Published in Hum Mutat on January 01, 2000
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem J (2005) 3.58
PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 3.06
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood (2009) 3.02
Protean PTEN: form and function. Am J Hum Genet (2002) 2.43
Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell (2012) 2.39
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell (2014) 2.25
Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. Genes Chromosomes Cancer (2008) 1.99
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J (2004) 1.87
Main roads to melanoma. J Transl Med (2009) 1.67
Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol (2005) 1.55
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol Biol Cell (2006) 1.38
PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia. Brain (2015) 1.33
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. Biochem J (2001) 1.29
Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas. Proc Natl Acad Sci U S A (2009) 1.27
MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells. Mol Cancer (2013) 1.25
PTEN: Multiple Functions in Human Malignant Tumors. Front Oncol (2015) 1.24
Different molecular patterns in glioblastoma multiforme subtypes upon recurrence. J Neurooncol (2009) 1.17
Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations. Breast Cancer Res (2010) 1.14
PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer. Clin Colorectal Cancer (2012) 1.13
Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res (2010) 1.05
Regulation of the pentose phosphate pathway in cancer. Protein Cell (2014) 1.03
PTEN: new insights into its regulation and function in skin cancer. J Invest Dermatol (2009) 0.98
MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer. Oncotarget (2016) 0.94
MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. J Transl Med (2015) 0.94
Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma. Br J Cancer (2007) 0.93
Bannayan-Riley-Ruvalcaba syndrome: further delineation of the phenotype and management of PTEN mutation-positive cases. Fam Cancer (2003) 0.92
Nuclear PTEN levels and G2 progression in melanoma cells. Melanoma Res (2009) 0.89
PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity. PLoS One (2013) 0.88
Redox Regulation in Cancer Stem Cells. Oxid Med Cell Longev (2015) 0.88
Cancer risk and genotype-phenotype correlations in PTEN hamartoma tumor syndrome. Fam Cancer (2014) 0.87
Crosstalking between androgen and PI3K/AKT signaling pathways in prostate cancer cells. J Biol Chem (2014) 0.87
Loss of heterozygosity on 10q and mutational status of PTEN and BMPR1A in colorectal primary tumours and metastases. Br J Cancer (2004) 0.86
Conditional deletion of the Pten gene in the mouse prostate induces prostatic intraepithelial neoplasms at early ages but a slow progression to prostate tumors. PLoS One (2013) 0.85
PTEN mutation spectrum in breast cancers and breast hyperplasia. J Cancer Res Clin Oncol (2010) 0.85
The PTEN tumor suppressor gene and its role in lymphoma pathogenesis. Aging (Albany NY) (2015) 0.84
Pills of PTEN? In and out for tumor suppression. Cell Res (2013) 0.84
The mTOR signaling pathway as a treatment target for intracranial neoplasms. Neuro Oncol (2014) 0.84
Autophagy and lysosomal related protein expression patterns in human glioblastoma. Cancer Biol Ther (2014) 0.83
Integrative analysis of cancer-related signaling pathways. Front Physiol (2013) 0.83
Mutation-positive and mutation-negative patients with Cowden and Bannayan-Riley-Ruvalcaba syndromes associated with distinct 10q haplotypes. Am J Hum Genet (2006) 0.83
Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer. J Surg Res (2013) 0.81
