after chemotherapy for advanced ovarian cancer: pilot study. Cytometry A (2003) 0.82
Biochemical alterations in guinea pig adrenal cortex following administration of PD 132301-2, an inhibitor of acyl-CoA:cholesterol acyltransferase. Life Sci (1995) 0.82
Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition. Biochem Pharmacol (1982) 0.82
The altruistic personality: in what contexts is it apparent? J Pers Soc Psychol (1991) 0.82