Published in Biochemistry on July 25, 2000
Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature (2014) 3.80
Text mining improves prediction of protein functional sites. PLoS One (2012) 1.16
Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli. J Biol Chem (2008) 1.00
Catalytic DNA with phosphatase activity. Proc Natl Acad Sci U S A (2013) 0.93
Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK. Philos Trans R Soc Lond B Biol Sci (2012) 0.81
Crystal structures of human muscle fructose-1,6-bisphosphatase: novel quaternary states, enhanced AMP affinity, and allosteric signal transmission pathway. PLoS One (2013) 0.79
Mechanism of displacement of a catalytically essential loop from the active site of mammalian fructose-1,6-bisphosphatase. Biochemistry (2013) 0.78
Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase. Proc Natl Acad Sci U S A (2016) 0.78
T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol (2016) 0.77
The mechanism of calcium-induced inhibition of muscle fructose 1,6-bisphosphatase and destabilization of glyconeogenic complex. PLoS One (2013) 0.77
Central cavity of fructose-1,6-bisphosphatase and the evolution of AMP/fructose 2,6-bisphosphate synergism in eukaryotic organisms. J Biol Chem (2014) 0.77
A quantitative measure of electrostatic perturbation in holo and apo enzymes induced by structural changes. PLoS One (2013) 0.77
Unexpected similarity in regulation between an archaeal inositol monophosphatase/fructose bisphosphatase and chloroplast fructose bisphosphatase. Protein Sci (2003) 0.76
Designing inhibitors against fructose 1,6-bisphosphatase: exploring natural products for novel inhibitor scaffolds. Eur J Med Chem (2010) 0.75
Quadruple space-group ambiguity owing to rotational and translational noncrystallographic symmetry in human liver fructose-1,6-bisphosphatase. Acta Crystallogr D Struct Biol (2016) 0.75
Mutational analysis of fructose-1,6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress. Microb Cell (2017) 0.75
Structures of Leishmania Fructose-1,6-bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition. J Mol Biol (2017) 0.75
Fructose-1,6-bisphosphatase inhibits ERK activation and bypasses gemcitabine resistance in pancreatic cancer by blocking IQGAP1-MAPK interaction. Cancer Res (2017) 0.75
Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli. J Mol Biol (1982) 2.46
Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms. J Mol Biol (1988) 1.96
Coenzyme A-linked aldehyde dehydrogenase from Escherichia coli. I. Partial purification, properties, and kinetic studies of the enzyme. J Biol Chem (1968) 1.92
The hexokinases: kinetic, physical, and regulatory properties. Adv Enzymol Relat Areas Mol Biol (1973) 1.80
A simplified schematic method for deriving steady-state rate equations using a modification of the "theory of graphs" procedure. Biochem Biophys Res Commun (1970) 1.74
Interactions of phosphate ligands with Escherichia coli aspartate carbamoyltransferase in the crystalline state. J Mol Biol (1982) 1.40
Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6-A resolution. Proc Natl Acad Sci U S A (1984) 1.36
The use of competitive inhibitors in studying the mechanism of action of some enzyme systems utilizing three substrates. Biochim Biophys Acta (1967) 1.34
Structural asymmetry in the CTP-liganded form of aspartate carbamoyltransferase from Escherichia coli. J Mol Biol (1987) 1.33
A computer program for fitting and statistically analyzing initial rate data applied to bovine hexokinase type III isozyme. Arch Biochem Biophys (1975) 1.26
Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate. J Mol Biol (1998) 1.24
Computer simulation studies with yeast hexokinase and additional evidence for the random Bi Bi mechanism. J Biol Chem (1971) 1.23
Structural heterogeneity in protein crystals. Biochemistry (1986) 1.22
Direct and 18-O-exchange measurements relevant to possible activated or phosphorylated states of myosin. Biochemistry (1966) 1.21
Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution. Proc Natl Acad Sci U S A (1981) 1.19
Regulation, genetics, and properties of adenylosuccinate synthetase: a review. Curr Top Cell Regul (1983) 1.18
Studies on factors influencing enzyme responses to adenylate energy charge. J Biol Chem (1972) 1.17
