Published in Birth Defects Res A Clin Mol Teratol on April 01, 2011
Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. J Am Coll Cardiol (2014) 1.77
HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme. Dev Cell (2014) 0.92
An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes. Stem Cells Transl Med (2014) 0.89
Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart. Differentiation (2012) 0.85
Characterization of circulating microRNA expression in patients with a ventricular septal defect. PLoS One (2014) 0.84
Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle. Cell Mol Life Sci (2013) 0.83
Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death. Dev Biol (2014) 0.79
MESP1 Mutations in Patients with Congenital Heart Defects. Hum Mutat (2016) 0.79
Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing. Physiol Rep (2015) 0.77
Different Cardiac Anomalies in Mother and Son with 4q-Syndrome. Case Rep Genet (2015) 0.75
CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart. Dev Dyn (2016) 0.75
MicroRNAs: pleiotropic players in congenital heart disease and regeneration. J Thorac Dis (2017) 0.75
Rare copy number variants in patients with congenital conotruncal heart defects. Birth Defects Res (2017) 0.75
A HAND2 Loss-of-Function Mutation Causes Familial Ventricular Septal Defect and Pulmonary Stenosis. G3 (Bethesda) (2016) 0.75
HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot. Pediatr Cardiol (2016) 0.75
The functions of animal microRNAs. Nature (2004) 64.85
The impact of microRNAs on protein output. Nature (2008) 32.39
Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature (2005) 17.17
The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell (2007) 12.72
Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation (1990) 7.87
A developmental view of microRNA function. Trends Biochem Sci (2007) 4.75
Noncompaction of the ventricular myocardium. Circulation (2004) 4.19
Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet (1997) 3.89
A genetic blueprint for cardiac development. Nature (2000) 3.45
Clinical features of isolated noncompaction of the ventricular myocardium: long-term clinical course, hemodynamic properties, and genetic background. J Am Coll Cardiol (1999) 3.38
Fibronectin regulates epithelial organization during myocardial migration in zebrafish. Dev Cell (2004) 3.34
The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat Genet (1998) 2.83
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development (2004) 2.61
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet (2000) 2.53
A subclass of bHLH proteins required for cardiac morphogenesis. Science (1995) 2.39
The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development (2000) 2.24
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Mol Cell (2003) 2.16
Vessel and blood specification override cardiac potential in anterior mesoderm. Dev Cell (2007) 2.16
Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol (2001) 2.15
Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat Cell Biol (2007) 1.98
Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet (1998) 1.98
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet (2005) 1.89
A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors. Gene (2003) 1.84
Cardiac neural crest. Semin Cell Dev Biol (2005) 1.77
A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development (1998) 1.71
Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. Development (2007) 1.70
Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev Biol (1995) 1.68
The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J Mol Cell Cardiol (2002) 1.64
A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development (2000) 1.63
A twist of insight - the role of Twist-family bHLH factors in development. Int J Dev Biol (2009) 1.62
Origin and fate of cardiac mesenchyme. Dev Dyn (2008) 1.61
Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo. Development (1992) 1.61
Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Circulation (2001) 1.58
Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development. ScientificWorldJournal (2007) 1.57
A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development (1992) 1.51
Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis. Cardiovasc Res (2004) 1.49
The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem (2000) 1.47
A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Science (1999) 1.44
Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy. Heart (1996) 1.41
Cardiac neural crest cells provide new insight into septation of the cardiac outflow tract: aortic sac to ventricular septal closure. Dev Biol (1998) 1.41
The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner. Mol Biol Cell (2001) 1.35
Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities. J Biol Chem (2007) 1.34
Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol (2007) 1.26
An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol (2008) 1.22
The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest (2000) 1.21
Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ Res (2010) 1.21
Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol (2007) 1.21
Selective modulation of integrin-mediated cell migration by distinct ADAM family members. Mol Biol Cell (2005) 1.20
Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ Res (2008) 1.19
Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development (2004) 1.17
Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development (2010) 1.13
