Published in Gene on May 30, 2000
A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A (2001) 33.71
Deciphering protein-protein interactions. Part I. Experimental techniques and databases. PLoS Comput Biol (2007) 2.84
Analysis of MADS box protein-protein interactions in living plant cells. Proc Natl Acad Sci U S A (2002) 1.67
Mapping the human translation elongation factor eEF1H complex using the yeast two-hybrid system. Biochem J (2002) 0.95
A split-ubiquitin yeast two-hybrid screen to examine the substrate specificity of atToc159 and atToc132, two Arabidopsis chloroplast preprotein import receptors. PLoS One (2014) 0.87
Resolving the network of cell signaling pathways using the evolving yeast two-hybrid system. Biotechniques (2008) 0.84
Identification of protein interactions involved in cellular signaling. Mol Cell Proteomics (2013) 0.84
False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform. J Am Soc Mass Spectrom (2013) 0.78
Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study. J Vis Exp (2016) 0.77
A dual-light reporter system to determine the efficiency of protein-protein interactions in mammalian cells. Nucleic Acids Res (2005) 0.75
Correlation of two-hybrid affinity data with in vitro measurements. Mol Cell Biol (1995) 4.63
The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. J Biol Chem (1997) 2.42
Integrin signalling: a new Cas(t) of characters enters the stage. Trends Cell Biol (2000) 2.39
Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22. Oncogene (1997) 2.31
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene (1999) 2.20
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Mol Cell Biol (1996) 2.12
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation. Mol Cell Biol (1995) 2.03
MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. Proc Natl Acad Sci U S A (1999) 1.99
HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells. Oncogene (2006) 1.94
Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol Cell Biol (1998) 1.56
ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. J Biol Chem (1997) 1.44
Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II. Oncogene (1998) 1.41
Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology. Mol Biol Cell (1995) 1.32
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites. Mol Cell Biol (2000) 1.31
Analysis of the interaction of the novel RNA polymerase II (pol II) subunit hsRPB4 with its partner hsRPB7 and with pol II. Mol Cell Biol (1998) 1.30
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. Mol Cell Biol (2001) 1.30
Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway. Eur J Immunol (2001) 1.25
Uses of lacZ to study gene function: evaluation of beta-galactosidase assays employed in the yeast two-hybrid system. Anal Biochem (2000) 1.23
Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. J Biol Chem (1997) 1.23
A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1. EMBO J (2000) 1.11
The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1. J Biol Chem (1997) 1.11
HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. Oncogene (2011) 1.10
Using the yeast interaction trap and other two-hybrid-based approaches to study protein-protein interactions. Methods (2001) 1.09
Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). J Biol Chem (1997) 1.07
A two-hybrid dual bait system to discriminate specificity of protein interactions. J Biol Chem (1999) 1.04
Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain. Exp Cell Res (1999) 1.00
Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death. Oncogene (2011) 0.98
Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells. Leuk Lymphoma (1997) 0.96
The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily. Physiol Genomics (1999) 0.94
Analysis of small GTPase signaling pathways using p21-activated kinase mutants that selectively couple to Cdc42. J Biol Chem (2001) 0.92
HEI10 negatively regulates cell invasion by inhibiting cyclin B/Cdk1 and other promotility proteins. Oncogene (2007) 0.92
The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1. J Biol Chem (1999) 0.91
A functional association between merlin and HEI10, a cell cycle regulator. Oncogene (2006) 0.90
Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer. Br J Cancer (2012) 0.89
Approaches to detecting false positives in yeast two-hybrid systems. Biotechniques (2000) 0.88
The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics. Neuroscience (2009) 0.88
Two-hybrid system and false positives. Approaches to detection and elimination. Methods Mol Biol (2001) 0.87
Streamlined yeast colorimetric reporter activity assays using scanners and plate readers. Biotechniques (2000) 0.86
Genomic analysis utilizing the yeast two-hybrid system. Methods Mol Biol (2001) 0.86
Ligand-free RAR can interact with the RNA polymerase II subunit hsRPB7 and repress transcription. Endocrine (1999) 0.86
Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. Oncogene (1996) 0.85
LexA-based two-hybrid systems. Methods Enzymol (2000) 0.85
Redefinition of the yeast two-hybrid system in dialogue with changing priorities in biological research. Biotechniques (2001) 0.84
Conversion of mRNA into double-stranded cDNA. Curr Protoc Mol Biol (2001) 0.81
DUSP6 regulates drug sensitivity by modulating DNA damage response. Br J Cancer (2013) 0.80
Two-hybrid dual bait system to discriminate specificity of protein interactions in small GTPases. Methods Enzymol (2001) 0.79
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Mol Biol (2001) 0.78
Interactions between the full complement of human RNA polymerase II subunits. FEBS Lett (1999) 0.78
Targeting proteins to specific cellular compartments to optimize physiological activity. Methods Enzymol (2001) 0.77
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Protein Sci (2001) 0.76
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Cell Biol (2001) 0.76
The yeast two-hybrid system: criteria for detecting physiologically significant protein-protein interactions. Curr Issues Mol Biol (1999) 0.75
Vectors to target protein domains to different cellular compartments. Biotechniques (1998) 0.75
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Neurosci (2001) 0.75
Encroaching genomics: adapting large-scale science to small academic laboratories. Physiol Genomics (2000) 0.75