Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMC 94518)

Published in J Bacteriol on June 01, 2000

Authors

D P Letley1, J C Atherton

Author Affiliations

1: Division of Gastroenterology and Institute of Infections and Immunity, University of Nottingham, Nottingham NG7 2UH, United Kingdom. Darren.Letley@nottingham.ac.uk

Articles citing this

Type V protein secretion pathway: the autotransporter story. Microbiol Mol Biol Rev (2004) 5.80

Helicobacter pylori persistence: biology and disease. J Clin Invest (2004) 4.75

The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J (2000) 2.08

Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains. Intern Med (2008) 1.62

A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation. J Bacteriol (2001) 1.47

Two different families of hopQ alleles in Helicobacter pylori. J Clin Microbiol (2002) 1.25

Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study. J Clin Microbiol (2014) 1.20

The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations. Clin Microbiol Infect (2009) 1.19

Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer. Gut Microbes (2013) 1.13

Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases. J Clin Microbiol (2009) 1.13

Epidemiological link between gastric disease and polymorphisms in VacA and CagA. J Clin Microbiol (2009) 1.13

The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East. Eur J Clin Microbiol Infect Dis (2009) 1.04

Polymorphisms in the intermediate region of VacA impact Helicobacter pylori-induced disease development. J Clin Microbiol (2010) 1.02

A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease. Front Microbiol (2010) 1.00

Remodeling the host environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA). Front Cell Infect Microbiol (2012) 0.96

Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach. J Bacteriol (2004) 0.94

Second and third line treatment options for Helicobacter pylori eradication. World J Gastroenterol (2014) 0.93

Virulence factor genotypes of Helicobacter pylori affect cure rates of eradication therapy. Arch Immunol Ther Exp (Warsz) (2009) 0.91

Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease. Gut Microbes (2013) 0.89

A novel method for genotyping the Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens. J Clin Microbiol (2012) 0.87

Toxigenic Helicobacter pylori induces changes in the gastric mucosal microcirculation in rats. Gut (2002) 0.87

Association of nonsynonymous substitutions in the intermediate region of the vacA gene of Helicobacter pylori with gastric diseases in Taiwan. J Clin Microbiol (2008) 0.87

Comparative genomics of Helicobacter pylori. World J Gastroenterol (2009) 0.83

Prevalence and correlation with clinical diseases of Helicobacter pylori cagA and vacA genotype among gastric patients from Northeast China. Biomed Res Int (2014) 0.83

Helicobacter pylori vacA s1a and s1b alleles from clinical isolates from different regions of Chile show a distinct geographic distribution. World J Gastroenterol (2005) 0.82

Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin. J Mol Biol (2012) 0.82

An Overview of Helicobacter pylori VacA Toxin Biology. Toxins (Basel) (2016) 0.81

Random mutagenesis of Helicobacter pylori vacA to identify amino acids essential for vacuolating cytotoxic activity. Infect Immun (2006) 0.81

Helicobacter pylori vacA i region polymorphism but not babA2 status associated to gastric cancer risk in northwestern Iran. Clin Exp Med (2014) 0.78

Relationship between vacA Types and Development of Gastroduodenal Diseases. Toxins (Basel) (2016) 0.77

Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders. World J Gastroenterol (2013) 0.77

Structural organization of membrane-inserted hexamers formed by Helicobacter pylori VacA toxin. Mol Microbiol (2016) 0.76

Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy. J Clin Pathol (2016) 0.75

Diversification of the vacAs1m1 and vacAs2m2 Strains of Helicobacter pylori in Meriones unguiculatus. Front Microbiol (2016) 0.75

Articles by these authors

Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab Invest (1995) 6.02

Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci U S A (2001) 4.05

Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. J Natl Cancer Inst (1997) 2.95

Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome. Proc Assoc Am Physicians (1999) 2.77

Expanding allelic diversity of Helicobacter pylori vacA. J Clin Microbiol (1998) 2.73

Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa? Gut (1999) 2.43

Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease. Hum Pathol (2001) 1.87

Detection of Helicobacter pylori gene expression in human gastric mucosa. J Clin Microbiol (1995) 1.86

A comprehensive review of the natural history of Helicobacter pylori infection in children. Arch Med Res (2001) 1.85

Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut (2008) 1.69

Improved analysis of picomole quantities of lithium, sodium, and potassium in biological fluids. Am J Physiol (1994) 1.57

