Published in Proc Natl Acad Sci U S A on June 22, 1999
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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol (2001) 5.78
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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest (2001) 4.93
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Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc Natl Acad Sci U S A (1999) 2.04
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Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. J Clin Invest (2004) 1.93
Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med (2008) 1.93
Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol (2003) 1.92
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Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt. Biochem J (2000) 1.87
mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab (2013) 1.86
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Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J (2002) 1.83
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FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab (2010) 1.81
Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol Cell Biol (2004) 1.76
Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol (2014) 1.76
FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts. EMBO J (2003) 1.70
A comparison between Skp2 and FOXO1 for their cytoplasmic localization by Akt1. Cell Cycle (2010) 1.69
Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem (2010) 1.68
Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs. Mol Cell Biol (2004) 1.63
Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21. Mol Cell Biol (2000) 1.63
FOXO transcription factors throughout T cell biology. Nat Rev Immunol (2012) 1.60
Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol (2006) 1.58
Modulation of transcription factor function by O-GlcNAc modification. Biochim Biophys Acta (2010) 1.55
Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. Structure (2008) 1.55
Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol Biol Cell (2001) 1.52
The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. J Virol (2004) 1.51
Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem (2009) 1.51
In control of biology: of mice, men and Foxes. Biochem J (2006) 1.50
Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators Inflamm (2010) 1.49
Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2006) 1.48
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PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc Natl Acad Sci U S A (2004) 1.43
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. Immunity (2014) 1.40
alpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway. Mol Biol Cell (2000) 1.39
PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes. J Exp Med (2015) 1.39
Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J Biol Chem (2010) 1.38
Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis. Blood (2006) 1.36
Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. EMBO J (2005) 1.35
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
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Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Mol Cell Biol (2006) 1.33
FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci (2014) 1.32
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Akt-dependent cytokine production in mast cells. J Exp Med (2000) 1.30
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. J Biol Chem (2010) 1.29
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Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer (2010) 1.24
Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J Cell Biol (2001) 1.23
Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem (2011) 1.23
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