A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides.

PubWeight™: 1.33‹?› | Rank: Top 10%

🔗 View Article (PMID 10893242)

Published in J Biol Chem on October 20, 2000

Authors

Z Chen1, R L Fitzgerald, M R Averna, G Schonfeld

Author Affiliations

1: Division of Atherosclerosis, Nutrition and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. zchen@im.wustl.edu

Articles citing this

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol (2005) 5.80

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc Natl Acad Sci U S A (2007) 3.30

Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Diabetes (2013) 1.87

Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. J Biol Chem (2006) 1.80

Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion. Arterioscler Thromb Vasc Biol (2008) 1.46

Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J Biol Chem (2009) 1.28

Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J Biol Chem (2012) 1.28

Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice. J Lipid Res (2009) 1.12

Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk. J Lipid Res (2011) 0.96

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB). J Biol Chem (2010) 0.95

Lipoprotein metabolism in nonalcoholic fatty liver disease. J Biomed Res (2012) 0.90

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol Metab (2013) 0.89

A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele. J Neurosci (2015) 0.89

ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J Lipid Res (2008) 0.88

Fatty liver and insulin resistance: not always linked. Trans Am Clin Climatol Assoc (2008) 0.87

Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice. PLoS One (2010) 0.87

Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism. PLoS One (2012) 0.86

Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding. PLoS One (2012) 0.79

Hepatosteatosis with hypobetalipoproteinemia. J Natl Med Assoc (2007) 0.77

Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression. JCI Insight (2017) 0.75

Articles by these authors

(truncated to the top 100)

Lipoprotein-cholesterol distributions in selected North American populations: the lipid research clinics program prevalence study. Circulation (1980) 2.72

Rationale of the diet-heart statement of the American Heart Association. Report of Nutrition Committee. Circulation (1982) 2.21

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res (1982) 2.01

The primary translation product of rat intestinal apolipoprotein A-I mRNA is an unusual preproprotein. J Biol Chem (1982) 1.69

Apolipoprotein B variant derived from rat intestine. Proc Natl Acad Sci U S A (1980) 1.60

A novel component of the metabolic syndrome: the oxidative stress. Nutr Metab Cardiovasc Dis (2009) 1.49

Role of insulin in lipoprotein secretion by cultured rat hepatocytes. J Clin Invest (1983) 1.48

Assay of total plasma apolipoprotein B concentration in human subjects. J Clin Invest (1974) 1.46

Genetic heterogeneity of lipoproteins in inbred strains of mice: analysis by gel-permeation chromatography. Metabolism (1990) 1.42

CTCL in patients under 20 years of age: a series of five cases. Pediatr Dermatol (1997) 1.39

Carotid atherosclerosis in renal transplant recipients: relationships with cardiovascular risk factors and plasma lipoproteins. Transplantation (1999) 1.38

Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis. J Exp Med (1993) 1.38

Linkage of a gene for familial hypobetalipoproteinemia to chromosome 3p21.1-22. Am J Hum Genet (2000) 1.37

In vivo metabolism of ApoB, ApoA-I, and VLDL triglycerides in a form of hypobetalipoproteinemia not linked to the ApoB gene. Arterioscler Thromb Vasc Biol (2000) 1.33

The structure of human high density lipoprotein and the levels of apolipoprotein A-I in plasma as determined by radioimmunoassay. J Clin Invest (1974) 1.26

Probucol attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Br J Pharmacol (1989) 1.24

Apolipoprotein C-II and C-III levels in hyperlipoproteinemia. Metabolism (1979) 1.19

Intestinal apoproteins during fat absorption. J Clin Invest (1978) 1.19

Role of microtubules in low density lipoprotein processing by cultured cells. J Clin Invest (1979) 1.18

Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity. J Clin Invest (1995) 1.18

Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits. Arteriosclerosis (1989) 1.17

Effects of dietary cholesterol and fatty acids on plasma lipoproteins. J Clin Invest (1982) 1.17

Genetic heterogeneity in familial hypobetalipoproteinemia: linkage and non-linkage to the apoB gene in Caucasian families. Am J Med Genet (1998) 1.14

Cigarette smoking and plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Program Prevalence Study. Circulation (1980) 1.11

Roles of apolipoproteins B and E in the cellular binding of very low density lipoproteins. J Clin Invest (1985) 1.10

Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry. Anal Biochem (2000) 1.07

Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathway. J Biol Chem (1997) 1.07

Plasma apoprotein and lipoprotein lipid levels in vegetarians. Metabolism (1978) 1.05

Carbohydrate diet-induced changes in very low density lipoprotein composition and structure. Diabetes (1978) 1.05

