Published in Development on June 01, 2000
Gene regulatory networks in the evolution and development of the heart. Science (2006) 7.67
Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Dev Cell (2011) 2.27
Vessel and blood specification override cardiac potential in anterior mesoderm. Dev Cell (2007) 2.16
Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovasc Res (2011) 2.03
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet (2005) 1.89
Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. Genes Dev (2002) 1.61
hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches. Development (2010) 1.54
Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev (2005) 1.51
Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell (2015) 1.50
The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem (2000) 1.47
Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. Genes Dev (2001) 1.40
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet (2010) 1.35
Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol (2008) 1.35
Evolutionary origins of the vertebrate heart: Specification of the cardiac lineage in Ciona intestinalis. Proc Natl Acad Sci U S A (2003) 1.34
Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart. Dev Biol (2008) 1.33
Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol (2009) 1.28
Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics. Semin Cell Dev Biol (2006) 1.25
Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases. Genome Biol (2008) 1.22
Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton. Development (2011) 1.21
Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proc Natl Acad Sci U S A (2005) 1.21
Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ Res (2010) 1.21
Characterization of vascular mural cells during zebrafish development. Mech Dev (2009) 1.21
Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function. Development (2011) 1.17
Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Dev Cell (2010) 1.16
Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res (2010) 1.14
Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development (2010) 1.13
Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Dev Biol (2008) 1.12
Zebrafish models in cardiac development and congenital heart birth defects. Differentiation (2012) 1.07
Genetic ablation of neural crest cell diversification. Development (2009) 1.04
Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development (2011) 1.04
Transcriptional regulation of endothelial cell and vascular development. Circ Res (2013) 1.03
Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects. Birth Defects Res A Clin Mol Teratol (2011) 1.03
The zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre-mRNA processing gene during neural crest development. Int J Dev Biol (2012) 1.03
Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Dev Biol (2010) 1.02
Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan. Proc Natl Acad Sci U S A (2006) 1.01
barx1 represses joints and promotes cartilage in the craniofacial skeleton. Development (2013) 0.99
Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation. Dev Biol (2012) 0.98
Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol (2009) 0.98
Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling. Dev Dyn (2009) 0.98
Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Dev Biol (2008) 0.98
Small heat shock protein Hsp27 is required for proper heart tube formation. Genesis (2007) 0.96
Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Dev Biol (2009) 0.94
The PAF1 complex differentially regulates cardiomyocyte specification. Dev Biol (2011) 0.94
Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants. Dev Dyn (2009) 0.94
Retinoic acid signaling is essential for formation of the heart tube in Xenopus. Dev Biol (2006) 0.94
Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet (2014) 0.92
A bHLH code for cardiac morphogenesis. Pediatr Cardiol (2009) 0.91
Pbx acts with Hand2 in early myocardial differentiation. Dev Biol (2009) 0.90
DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development (2009) 0.89
Vgll2a is required for neural crest cell survival during zebrafish craniofacial development. Dev Biol (2011) 0.88
The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis. Dev Biol (2007) 0.88
Developmental change in the function of movement systems: transition of the pectoral fins between respiratory and locomotor roles in zebrafish. Integr Comp Biol (2014) 0.85
Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation. Dev Biol (2011) 0.85
Patterning the limb before and after SHH signalling. J Anat (2003) 0.84
Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development (2013) 0.84
Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genet (2014) 0.83
Myocardium and BMP signaling are required for endocardial differentiation. Development (2015) 0.83
edn1 and hand2 Interact in early regulation of pharyngeal arch outgrowth during zebrafish development. PLoS One (2013) 0.83
MicroRNAs in heart failure: Small molecules with major impact. Glob Cardiol Sci Pract (2014) 0.82
Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. Development (2014) 0.82
Bmp and Shh signaling mediate the expression of satb2 in the pharyngeal arches. PLoS One (2013) 0.81
