Published in Genetics on July 01, 2000
DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc Natl Acad Sci U S A (2004) 2.51
Evidence for mutation showers. Proc Natl Acad Sci U S A (2007) 2.00
Changes in DNA repair during aging. Nucleic Acids Res (2007) 1.42
Estimating mutation rate: how to count mutations? Genetics (2003) 1.08
Base excision repair, aging and health span. Mech Ageing Dev (2008) 0.97
Age related shift in the mutation spectra of germline and somatic NF2 mutations: hypothetical role of DNA repair mechanisms. J Med Genet (2005) 0.85
Metabolism, genomics, and DNA repair in the mouse aging liver. Curr Gerontol Geriatr Res (2011) 0.84
DNA double strand break repair, aging and the chromatin connection. Mutat Res (2016) 0.79
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases. Nat Rev Mol Cell Biol (2017) 0.75
Rates of spontaneous mutation. Genetics (1998) 14.89
Molecular basis of base substitution hotspots in Escherichia coli. Nature (1978) 13.79
DNA methylation and the frequency of CpG in animal DNA. Nucleic Acids Res (1980) 9.34
The CpG dinucleotide and human genetic disease. Hum Genet (1988) 7.86
Mutator phenotype may be required for multistage carcinogenesis. Cancer Res (1991) 7.29
Sequence of the lacI gene. Nature (1978) 5.85
A mammalian protein with specific demethylase activity for mCpG DNA. Nature (1999) 4.48
Rates of nucleotide substitution in primates and rodents and the generation-time effect hypothesis. Mol Phylogenet Evol (1996) 3.97
The molecular clock runs more slowly in man than in apes and monkeys. Nature (1987) 3.42
Cytosine methylation and the fate of CpG dinucleotides in vertebrate genomes. Hum Genet (1989) 3.27
Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. Environ Mol Mutagen (1995) 2.76
Genomic 5-methyldeoxycytidine decreases with age. J Biol Chem (1987) 2.74
Tissue-specific differences in DNA methylation in various mammals. Biochim Biophys Acta (1983) 2.40
The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA. Nucleic Acids Res (1994) 2.37
A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine. Cell (1987) 2.30
Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc Natl Acad Sci U S A (1991) 2.29
High frequency mutagenesis by a DNA methyltransferase. Cell (1992) 2.08
Cell polyploidy: its relation to tissue growth and function. Int Rev Cytol (1977) 1.79
Mutations causing hemophilia B: direct estimate of the underlying rates of spontaneous germ-line transitions, transversions, and deletions in a human gene. Am J Hum Genet (1990) 1.78
DNA methylation is a reversible biological signal. Proc Natl Acad Sci U S A (1999) 1.69
Mutation frequency declines during spermatogenesis in young mice but increases in old mice. Proc Natl Acad Sci U S A (1998) 1.49
Identifying 5-methylcytosine and related modifications in DNA genomes. Nucleic Acids Res (1998) 1.38
Evidence for erosion of mouse CpG islands during mammalian evolution. Somat Cell Mol Genet (1993) 1.36
DNA mismatch repair and DNA methylation in adult brain neurons. J Neurosci (1996) 1.34
The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mutat Res (1994) 1.27
Development of a short-term, in vivo mutagenesis assay: the effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice. Nucleic Acids Res (1990) 1.26
The rate of CpG mutation in Alu repetitive elements within the p53 tumor suppressor gene in the primate germline. J Mol Biol (1996) 1.15
DNA methylation in aging of mice. Mech Ageing Dev (1987) 1.15
Activation of the lac repressor in the transgenic mouse. Genetics (1997) 1.13
Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice. Genetics (2000) 1.06
Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice. Oncogene (1997) 1.03
Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging. Environ Health Perspect (1998) 1.01
