Published in Respir Med on June 01, 2000
Summary of recommendations from the Canadian Asthma Consensus guidelines, 2003. CMAJ (2005) 2.12
Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children. Cochrane Database Syst Rev (2010) 1.52
Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness. Curr Allergy Asthma Rep (2011) 1.28
Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma. Cochrane Database Syst Rev (2010) 1.16
Addition of inhaled long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults and children. Cochrane Database Syst Rev (2009) 1.14
Montelukast: its role in the treatment of childhood asthma. Ther Clin Risk Manag (2007) 0.98
Management of asthma in adults: current therapy and future directions. Postgrad Med J (2003) 0.88
Blocking leukotrienes optimize asthma control: the BLOC survey. Ann Thorac Med (2007) 0.76
2003 canadian asthma consensus guidelines executive summary. Allergy Asthma Clin Immunol (2006) 0.75
In children with asthma who are currently using inhaled corticosteroids, are antileukotrienes more effective than placebo in improving clinical outcomes?: Part A. Paediatr Child Health (2003) 0.75
Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J (2008) 10.08
Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med (1990) 7.46
A self management plan in the treatment of adult asthma. Thorax (1989) 5.85
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2001) 5.25
Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J (2005) 5.24
A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy (2001) 5.07
Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med (1999) 4.72
Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis (1985) 4.59
Mucosal inflammation in asthma. Am Rev Respir Dis (1990) 4.11
Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis (1989) 3.86
Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl (1993) 3.82
Randomised comparison of guided self management and traditional treatment of asthma over one year. BMJ (1996) 3.79
Subepithelial fibrosis in the bronchi of asthmatics. Lancet (1989) 3.70
CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1998) 3.69
Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J (2008) 3.36
Prevalence of respiratory symptoms among 7 and 11 year old schoolchildren and association with asthma. Arch Dis Child (1989) 3.25
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10
Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med (1994) 3.06
Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol (1993) 3.01
No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study. Allergy (2002) 2.99
Induction of nitric oxide synthase in asthma. Lancet (1994) 2.93
T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol (1996) 2.92
The Brussels Declaration: the need for change in asthma management. Eur Respir J (2008) 2.91
Rhinoviruses infect the lower airways. J Infect Dis (2000) 2.83
Comparison of the effects of intravenous and oral montelukast on airway function: a double blind, placebo controlled, three period, crossover study in asthmatic patients. Thorax (2000) 2.74
Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol (1994) 2.73
Standards for practical allergen-specific immunotherapy. Allergy (2006) 2.70
Severity of airflow limitation is associated with severity of airway inflammation in smokers. Am J Respir Crit Care Med (1998) 2.62
Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2001) 2.58
Global Strategy for the Diagnosis, Management and Prevention of COPD: 2003 update. Eur Respir J (2003) 2.57
Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax (1996) 2.52
CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1999) 2.52
Protection against allergen-induced asthma by salmeterol. Lancet (1990) 2.51
Practical guide to skin prick tests in allergy to aeroallergens. Allergy (2011) 2.51
Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects. Am J Respir Crit Care Med (1995) 2.48
Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med (1997) 2.47
Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis (1990) 2.45
Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J (2000) 2.42
Age specific trends in asthma mortality in England and Wales, 1983-95: results of an observational study. BMJ (1997) 2.40
Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma. Am J Respir Crit Care Med (2000) 2.36
Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med (1998) 2.36
Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report. Allergy (2010) 2.34
Daily versus as-needed inhaled corticosteroid for mild persistent asthma (The Helsinki early intervention childhood asthma study). Arch Dis Child (2007) 2.33
Phylogeny of nitrogenase sequences in Frankia and other nitrogen-fixing microorganisms. J Mol Evol (1989) 2.33
Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1. Am J Respir Cell Mol Biol (1995) 2.30
Personal exposures of children to nitrogen dioxide relative to concentrations in outdoor air. Occup Environ Med (2000) 2.29
Montelukast, a leukotriene receptor antagonist, for the treatment of persistent asthma in children aged 2 to 5 years. Pediatrics (2001) 2.28
Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler. BMJ (1992) 2.25
Cost-effectiveness of omalizumab in patients with severe persistent allergic asthma. Allergy (2007) 2.22
Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax (1984) 2.20
Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax (2005) 2.19
Montelukast added to budesonide in children with persistent asthma: a randomized, double-blind, crossover study. J Pediatr (2001) 2.17
Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol (2012) 2.17
A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J Allergy Clin Immunol (1992) 2.16
Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol (1990) 2.14
Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest (1998) 2.13
Chronic rhinosinusitis in Europe--an underestimated disease. A GA²LEN study. Allergy (2011) 2.13
Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol (1983) 2.10
Quality of life in allergic rhinitis and asthma. A population-based study of young adults. Am J Respir Crit Care Med (2000) 2.08
Longitudinal changes in skin-prick test reactivity over 2 years in a population of schoolchildren with respiratory symptoms. Clin Exp Allergy (1992) 2.06
Bronchoconstrictor properties of preservatives in ipratropium bromide (Atrovent) nebuliser solution. Br Med J (Clin Res Ed) (1987) 2.05
The natural history of respiratory symptoms in a cohort of adolescents. Am J Respir Crit Care Med (1998) 2.05
The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest (2001) 2.05
Fatal asthma attack during an inhalation challenge with ultrasonically nebulized distilled water. J Allergy Clin Immunol (1995) 2.04
Pro: Immunotherapy is clinically indicated in the management of allergic asthma. Am J Respir Crit Care Med (2001) 2.04
Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am Rev Respir Dis (1993) 2.02
A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects. Biomarkers (2007) 2.02
Roflumilast with long-acting β2-agonists for COPD: influence of exacerbation history. Eur Respir J (2011) 1.99
Leukotriene E4 and granulocytic infiltration into asthmatic airways. Lancet (1993) 1.98
Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. Am J Respir Crit Care Med (1995) 1.96
Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax (2001) 1.95
The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men. N Engl J Med (1984) 1.95
Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax (2003) 1.94
The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial. Thorax (2008) 1.93
Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma. Thorax (2003) 1.93
Longitudinal study of lung function in a cohort of primary ciliary dyskinesia. Eur Respir J (1997) 1.91
beta-adrenergic agonist resistance in normal human airways. Lancet (1977) 1.91
Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. J Allergy Clin Immunol (1993) 1.91
Neutrophilic infiltration within the airway smooth muscle in patients with COPD. Thorax (2004) 1.89
Exacerbations of Bronchitis: bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants. Am J Respir Crit Care Med (2001) 1.88
Corticosteroid reversibility in COPD is related to features of asthma. Am J Respir Crit Care Med (1997) 1.87
PEP-spacer: an adaptation for administration of MDI to infants. Allergy (1989) 1.86
Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study. Thorax (1991) 1.86
Importance of airway inflammation for hyperresponsiveness induced by ozone. Am Rev Respir Dis (1983) 1.85
The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma. Chest (2001) 1.85
Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients. Eur Respir J (2003) 1.84
Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin Exp Allergy (2004) 1.84
Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma. A longitudinal study. Am Rev Respir Dis (1989) 1.82
Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs. Proc Natl Acad Sci U S A (1980) 1.82
Natural history of asthma in childhood--a birth cohort study. Arch Dis Child (1991) 1.82
Development of new IgE specificities to allergenic components in birch pollen extract during specific immunotherapy studied with immunoblotting and Pharmacia CAP System. Allergy (2002) 1.82