Evidence for mutation showers.

Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 16.72

Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell (2012) 4.52

Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell (2012) 4.03

Mutation as a stress response and the regulation of evolvability. Crit Rev Biochem Mol Biol (2007) 3.66

Peto's Paradox: evolution's prescription for cancer prevention. Trends Ecol Evol (2011) 2.48

Break-induced replication is highly inaccurate. PLoS Biol (2011) 2.45

Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet (2008) 2.00

Is evolution Darwinian or/and Lamarckian? Biol Direct (2009) 1.67

Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer (2014) 1.67

Localized hypermutation and associated gene losses in legume chloroplast genomes. Genome Res (2010) 1.48

Too many mutants with multiple mutations. Crit Rev Biochem Mol Biol (2007) 1.38

Mutator alleles of yeast DNA polymerase zeta. DNA Repair (Amst) (2007) 1.21

The rate of establishment of complex adaptations. Mol Biol Evol (2010) 1.17

Two mechanisms produce mutation hotspots at DNA breaks in Escherichia coli. Cell Rep (2012) 1.14

Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli. PLoS Genet (2008) 1.12

Genomic mutation rates: what high-throughput methods can tell us. Bioessays (2009) 1.08

Damage-induced localized hypermutability. Cell Cycle (2011) 1.05

A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast. DNA Repair (Amst) (2010) 1.03

Correlated evolution of nearby residues in Drosophilid proteins. PLoS Genet (2011) 0.98

Do mutator mutations fuel tumorigenesis? Cancer Metastasis Rev (2013) 0.96

Analysis of cancer mutation signatures in blood by a novel ultra-sensitive assay: monitoring of therapy or recurrence in non-metastatic breast cancer. PLoS One (2009) 0.94

Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events. PLoS One (2008) 0.94

Mutator phenotypes due to DNA replication infidelity. Semin Cancer Biol (2010) 0.93

High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. PLoS One (2009) 0.91

AID/APOBEC deaminases and cancer. Oncoscience (2015) 0.89

Mutations in clusters and showers. Proc Natl Acad Sci U S A (2007) 0.88

Gene conversion in human genetic disease. Genes (Basel) (2010) 0.85

Small variable segments constitute a major type of diversity of bacterial genomes at the species level. Genome Biol (2010) 0.85

Prevalence of multinucleotide replacements in evolution of primates and Drosophila. Mol Biol Evol (2013) 0.83

The rate of spontaneous mutations in human myeloid cells. Mutat Res (2013) 0.79

Clusters of Multiple Mutations: Incidence and Molecular Mechanisms. Annu Rev Genet (2015) 0.78

Mutational clusters generated by non-processive polymerases: A case study using DNA polymerase betain vitro. DNA Repair (Amst) (2010) 0.78

Endogenous mutagenesis in recombinant sulfolobus plasmids. J Bacteriol (2013) 0.75

The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54

Multiple mutations and cancer. Proc Natl Acad Sci U S A (2003) 4.21

Note on an exact treatment of contingency, goodness of fit and other problems of significance. Biometrika (1951) 3.29

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J (1998) 3.12

The p53-deficient mouse: a model for basic and applied cancer studies. Semin Cancer Biol (1996) 1.86

The effects of dNTP pool imbalances on frameshift fidelity during DNA replication. J Biol Chem (1992) 1.85

Deoxyribonucleotide pool imbalance stimulates deletions in HeLa cell mitochondrial DNA. J Biol Chem (2003) 1.52

Clusters of mutations from transient hypermutability. Proc Natl Acad Sci U S A (2005) 1.35

DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae. Genetics (1998) 1.35

Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector. Environ Mol Mutagen (1991) 1.32

The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mutat Res (1994) 1.27

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis (2006) 1.19

Generation of mutator mutants during carcinogenesis. DNA Repair (Amst) (2005) 1.18

Evidence that proximal multiple mutations in Big Blue transgenic mice are dependent events. Mutat Res (2000) 1.11

The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage. Proc Natl Acad Sci U S A (2002) 1.10

Study design and sample sizes for a lacI transgenic mouse mutation assay. Environ Mol Mutagen (1995) 1.06

Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium. Oncogene (2002) 1.04

Spontaneous microdeletions and microinsertions in a transgenic mouse mutation detection system: analysis of age, tissue, and sequence specificity. Environ Mol Mutagen (2001) 1.04

Molecular analysis of mutations in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP pools. J Mol Biol (1995) 1.01

Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice. Environ Mol Mutagen (2005) 1.01

In vivo transgenic mutation assays. Mutat Res (2003) 1.01

Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types. Environ Mol Mutagen (2004) 0.99