Effect of DNA cytosine methylation upon deamination-induced mutagenesis in a natural target sequence in duplex DNA. J Biol Chem (1994) 0.99
The growth of liver parenchymal nuclei and its endocrine regulation. Int Rev Cytol (1969) 0.98
Changes of DNA methylation level during pre- and postnatal periods in mice. Differentiation (1990) 0.96
Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice. Environ Mol Mutagen (1995) 0.96
Comparison of somatic mutation in a transgenic versus host locus. Proc Natl Acad Sci U S A (1993) 0.96
Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice. Proc Natl Acad Sci U S A (1994) 0.96
Methylation of CpG dinucleotides in the lacI gene of the Big Blue transgenic mouse. Mutat Res (1998) 0.90
Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice. Environ Mol Mutagen (1997) 0.89
Enzymatic DNA methylation in higher eukaryotes. Int J Biochem (1980) 0.88
Transgenic animal models for measuring mutations in vivo. Crit Rev Toxicol (1994) 0.87
Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice. Cancer Res (1996) 0.87
Cell proliferation rates in common cancer target tissues of B6C3F1 mice and F344 rats: effects of age, gender, and choice of marker. Fundam Appl Toxicol (1996) 0.85
Linked spontaneous CG----TA mutations at CpG sites in the gene for protein kinase regulatory subunit. Mol Cell Biol (1992) 0.85
Mutation rate: a simple concept has become complex. Environ Mol Mutagen (1998) 0.85
Growth fraction and cycle duration of hepatocytes in the three-week-old rat. Cell Tissue Kinet (1978) 0.82
The role of proliferation in the origin of mutations in mammalian cells. Drug Metab Rev (1998) 0.82
Genetic factors in aging. Adv Genet (1971) 0.81
Effect of target gene CpG content on spontaneous mutation in299 transgenic mice. Mutat Res (1998) 0.80
Expression of long-patch and short-patch DNA mismatch repair proteins in the embryonic and adult mammalian brain. Brain Res Mol Brain Res (1998) 0.80
The lacI gene as a target for mutation in transgenic rodents and Escherichia coli. Genetics (1998) 0.80
Biological significance of liver cell polyploidy: an hypothesis. J Theor Biol (1981) 0.80
Spontaneous mutants recovered from liver and germ cell tissue of low copy number lacI transgenic rats. Mutat Res (1996) 0.79
Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents. Carcinogenesis (1997) 0.78
Life span prediction from the rate of age-related DNA demethylation in normal and cancer cell lines. Exp Gerontol (1996) 0.78
The effects of age on total DNA and cell number in the mouse brain. Gerontologia (1974) 0.77
Methylation of DNA of the brain and liver of young and old rats. Indian J Biochem Biophys (1992) 0.77
DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue mice does not correlate with mutagenicity. Mutagenesis (1998) 0.76
Nutrition and cell growth. Curr Concepts Nutr (1972) 0.76
Chronic low-dose lesion equilibrium along genes: measurement, molecular epidemiology, and theory of the minimal relevant dose. Mutat Res (1998) 0.76
Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc Natl Acad Sci U S A (1980) 10.16
Mechanisms of spontaneous mutagenesis: an analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene. J Mol Biol (1986) 3.84
Structural intermediates of deletion mutagenesis: a role for palindromic DNA. Proc Natl Acad Sci U S A (1984) 3.17
Spontaneous mutagenesis in Escherichia coli strains lacking 6-methyladenine residues in their DNA: an altered mutational spectrum in dam- mutants. Mutat Res (1979) 2.50
The specificity of UV-induced mutations at an endogenous locus in mammalian cells. Proc Natl Acad Sci U S A (1987) 2.26
Patterns of somatic mutations in immunoglobulin variable genes. Genetics (1987) 2.24
Replicational fidelity: mechanisms of mutation avoidance and mutation fixation. Cold Spring Harb Symp Quant Biol (1979) 2.10
