Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

PubWeight™: 9.36‹?› | Rank: Top 0.1%

🔗 View Article (PMC 1170601)

Published in EMBO J on May 01, 1998

Authors

M Saitoh1, H Nishitoh, M Fujii, K Takeda, K Tobiume, Y Sawada, M Kawabata, K Miyazono, H Ichijo

Author Affiliations

1: Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan.

Articles citing this

(truncated to the top 100)

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta (2006) 7.33

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev (2002) 6.44

Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep (2001) 5.32

Signal transduction by reactive oxygen species. J Cell Biol (2011) 5.21

Radical-free biology of oxidative stress. Am J Physiol Cell Physiol (2008) 4.33

Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol (2001) 4.09

Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol (2013) 3.73

Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res (2010) 3.71

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56

Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med (2008) 3.38

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell (1999) 3.27

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J (1999) 3.22

Reactive oxygen species in cancer. Free Radic Res (2010) 3.20

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol (2000) 3.08

Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem (2008) 3.08

Mitochondrial energetics and therapeutics. Annu Rev Pathol (2010) 3.07

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J (2003) 2.97

A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev (2012) 2.76

Signaling functions of reactive oxygen species. Biochemistry (2010) 2.67

Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal (2008) 2.67

ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep (2002) 2.61

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci U S A (2001) 2.58

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev (2001) 2.48

Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci U S A (1999) 2.41

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J (2001) 2.38

Redox compartmentalization in eukaryotic cells. Biochim Biophys Acta (2008) 2.35

Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid Redox Signal (2009) 2.33

Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol (2000) 2.25

Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest (2003) 2.19

Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology (2002) 2.18

The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange. J Biol Chem (2006) 2.15

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A (2007) 2.11

Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem (2009) 2.04

BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci U S A (2001) 2.01

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems. Proc Natl Acad Sci U S A (2002) 2.00

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets. Clin Sci (Lond) (2008) 1.95

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc Natl Acad Sci U S A (2005) 1.91

Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product. Proc Natl Acad Sci U S A (1999) 1.85

Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal (2011) 1.82

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest (2004) 1.79

Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells. J Clin Invest (2005) 1.77

Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proc Natl Acad Sci U S A (2004) 1.76

The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res (2008) 1.75

A yeast two-hybrid knockout strain to explore thioredoxin-interacting proteins in vivo. Proc Natl Acad Sci U S A (2005) 1.74

Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proc Natl Acad Sci U S A (2003) 1.73

DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci U S A (2009) 1.69

Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. Mol Cell Biol (2007) 1.68

The Arabidopsis cytosolic thioredoxin h5 gene induction by oxidative stress and its W-box-mediated response to pathogen elicitor. Plant Physiol (2004) 1.64

Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans. PLoS Pathog (2011) 1.59

Oxidative stress induces overgrowth of the Drosophila neuromuscular junction. Proc Natl Acad Sci U S A (2011) 1.58

Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling. J Neurosci (2008) 1.56

TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. Arterioscler Thromb Vasc Biol (2007) 1.55

Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol (2014) 1.54

Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. FASEB J (2006) 1.54

Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain. Biochem J (2004) 1.54

SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis. J Cell Biol (1998) 1.53

AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. J Clin Invest (2003) 1.52

Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage. Proc Natl Acad Sci U S A (1999) 1.50

Oxidative stress-mediated regulation of proteasome complexes. Mol Cell Proteomics (2011) 1.50

S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal (2011) 1.49

Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48

Glutathione and apoptosis. Free Radic Res (2008) 1.48

Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. J Biol Chem (2008) 1.47

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J (2009) 1.46

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Mol Cell Biol (2006) 1.45

Structural and functional characterization of the human protein kinase ASK1. Structure (2007) 1.42

Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. EMBO Rep (2004) 1.42

Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1. Biochem J (2003) 1.40

Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3. J Clin Invest (2001) 1.40

Flow shear stress and atherosclerosis: a matter of site specificity. Antioxid Redox Signal (2011) 1.39

Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons. Mol Cell Biol (2000) 1.39

Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes (2009) 1.39

ROS-dependent signal transduction. Curr Opin Cell Biol (2014) 1.37

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J Biol Chem (2008) 1.37

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. Arch Biochem Biophys (2008) 1.36

Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance. Antioxid Redox Signal (2012) 1.36

Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol (2002) 1.35

Thiol chemistry in peroxidase catalysis and redox signaling. Antioxid Redox Signal (2008) 1.35

TNF and MAP kinase signalling pathways. Semin Immunol (2014) 1.35

Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34

Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1. J Biol Chem (2008) 1.33

Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal (2012) 1.32

The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase. Antioxid Redox Signal (2009) 1.32

The roles of ASK family proteins in stress responses and diseases. Cell Commun Signal (2009) 1.32

Chaperone properties of Escherichia coli thioredoxin and thioredoxin reductase. Biochem J (2003) 1.30

Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J Exp Med (1998) 1.30

Cytokines in radiobiological responses: a review. Radiat Res (2012) 1.29

A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis. Blood (2005) 1.28

Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal (2012) 1.27

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem (2008) 1.27

ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice. Circ Res (2009) 1.26

Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. Circ Res (2010) 1.26

Redox control systems in the nucleus: mechanisms and functions. Antioxid Redox Signal (2010) 1.25

The plastidic 2-cysteine peroxiredoxin is a target for a thioredoxin involved in the protection of the photosynthetic apparatus against oxidative damage. Plant Cell (2002) 1.24

Redox sensing: orthogonal control in cell cycle and apoptosis signalling. J Intern Med (2010) 1.24

Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. J Biol Chem (2009) 1.24

Articles cited by this

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (1988) 52.71

Apoptosis in the pathogenesis and treatment of disease. Science (1995) 20.24

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (1995) 17.76

H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response. Cell (1994) 14.10

Thioredoxin. Annu Rev Biochem (1985) 9.82

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem (1995) 9.56

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science (1997) 9.53

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell (1995) 8.80

Thioredoxin and glutaredoxin systems. J Biol Chem (1989) 8.27

Mechanisms and genes of cellular suicide. Science (1995) 8.05

Caspases: intracellular signaling by proteolysis. Cell (1997) 7.46

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature (1996) 6.75

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 6.50

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev (1994) 5.96

Oxidative stress as a mediator of apoptosis. Immunol Today (1994) 5.80

Mitochondrial control of apoptosis. Immunol Today (1997) 4.74

The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci (1993) 4.62

MAPKs: new JNK expands the group. Trends Biochem Sci (1994) 4.10

Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays (1996) 3.96

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci U S A (1996) 3.85

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol (1995) 3.79

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci U S A (1997) 3.21

Redox regulation of cellular activation. Annu Rev Immunol (1997) 3.17

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol (1994) 2.93

A conserved kinase cascade for MAP kinase activation in yeast. Curr Opin Cell Biol (1993) 2.89

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem J (1989) 2.85

Reactive oxygen species and programmed cell death. Trends Biochem Sci (1996) 2.68

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem (1991) 2.65

ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J (1989) 2.62

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J (1997) 2.60

Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev Biol (1996) 2.30

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J Cell Biol (1994) 2.27

Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide. Structure (1995) 2.14

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin. J Biol Chem (1993) 2.14

MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases? Curr Opin Genet Dev (1997) 2.09

Structural and functional relations among thioredoxins of different species. Proteins (1991) 2.05

Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes. J Biol Chem (1995) 1.96

Construction of nondefective adenovirus type 5 bearing a 2.8-kilobase hepatitis B virus DNA near the right end of its genome. J Virol (1985) 1.88

Reactive oxygen metabolites and reperfusion injury: aberrant triggering of reticuloendothelial function. Lancet (1994) 1.78

Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin. Biochem Biophys Res Commun (1992) 1.66

1-Chloro-2,4-dinitrobenzene is an irreversible inhibitor of human thioredoxin reductase. Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity. J Biol Chem (1995) 1.64

Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism. Immunology (1987) 1.61

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc Natl Acad Sci U S A (1994) 1.60

Thioredoxin: a multifunctional regulatory protein with a bright future in technology and medicine. Arch Biochem Biophys (1994) 1.59