A novel germline mutation of PTEN associated with brain tumours of multiple lineages. Br J Cancer (2002) 0.81
Elevation of methylated DNA in KILLIN/PTEN in the plasma of patients with thyroid and/or breast cancer. Onco Targets Ther (2014) 0.80
R-RAS2 overexpression in tumors of the human central nervous system. Mol Cancer (2013) 0.79
Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish. Dis Model Mech (2013) 0.78
PTEN/MMAC1 expression in melanoma resection specimens. Br J Cancer (2002) 0.78
MicroRNA-92 regulates cervical tumorigenesis and its expression is upregulated by human papillomavirus-16 E6 in cervical cancer cells. Oncol Lett (2013) 0.78
Cancer. Adv Exp Med Biol (2005) 0.77
A PTENtial cause for the selectivity of oncolytic viruses? Nat Immunol (2016) 0.77
Important role of indels in somatic mutations of human cancer genes. BMC Med Genet (2010) 0.77
Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line. BMC Cancer (2011) 0.77
Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. Genes Dev (2015) 0.76
Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development. PLoS One (2016) 0.76
Superdomains in the protein structure hierarchy: The case of PTP-C2. Protein Sci (2015) 0.76
Gene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients. Oncoimmunology (2015) 0.76
FISH analysis of PTEN in endometrial carcinoma. Comparison with SNP arrays and MLPA. Histopathology (2014) 0.75
Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome. Head Neck Pathol (2016) 0.75
Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet (1996) 3.53
WNT pathway and mammary carcinogenesis: loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type. Oncogene (2001) 2.32
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res (1997) 2.06
A refined molecular taxonomy of breast cancer. Oncogene (2011) 1.78
Detection of 11 germline inactivating TP53 mutations and absence of TP63 and HCHK2 mutations in 17 French families with Li-Fraumeni or Li-Fraumeni-like syndrome. J Med Genet (2001) 1.70
Loss of heterozygosity and linkage analysis in breast carcinoma: indication for a putative third susceptibility gene on the short arm of chromosome 8. Oncogene (1995) 1.58
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. Br J Cancer (1999) 1.54
A critical analysis of treatment strategies in desmoid tumours: a review of a series of 106 cases. Eur J Surg Oncol (2008) 1.44
Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes Chromosomes Cancer (1998) 1.43
Timing of transabdominal chorionic villus sampling. Lancet (1990) 1.39
Mutations at BRCA1: the medullary breast carcinoma revisited. Cancer Res (1998) 1.39
FGFRI and PLAT genes and DNA amplification at 8p12 in breast and ovarian cancers. Genes Chromosomes Cancer (1993) 1.37
Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas. Cancer Res (1997) 1.33
Germ line mutation at BRCA1 affects the histoprognostic grade in hereditary breast cancer. Cancer Res (1996) 1.21
PTEN/MMAC1/TEP1 involvement in primary prostate cancers. Oncogene (1998) 1.20
Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas. Cancer Res (1997) 1.13
Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations. Int J Cancer (1999) 1.09
Allelic imbalance study of 16q in human primary breast carcinomas using microsatellite markers. Genes Chromosomes Cancer (1995) 1.05
Loss of heterozygosity on chromosome arm 16q in breast cancer metastases. Genes Chromosomes Cancer (1997) 1.01
[Li-Fraumeni syndrome: update, new data and guidelines for clinical management]. Bull Cancer (2001) 0.92
Familial non-medullary thyroid carcinoma: pathology review in 27 affected cases from 13 French families. Clin Endocrinol (Oxf) (1999) 0.91