Mutational specificity of UV light in Escherichia coli: indications for a role of DNA secondary structure. Proc Natl Acad Sci U S A (1982) 2.02
Unique self-complementarity of palindromic sequences provides DNA structural intermediates for mutation. Cold Spring Harb Symp Quant Biol (1983) 1.77
Rapid repeated cloning of mutant lac repressor genes. Gene (1985) 1.67
A mutant of Escherichia coli K12 deficient in the 5'-3' exonucleolytic activity of DNA polymerase I. I. General characterization. Mol Gen Genet (1973) 1.64
The C-C (6-4) UV photoproduct is mutagenic in Escherichia coli. Proc Natl Acad Sci U S A (1986) 1.61
Mechanisms of ultraviolet-induced mutation. Mutational spectra in the Escherichia coli lacI gene for a wild-type and an excision-repair-deficient strain. J Mol Biol (1987) 1.57
Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: an analysis at the DNA sequence level. Proc Natl Acad Sci U S A (1988) 1.51
Mechanisms of spontaneous mutation in DNA repair-proficient Escherichia coli. Mutat Res (1991) 1.48
A mutant of Escherichia coli K12 deficient in the 5'-3' exonucleolytic activity of DNA polymerase I. II. Purification and properties of the mutant enzyme. Mol Gen Genet (1973) 1.43
Mutagenesis resulting from depurination is an SOS process. Mutat Res (1982) 1.42
Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells. Proc Natl Acad Sci U S A (1988) 1.39
Human DNA repair systems: an overview. Environ Mol Mutagen (1999) 1.36
Sequence-directed mutagenesis: evidence from a phylogenetic history of human alpha-interferon genes. Proc Natl Acad Sci U S A (1985) 1.32
The infidelity of conjugal DNA transfer in Escherichia coli. Genetics (1983) 1.31
Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Mol Gen Genet (1983) 1.28
Mutational specificity of alkylating agents and the influence of DNA repair. Environ Mol Mutagen (1990) 1.28
The role of pyrimidine dimers as premutagenic lesions: a study of targeted vs. untargeted mutagenesis in the lacI gene of Escherichia coli. Genetics (1984) 1.28
The isolation and characterization of an X-ray-sensitive ultraviolet-resistant mutant of Escherichia coli. Biochim Biophys Acta (1971) 1.22
gamma-Ray induced mutational spectrum in the lacI gene of Escherichia coli: comparison of induced and spontaneous spectra at the molecular level. Mutat Res (1980) 1.22
Role of depurination in mutagenesis by chemical carcinogens. Cancer Res (1982) 1.21
Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenous aprt gene in CHO cells. Somat Cell Mol Genet (1988) 1.21
DNA sequence analysis of mutagenicity and site specificity of ethyl methanesulfonate in Uvr+ and UvrB- strains of Escherichia coli. Genetics (1986) 1.19
Radiation-induced base substitution mutagenesis in single-stranded DNA phage M13. Nature (1981) 1.18
Characterization of mutational specificity within the lacI gene for a mutD5 mutator strain of Escherichia coli defective in 3'----5' exonuclease (proofreading) activity. J Bacteriol (1986) 1.16
Influence of neighbouring base sequence on N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in the lacI gene of Escherichia coli. J Mol Biol (1987) 1.15
The Chinese hamster aprt gene as a mutational target. Its sequence and an analysis of direct and inverted repeats. Mutat Res (1989) 1.12
Missense mutation in the lacI gene of Escherichia coli. Inferences on the structure of the repressor protein. J Mol Biol (1988) 1.12
Human DNA repair genes. Environ Mol Mutagen (2001) 1.12
Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesions in Escherichia coli. Cancer Res (1988) 1.10
Strand bias in mutation involving 5-methylcytosine deamination in the human hprt gene. Mutat Res (1994) 1.09
Southern analysis of genomic alterations in gamma-ray-induced aprt- hamster cell mutants. Genetics (1986) 1.08
Sequence specificity of mutation induced by the anti-tumor drug cisplatin in the CHO aprt gene. Carcinogenesis (1989) 1.06
Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice. Genetics (2000) 1.06
Human micronucleus counts are correlated with age, smoking, and cesium-137 dose in the Goiânia (Brazil) radiological accident. Mutat Res (1994) 1.04
DNA sequence analysis of spontaneous mutation in a PolA1 strain of Escherichia coli indicates sequence-specific effects. Mol Gen Genet (1987) 1.03
Asymmetric cytosine deamination revealed by spontaneous mutational specificity in an Ung- strain of Escherichia coli. Mol Gen Genet (1987) 1.01
Sites of preferential induction of cyclobutane pyrimidine dimers in the nontranscribed strand of lacI correspond with sites of UV-induced mutation in Escherichia coli. J Biol Chem (1991) 0.99
Mutational specificity of N-methyl-N-nitrosourea in the lacI gene of Escherichia coli. Carcinogenesis (1988) 0.98
In vivo transgenic mutation assays. Environ Mol Mutagen (2000) 0.98
Deoxyuridine misincorporation causes site-specific mutational lesions in the lacI gene of Escherichia coli. Mutat Res (1986) 0.98
Spontaneous mutation in lacI transgenic mice: a comparison of tissues. Mutagenesis (1998) 0.97
Mutational analysis of the structure and function of the adenine phosphoribosyltransferase enzyme of Chinese hamster. J Mol Biol (1991) 0.96
Influence of sex, smoking and age on human hprt mutation frequencies and spectra. Genetics (1999) 0.96
Large-scale mutational analysis of EMS-induced mutation in the lacI gene of Escherichia coli. Mutat Res (1993) 0.95
Perspectives on UV light mutagenesis: investigation of the CHO aprt gene carried on a retroviral shuttle vector. Somat Cell Mol Genet (1989) 0.95
Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer. Br J Cancer (1999) 0.94
Identification of single nucleotide polymorphisms in human DNA repair genes. Carcinogenesis (2000) 0.94
Influence of DNA-repair deficiencies on MMS- and EMS-induced mutagenesis in Escherichia coli K-12. Mutat Res (1981) 0.93
Prostate mutations in rats induced by the suspected human carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Res (2000) 0.92
Mutability of bacteriophage M13 by ultraviolet light: role of pyrimidine dimers. Mol Gen Genet (1982) 0.90
Specificity of spontaneous mutation in the lacI gene cloned into bacteriophage M13. Mutat Res (1990) 0.90
Loss of heterozygosity in mammalian cell mutagenesis: molecular analysis of spontaneous mutations at the aprt locus in CHO cells. Carcinogenesis (1990) 0.90
The influence of local DNA sequence and DNA repair background on the mutational specificity of 1-nitroso-8-nitropyrene in Escherichia coli: inferences for mutagenic mechanisms. Genetics (1992) 0.89
The mutational specificity of simulated sunlight at the aprt locus in rodent cells. Carcinogenesis (1994) 0.89
Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived. Mutat Res (1999) 0.89
Spectra of base substitution mutations induced in Escherichia coli by tritiated water and the decay of incorporated tritiated thymidine. Radiat Res (1984) 0.89
Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice. Environ Mol Mutagen (1997) 0.89
Mutational specificities of environmental carcinogens in the lacI gene of Escherichia coli. VI: Analysis of methylene chloride-induced mutational distribution in Uvr+ and UvrB- strains. Carcinogenesis (1993) 0.88
Introduction to DNA-Based Genetic Diagnostics. Can Fam Physician (1988) 0.87
Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice. Cancer Res (1996) 0.87
Evidence for local DNA influences on patterns of substitutions in the human alpha-interferon gene family. Can J Genet Cytol (1986) 0.86
Mechanisms of spontaneous mutagenesis: clues from mutational specificity. Basic Life Sci (1986) 0.86
Endogenous gene systems for the study of mutational specificity in mammalian cells. Cancer Cells (1990) 0.85
