Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt.

PubWeight™: 1.87‹?› | Rank: Top 3%

🔗 View Article (PMC 1221114)

Published in Biochem J on July 01, 2000

Authors

M Fleischmann1, P B Iynedjian

Author Affiliations

1: Division of Clinical Biochemistry and Experimental Diabetes Research, University of Geneva School of Medicine, 1 Rue Michel-Servet, CH-1211 Geneva 4, Switzerland.

Articles citing this

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab (2008) 6.60

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A (2010) 4.40

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab (2011) 2.91

Molecular physiology of mammalian glucokinase. Cell Mol Life Sci (2009) 2.66

New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J (2002) 2.41

Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab (2009) 2.23

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23

Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc Natl Acad Sci U S A (2005) 2.13

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab (2011) 1.55

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance. Diabetologia (2009) 1.40

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity. J Lipid Res (2009) 1.40

Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. J Lipid Res (2005) 1.28

Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. J Biol Chem (2009) 1.28

Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol Life Sci (2009) 1.24

Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. J Biol Chem (2009) 1.22

Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway. J Biol Chem (2009) 1.22

Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition. J Lipid Res (2008) 1.17

The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep (2012) 1.16

Lack of evidence for a role of TRB3/NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes. Biochem J (2005) 1.09

From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis. Ann N Y Acad Sci (2009) 1.08

Androgen receptor survival signaling is blocked by anti-beta2-microglobulin monoclonal antibody via a MAPK/lipogenic pathway in human prostate cancer cells. J Biol Chem (2010) 1.04

The metabolic syndrome and nonalcoholic fatty liver disease in children. Curr Opin Pediatr (2009) 1.03

Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase. Biochem J (2000) 1.02

Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors. Diabetologia (2012) 0.99

FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J Biol Chem (2012) 0.99

Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice. J Biol Chem (2011) 0.97

Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytes. Biochem J (2003) 0.96

A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem (2009) 0.96

Mosaic analysis of insulin receptor function. J Clin Invest (2004) 0.95

The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer (2016) 0.95

Time of day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver. J Biol Chem (2010) 0.91

Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor. Biochem J (2006) 0.91

Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice. J Lipid Res (2009) 0.88

Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice. J Exp Clin Cancer Res (2015) 0.83

A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes. J Lipid Res (2013) 0.81

Cholesterol: from feeding to gene regulation. Genes Nutr (2007) 0.81

Atypical protein kinase C in cardiometabolic abnormalities. Curr Opin Lipidol (2012) 0.79

Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. J Clin Med (2014) 0.77

The interplay between cell signalling and the mevalonate pathway in cancer. Nat Rev Cancer (2016) 0.76

Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytes. PLoS One (2015) 0.76

BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans. Metabolism (2015) 0.76

Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart. J Biol Chem (2015) 0.76

Pediatric Metabolic Syndrome: Pathophysiology and Laboratory Assessment. EJIFCC (2017) 0.75

POSSIBLE REGULATION OF LDL-RECEPTOR BY NARINGENIN IN HEPG2 HEPATOMA CELL LINE. Afr J Tradit Complement Altern Med (2016) 0.75

The relationship among brain natriuretic peptide (BNP), cholesterol and lipoprotein. Heart Asia (2012) 0.75

Effect of bilirubin on triglyceride synthesis in streptozotocin-induced diabetic nephropathy. J Korean Med Sci (2014) 0.75

Articles cited by this

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res (1985) 10.76

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A (1999) 7.70

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell (1993) 6.95

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J (1998) 6.28

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 5.81

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol (1993) 5.34

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci U S A (1999) 4.88

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest (1998) 4.85

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J (1999) 4.80

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci U S A (1993) 4.61

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem (1999) 4.31

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J (1998) 3.94

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci U S A (1996) 3.85

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem (1999) 3.72

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol Cell Biol (1999) 3.63

Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol (1995) 3.10

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J Biol Chem (1998) 2.93

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J (1995) 2.92

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol (1999) 2.54

Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. J Biol Chem (1999) 2.13

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc Natl Acad Sci U S A (1999) 2.04

Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. J Biol Chem (1989) 1.70

Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt. J Biol Chem (1998) 1.42

Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem (1999) 1.40

Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene. J Biol Chem (1998) 1.30

Insulin inhibits the activation of transcription by a C-terminal fragment of the forkhead transcription factor FKHR. A mechanism for insulin inhibition of insulin-like growth factor-binding protein-1 transcription. J Biol Chem (2000) 1.21