BRCA2 mutations in hereditary breast and ovarian cancer in France. Am J Hum Genet (1997) 0.91
Thyroid pathologic findings in patients with Cowden disease. Ann Diagn Pathol (1999) 0.90
Loss of heterozygosity in human breast carcinomas in the ataxia telangiectasia, Cowden disease and BRCA1 gene regions. Oncogene (1997) 0.90
MLH1 and MSH2 protein immunohistochemistry is useful for detection of hereditary non-polyposis colorectal cancer in young patients. Histopathology (2001) 0.89
Abnormal phenotype in a child with a "balanced" translocation 8/12 in mosaic state. Am J Med Genet (1987) 0.88
High-resolution integrated map encompassing the breast cancer loss of heterozygosity region on human chromosome 16q22.1. Genomics (2000) 0.87
Identification of gene polymorphisms of human DNA topoisomerase I in the National Cancer Institute panel of human tumour cell lines. Br J Cancer (2006) 0.86
Contribution of PTEN large rearrangements in Cowden disease: a multiplex amplifiable probe hybridisation (MAPH) screening approach. J Med Genet (2008) 0.83
Marker segregation information in breast/ovarian cancer genetic counseling: is it still useful? Groupe Génétique et Cancer de la Fédération Nationale des Centres de Lutte Contre le Cancer. Am J Med Genet (1998) 0.77
[African human trypanosomiasis. Unusual discovery owing to recurrent acute pneumopathy]. Nouv Presse Med (1979) 0.77
No evidence for germline PTEN mutations in families with breast and brain tumours. Int J Cancer (1999) 0.77
[Thrombosis of the inferior vena cava with congenital deficiency of antithrombin III]. Nouv Presse Med (1980) 0.76
Feasibility of placental biopsy in the second trimester for fetal diagnosis. Am J Obstet Gynecol (1990) 0.75
[Glomerular nephropathy and schistosomiasis (author's transl)]. Med Trop (Mars) (1980) 0.75
Genetic alterations in colorectal cancer, comparative analysis of deletion events, and point mutations. Cancer Genet Cytogenet (1998) 0.75
Feto-placental discrepancy on direct chromosomal preparation from chorionic villus sampling of the second trimester. Clin Genet (1988) 0.75
[Value of skin immunofluorescence during B virus infections. Preliminary results]. Rev Med Interne (1980) 0.75
[Cutaneous and rectosigmoid cavernous hemangiomas. Bean's syndrome]. Sem Hop (1974) 0.75
A simple method of chromosomal analysis for malignant solid tumors. Cancer Genet Cytogenet (1992) 0.75
[Improvement of a chromosomal technic for trophoblast biopsy. Apropos of 200 cases]. J Genet Hum (1988) 0.75
[Adrenal cortical adenoma and arterial hypertension. Adrenal vizualisation by scintillation with 131 I 19 iodo cholesterol (author's transl)]. Sem Hop (1981) 0.75
[Cowden's disease in an adolescent]. Ann Chir (2002) 0.75
[Chemodectomas. Their place in the A.P.U.D. system. Classification of neural crest diseases]. Rev Laryngol Otol Rhinol (Bord) (1981) 0.75
Polymerase chain reaction diagnosis of t(14;18) from paraffin-embedded tissues fixed with Holland Bouin fluid. Diagn Mol Pathol (1998) 0.75
[Unusual genealogies in inflammatory cryptogenic colitis]. Rev Med Interne (1981) 0.75
Myxoma of the mitral valve diagnosed by echocardiography. Am Heart J (1986) 0.75
[Collagenoses in otorhinolaryngology. Clinical, pathogenetic and therapeutic features]. Rev Laryngol Otol Rhinol (Bord) (1982) 0.75
[Basal decidual hematoma persisting after biopsy of the trophoblast]. J Gynecol Obstet Biol Reprod (Paris) (1988) 0.75
[Total atrophy of the villi during primary agammaglobulinemia in adults. Therapeutic problems (author's transl)]. Ann Med Interne (Paris) (1979) 0.75
Cowden's syndrome: possible association with testicular seminoma. Br J Dermatol (2004) 0.75
Risks of transabdominal chorionic villus sampling before the 12th week of amenorrhea. Prenat Diagn (1990) 0.75
