Published in Genes Dev on February 15, 2002
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A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev (2008) 2.66
Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development. Cell Cycle (2010) 2.32
A twist of insight - the role of Twist-family bHLH factors in development. Int J Dev Biol (2009) 1.62
FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell (2009) 1.53
Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Dev Biol (2007) 1.49
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Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities. J Biol Chem (2007) 1.34
Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system. Cold Spring Harb Perspect Biol (2009) 1.31
Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet (2009) 1.31
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol (2007) 1.15
Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb. Dev Biol (2006) 1.13
Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Dev Biol (2008) 1.12
Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood (2007) 1.09
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell (2012) 1.07
The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. Blood (2005) 1.04
Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Nature (2014) 1.03
Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development (2010) 1.02
Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish. BMC Dev Biol (2007) 0.99
Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev (2008) 0.99
Twist1 activity thresholds define multiple functions in limb development. Dev Biol (2010) 0.97
Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev Biol (2010) 0.96
Axial Hox9 activity establishes the posterior field in the developing forelimb. Proc Natl Acad Sci U S A (2011) 0.95
Heterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin development. PLoS One (2009) 0.93
HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme. Dev Cell (2014) 0.92
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3. Dev Biol (2012) 0.91
Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds. BMC Dev Biol (2012) 0.90
The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol (2011) 0.89
DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development (2009) 0.89
Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart. Differentiation (2012) 0.85
A novel Gli3 enhancer controls the Gli3 spatiotemporal expression pattern through a TALE homeodomain protein binding site. Mol Cell Biol (2011) 0.84
Patterning the limb before and after SHH signalling. J Anat (2003) 0.84
Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A (2015) 0.83
Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants. Dev Biol (2013) 0.82
T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One (2015) 0.81
Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway. Dev Biol (2014) 0.81
A shift in anterior-posterior positional information underlies the fin-to-limb evolution. Elife (2015) 0.81
Molecular anatomy of the developing limb in the coquí frog, Eleutherodactylus coqui. Evol Dev (2012) 0.80
Sonic Hedgehog Signaling and VACTERL Association. Mol Syndromol (2013) 0.79
The Hedgehog signalling pathway in bone formation. Int J Oral Sci (2015) 0.78
Sonic Hedgehog regulates thymic epithelial cell differentiation. J Autoimmun (2016) 0.77
Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development. Dev Growth Differ (2015) 0.76
Saunders's framework for understanding limb development as a platform for investigating limb evolution. Dev Biol (2016) 0.76
Cilia-dependent GLI processing in neural crest cells is required for tongue development. Dev Biol (2017) 0.75
Inactivation of Sonic Hedgehog Signaling and Polydactyly in Limbs of Hereditary Multiple Malformation, a Novel Type of Talpid Mutant. Front Cell Dev Biol (2016) 0.75
Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin. PLoS One (2015) 0.75
Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet (2016) 0.75
Hedgehog Signalling in the Embryonic Mouse Thymus. J Dev Biol (2016) 0.75
Limb patterning genes and heterochronic development of the emu wing bud. Evodevo (2016) 0.75
The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh. J Exp Med (2017) 0.75
Transcriptional changes in chick wing bud polarization induced by retinoic acid. Dev Dyn (2017) 0.75
John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work? Dev Biol (2017) 0.75
Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis. Development (2017) 0.75
A series of normal stages in the development of the chick embryo. J Morphol (1951) 17.89
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell (2000) 6.08
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet (1993) 3.99
Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet (1997) 3.89
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82
Molecular models for vertebrate limb development. Cell (1997) 2.78
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69
Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet (2000) 2.59
The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development (2000) 2.24
Some distal limb structures develop in mice lacking Sonic hedgehog signaling. Mech Dev (2001) 1.98
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol (1996) 1.85
Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development (1997) 1.77
A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev (1995) 1.76
The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development (2000) 1.76