MMS mutagenesis in strains of Escherichia coli carrying the R46 mutagenic enhancing plasmid: phenotypic analysis of Arg+ revertants. Mutat Res (1979) 0.85
ERCC1: a comparative genomic perspective. Environ Mol Mutagen (2001) 0.85
Randomness of base substitution mutations induced in the lacI gene of Escherichia coli by ionizing radiation. Radiat Res (1985) 0.85
LacI mutation spectra following benzo[a]pyrene treatment of Big Blue mice. Carcinogenesis (2000) 0.85
Mutagenesis by 8-methoxypsoralen plus near-UV treatment: analysis of specificity in the lacI gene of Escherichia coli. Mutat Res (1986) 0.85
Defect in excision repair alters the mutational specificity of PUVA treatment in the lacI gene of Escherichia coli. J Mol Biol (1987) 0.84
The distribution of UV damage in the lacI gene of Escherichia coli: correlation with mutation spectrum. Mutat Res (1992) 0.84
Thermosensitive mutants of Escherichia coli unable to propagate RNA phage at 42 degrees C and altered in protein synthesis. Eur J Biochem (1974) 0.84
N-methyl-N'-nitro-N-nitrosoguanidine induced DNA sequence alteration; non-random components in alkylation mutagenesis. Mutat Res (1990) 0.84
Colony hybridisation in Escherichia coli: a rapid procedure for determining the distribution of specific classes of mutations among a number of preselected sites. Environ Mol Mutagen (1990) 0.84
Limitations in the use of SSCP analysis. Mutat Res (1993) 0.83
N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation in a RecA strain of Escherichia coli. Mutat Res (1988) 0.83
Specificity of recA441-mediated (tif-1) mutational events. Mol Gen Genet (1991) 0.83
Mechanism of mutation by thymine starvation in Escherichia coli: clues from mutagenic specificity. J Bacteriol (1985) 0.83
Caffeine does not potentiate gamma-radiation induced DNA damage in ataxia telangiectasia lymphoblastoid cells. Mutat Res (1998) 0.83
Differential enhancement of spontaneous transition mutations in the lacI gene of an Ung- strain of Escherichia coli. Mutat Res (1986) 0.83
Msh2 DNA mismatch repair gene deficiency and the food-borne mutagen 2-amino-1-methy1-6-phenolimidazo [4,5-b] pyridine (PhIP) synergistically affect mutagenesis in mouse colon. Oncogene (2001) 0.82
Spectrum of mutations in kidney, stomach, and liver from lacI transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate. Environ Mol Mutagen (1996) 0.82
The role of DNA polymerase I in excision-repair. Basic Life Sci (1975) 0.82
Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacI transgenic rats and mice following exposure to aflatoxin B1. Carcinogenesis (1996) 0.81
The nature of ultraviolet light-induced mutations at the heterozygous aprt locus in Chinese hamster ovary cells. Mutat Res (1990) 0.81
Radiation induced apoptosis in ataxia telangiectasia homozygote, heterozygote and normal cells. Mutat Res (2001) 0.81
Monitoring hprt mutant frequency over time in T-lymphocytes of people accidentally exposed to high doses of ionizing radiation. Environ Mol Mutagen (1996) 0.81
An efficient laboratory protocol for the sequencing of large numbers of lacI mutants recovered from Big Blue transgenic animals. Environ Mol Mutagen (1996) 0.81
The action of 1-nitroso-8-nitropyrene in Escherichia coli: DNA adduct formation and mutational consequences in the absence of nucleotide excision-repair. Carcinogenesis (1991) 0.81
Protein domain structure influences observed distribution of mutation. Mutat Res (1988) 0.81
Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thione. Nutr Cancer (2001) 0.81
Protective effect of green tea against benzo[a]pyrene-induced mutations in the liver of Big Blue transgenic mice. Mutat Res (2001) 0.81
p53 mutations in hairy cell leukemia. Leukemia (2000) 0.81
rorA mutation of Escherichia coli K-12 affects the recB subunit of exonuclease V. J Bacteriol (1979) 0.80