Protective effect of N-acetylcysteine in tumor necrosis factor-alpha-induced apoptosis in U937 cells: the role of mitochondria. Exp Cell Res (1995) 1.57

Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor. J Biol Chem (1995) 1.57

Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide. Immunol Lett (1994) 1.47

Intracellular hydroxyl radical production induced by recombinant human tumor necrosis factor and its implication in the killing of tumor cells in vitro. Cancer Res (1989) 1.46

Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity. J Clin Invest (1996) 1.44

Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells. J Immunol (1991) 1.40

Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells. Cancer Res (1996) 1.33

Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin. J Biol Chem (1994) 1.33

The oxidative stress response. New Horiz (1995) 1.31

Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system. J Clin Invest (1996) 1.23

Survival factor-insensitive generation of reactive oxygen species induced by serum deprivation in neuronal cells. Brain Res (1996) 1.22

Inhibition of amino acid transport into lymphoid cells by the glutamine analog L-2-amino-4-oxo-5-chloropentanoate. Proc Natl Acad Sci U S A (1979) 1.20

Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. Biochem Biophys Res Commun (1997) 1.18

Apoptosis: telling cells their time is up. Curr Biol (1996) 1.13

Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab Invest (1997) 1.13

Articles by these authors

A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34

Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86

TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (1997) 15.75

Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science (1997) 9.53

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature (1997) 7.69

Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54

Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med (1997) 7.12

Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep (2001) 5.32

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science (1999) 4.69

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J (1997) 4.48

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem (1999) 4.38

Smad6 inhibits signalling by the TGF-beta superfamily. Nature (1997) 4.34

Endovascular stent-graft placement for the treatment of acute aortic dissection. N Engl J Med (1999) 4.33

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol (2011) 4.22

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem (2001) 4.22

Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature (1998) 4.06

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol (1999) 4.00

ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell (1998) 3.98

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol (1989) 3.89

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (1989) 3.80

The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med (1999) 3.72

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science (1998) 3.72

Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology (1983) 3.67

Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell (1993) 3.57

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56

Pig cloning by microinjection of fetal fibroblast nuclei. Science (2000) 3.51

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A (2001) 3.49

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem (1994) 3.49

Characterization of Rose Bengal binding to sinusoidal and bile canalicular plasma membrane from rat liver. Biochim Biophys Acta (1989) 3.47

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44

Plasmid-mediated penicillin beta-lactamases in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1976) 3.40

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell (1999) 3.27

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J (1999) 3.22

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19

Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol (2000) 3.10

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol (2000) 3.08

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05

High-dose intravenous immune globulin for stiff-person syndrome. N Engl J Med (2001) 3.04

Three-year follow-up after implantation of metallic coronary-artery stents. N Engl J Med (1996) 2.95

Characterization of type I receptors for transforming growth factor-beta and activin. Science (1994) 2.94

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84

Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity (2000) 2.81

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol (1996) 2.80

Transformation of Bacillus stearothermophilus with plasmid DNA and characterization of shuttle vector plasmids between Bacillus stearothermophilus and Bacillus subtilis. J Bacteriol (1982) 2.80

PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression. Mol Cell (1998) 2.75

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur J Immunol (1996) 2.67

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A (1996) 2.64

Purification and characterization of the human interleukin-18 receptor. J Biol Chem (1997) 2.58

Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev (1998) 2.56

TLR6: A novel member of an expanding toll-like receptor family. Gene (1999) 2.55

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett (1996) 2.53

Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem (2000) 2.50

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest (1999) 2.50

TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Cell (1990) 2.46

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. J Biol Chem (1999) 2.44

Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol (2000) 2.41

Isolation and characterization of antibiotic resistance plasmids from thermophilic bacilli and construction of deletion plasmids. J Bacteriol (1981) 2.40

BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol (2000) 2.40

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J (2001) 2.38

High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells. J Exp Med (1986) 2.37

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J Exp Med (2001) 2.37

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Biol (1995) 2.36

Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A (1997) 2.35

Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process. Lancet (1990) 2.35

Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management. Arch Surg (1999) 2.33

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem (1999) 2.32

The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med (1999) 2.32

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A (2000) 2.31