[Macrocephaly and multiple hamartoma: a very variable entity]. Arch Pediatr (2004) 0.75
[Corticosensitive pseudoperiarteritis nodosa. Look for cholesterol embolism and aortic aneurysm]. Presse Med (1983) 0.75
[Placentocentesis, a new technic in the prenatal diagnosis of chromosome aberrations in the 3d trimester. A preliminary study apropos of 5 cases]. J Gynecol Obstet Biol Reprod (Paris) (1988) 0.75
[Is drepanocitic trait asymptomatic? (author's transl)]. Med Trop (Mars) (1979) 0.75
A study comparing transcervical with trans-abdominal chorionic villi sampling (CVS) Br J Obstet Gynaecol (1989) 0.75
[Myxoma of the mitral leaflet. Apropos of a case]. Arch Mal Coeur Vaiss (1985) 0.75
[Evaluation of the risks of transabdominal chorionic villus sampling. 600 cases]. J Gynecol Obstet Biol Reprod (Paris) (1991) 0.75
De novo inv del(4) in an infant with the Wolf-Hirschhorn syndrome. Ann Genet (1987) 0.75
[Streptozotocin and malignant insulinomas. Apropos of the case. Review of the literature]. Sem Hop (1976) 0.75
[Renal lesions in progressive systemic sclerosis. A report on five cases (author's transl)]. Sem Hop (1979) 0.75
[Multiple congenital arteriovenous fistulas. Case report concerning a late manifestation]. Rofo (1978) 0.75
Direct chromosome analysis in the second and third trimesters by placental biopsy in 30 pregnancies. Br J Obstet Gynaecol (1989) 0.75
[Hydatid cysts of the spleen. Current means of diagnosis]. Med Chir Dig (1974) 0.75
[Acute febrile muscle calcification of the biceps: microcrystalline myositis ossificans? (author's transl)]. Ann Radiol (Paris) (1981) 0.75
[Familial Mediterranean fever and fatty liver. effect of a long time colchicine treatment on triglyceride storage (author's transl)]. Ann Med Interne (Paris) (1981) 0.75
[Double trisomy and transmitted pericentric inversion (48,XXY, +21,inv(22)). Interchromosomal effect]. Ann Genet (1983) 0.75
[Cutaneous and rectosigmoidal cavernous hemangiomas. Bean's syndrome]. Lille Med (1976) 0.75
[Refractory anemia with partial myeloblastosis associated with bronchial cancer]. Nouv Presse Med (1978) 0.75
[Plasma cells leukaemia, cryoglobulins and antithrombin (author's transl)]. Sem Hop (1980) 0.75
[Partial trisomy of the proximal part of the long arm of chromosome 13]. Pediatrie (1982) 0.75
Allelic loss at chromosome 8p in human breast-cancer. Oncol Rep (1994) 0.75
Acute promyelocytic leukemia with (15;17) translocation and chromosome no. 11 deletion (q23). Leuk Res (1982) 0.75
[Sciatica due to chronic spontaneous lumbar epidural haematoma. Report of a case simulating a protruded disk syndrome (author's transl)]. Sem Hop (1981) 0.75
[Peripheral thrombophlebitis. "Paratuberculous syndrome" (author's transl)]. Sem Hop (1980) 0.75
[Bilharzial myelopathies (case report) (author's transl)]. Med Trop (Mars) (1980) 0.75
A simple method of chromosomal analysis for colonic adenomatous polyps. Cancer Genet Cytogenet (1989) 0.75
[Perisinusoidal fibrosis in idiopathic thrombopenic purpura]. Gastroenterol Clin Biol (1987) 0.75
[Isotope scan using labelled cholesterol in the diagnosis of hypertension due to adrenal tumors (author's transl)]. Nouv Presse Med (1979) 0.75
[Portal hypertension in schistosomiasis (author's transl)]. Med Trop (Mars) (1980) 0.75
[Extra-dural spinal hematoma and atypical lumbo-sciatica]. Nouv Presse Med (1980) 0.75
[Asystole caused by multiple rhizomelic congenital arteriovenous fistulas. Value of palliative surgery]. Nouv Presse Med (1980) 0.75
[A new case of Darier's atypical tuberculous ulcers]. Ann Dermatol Venereol (1986) 0.75
[Voluminous hypernephroma of intermittent development. Diagnostic difficulties (author's transl)]. J Radiol Electrol Med Nucl (1978) 0.75