Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.

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Published in Mol Cell Biol on July 01, 1996

Authors

S F Law1, J Estojak, B Wang, T Mysliwiec, G Kruh, E A Golemis

Author Affiliations

1: Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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Basic local alignment search tool. J Mol Biol (1990) 659.07

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Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell (1992) 10.94

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature (1987) 8.87

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Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol (1995) 6.74

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A ras-related gene with transformation suppressor activity. Cell (1989) 5.81

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The yeast actin cytoskeleton. Curr Opin Cell Biol (1994) 2.54

Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins. Mol Cell Biol (1989) 2.49

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