The time course of changes in renal tissue composition during mannitol diuresis in the rat. J Physiol (1968) 1.50

Influence of lysine-vasopressin dosage on the time course of changes in renal tissue and urinary composition in the conscious rat. J Physiol (1971) 1.46

Helicobacter pylori vacA and cagA genotypes in Mexican adults and children. J Infect Dis (2000) 1.44

Absence of translationally selected synonymous codon usage bias in Helicobacter pylori. Microbiology (2000) 1.42

Colonization of Mexican patients by multiple Helicobacter pylori strains with different vacA and cagA genotypes. J Clin Microbiol (1999) 1.39

The time course of changes in renal tissue composition duruig water diuresis in the rat. J Physiol (1968) 1.35

Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding. Aliment Pharmacol Ther (2002) 1.35

Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele. J Clin Microbiol (1999) 1.28

Effects of water diuresis and osmotic (mannitol) diuresis on urinary solute excretion by the conscious rat. J Physiol (1968) 1.26

Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion. Infect Immun (2000) 1.23

Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains. Infect Immun (1998) 1.20

Conservation of the cag pathogenicity island is associated with vacA alleles and gastroduodenal disease in South African Helicobacter pylori isolates. Gut (2001) 1.13

Changes in water and electrolyte balance, plasma volume and composition during pregnancy in the rat. J Physiol (1982) 1.13

Effects of pregnancy on glomerular filtration rate and sodium reabsorption in the rat kidney [proceedings]. J Physiol (1977) 1.11

Influence of variations in hydration and in solute excretion of the effects of lysine-vasopressin infusion on urinary and renal tissue composition in the conscious rat. J Physiol (1971) 1.09

High prevalence of potentially virulent strains of Helicobacter pylori in the general male British population. Gut (2000) 1.08

The effect of pregnancy on glomerular filtration rate and salt and water reabsorption in the rat. J Physiol (1981) 1.06

Effects of 0-9 per cent saline infusion on urinary and renal tissue composition in the hydropaenic, normal and hydrated conscious rat. J Physiol (1970) 1.02

Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management. Gut (2006) 1.00

Hormone profiles for progesterone, oestradiol, prolactin, plasma renin activity, aldosterone and corticosterone during pregnancy and pseudopregnancy in two strains of rat: correlation with renal studies. J Endocrinol (1987) 0.99

Healing of duodenal ulcer after eradication of Helicobacter heilmannii. Lancet (1997) 0.98

Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status. Cell Microbiol (2003) 0.97

Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats. Gut (2002) 0.97

Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner. Gut (2003) 0.97

Safety and efficacy of 7-day rabeprazole- and omeprazole-based triple therapy regimens for the eradication of Helicobacter pylori in patients with documented peptic ulcer disease. Aliment Pharmacol Ther (2003) 0.95

Comparison of effects of calcium carbasalate and aspirin on gastroduodenal mucosal damage in human volunteers. Gut (1996) 0.93

Detection of anti-VacA antibody responses in serum and gastric juice samples using type s1/m1 and s2/m2 Helicobacter pylori VacA antigens. Clin Diagn Lab Immunol (1999) 0.92

Acute effects of lysine vasopressin injection (single and continuous) on urinary composition in the conscious water diuretic rat. Pflugers Arch (1969) 0.91

Glomerular filtration rate and sodium and water reabsorption in the early post-partum rat [proceedings]. J Physiol (1978) 0.91

Effect of dietary sodium chloride and posture on plasma immunoreactive atrial natriuretic peptide concentrations in man. Clin Sci (Lond) (1987) 0.90

Effect of posture on plasma immunoreactive atrial natriuretic peptide concentrations in man. Clin Sci (Lond) (1986) 0.89

Evaluation of a method for weighing small tissue samples: investigations into freezing and evaporation. Pflugers Arch (1969) 0.87

Toxigenic Helicobacter pylori induces changes in the gastric mucosal microcirculation in rats. Gut (2002) 0.87

Effects of Helicobacter pylori on the cadherin-catenin complex. J Clin Pathol (2006) 0.87

Clarification of the link between polyunsaturated fatty acids and Helicobacter pylori-associated duodenal ulcer disease: a dietary intervention study. Br J Nutr (1997) 0.86

