Published in Br J Pharmacol on July 01, 2000
The effect of grapefruit juice on drug disposition. Expert Opin Drug Metab Toxicol (2011) 1.28
Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol (2010) 1.20
Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br J Pharmacol (2004) 1.06
P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review. J Adv Res (2014) 1.00
Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect. Drug Metab Dispos (2012) 0.89
Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol (2004) 0.88
Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model. Br J Clin Pharmacol (2000) 0.86
Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra-Performance Liquid Chromatography. Phytochem Anal (2013) 0.83
Impact of citrus soft drinks relative to grapefruit juice on ciclosporin disposition. Br J Clin Pharmacol (2006) 0.81
Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel. Eur J Clin Pharmacol (2003) 0.78
Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats. Evid Based Complement Alternat Med (2011) 0.77
Effect of Low-Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics. J Clin Pharmacol (2016) 0.75
Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor. Front Pharmacol (2017) 0.75
Effect of tangerine juice on cyclosporine levels in renal transplant children. Pediatr Nephrol (2007) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Interaction of citrus juices with felodipine and nifedipine. Lancet (1991) 2.97
Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. J Clin Invest (1997) 2.89
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog (1995) 2.25
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther (1997) 2.17
Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem (1992) 2.14
MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci U S A (1999) 1.59
Interaction between grapefruit juice and midazolam in humans. Clin Pharmacol Ther (1995) 1.53
Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. J Pharmacol Exp Ther (1992) 1.52
Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab Dispos (1997) 1.43
Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther (1992) 1.35
Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol (1999) 1.25
Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos (1996) 1.22
Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans. Clin Pharmacol Ther (1991) 1.16
Trough concentrations of cyclosporine in blood following administration with grapefruit juice. Br J Clin Pharmacol (1993) 1.15
Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. Clin Pharmacol Ther (1993) 1.15
Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice. Chem Res Toxicol (1998) 1.14
Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin Pharmacol (1993) 1.12
Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man. Br J Clin Pharmacol (1998) 1.12
Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney. J Histochem Cytochem (1999) 1.10
The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450. Br J Clin Pharmacol (1988) 1.05
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett (1998) 1.03
Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice. Clin Pharmacol Ther (1995) 0.99
Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram. Clin Pharmacol Ther (1996) 0.98
Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. J Am Soc Nephrol (1999) 0.97
Structure and function of P-glycoprotein in normal liver and small intestine. Adv Pharmacol (1993) 0.95
Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction. Pharmacogenetics (1997) 0.94
Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells. Biol Pharm Bull (1998) 0.92
Can grapefruit juice influence ethinylestradiol bioavailability? Contraception (1996) 0.91
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J Biol Chem (1998) 0.87
Transport of genistein-7-glucoside by human intestinal CACO-2 cells: potential role for MRP2. Res Commun Mol Pathol Pharmacol (1999) 0.87
In vitro inhibition of midazolam and quinidine metabolism by flavonoids. Eur J Clin Pharmacol (1995) 0.84
Multidrug resistance. Anticancer Drugs (1995) 0.80
Interaction between grapefruit juice and diazepam in humans. Eur J Drug Metab Pharmacokinet (1998) 0.79
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature (1999) 17.72
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J (1998) 9.36
A role for ghrelin in the central regulation of feeding. Nature (2001) 8.12
Phenanthrenequinone as an analytical reagent for arginine and other monosubstituted guanidines. Biochim Biophys Acta (1966) 7.11
Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature (1987) 6.66
CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res (1998) 6.42
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell (1999) 6.40
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature (1989) 6.07
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature (1996) 5.32
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest (2000) 5.07
Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature (1989) 4.55
Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill (2013) 4.44
Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun (1993) 4.32
A new natriuretic peptide in porcine brain. Nature (1988) 4.22
Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res (2001) 3.51
Characterization of Rose Bengal binding to sinusoidal and bile canalicular plasma membrane from rat liver. Biochim Biophys Acta (1989) 3.47
Plasmid-mediated penicillin beta-lactamases in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1976) 3.40
Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med (1992) 3.31
Three-year follow-up after implantation of metallic coronary-artery stents. N Engl J Med (1996) 2.95
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases. Biochem Biophys Res Commun (1988) 2.89
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence. Biochem Biophys Res Commun (1971) 2.67
Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65
Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol (1999) 2.56
Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol Immunol (2001) 2.52
Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension. J Am Coll Cardiol (1998) 2.52
Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones. Science (1971) 2.43
Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta (2001) 2.41
Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun (2000) 2.41
Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP). Biochem Biophys Res Commun (1984) 2.40
Reduction of risk of pneumonia associated with use of angiotensin I converting enzyme inhibitors in elderly inpatients. Am J Hypertens (1999) 2.36
Isolation and properties of the FSH and LH-releasing hormone. Biochem Biophys Res Commun (1971) 2.29
A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. Nature (1990) 2.29
Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev (2001) 2.26
Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science (1991) 2.25
Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis. Nature (1993) 2.25
Structure and gene organization in the transformed Hind III-G fragment of Ad12. Cell (1980) 2.22
Extracellular accumulation of a new amino acid, O-2-hydroxypropylhomoserine, from 1,2-propanediol by flavobacterium rigense. Appl Environ Microbiol (1978) 2.21
Pathophysiology of "tethered cord syndrome". J Neurosurg (1981) 2.17
Identification of amyloid prealbumin variant in familial amyloidotic polyneuropathy (Japanese type). Biochem Biophys Res Commun (1983) 2.16
Significance of fill-in after thallium-201 reinjection following delayed imaging: comparison with regional wall motion and angiographic findings. J Nucl Med (1990) 2.15
Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med (1997) 2.14
Simple, rapid, quantitative, and sensitive detection of telomere repeats in cell lysate by a hybridization protection assay. Clin Chem (1999) 2.11
The results, indications, and physiology of posteroventral pallidotomy for patients with Parkinson's disease. Neurosurgery (1995) 2.09
Genetic dissection of nodal function in patterning the mouse embryo. Development (2001) 2.07
Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J Cell Biol (2000) 2.04
Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone. Am J Cardiol (2001) 2.03
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology (2001) 2.02
C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun (1990) 2.00
Chronic active and lupoid hepatitis caused by a laxative, oxyphenisatin. N Engl J Med (1971) 1.98
FGF-2 stimulates periodontal regeneration: results of a multi-center randomized clinical trial. J Dent Res (2010) 1.92
Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development (1994) 1.87
Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell (1998) 1.87
Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Update (2004) 1.81
Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis. Br J Cancer (2004) 1.80
A new approach for evaluation of left ventricular diastolic function: spatial and temporal analysis of left ventricular filling flow propagation by color M-mode Doppler echocardiography. J Am Coll Cardiol (1996) 1.79
Temperature sensitive mutants of Escherichia coli for tRNA synthesis. Nucleic Acids Res (1974) 1.79
Locating the central sulcus: comparison of MR anatomic and magnetoencephalographic functional methods. AJNR Am J Neuroradiol (1993) 1.76
Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci U S A (1992) 1.76
IgG subclasses in patients with membranoproliferative glomerulonephritis, membranous nephropathy, and lupus nephritis. Kidney Int (1997) 1.72
Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia. Blood (1994) 1.72
Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A. J Antibiot (Tokyo) (1984) 1.71
Experimental investigation of heat conduction mechanisms in nanofluids. Clue on clustering. Nano Lett (2009) 1.71
Semisynthetic -lactam antibiotics. 2. Synthesis and properties of D- and L- -sulfobenzylpenicillins. J Med Chem (1972) 1.70
Fibroblast growth factor in the extracellular matrix of dystrophic (mdx) mouse muscle. Science (1989) 1.68
Pathological changes observed in the finger biopsy of patients with vibration-induced white finger. Scand J Work Environ Health (1986) 1.67
L-Glutamine formation by Flavobacterium rigense. Appl Environ Microbiol (1979) 1.66
alpha-Neo-endorphin : a "big" Leu-enkephalin with potent opiate activity from porcine hypothalami. Biochem Biophys Res Commun (1979) 1.65
A 'hot-spot' mutation alters the mechanical properties of keratin filament networks. Nat Cell Biol (2001) 1.65
Histologic diagnostic rate of cardiac sarcoidosis: evaluation of endomyocardial biopsies. Am Heart J (1999) 1.62
Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord. Biochem Biophys Res Commun (1983) 1.61
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab (2001) 1.61
Diphenylphosphoryl azide. A new convenient reagent for a modified Curtus reaction and for the peptide synthesis. J Am Chem Soc (1972) 1.61
Nasal reconstruction based on aesthetic subunits in Orientals. Plast Reconstr Surg (2000) 1.60
Diffusion and deformations of single hydra cells in cellular aggregates. Biophys J (2000) 1.60
Endothelial cells actively synthesize and secrete adrenomedullin. Biochem Biophys Res Commun (1994) 1.60
Real-time observation of acrosomal dispersal from mouse sperm using GFP as a marker protein. FEBS Lett (1999) 1.57
Left ventricular ejection performance, wall stress, and contractile state in aortic regurgitation before and after aortic valve replacement. Circulation (1990) 1.56
Movements of truncated kinesin fragments with a short or an artificial flexible neck. Proc Natl Acad Sci U S A (1997) 1.55
Marked increase in plasma interleukin-6 in burn patients. J Lab Clin Med (1992) 1.55
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy. Proc Natl Acad Sci U S A (2000) 1.55
Inhibitory regulation of hypertrophy by endogenous atrial natriuretic peptide in cultured cardiac myocytes. Hypertension (2000) 1.54
Bone metastasis and poor performance status are prognostic factors for survival of carcinoma of unknown primary site in patients treated with systematic chemotherapy. Ann Oncol (2009) 1.54
Meningo-encephalitis associated with HHV-6 related exanthem subitum. Acta Paediatr Scand (1990) 1.54
Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model. Circulation (2000) 1.53
Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat Med (2000) 1.53
Traditional Chinese medicine and Kampo: a review from the distant past for the future. J Int Med Res (2006) 1.52
Serum hepatocyte growth factor levels in hepatectomized and nonhepatectomized surgical patients. Gastroenterology (1992) 1.52
A novel method for the determination of C-terminal amino acid in polypeptides by selective tritium labelling. Biochem Biophys Res Commun (1966) 1.51
Metallic stents for malignant and benign ureteric obstruction. BJU Int (2000) 1.51
Collagenofibrotic glomerulopathy: a systemic disease. Am J Kidney Dis (1999) 1.51
Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem Biophys Res Commun (1993) 1.51
Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese. J Clin Endocrinol Metab (1998) 1.50
Immunohistochemical investigation of new suppressor oncogene p130 in oral squamous cell carcinoma. Oral Oncol (1999) 1.49
Reconstruction of defects involving the upper one-third of the auricle. Plast Reconstr Surg (1998) 1.48
Preparation and physicochemical properties of green pea superoxide dismutase. Biochim Biophys Acta (1972) 1.48
Phage conversion of exfoliative toxin A production in Staphylococcus aureus. Mol Microbiol (2000) 1.47
Orally active antioxidative copper(II) aspirinate: synthesis, structure characterization, superoxide scavenging activity, and in vitro and in vivo antioxidative evaluations. J Biol Inorg Chem (2005) 1.47