The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase. Proc Natl Acad Sci U S A (1996) 1.14
Structure of an actively exchanging complex between carboxypeptidase A and a substrate analogue. Proc Natl Acad Sci U S A (1980) 1.13
Steady-state and pre-steady-state kinetics of coenzyme A linked aldehyde dehydrogenase from Escherichia coli. Biochemistry (1981) 1.12
Crystal structure of glucoamylase from Aspergillus awamori var. X100 to 2.2-A resolution. J Biol Chem (1992) 1.12
Plotting methods for analyzing enzyme rate data. Methods Enzymol (1979) 1.10
Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. J Mol Biol (2000) 1.09
Studies on the kinetic mechanism and allosteric nature of bovine brain hexokinase. J Biol Chem (1969) 1.07
The kinetics and regulation of rat brain hexokinase. J Biol Chem (1971) 1.06
Crystal structure of adenylosuccinate synthetase from Escherichia coli. Evidence for convergent evolution of GTP-binding domains. J Biol Chem (1993) 1.05
Crystal structure of S-glutathiolated carbonic anhydrase III. FEBS Lett (2000) 1.02
Identification of an essential second metal ion in the reaction mechanism of Escherichia coli adenylosuccinate synthetase. J Biol Chem (1995) 1.01
Kinetic studies of the brain hexokinase reaction. A reinvestigation with the solubilized bovine enzyme. Biochemistry (1967) 0.99
The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate. Structure (1998) 0.98
Additional factors influencing enzyme responses to the adenylate energy charge. J Biol Chem (1973) 0.98
Initial rate studies of adenylosuccinate synthetase with product and competitive inhibitors. J Biol Chem (1969) 0.98
Gross quaternary changes in aspartate carbamoyltransferase are induced by the binding of N-(phosphonacetyl)-L-aspartate: A 3.5-A resolution study. Proc Natl Acad Sci U S A (1982) 0.98
A 3.0-A resolution study of nucleotide complexes with aspartate carbamoyltransferase. Proc Natl Acad Sci U S A (1979) 0.96
Replacement of Asp333 with Asn by site-directed mutagenesis changes the substrate specificity of Escherichia coli adenylosuccinate synthetase from guanosine 5'-triphosphate to xanthosine 5'-triphosphate. J Biol Chem (1994) 0.95
Summary of kinetic reaction mechanisms. Methods Enzymol (1979) 0.93
Rat skeletal muscle hexokinase. I. Kinetics and reaction mechanism. J Biol Chem (1965) 0.93
Use of competitive inhibitors to study substrate binding order. Methods Enzymol (1979) 0.93
Refined crystal structures of glucoamylase from Aspergillus awamori var. X100. J Mol Biol (1994) 0.92
Refined structure for the complex of acarbose with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution. J Biol Chem (1994) 0.92
Refined structure for the complex of 1-deoxynojirimycin with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution. Biochemistry (1993) 0.91
Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphatase. Proc Natl Acad Sci U S A (1995) 0.91
The effect of fructose 2,6-bisphosphate on the reverse reaction kinetics of fructose 1,6-bisphosphatase from bovine liver. Biochem Biophys Res Commun (1982) 0.90
Guanosine 5'-diphosphate-3'-diphosphate inhibition of adenylosuccinate synthetase. J Biol Chem (1979) 0.89
Raman spectroscopy of avidin: secondary structure, disulfide conformation, and the environment of tyrosine. Biochemistry (1982) 0.88
Use of isotope competition and alternative substrates for studying the kinetic mechanism of enzyme action. I. Experiments with hexokinase and alcohol dehydroeenase. Biochemistry (1970) 0.88
Dual mechanisms for glucose 6-phosphate inhibition of human brain hexokinase. J Biol Chem (1999) 0.88
Tryptophan fluorescence reveals the conformational state of a dynamic loop in recombinant porcine fructose-1,6-bisphosphatase. Biochemistry (2000) 0.88
Role of a dynamic loop in cation activation and allosteric regulation of recombinant porcine fructose-1,6-bisphosphatase. Biochemistry (1998) 0.88
Ribitol dehydrogenase. IV. Purification and crystallization of the enzyme. Arch Biochem Biophys (1966) 0.88
Refined crystal structures of unligated adenylosuccinate synthetase from Escherichia coli. J Mol Biol (1995) 0.88
Kinetic studies of solubilized brain hexokinase with D-fructose as a substrate. Biochem Biophys Res Commun (1968) 0.88
The mechanism of the adenylosuccinate synthetase reaction as studied by positional isotope exchange. J Biol Chem (1984) 0.88