Report of the New England Regional Infant Cardiac Program, by Donald C. Fyler, MD, Pediatrics, 1980;65(suppl):375-461. Pediatrics (1998) 1.12
Hand2 regulates epithelial formation during myocardial diferentiation. Curr Biol (2005) 1.12
Expanding roles for alpha 4 integrin and its ligands in development. Cell Adhes Commun (1994) 1.10
The rate and anisotropy of impulse propagation in the postnatal terminal crest are correlated with remodeling of Cx43 gap junction pattern. Cardiovasc Res (2000) 1.07
Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn (2007) 1.06
HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a. Dev Biol (2003) 1.04
Double outlet right ventricle: aetiologies and associations. J Med Genet (2008) 1.01
Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart. Development (2006) 1.01
Beta-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts. Cardiovasc Res (2003) 1.00
alpha4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development. Mech Dev (2001) 0.98
The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA. J Biol Chem (2003) 0.97
Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev Biol (2010) 0.96
Remodeling of the hypertrophied human myocardium by cardiac bHLH transcription factors. J Cell Biochem (1999) 0.94
Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn (2010) 0.94
Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart. Mol Cell Biol (2004) 0.93
A bHLH code for cardiac morphogenesis. Pediatr Cardiol (2009) 0.91
Signals controlling neural crest contributions to the heart. Wiley Interdiscip Rev Syst Biol Med (2010) 0.91
Pbx acts with Hand2 in early myocardial differentiation. Dev Biol (2009) 0.90
Transcription factor HAND2 mutations in sporadic Chinese patients with congenital heart disease. Chin Med J (Engl) (2010) 0.90
Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice. J Mol Cell Cardiol (2009) 0.90
DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development (2009) 0.89
Identification of Thymosin β4 as an effector of Hand1-mediated vascular development. Nat Commun (2010) 0.88
The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis. Dev Biol (2007) 0.88
Deletion (4)(q33 --> qter): a case report and review of the literature. J Child Neurol (1997) 0.88
Fibronectin peptides in cell migration and wound repair. J Clin Invest (2000) 0.86
The molecular basis of congenital heart disease. Semin Thorac Cardiovasc Surg (2007) 0.86
HAND proteins: molecular mediators of cardiac development and congenital heart disease. Trends Cardiovasc Med (1999) 0.86
A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Gene Expr Patterns (2002) 0.85
Unbalanced t(4;11)(q32;q23) in a 34-year-old man with manifestations of distal monosomy 11q and trisomy 4q syndromes. Am J Med Genet (1997) 0.83
Thymosin beta4 and cardiac repair. Ann N Y Acad Sci (2010) 0.83
Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability. Dev Dyn (2010) 0.80
Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Dev Genes Evol (2009) 0.80
Ventricular non-compaction in the setting of double-outlet right ventricle (tetralogy of Fallot type) with doubly committed subarterial ventricular septal defect. Heart (2007) 0.76
Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res (2008) 2.44
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Mol Cell (2003) 2.16
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet (2005) 1.89
The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J Mol Cell Cardiol (2002) 1.64
A twist of insight - the role of Twist-family bHLH factors in development. Int J Dev Biol (2009) 1.62
Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ Res (2011) 1.57
Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer. Dev Biol (2007) 1.35
Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities. J Biol Chem (2007) 1.34
Cardiovascular development and the colonizing cardiac neural crest lineage. ScientificWorldJournal (2007) 1.26
An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol (2008) 1.22
Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells. Blood (2011) 1.06
Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev Dyn (2008) 1.05
HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a. Dev Biol (2003) 1.04
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. J Immunol (2012) 1.02
Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev Biol (2010) 0.96
Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn (2010) 0.94
A bHLH code for cardiac morphogenesis. Pediatr Cardiol (2009) 0.91
HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. Biochem Biophys Res Commun (2002) 0.87
Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest. PLoS Genet (2013) 0.87
A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis. J Neurosci (2012) 0.86
Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development (2013) 0.86
Riley Heart Center Symposium on Cardiac Development 2009: Transcriptional Unification of Heart Morphogenesis. Pediatr Cardiol (2010) 0.85
Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart. Differentiation (2012) 0.85
The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain. J Biol Chem (2013) 0.83
Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability. Dev Dyn (2010) 0.80
Another hat for myocardin. J Mol Cell Cardiol (2002) 0.77
Functional screening of intracardiac cell transplants using two-photon fluorescence microscopy. Pediatr Cardiol (2012) 0.75
A glimpse of Cre-mediated controversies in epicardial signalling. Cardiovasc Res (2013) 0.75
Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease. Pediatr Cardiol (2012) 0.75