Lipolysis produces changes in the immunoreactivity and cell reactivity of very low density lipoproteins. J Clin Invest (1979) 1.04

The effects of probucol on the progression of atherosclerosis in mature Watanabe heritable hyperlipidaemic rabbits. Br J Pharmacol (1991) 1.03

Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis (2005) 1.02

Characterization of human high density lipoproteins by zonal ultracentrifugation. J Biol Chem (1980) 1.01

Effects of fatty acids on carbohydrate and fatty acid metabolism of rat diaphragm. Am J Physiol (1968) 1.01

Alterations in levels and interrelations of plasma apolipoproteins induced by diet. Metabolism (1976) 1.00

Oleic acid stimulation of apolipoprotein B secretion from HepG2 and Caco-2 cells occurs post-transcriptionally. Biochim Biophys Acta (1990) 1.00

Aortic accumulation and plasma clearance of beta-VLDL and HDL: effects of diet-induced hypercholesterolemia in rabbits. J Lipid Res (1985) 0.99

Apolipoprotein B levels and altered lipoprotein composition in diabetes. Diabetes (1974) 0.99

Inhibition of cholesteryl ester deposition in macrophages by calcium entry blockers: an effect dissociable from calcium entry blockade. Br J Pharmacol (1987) 0.99

Loci of catabolism of beta-very low density lipoprotein in vivo delineated with a residualizing label, 125I-dilactitol tyramine. J Biol Chem (1985) 0.98

Overproduction of very low-density lipoproteins by livers of genetically obese rats. Am J Physiol (1971) 0.98

In vivo MRS measurement of liver lipid levels in mice. J Lipid Res (2004) 0.97

Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes. J Lipid Res (1991) 0.97

Current techniques in mycobacterial detection and speciation. Crit Rev Clin Lab Sci (1996) 0.96

Antigenic mapping of human low density lipoprotein with monoclonal antibodies. J Lipid Res (1982) 0.96

Effect of fatty acids on lipid and apoprotein secretion and association in hepatocyte cultures. J Clin Invest (1983) 0.96

Metabolism of very low density lipoproteins after cessation of cholesterol feeding in rabbits. A factor potentially contributing to the slow regression of atheromatous plaques. J Clin Invest (1986) 0.95

Nonenzymatic glycosylation of low density lipoproteins in vitro. Effects on cell-interactive properties. Diabetes (1981) 0.95

Characterization of the plasma lipoproteins of the genetically obese hyperlipoproteinemic Zucker fatty rat. J Lipid Res (1974) 0.95

Viscosity of culture medium as a regulator of synthesis and secretion of very low density lipoproteins by cultured hepatocytes. J Biol Chem (1982) 0.94

Effects of probucol on plasma cholesterol, high and low density lipoprotein cholesterol, and apolipoproteins A1 and A2 in adults with primary familial hypercholesterolemia. Metabolism (1980) 0.93

Utilization of exogenous free fatty acids for the production of very low density lipoprotein triglyceride by livers of carbohydrate-fed rats. J Lipid Res (1971) 0.93

Two distinct truncated apolipoprotein B species in a kindred with hypobetalipoproteinemia. Arteriosclerosis (1990) 0.91

Positive linear correlation between the length of truncated apolipoprotein B and its secretion rate: in vivo studies in human apoB-89, apoB-75, apoB-54.8, and apoB-31 heterozygotes. J Lipid Res (1996) 0.91

Elevated cholesterol and bile acid synthesis in a young patient with homozygous familial hypercholesterolemia. J Clin Invest (1979) 0.90

In vivo regulation of low-density lipoprotein receptors by estrogen differs at the post-transcriptional level in rat and mouse. Eur J Biochem (1993) 0.89

ApoB-75, a truncation of apolipoprotein B associated with familial hypobetalipoproteinemia: genetic and kinetic studies. J Lipid Res (1992) 0.89

Efficacy and safety of pravastatin in patients with primary hypercholesterolemia. I. A dose-response study. Atherosclerosis (1990) 0.88

Babesiosis in two infants from Eastern Long Island, NY. Am J Dis Child (1986) 0.88

Dependence of metabolic and structural heterogeneity of cholesterol ester-rich very low density lipoproteins on the duration of cholesterol feeding in rabbits. J Clin Invest (1988) 0.88

Known mutations of apoB account for only a small minority of hypobetalipoproteinemia. J Lipid Res (1999) 0.88

Lengths of truncated forms of apolipoprotein B (apoB) determine their intestinal production. Biochem Biophys Res Commun (1992) 0.88

Bile sequestrant therapy alters the compositions of low-density and high-density lipoproteins. Metabolism (1979) 0.88

Cholesteryl ester storage disease: complex molecular effects of chronic lovastatin therapy. J Lipid Res (1992) 0.88