Glucokinase and cytosolic phosphoenolpyruvate carboxykinase (GTP) in the human liver. Regulation of gene expression in cultured hepatocytes. J Clin Invest (1995) 1.03

Correction of ornithine transcarbamylase deficiency in adult spf(ash) mice and in OTC-deficient human hepatocytes with recombinant adenoviruses bearing the CAG promoter. Hum Gene Ther (1996) 0.98

Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization. Biochem J (2000) 0.89

Articles by these authors

Molecular cloning of glucokinase cDNA. Developmental and dietary regulation of glucokinase mRNA in rat liver. J Biol Chem (1987) 1.53

Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets. Proc Natl Acad Sci U S A (1986) 1.53

Increase in level of functional messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) during induction by cyclic adenosine 3':5'-monophosphate. J Biol Chem (1977) 1.32

Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. Proc Natl Acad Sci U S A (1997) 1.24

The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type. J Biol Chem (1993) 1.20

The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids. J Biol Chem (1975) 1.11

Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells. Biochem J (1987) 1.06

Regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat liver cells. Rapid induction of specific mRNA by glucagon or cyclic AMP and permissive effect of dexamethasone. J Biol Chem (1982) 1.05

Alterations in translatable messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat liver cytosol during deinduction. J Biol Chem (1978) 0.99

Insulin and tri-iodothyronine induce glucokinase mRNA in primary cultures of neonatal rat hepatocytes. Biochem J (1990) 0.99

Alternative splicing of glucokinase mRNA in rat liver. Biochem J (1990) 0.97

Insulin signalling and regulation of glucokinase gene expression in cultured hepatocytes. Eur J Biochem (1992) 0.96

Diagnostic heterogeneity of diabetes in lean young adults: classification based on immunological and genetic parameters. Diabetes (1997) 0.94

Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization. Biochem J (2000) 0.89

Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase. J Biol Chem (1997) 0.89

Coordinate induction of several mRNA species in rat kidney during glucocorticoid treatment. J Biol Chem (1981) 0.88

IL-1 receptor antagonist (IL-1Ra) does not inhibit the production of C-reactive protein or serum amyloid A protein by human primary hepatocytes. Differential regulation in normal and tumour cells. Clin Exp Immunol (1995) 0.87

Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria. FEBS Lett (1991) 0.87

Pretranslational regulation of tyrosine aminotransferase and phosphoenolpyruvate carboxykinase (GTP) synthesis by glucagon and dexamethasone in adult rat hepatocytes. Biochem J (1985) 0.87

The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes. Diabetologia (2005) 0.84

Messenger RNA for renal phosphoenolpyruvate carboxykinase (GTP). Its translation in a heterologous cell-free system and its regulation by glucocorticoids and by changes in acid-base balance. J Biol Chem (1977) 0.83

Effects of glucagon, dexamethasone and triiodothyronine on phosphoenolpyruvate carboxykinase (GTP) synthesis and mRNA level in rat liver cells. Eur J Biochem (1984) 0.82

Glycolysis, turbo design and the endocrine pancreatic beta cell. Trends Biochem Sci (1998) 0.79

Glucocorticoid-dependent induction of mRNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat kidney. Its inhibition by cycloheximide. Eur J Biochem (1980) 0.79

Unimpaired effect of insulin on glucokinase gene expression in hepatocytes challenged with amylin. FEBS Lett (1992) 0.78

Phosphoenolpyruvate carboxykinase and gluconeogenesis in renal cortex of starved rats. Am J Physiol (1974) 0.78

Nomenclature for mammalian glucokinase. Biochem J (1991) 0.75

[Metabolic effects of drugs]. Ther Umsch (1970) 0.75

Role of the kidneys in hyperglycemia provoked by anti-insulin serum in rats. Diabetologia (1974) 0.75

Phosphorylation of histones and non-histone nuclear proteins in liver cells stimulated by glucagon and cyclic AMP. FEBS Lett (1984) 0.75

Purification of phosphoenolpyruvate carboxykinase (GTP) by affinity chromatography on agarose-hydrazide-GTP. Enzyme (1979) 0.75

Possible contribution of renal gluconeogenesis to the development of n-monomethylacetamide-induced hyperglycemia in the rat. Diabetologia (1973) 0.75

Regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in the kidney. Curr Probl Clin Biochem (1978) 0.75

Partial purification and characterization of rat-liver messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP). Eur J Biochem (1978) 0.75