Published in Oncogene on July 10, 1997
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A (1999) 4.28
DNA replication fidelity and cancer. Semin Cancer Biol (2010) 1.69
Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene. Proc Natl Acad Sci U S A (1999) 1.32
Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer. Eur J Hum Genet (2010) 1.30
The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells. Mol Cell Biol (2004) 1.29
Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent. Proc Natl Acad Sci U S A (1998) 1.20
Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice. Genetics (2000) 1.06
Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activity. Nucleic Acids Res (2001) 0.91
Through a glass, darkly: reflections of mutation from lacI transgenic mice. Genetics (2000) 0.90
Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability. Proc Natl Acad Sci U S A (1998) 0.87
Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas. Proc Natl Acad Sci U S A (2009) 0.83
DNA mismatch repair deficiency accelerates lung neoplasm development in K-ras(LA1/+) mice: a brief report. Cancer Med (2015) 0.75
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 13.98
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med (2000) 13.13
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (1999) 12.32
Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity (1995) 10.65
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature (1984) 10.02
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell (1993) 9.84
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33
DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol (1998) 6.38
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity (1997) 6.15
Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell (1998) 5.92
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science (2000) 5.84
Regulation of PTEN transcription by p53. Mol Cell (2001) 5.44
Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell (1998) 5.32
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science (1998) 5.29
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell (1996) 5.10
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell (1986) 4.68
T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity (2001) 4.62
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev (2000) 4.51
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol (1994) 4.34
Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell (1984) 4.34
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science (1997) 4.23
T-cell co-stimulation through B7RP-1 and ICOS. Nature (1999) 4.20
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell (1991) 4.05
ICOS is essential for effective T-helper-cell responses. Nature (2001) 4.01
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev (1998) 3.92
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell (2001) 3.80
Catatonia. I. Rating scale and standardized examination. Acta Psychiatr Scand (1996) 3.76
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell (1994) 3.56
Sequence and expression of transcripts of the human T-cell receptor beta-chain genes. Nature (1985) 3.53
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet (2001) 3.45
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron (2001) 3.42
Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line. Proc Natl Acad Sci U S A (1985) 3.41
The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41
Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci U S A (1998) 3.35
Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development (1995) 3.30
Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. Proc Natl Acad Sci U S A (1985) 3.29
International trends in cancer mortality in France, West Germany, Italy, Japan, England and Wales, and the USA. Lancet (1990) 3.29
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity (2000) 3.29
Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci U S A (2008) 3.27
A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. J Virol (1996) 3.26
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res (2000) 3.24
The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18
Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13
Computer support for interpreting family histories of breast and ovarian cancer in primary care: comparative study with simulated cases. BMJ (2000) 3.12
Pathogenicity of Helicobacter pylori: a perspective. Infect Immun (1993) 3.08
Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain. Nature (1985) 3.08
Genes of the T-cell antigen receptor in normal and malignant T cells. Annu Rev Immunol (1987) 3.01
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (1999) 2.96
Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation (2000) 2.95
Cattle as a possible source of verocytotoxin-producing Escherichia coli O157 infections in man. Epidemiol Infect (1993) 2.94
Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J Exp Med (1997) 2.91
Human T-cell receptor variable gene segment families. Immunogenetics (1995) 2.86
Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc Natl Acad Sci U S A (1998) 2.86
Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science (1994) 2.86
Two distinct pathways leading to nuclear apoptosis. J Exp Med (2000) 2.84
Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature (1985) 2.84
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature (1995) 2.79
Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J Immunol (1999) 2.77
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev (1998) 2.72
CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood (1997) 2.71
Evaluation of computer support for prescribing (CAPSULE) using simulated cases. BMJ (1997) 2.61
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science (1992) 2.60
Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J (1998) 2.56
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science (1996) 2.56
Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol (1999) 2.55
Ultrastructure of the gastric mucosa harboring Campylobacter-like organisms. Am J Clin Pathol (1986) 2.52
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem (2001) 2.50
Characterization of reticuloendotheliosis virus strain T DNA and isolation of a novel variant of reticuloendotheliosis virus strain T by molecular cloning. J Virol (1981) 2.49
WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity (2001) 2.49
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J (2000) 2.48
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature (1997) 2.46
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science (2013) 2.38
Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. Genomics (1993) 2.33
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res (1995) 2.33
Helicobacter pylori and gastric carcinoma. Serum antibody prevalence in populations with contrasting cancer risks. Cancer (1990) 2.32
Sequences and repertoire of the human T cell receptor alpha and beta chain variable region genes in thymocytes. Eur J Immunol (1987) 2.32
Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science (1994) 2.28
Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat Genet (1997) 2.28
Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity (1997) 2.25
Mouse T-cell receptor variable gene segment families. Immunogenetics (1995) 2.24
Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J Exp Med (1991) 2.24
Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein. Proc Natl Acad Sci U S A (1983) 2.23
T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes. J Exp Med (1986) 2.20
Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev (1997) 2.20
LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med (1996) 2.14
The Friend virus genome: evidence for the stable association of MuLV sequences and sequences involved in erythroleukemic transformation. Cell (1977) 2.12
Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells. J Immunol (1993) 2.10
Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity (1996) 2.08
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity (1998) 2.06
Cross-reaction of immune sera from patients with rickettsial diseases. J Med Microbiol (1989) 2.04
Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood (2001) 2.03
Perinatal outcome in SGA births defined by customised versus population-based birthweight standards. BJOG (2001) 2.02
Birthweights and growth of infants in five Aboriginal communities. Aust N Z J Public Health (2000) 2.01