Spontaneous multiple mutations show both proximal spacing consistent with chronocoordinate events and alterations with p53-deficiency. Mutat Res (2004) 0.95

Through a glass, darkly: reflections of mutation from lacI transgenic mice. Genetics (2000) 0.90

Methylation of CpG dinucleotides in the lacI gene of the Big Blue transgenic mouse. Mutat Res (1998) 0.90

Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type. Environ Mol Mutagen (1996) 0.90

Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived. Mutat Res (1999) 0.89

Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G:C to T:A transversions and accumulate with age. Environ Mol Mutagen (1999) 0.88

Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/Big Blue double transgenic mice. Oncogene (1996) 0.87

Spontaneous tandem-base mutations (TBM) show dramatic tissue, age, pattern and spectrum specificity. Mutat Res (2003) 0.86

Towards validation of the Big Blue transgenic mouse mutagenesis assay: the mutational spectrum of ex vivo pinpoint mutant plaques. Mutat Res (1996) 0.85

The Big Blue(R) transgenic mouse mutation detection assay: the mutation pattern of sectored mutant plaques. Mutat Res (1999) 0.84

Most spontaneous tumors in a mouse model of Li-Fraumeni syndrome do not have a mutator phenotype. Carcinogenesis (2006) 0.83

Does cancer kill the individual and save the species? Hum Mutat (1994) 0.83

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system. Mutat Res (1997) 0.83

Preferential occurrence of 1-2 microindels. Hum Mutat (2006) 0.81

Spontaneous mutation frequency and pattern in Big Blue mice fed a vitamin E-supplemented diet. Environ Mol Mutagen (1999) 0.79

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A (2006) 10.09

Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol (2009) 4.84

High frequency of neurexin 1beta signal peptide structural variants in patients with autism. Neurosci Lett (2006) 3.64

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature (2012) 3.41

MicroRNA control of muscle development and disease. Curr Opin Cell Biol (2009) 3.04

MicroRNAs flex their muscles. Trends Genet (2008) 2.94

SNPs in human miRNA genes affect biogenesis and function. RNA (2009) 2.08

Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun (2013) 2.00

Neurexin 1alpha structural variants associated with autism. Neurosci Lett (2008) 1.80

Research on bell-shaped vibratory angular rate gyro's character of resonator. Sensors (Basel) (2013) 1.66

Determinants of change in prostate-specific antigen over time and its association with recurrence after external beam radiation therapy for prostate cancer in five large cohorts. Int J Radiat Oncol Biol Phys (2008) 1.63

Scene-selective cortical regions in human and nonhuman primates. J Neurosci (2011) 1.62

Tumor pretargeting in mice using (99m)Tc-labeled morpholino, a DNA analog. J Nucl Med (2002) 1.62

Bis(benzyl-trimethyl-ammonium) tetra-bromidocuprate(II). Acta Crystallogr Sect E Struct Rep Online (2011) 1.52

MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism. Am J Med Genet B Neuropsychiatr Genet (2004) 1.51

MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. Brain Res (2011) 1.48

The value of patient-matched instrumentation in total knee arthroplasty. J Arthroplasty (2011) 1.47

HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol (2013) 1.47

An electrical impedance spectroscopy system for breast cancer detection. Conf Proc IEEE Eng Med Biol Soc (2007) 1.46

Use of individual fraction size data from 3756 patients to directly determine the alpha/beta ratio of prostate cancer. Int J Radiat Oncol Biol Phys (2007) 1.39

MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation. Brain Res (2009) 1.37

H1N1 influenza vaccination during pregnancy and fetal and neonatal outcomes. Am J Public Health (2012) 1.36

Anisometropia in Hispanic and african american infants and young children the multi-ethnic pediatric eye disease study. Ophthalmology (2009) 1.35

Quantum dot-based local field imaging reveals plasmon-based interferometric logic in silver nanowire networks. Nano Lett (2010) 1.34

Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A (2012) 1.33

A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell (2012) 1.32

MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. PLoS One (2012) 1.31

Regulation of survivin by PI3K/Akt/p70S6K1 pathway. Biochem Biophys Res Commun (2010) 1.30

MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. J Cancer Res Clin Oncol (2011) 1.27

Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia. Biochem Biophys Res Commun (2007) 1.26

Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer. JAMA (2005) 1.24

Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer. Ann Surg (2011) 1.24

MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1. Cancer Sci (2010) 1.23

miR-133a regulates adipocyte browning in vivo. PLoS Genet (2013) 1.22

Bis(benzyl-trimethyl-ammonium) dichromate(VI). Acta Crystallogr Sect E Struct Rep Online (2011) 1.21

Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncol Rep (2010) 1.19

Exploring the rising incidence of neuroendocrine tumors: a population-based analysis of epidemiology, metastatic presentation, and outcomes. Cancer (2014) 1.18

Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2. Proc Natl Acad Sci U S A (2010) 1.14

Analysis of the neuroligin 4Y gene in patients with autism. Psychiatr Genet (2008) 1.14

Regulatory long non-coding RNA and its functions. J Physiol Biochem (2012) 1.13

IL-37 ameliorates the inflammatory process in psoriasis by suppressing proinflammatory cytokine production. J Immunol (2014) 1.11

High levels of β-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J Bone Miner Res (2011) 1.10

Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas. Eur J Cancer (2013) 1.09

MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression. Chin Med J (Engl) (2011) 1.09

Evidence for X-chromosomal schizophrenia associated with microRNA alterations. PLoS One (2009) 1.08

Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. J Cell Biol (2012) 1.08

A review of photocatalysis using self-organized TiO2 nanotubes and other ordered oxide nanostructures. Small (2012) 1.06

Regulation of let-7 and its target oncogenes (Review). Oncol Lett (2012) 1.06

MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas. RNA (2013) 1.06

High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression. Neuro Oncol (2011) 1.06

Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3. J Clin Invest (2015) 1.06

Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol (2013) 1.05

MiR-622 suppresses proliferation, invasion and migration by directly targeting activating transcription factor 2 in glioma cells. J Neurooncol (2014) 1.05

Distribution and regulation of protein expression of the free fatty acid receptor GPR120. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.04

Clinical significance of Hiwi gene expression in gliomas. Brain Res (2010) 1.04

FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Res (2013) 1.03

A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin. Proc Natl Acad Sci U S A (2007) 1.03

Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. Drug Metab Dispos (2003) 1.03

Detection of extremely rare alleles by bidirectional pyrophosphorolysis-activated polymerization allele-specific amplification (Bi-PAP-A): measurement of mutation load in mammalian tissues. Biotechniques (2004) 1.03

Mutation rates in the dystrophin gene: a hotspot of mutation at a CpG dinucleotide. Hum Mutat (2005) 1.03

Database of somatic mutations in EGFR with analyses revealing indel hotspots but no smoking-associated signature. Hum Mutat (2007) 1.03

Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS One (2009) 1.02

Genetic and physiologic correlates of longitudinal immunoreactive trypsinogen decline in infants with cystic fibrosis identified through newborn screening. J Pediatr (2006) 1.02

Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers. Hum Mutat (2005) 1.02

MiR-21 modulates hTERT through a STAT3-dependent manner on glioblastoma cell growth. CNS Neurosci Ther (2012) 1.01

Drastic symmetry breaking in supramolecular organization of enantiomerically unbalanced monolayers at surfaces. Nat Chem (2009) 1.01

Distribution of residual cancer cells in the bowel wall after neoadjuvant chemoradiation in patients with rectal cancer. Dis Colon Rectum (2013) 1.01

MicroRNA-27a promotes proliferation and suppresses apoptosis by targeting PLK2 in laryngeal carcinoma. BMC Cancer (2014) 1.01

Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice. Environ Mol Mutagen (2005) 1.01

In vivo imaging of autophagy in a mouse stroke model. Autophagy (2010) 1.00

Toll-like receptors, tumor necrosis factor-α, and interleukin-10 gene polymorphisms in risk of pulmonary tuberculosis and disease severity. Hum Immunol (2010) 1.00

Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol (2013) 1.00

MECP2 coding sequence and 3'UTR variation in 172 unrelated autistic patients. Am J Med Genet B Neuropsychiatr Genet (2007) 0.99

Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types. Environ Mol Mutagen (2004) 0.99

Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the avβ3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells. Eur J Cell Biol (2011) 0.99

P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor. Drug Metab Lett (2010) 0.98

Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury. Glia (2013) 0.98

Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy. Stroke (2010) 0.98

Selective dissociation between core and extended regions of the face processing network in congenital prosopagnosia. Cereb Cortex (2013) 0.97

Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells. Neuro Oncol (2010) 0.97

Treatment of giant congenital melanocytic nevus of the left upper extremity with staged expanded flap. J Plast Reconstr Aesthet Surg (2011) 0.97

Amygdala lesions disrupt modulation of functional MRI activity evoked by facial expression in the monkey inferior temporal cortex. Proc Natl Acad Sci U S A (2012) 0.97

Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN. Neuro Oncol (2013) 0.96

Mutations in the dystrophin gene are associated with sporadic dilated cardiomyopathy. Mol Genet Metab (2002) 0.96

MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas. J Neurooncol (2011) 0.96

MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells. J Biomed Res (2010) 0.96