Published in Development on May 01, 2001
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A (2006) 3.85
Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proc Natl Acad Sci U S A (2008) 2.99
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat Rev Mol Cell Biol (2009) 2.86
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
Early steps in the development of the forebrain. Dev Cell (2004) 2.34
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Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev (2003) 1.91
The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol Cell Biol (2004) 1.87
Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev (2002) 1.68
The molecular genetics of holoprosencephaly. Am J Med Genet C Semin Med Genet (2010) 1.57
Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell (2008) 1.57
NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Biol Reprod (2012) 1.52
Vertebrate intestinal endoderm development. Dev Dyn (2011) 1.41
Hyperglycemia impairs left-right axis formation and thereby disturbs heart morphogenesis in mouse embryos. Proc Natl Acad Sci U S A (2015) 1.40
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Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A (2011) 1.33
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J Cell Sci (2011) 1.30
Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain. Dev Biol (2008) 1.30
Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly. Mol Genet Metab (2009) 1.21
Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS One (2008) 1.21
Nodal signaling via an autocrine pathway promotes proliferation of mouse spermatogonial stem/progenitor cells through Smad2/3 and Oct-4 activation. Stem Cells (2009) 1.15
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Thyrotropin-independent induction of thyroid endoderm from embryonic stem cells by activin A. Endocrinology (2008) 1.14
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The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development. Mol Cell Biol (2005) 1.12
ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol Cell Biol (2004) 1.06
Multiple functions of Cerberus cooperate to induce heart downstream of Nodal. Dev Biol (2006) 1.06
Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto. Genes Dev (2003) 1.01
Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction. J Cell Biol (2008) 1.01
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Zic-associated holoprosencephaly: zebrafish Zic1 controls midline formation and forebrain patterning by regulating Nodal, Hedgehog, and retinoic acid signaling. Genes Dev (2009) 1.00
Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. Philos Trans R Soc Lond B Biol Sci (2003) 0.99
Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS One (2010) 0.99
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Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. J Am Soc Nephrol (2013) 0.97
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development (2013) 0.96
Transitions between epithelial and mesenchymal states and the morphogenesis of the early mouse embryo. Cell Adh Migr (2010) 0.95
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Early activation of FGF and nodal pathways mediates cardiac specification independently of Wnt/beta-catenin signaling. PLoS One (2009) 0.95
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Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open (2012) 0.90
Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells. Development (2012) 0.89
Gutsy moves in mice: cellular and molecular dynamics of endoderm morphogenesis. Philos Trans R Soc Lond B Biol Sci (2014) 0.89
Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Dev Dyn (2008) 0.89
Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO Rep (2012) 0.89
Generating β cells from stem cells-the story so far. Cold Spring Harb Perspect Med (2012) 0.88
Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus. Dev Biol (2006) 0.88
Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans. Wiley Interdiscip Rev Dev Biol (2014) 0.88
Nodal expression in the uterus of the mouse is regulated by the embryo and correlates with implantation. Biol Reprod (2011) 0.87
Left-right symmetry breaking in mice by left-right dynein may occur via a biased chromatid segregation mechanism, without directly involving the Nodal gene. Front Oncol (2012) 0.86
Nt mutation causing laterality defects associated with deletion of rotatin. Mamm Genome (2007) 0.85
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BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. Hum Mol Genet (2010) 0.84
Activin/Nodal signalling before implantation: setting the stage for embryo patterning. Philos Trans R Soc Lond B Biol Sci (2014) 0.84
A gutsy task: generating intestinal tissue from human pluripotent stem cells. Dig Dis Sci (2013) 0.83
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Enhanced differentiation of adult bone marrow-derived stem cells to liver lineage in aggregate culture. Tissue Eng Part A (2011) 0.81
Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. PLoS One (2011) 0.80
Meteorin regulates mesendoderm development by enhancing nodal expression. PLoS One (2014) 0.79
The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biol (2015) 0.79
Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells. Philos Trans R Soc Lond B Biol Sci (2015) 0.78
NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos. Dis Model Mech (2012) 0.78
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Heterotaxy-spectrum heart defects in Zic3 hypomorphic mice. Pediatr Res (2013) 0.78
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Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning. Philos Trans R Soc Lond B Biol Sci (2016) 0.77
Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation. Dev Biol (2013) 0.77
Nodal signaling from the visceral endoderm is required to maintain Nodal gene expression in the epiblast and drive DVE/AVE migration. Dev Biol (2014) 0.77
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Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis. Biol Open (2012) 0.76
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Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res Ther (2011) 0.75
Analysis of compound heterozygotes reveals that the mouse floxed Pax6 (tm1Ued) allele produces abnormal eye phenotypes. Transgenic Res (2016) 0.75
Mechanism for generation of left isomerism in Ccdc40 mutant embryos. PLoS One (2017) 0.75
Rare copy number variants in patients with congenital conotruncal heart defects. Birth Defects Res (2017) 0.75
ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm. Development (2015) 0.75
Endoderm complexity in the mouse gastrula is revealed through the expression of spink3. Biores Open Access (2014) 0.75
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