Specification of jaw identity by the Hand2 transcription factor. Sci Rep (2016) 0.80
tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. Dev Biol (2013) 0.79
Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development. BMC Dev Biol (2010) 0.79
Dermoskeleton morphogenesis in zebrafish fins. Dev Dyn (2010) 0.79
Retinoic acid signaling plays a restrictive role in zebrafish primitive myelopoiesis. PLoS One (2012) 0.79
Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. PLoS One (2013) 0.79
Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genet (2016) 0.77
Knockdown of FABP3 impairs cardiac development in Zebrafish through the retinoic acid signaling pathway. Int J Mol Sci (2013) 0.77
Transcriptional Regulation of Heart Development in Zebrafish. J Cardiovasc Dev Dis (2016) 0.77
Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation. J Dev Biol (2016) 0.76
Comparative transcriptomics of anal fin pigmentation patterns in cichlid fishes. BMC Genomics (2016) 0.75
A HAND2 Loss-of-Function Mutation Causes Familial Ventricular Septal Defect and Pulmonary Stenosis. G3 (Bethesda) (2016) 0.75
Low temperature mitigates cardia bifida in zebrafish embryos. PLoS One (2013) 0.75
Development of the lateral plate mesoderm in medaka Oryzias latipes and Nile tilapia Oreochromis niloticus: insight into the diversification of pelvic fin position. J Anat (2014) 0.75
Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm. Elife (2016) 0.75
Vegfa Impacts Early Myocardium Development in Zebrafish. Int J Mol Sci (2017) 0.75
Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Front Bioeng Biotechnol (2016) 0.75
Zebrafish hox clusters and vertebrate genome evolution. Science (1998) 8.50
A genetic screen for mutations affecting embryogenesis in zebrafish. Development (1996) 7.12
Universal GFP reporter for the study of vascular development. Genesis (2000) 3.97
Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dyn (1996) 3.34
Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation. Cell (1993) 3.25
no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development (1994) 3.14
Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish. Dev Biol (1999) 3.10
A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. Nature (2000) 3.07
Gata5 is required for the development of the heart and endoderm in zebrafish. Genes Dev (1999) 2.95
The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. Development (1992) 2.76
Mouse t haplotypes. Annu Rev Genet (1985) 2.65
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development (1998) 2.58
Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Cell (1984) 2.55
Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes. Cell (1986) 2.40
Genetic analysis of digestive physiology using fluorescent phospholipid reporters. Science (2001) 2.36
Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae. J Neurosci (1989) 2.28
The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation. Development (1997) 2.27
A homeobox gene essential for zebrafish notochord development. Nature (1995) 2.25
Hematopoietic mutations in the zebrafish. Development (1996) 2.25
Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. Curr Biol (2001) 2.16
UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Science (2001) 2.16
Transcriptional initiation and 5' termini of yeast mitochondrial RNA. J Biol Chem (1981) 2.12
Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature (1998) 2.10
Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning. Dev Genet (1998) 1.91
Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation. Dev Biol (1996) 1.86
Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk. Development (1998) 1.86
casanova plays an early and essential role in endoderm formation in zebrafish. Dev Biol (1999) 1.81
Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice. Nat Genet (1996) 1.81
Patterning the zebrafish axial skeleton requires early chordin function. Nat Genet (1999) 1.80
Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar). Development (2000) 1.78
The T-box gene family. Bioessays (1998) 1.78
The ethical validity of using nuclear transfer in human transplantation. JAMA (2000) 1.77
A molecular pathway leading to endoderm formation in zebrafish. Curr Biol (1999) 1.76
Mutations affecting the development of the embryonic zebrafish brain. Development (1996) 1.73
Evolution of mouse chromosome 17 and the origin of inversions associated with t haplotypes. Proc Natl Acad Sci U S A (1989) 1.71
Mutations affecting development of the zebrafish retina. Development (1996) 1.70
Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino. Development (1998) 1.69
Molecular genetics of Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol (1985) 1.68
Discussion point. Origin and specification of the neural tube floor plate: insights from the chick and zebrafish. Curr Opin Neurobiol (2000) 1.67
Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development (1996) 1.65
Mutations affecting craniofacial development in zebrafish. Development (1996) 1.65
Molecular probes define different regions of the mouse t complex. Cell (1985) 1.65
Asymmetric nodal signaling in the zebrafish diencephalon positions the pineal organ. Development (2000) 1.62
casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes Dev (2001) 1.61
Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity. Mech Dev (1996) 1.56
A method for determination of the in situ distribution of chromosomal proteins. Proc Natl Acad Sci U S A (1976) 1.53
An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nat Genet (1994) 1.51
Origins of phage T4 DNA replication as revealed by hybridization to cloned genes. Proc Natl Acad Sci U S A (1979) 1.51
Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences. J Virol (1983) 1.50
The zebrafish klf gene family. Blood (2001) 1.49
Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6. Genomics (1989) 1.48
Mutations affecting development of the notochord in zebrafish. Development (1996) 1.42
The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system. Nature (1991) 1.39
Multiple roles for Gata5 in zebrafish endoderm formation. Development (2001) 1.37
Regional cell movement and tissue patterning in the zebrafish embryo revealed by fate mapping with caged fluorescein. Biochem Cell Biol (1997) 1.36
Evolution of mouse T-box genes by tandem duplication and cluster dispersion. Genetics (1996) 1.35
The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes Dev (2000) 1.35
In vitro characterization of the yeast mitochondrial promoter using single-base substitution mutants. J Biol Chem (1987) 1.34
Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development (2000) 1.32
Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin. Mech Dev (1999) 1.32
A major testicular cell protein specified by a mouse T/t complex gene. Cell (1979) 1.30
The development of the posterior body in zebrafish. Development (1997) 1.29
Too much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo. Dev Biol (2000) 1.29
Mutations affecting development of the zebrafish ear. Development (1996) 1.28
Differential regulation of chordin expression domains in mutant zebrafish. Dev Biol (1997) 1.27
Genes dependent on zebrafish cyclops function identified by AFLP differential gene expression screen. Genesis (2000) 1.24
Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Dev Biol (1994) 1.24
Peripheral pathways are pioneered by an array of central and peripheral neurones in grasshopper embryos. Nature (1982) 1.23
Five of the nine genetically defined regions of mouse t haplotypes are involved in transmission ratio distortion. Genet Res (1987) 1.22
Identification of the neuropeptide transmitter proctolin in Drosophila larvae: characterization of muscle fiber-specific neuromuscular endings. J Neurosci (1988) 1.20
A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene. Curr Biol (1999) 1.20
tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish. Mech Dev (2000) 1.19
Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development. Development (1998) 1.19
Phylogenetic relationships of amphibian families inferred from DNA sequences of mitochondrial 12S and 16S ribosomal RNA genes. Mol Biol Evol (1995) 1.19
Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex. Genes Dev (1987) 1.19
A protein released by DNAase I digestion of drosophila nuclei is preferentially associated with puffs. Cell (1978) 1.19
Genetic organization of the mouse t complex. Cell (1981) 1.18
Cellular mechanisms governing synaptic development in Drosophila melanogaster. J Neurobiol (1993) 1.18
A diversified set of testicular cell proteins specified by genes within the mouse t complex. Cell (1983) 1.16
Expression of T-box genes Tbx2-Tbx5 during chick organogenesis. Mech Dev (1998) 1.15
Nonhomologous pairing in mice heterozygous for a t haplotype can produce recombinant chromosomes with duplications and deletions. Genetics (1986) 1.14
Recombination suppression of mouse t-haplotypes due to chromatin mismatching. Nature (1981) 1.14
Distribution patterns of three subfractions of drosophila nonhistone chromosomal proteins: possible correlations with gene activity. Cell (1977) 1.14
Rescue of Caenorhabditis elegans pharyngeal development by a vertebrate heart specification gene. Proc Natl Acad Sci U S A (1998) 1.13
Cardiovascular development in the zebrafish. II. Endocardial progenitors are sequestered within the heart field. Development (1994) 1.12
Axonal guidance and the development of muscle fiber-specific innervation in Drosophila embryos. J Neurosci (1989) 1.12
Bouncing off microsatellites. Nat Genet (1992) 1.12
Phylogenetic analysis of the alpha-globin pseudogene-4 (Hba-ps4) locus in the house mouse species complex reveals a stepwise evolution of t haplotypes. Mol Biol Evol (1993) 1.11
Characterization of the zebrafish Orb/CPEB-related RNA binding protein and localization of maternal components in the zebrafish oocyte. Mech Dev (1998) 1.11
Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5. Dev Biol (2001) 1.11
A candidate gene family for the mouse t complex responder (Tcr) locus responsible for haploid effects on sperm function. Cell (1988) 1.11
The evolution of paired appendages in vertebrates: T-box genes in the zebrafish. Dev Genes Evol (2000) 1.10
Genomic analysis of the H-2 complex region associated with mouse t haplotypes. Cell (1982) 1.10
An unstable family of large DNA elements in the center of the mouse t complex. J Mol Biol (1987) 1.10
Muscle pioneers: large mesodermal cells that erect a scaffold for developing muscles and motoneurones in grasshopper embryos. Nature (1983) 1.08