Kinetics, mechanism, and regulation of rat skeletal muscle hexokinase. J Biol Chem (1974) 0.87
Relationship between thiol group modification and the binding site for fructose 2,6-bisphosphate on rabbit liver fructose-1,6-bisphosphatase. J Biol Chem (1988) 0.87
Refinement of a molecular model for lamprey hemoglobin from Petromyzon marinus. J Mol Biol (1985) 0.87
Comments on the kinetics and mechanism of yeast hexokinase action. Is the binding sequence of substrates to the enzyme ordered or random? Eur J Biochem (1969) 0.86
The purification and properties of aspartase from Escherichia coli. Arch Biochem Biophys (1971) 0.86
Metal cation influence on activity and regulation of aspartate carbamoyltransferase. Proc Natl Acad Sci U S A (1981) 0.85
Rat skeletal muscle hexokinase. II. Kinetic evidence for a second hexokinase in muscle tissue. J Biol Chem (1967) 0.85
Regulation of rabbit liver fructose-1,6-bisphosphatase by metals, nucleotides, and fructose 2,6-bisphosphate as determined from fluorescence studies. Biochemistry (1986) 0.85
Studies on the mechanism of orthophosphate regulation of bovine brain hexokinase. J Biol Chem (1975) 0.85
Crystallographic complexes of glucoamylase with maltooligosaccharide analogs: relationship of stereochemical distortions at the nonreducing end to the catalytic mechanism. Biochemistry (1996) 0.85
Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution. Biochemistry (1999) 0.85
Crystal structures of adenylosuccinate synthetase from Escherichia coli complexed with GDP, IMP hadacidin, NO3-, and Mg2+. J Mol Biol (1996) 0.85
Mutations in the hinge of a dynamic loop broadly influence functional properties of fructose-1,6-bisphosphatase. J Biol Chem (2000) 0.84
Use of isotope competition and alternative substrates for studying the kinetic mechanism of enzyme action. II. Rate equations for three substrate enzyme systems. Arch Biochem Biophys (1971) 0.84
Computer-assisted derivation of steady-state rate equations. Methods Enzymol (1979) 0.84
Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase. J Biol Chem (1999) 0.83
ATP-binding site of human brain hexokinase as studied by molecular modeling and site-directed mutagenesis. Biochemistry (1996) 0.83
Kinetic studies of bovine liver fructose-1,6-bisphosphatase. J Biol Chem (1979) 0.83
Chemical modification of adenylosuccinate synthetase from Escherichia coli by pyridoxal 5'-phosphate. Identification of an active site lysyl residue. J Biol Chem (1990) 0.83
Evaluation of the phosphoryl-enzyme intermediate concept in the acetate kinase and hexokinase reactions from kinetic studies. Arch Biochem Biophys (1972) 0.82
Activation of brain hexokinase by magnesium ions and by magnesium ion--adenosine triphosphate complex. Biochem J (1972) 0.82
Site-directed mutagenesis of the phosphate-binding consensus sequence in Escherichia coli adenylosuccinate synthetase. J Biol Chem (1992) 0.82
Ambiguities in mapping the active site of a conformationally dynamic enzyme by directed mutation. Role of dynamics in structure-function correlations in Escherichia coli adenylosuccinate synthetase. J Biol Chem (1998) 0.82
Identification of a phosphate regulatory site and a low affinity binding site for glucose 6-phosphate in the N-terminal half of human brain hexokinase. J Biol Chem (1998) 0.82
Application of equilibrium exchange kinetics to studies of kinetic properties at high enzyme concentrations: experiments with yeast hexokinase P-II. Biochem Biophys Res Commun (1972) 0.82
Involvement of arginine 143 in nucleotide substrate binding at the active site of adenylosuccinate synthetase from Escherichia coli. Biochemistry (1996) 0.82
A computer analysis of the validity of the integrated Michaelis-Menten equation. J Theor Biol (1979) 0.82
Structure-function studies of adenylosuccinate synthetase from Escherichia coli. Arch Biochem Biophys (1999) 0.82
Kinetics and mechanisms of activation and inhibition of porcine liver fructose-1,6-bisphosphatase by monovalent cations. Biochemistry (1996) 0.81
pH kinetic studies of bovine brain hexokinase. Biochemistry (1980) 0.81
Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli. J Biol Chem (1996) 0.81
Inhibition of rabbit skeletal muscle adenylate kinase by the transition state analogue, P 1 ,P 4 -di(adenosine-5')tetraphosphate. Biochim Biophys Acta (1972) 0.81