Plasma apoproteins and the severity of coronary artery disease. Circulation (1986) 0.88

Apoprotein B-100 production is decreased in subjects heterozygous for truncations of apoprotein B. Arterioscler Thromb Vasc Biol (1995) 0.87

Regional specificities of monoclonal anti-human apolipoprotein B antibodies. J Lipid Res (1988) 0.87

Structure of high density lipoprotein. The immunologic reactivities of the COOH- and NH2-terminal regions of apolipoprotein A-I. J Biol Chem (1976) 0.87

Characterization of lipoprotein in a kindred with familial hypercholesterolemia. J Lipid Res (1982) 0.87

Plasma, apolipoprotein, A-I and A-II levels in hyperlipidemia. Lipids (1978) 0.87

Receptors for homologous plasma lipoproteins on a rat hepatoma cell line. J Lipid Res (1983) 0.87

Effects of NIDDM on very-low-density lipoprotein triglyceride and apolipoprotein B metabolism. Studies before and after sulfonylurea therapy. Diabetes (1986) 0.87

Apolipoprotein A-II content of human plasma high density lipoproteins measured by radioimmunoassay. J Lipid Res (1977) 0.87

Enhanced clearance from plasma of low density lipoproteins containing a truncated apolipoprotein, apoB-89. J Lipid Res (1990) 0.86

Lipoproteins in atherogenesis. Artery (1979) 0.86

In vivo regulation of low-density lipoprotein receptor and apolipoprotein B gene expressions by dietary fat and cholesterol in inbred strains of mice. Biochim Biophys Acta (1991) 0.86

Exercise training decreases plasma cholesteryl ester transfer protein. Arterioscler Thromb (1993) 0.85

Racial differences in plasma high-density lipoproteins in patients receiving hemodialysis. A possible mechanism for accelerated atherosclerosis in white men. N Engl J Med (1983) 0.85

Apolipoprotein A-I, A-II and C-II in black and white residents of Evans County. Circulation (1980) 0.85

Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function. J Lipid Res (1988) 0.85

Type III hyperlipoproteinemia: development of a VLDL ApoE gel isoelectric focusing technique and application in family studies. J Lab Clin Med (1979) 0.85

Apolipoprotein expression and cellular differentiation in Caco-2 intestinal cells. Am J Physiol (1992) 0.85

Effect of probucol on the composition of lipoproteins and on VLDL apoprotein B turnover. Atherosclerosis (1983) 0.85

Abnormal cell-interactive properties of low-density lipoproteins isolated from patients with chronic renal failure. Metabolism (1985) 0.84

Measurement of apolipoprotein A-I in rat high density lipoprotein and in rat plasma by radioimmunoassay. J Lipid Res (1976) 0.84

Lipolysis of LDL with phospholipase A2 alters the expression of selected apoB-100 epitopes and the interaction of LDL with cells. J Lipid Res (1988) 0.84

Measurements of rate of transcription in isolated nuclei by nuclear "run-off" assay. Methods Mol Biol (1994) 0.84

The familial dyslipoproteinemias. Prog Med Genet (1973) 0.84

Effects of diet on apoprotein E levels and on the apoprotein E subspecies in human plasma lipoproteins. J Clin Endocrinol Metab (1980) 0.83

Lipoproteins containing the truncated apolipoprotein, Apo B-89, are cleared from human plasma more rapidly than Apo B-100-containing lipoproteins in vivo. J Clin Invest (1992) 0.83

Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits. J Clin Invest (1995) 0.83

Lipoprotein levels in morbidly obese patients with massive, surgically-induced weight loss. Metabolism (1983) 0.83

The molecular basis of truncated forms of apolipoprotein B in a kindred with compound heterozygous hypobetalipoproteinemia. J Lipid Res (1989) 0.83

Modification of the core lipids of low density lipoproteins produces selective alterations in the expression of apoB-100 epitopes. J Lipid Res (1990) 0.82

Effects of sex hormones on rat lipoproteins. Endocrinology (1980) 0.82

Genetic risk factors in myocardial infarction at young age. Minerva Cardioangiol (2004) 0.82

The C(-260)>T gene polymorphism in the promoter of the CD14 monocyte receptor gene is not associated with acute myocardial infarction. Clin Exp Med (2003) 0.82

Apolipoprotein B subspecies in chylomicrons isolated from a patient with chyluria. Am J Med (1983) 0.82

Regulation of low density lipoprotein receptor gene expression in HepG2 and Caco2 cells by palmitate, oleate, and 25-hydroxycholesterol. J Lipid Res (1995) 0.82

Metabolic modes of action of the statins in the hyperlipoproteinemias. Atherosclerosis (1998) 0.82