Stimulation of adhesion molecule expression by Helicobacter pylori and increased neutrophil adhesion to human umbilical vein endothelial cells. FEBS Lett (2002) 0.86

The effect of pseudopregnancy on glomerular filtration rate and salt and water reabsorption in the rat. J Physiol (1982) 0.85

Time course of changes in renal tissue and urinary composition after cessation of constant infusion of lysine vasopressin in the conscious, hydrated rat. J Physiol (1972) 0.85

Glomerular filtration rate and sodium and water reabsorption in the pseudo-pregnant rat [proceedings]. J Physiol (1979) 0.84

Helicobacter pylori downregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion. Cell Microbiol (2013) 0.82

Effects of lysine-vasopressin dosage on renal tissue and urinary composition in the conscious, water diuretic rat. J Physiol (1970) 0.82

Helicobacter pylori induces cyclooxygenase-1 and cyclooxygenase-2 expression in vascular endothelial cells. Scand J Gastroenterol (2003) 0.82

Safety and efficacy of rabeprazole in combination with four antibiotic regimens for the eradication of Helicobacter pylori in patients with chronic gastritis with or without peptic ulceration. Am J Gastroenterol (1998) 0.81

Comparison of chloride concentration and osmolality in proximal tubular fluid, peritubular capillary plasma and systemic plasma in the rat. J Physiol (1977) 0.81

Clustering of South African Helicobacter pylori isolates from peptic ulcer disease patients is demonstrated by repetitive extragenic palindromic-PCR fingerprinting. J Clin Microbiol (2001) 0.80

Factors influencing the effect of lysine-vasopressin infusion on renal medullary osmolality in conscious rats. J Endocrinol (1970) 0.79

Effects of genotypically different strains of Helicobacter pylori on human microvascular endothelial cells in vitro. Dig Dis Sci (2001) 0.79

Renal function in pregnancy. Clin Sci (Lond) (1983) 0.79

Transient saluresis due to lysine-vasopressin administration in the conscious water diuretic rat. J Physiol (1967) 0.78

Lability of renal papillary tissue composition in the rat. J Physiol (1978) 0.78

Assessment of the nephron segments involved in post-obstructive diuresis in man, using lithium clearance. Br J Urol (1989) 0.78

Glomerular filtration rate and salt and water reabsorption during pregnancy in the conscious rat. J Physiol (1983) 0.77

Depletion of medullary urea concentration gradient in rat kidney during osmotic diuresis. J Physiol (1968) 0.76

Helicobacter pylori unmasked--the complete genome sequence. Eur J Gastroenterol Hepatol (1997) 0.76

The rapid effects of lysine-vasopressin clearance on renal tissue composition in the conscious water-diuretic rat. J Physiol (1971) 0.76

Effect of low dose infusion of atrial natriuretic peptide on renal function in man. Clin Sci (Lond) (1988) 0.76

Mycophenolate mofetil for Crohn's disease. Gut (2000) 0.75

Risk of connective tissue disease among women with breast implants. Authors should have made better use of matched control group. BMJ (1998) 0.75

Effect of a meal containing protein on lithium clearance and plasma immunoreactive atrial natriuretic peptide in man. Clin Sci (Lond) (1988) 0.75

MRCP and the diagnosis of suspected bile duct obstruction. Gut (1999) 0.75

H. pylori and risk of ulcer bleeding among users of NSAIDS. Gastroenterology (2000) 0.75

Kidney function in rats with corticomedullary nephrocalcinosis: effects of alterations in dietary calcium and magnesium. J Physiol (1986) 0.75

Effects of urea infusion on water and electrolyte excretion in the hydropaenic rat. J Physiol (1973) 0.75

Influence of saline diuresis on urinary and renal medullary responses to lysine vasopressin infusion in the rat. J Physiol (1970) 0.75

The natriuretic effects of AVP and dDAVP: a lithium clearance study in conscious rats. Acta Physiol Scand Suppl (1990) 0.75

Renal tubular function in the gravid rat. Baillieres Clin Obstet Gynaecol (1987) 0.75

A case of dysphagia with clinically isolated syndrome. Mult Scler (2008) 0.75

Is urea actively transported by the rat kidney? J Physiol (1967) 0.75

Renal physiology. Br J Anaesth (1972) 0.75

A novel computer-driven, servo-controlled fluid replacement technique and its application to renal function studies in conscious rats. Clin Sci (Lond) (1993) 0.75