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech Dev (1997) 1.55
Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Development (2000) 1.54
The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem (2000) 1.47
Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell (1994) 1.34
Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev Biol (1997) 1.31
Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development (2001) 1.20
Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development (1999) 1.12
Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development (1992) 1.11
The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development. Development (1998) 1.09
Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation. Development (1997) 1.05
The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation. Development (1995) 1.02
Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly. Development (2000) 1.02
Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes. Mech Dev (1999) 0.93
Developmental biology. Giving limbs a hand. Nature (2000) 0.82
Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc (2008) 2.80
Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science (2002) 2.45
Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development (2004) 2.39
Tissue remodelling through branching morphogenesis. Nat Rev Mol Cell Biol (2009) 2.06
Dual RMCE for efficient re-engineering of mouse mutant alleles. Nat Methods (2010) 2.05
Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering. Proc Natl Acad Sci U S A (2010) 1.96
Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci U S A (2003) 1.79
Transparency in Research involving Animals: The Basel Declaration and new principles for reporting research in BJP manuscripts. Br J Pharmacol (2015) 1.79
Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development (2007) 1.72
Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev (2004) 1.60
Initiation of proximal-distal patterning in the vertebrate limb by signals and growth. Science (2011) 1.58
A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science (2009) 1.58
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet (2010) 1.35
Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system. Cold Spring Harb Perspect Biol (2009) 1.31
Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling. Development (2006) 1.22
The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb. Development (2003) 1.19
Paraffin embedding tissue samples for sectioning. CSH Protoc (2008) 1.18
Ultraconserved non-coding sequence element controls a subset of spatiotemporal GLI3 expression. Dev Growth Differ (2007) 1.16
Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol (2010) 1.15
Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis. Mech Dev (2002) 1.08
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell (2012) 1.07
Reduced mobility of fibroblast growth factor (FGF)-deficient myoblasts might contribute to dystrophic changes in the musculature of FGF2/FGF6/mdx triple-mutant mice. Mol Cell Biol (2003) 1.03
Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development. Dev Dyn (2004) 1.02
Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth. Development (2013) 0.99
SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development (2011) 0.95
The molecular basis of human congenital limb malformations. Wiley Interdiscip Rev Dev Biol (2012) 0.95
Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos. Development (2003) 0.95
Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development. Development (2007) 0.92
Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2. Liver Int (2004) 0.92
Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development (2012) 0.91
Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds. BMC Dev Biol (2012) 0.90
Genetic interaction of Gli3 and Alx4 during limb development. Int J Dev Biol (2005) 0.90
How do we get a perfect complement of digits? Curr Opin Genet Dev (2008) 0.88
Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development (2012) 0.87
Cutting sections of paraffin-embedded tissues. CSH Protoc (2008) 0.85
Cryosectioning tissues. CSH Protoc (2008) 0.85
Patterning the limb before and after SHH signalling. J Anat (2003) 0.84
Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos. PLoS One (2011) 0.82
The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development. Differentiation (2013) 0.82
Fixation and permeabilization of cells and tissues. CSH Protoc (2008) 0.81
1 Patterning the limb before and after SHH. J Anat (2002) 0.80
Making sense-data-based simulations of vertebrate limb development. Curr Opin Genet Dev (2012) 0.79
Preparation of slides and coverslips for microscopy. CSH Protoc (2008) 0.78
Developmental biology: first come, first served. Nature (2002) 0.78
Dual requirement of ectodermal Smad4 during AER formation and termination of feedback signaling in mouse limb buds. Genesis (2013) 0.78
Mounting live cells attached to coverslips for microscopy. CSH Protoc (2008) 0.77
From cells to organs: new insight into organ morphogenesis. Curr Opin Genet Dev (2009) 0.77
FGF2 signaling is required for the development of neuronal circuits regulating blood pressure. Circ Res (2002) 0.76
Decalcifying tissues for paraffin embedding. CSH Protoc (2008) 0.75
Media for mounting fixed cells on microscope slides. CSH Protoc (2008) 0.75
Forward to the special issue on Hox/Tale transcription factors in development and disease. Dev Dyn (2013) 0.75