Published in Genomics on December 15, 2000
Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell (2008) 2.21
CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer. BMC Cancer (2006) 1.41
A comprehensive study of chromosome 16q in invasive ductal and lobular breast carcinoma using array CGH. Oncogene (2006) 1.01
Expression of the transcription factor CTCF in invasive breast cancer: a candidate gene located at 16q22.1. Br J Cancer (2004) 0.81
Regulated expression of a transgene introduced on an oriP/EBNA-1 PAC shuttle vector into human cells. BMC Biotechnol (2009) 0.75
CpG islands as gene markers in the human genome. Genomics (1992) 7.45
ArrayExpress--a public repository for microarray gene expression data at the EBI. Nucleic Acids Res (2005) 6.73
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum Mol Genet (1998) 4.72
Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet (1996) 3.53
Treatment of Early Mammary Carcinoma: A Cooperative International Study. Ann Surg (1963) 3.07
Affecting gene expression by altering the length and sequence of the 5' leader. Proc Natl Acad Sci U S A (1984) 2.58
WNT pathway and mammary carcinogenesis: loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type. Oncogene (2001) 2.32
Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature (1984) 2.16
Mutations of the human PTEN gene. Hum Mutat (2000) 2.11
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res (1997) 2.06
Cellular cooperation in endothelial cell thromboplastin synthesis. Br J Haematol (1983) 2.05
Functional and clinical aspects of the myelomonocyte protein calprotectin. Mol Pathol (1997) 1.98
Prevalence and distribution of Haemophilus somnus in the male bovine reproductive tract. Am J Vet Res (1982) 1.97
Infectious causes of equine respiratory disease on Ontario standardbred racetracks. J Clin Microbiol (1977) 1.95
Tissue thromboplastin activity of isolated human monocytes. Thromb Haemost (1978) 1.81
A refined molecular taxonomy of breast cancer. Oncogene (2011) 1.78
Detection of 11 germline inactivating TP53 mutations and absence of TP63 and HCHK2 mutations in 17 French families with Li-Fraumeni or Li-Fraumeni-like syndrome. J Med Genet (2001) 1.70
Loss of heterozygosity and linkage analysis in breast carcinoma: indication for a putative third susceptibility gene on the short arm of chromosome 8. Oncogene (1995) 1.58
Occurrence of "Haemophilus somnus" in bovine semen and in the prepuce of bulls and steers. Can J Comp Med (1982) 1.57
DNA synthesis in isolated HeLa cell nuclei. Optimalization of the system and characterization of the product. Biochemistry (1975) 1.56
The effect of aphidicolin on DNA synthesis in isolated HeLa cell nuclei. Nucleic Acids Res (1979) 1.55
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. Br J Cancer (1999) 1.54
Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Res (1996) 1.52
Differential activation of the mouse beta-globin promoter by enhancers. Mol Cell Biol (1983) 1.47
Effect of alteration in triglyceride levels on factor VII-phospholipid complexes in plasma. Arteriosclerosis (1990) 1.46
Sequencing of the rat light neurofilament promoter reveals differences in methylation between expressing and non-expressing cell lines, but not tissues. Gene (1995) 1.45
Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. Nucleic Acids Res (1998) 1.45
Regulated expression allows high level production and secretion of HIV-1 gp120 envelope glycoprotein in Drosophila Schneider cells. Biotechnology (N Y) (1991) 1.44
A critical analysis of treatment strategies in desmoid tumours: a review of a series of 106 cases. Eur J Surg Oncol (2008) 1.44
Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes. Nucleic Acids Res (2000) 1.44
Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes Chromosomes Cancer (1998) 1.43
An estimate of the sequencing error frequency in the DNA sequence databases. DNA Seq (1992) 1.41
Control of equine respiratory disease on Ontario Standardbred racetracks. Can Vet J (1977) 1.41
Bovine spongiform encephalopathy. Can Vet J (1989) 1.39
Timing of transabdominal chorionic villus sampling. Lancet (1990) 1.39
Mutations at BRCA1: the medullary breast carcinoma revisited. Cancer Res (1998) 1.39
A novel immunodeficient mouse model--RAG2 x common cytokine receptor gamma chain double mutants--requiring exogenous cytokine administration for human hematopoietic stem cell engraftment. J Interferon Cytokine Res (1999) 1.38
Simple mastectomy plus postoperative irradiation by the method of McWhirter for mammary carcinoma. Ann Surg (1969) 1.37
FGFRI and PLAT genes and DNA amplification at 8p12 in breast and ovarian cancers. Genes Chromosomes Cancer (1993) 1.37
Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas. Cancer Res (1997) 1.33
HeLa cell plasma membranes. I. 5'-Nucleotidase and ouabain-sensitive ATPase as markers for plasma membranes. J Cell Biol (1974) 1.32
Some characteristics of phospholipase C from Bacillus cereus. Eur J Biochem (1977) 1.32
Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22. Genomics (1994) 1.27
Binding of human factor VIIa to tissue factor induces cytosolic Ca2+ signals in J82 cells, transfected COS-1 cells, Madin-Darby canine kidney cells and in human endothelial cells induced to synthesize tissue factor. J Biol Chem (1995) 1.27
The maintenance of methylation-free islands in transgenic mice. Nucleic Acids Res (1986) 1.26
Molecular analysis of the CBP gene in 60 patients with Rubinstein-Taybi syndrome. J Med Genet (2002) 1.26
Early amniocentesis versus chorionic villus sampling for fetal karyotyping. Lancet (1994) 1.25
Germ line mutation at BRCA1 affects the histoprognostic grade in hereditary breast cancer. Cancer Res (1996) 1.21
Transmissible gastroenteritis of swine in Ontario. Can J Comp Med (1969) 1.20
PTEN/MMAC1/TEP1 involvement in primary prostate cancers. Oncogene (1998) 1.20
NAD(P)H dehydrogenase and its role in the vitamin K (2-methyl-3-phytyl-1,4-naphthaquinone)-dependent carboxylation reaction. Biochem J (1978) 1.20
Database contamination. Nature (1992) 1.19
A study of procine enteroviruses isolated from swine in the Toronto area. I. Isolation and serological grouping of viruses. Can J Comp Med Vet Sci (1966) 1.18
Contribution of factor VII genotype to activated FVII levels. Differences in genotype frequencies between northern and southern European populations. Arterioscler Thromb Vasc Biol (1997) 1.17
Association of microbiologic flora with clinical, endoscopic, and pulmonary cytologic findings in foals with distal respiratory tract infection. Am J Vet Res (1993) 1.15
Case with autistic syndrome and chromosome 22q13.3 deletion detected by FISH. Am J Med Genet (2000) 1.14
Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas. Cancer Res (1997) 1.13
Experimental immunization of sows with cell-cultured TGE virus. Can J Comp Med (1970) 1.11
Infectious agents in acute respiratory disease in horses in Ontario. J Vet Diagn Invest (1997) 1.11
Binding of factor VIIa to tissue factor on keratinocytes induces gene expression. J Biol Chem (2000) 1.10
Confirmation of assignment of a locus for Rubinstein-Taybi syndrome gene to 16p13.3. Am J Med Genet (1992) 1.09
Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations. Int J Cancer (1999) 1.09
Major risk factors for cardiovascular disease mortality in adults: results from the Nutrition Canada Survey cohort. Int J Epidemiol (1988) 1.09
Further link between complement activation and blood coagulation. Nature (1977) 1.09
Coagulation factors VII and X induce Ca2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active. J Biol Chem (1996) 1.08
DNA synthesis in isolated HeLa cell nuclei. Evidence for in vitro initiation of synthesis of small pieces of DNA and their subsequent ligation. Biochemistry (1975) 1.07
Phospholipase C from Bacillus cereus and its use in studies of tissue thromboplastin. Eur J Biochem (1972) 1.07
Electroimmunoassay of factor IX in hemophilia B. Thromb Res (1975) 1.05
Allelic imbalance study of 16q in human primary breast carcinomas using microsatellite markers. Genes Chromosomes Cancer (1995) 1.05
Species specificity of tissue thromboplastin. Haemostasis (1984) 1.05
The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man. Hum Genet (1984) 1.04
Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene. J Biol Chem (1999) 1.04
Cloning and characterization of MDDX28, a putative dead-box helicase with mitochondrial and nuclear localization. J Biol Chem (2001) 1.03
Activation of the coagulation factor VII by tissue thromboplastin and calcium. Biochemistry (1972) 1.03
Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. Nucleic Acids Res (1996) 1.03
Migratory patterns of lac-z transfected human glioma cells in the rat brain. Int J Cancer (1995) 1.03
An improved method for detection of 5-methylcytosine by PCR-based genomic sequencing. Biotechniques (1994) 1.02
In vitro stimulation of tissue thromboplastin (factor III) activity in human monocytes by immune complexes and lectins. Thromb Res (1979) 1.01
Organisation of the Danish adjuvant trials in breast cancer. Dan Med Bull (1981) 1.01
Loss of heterozygosity on chromosome arm 16q in breast cancer metastases. Genes Chromosomes Cancer (1997) 1.01
Overview of randomized trials comparing radical mastectomy without radiotherapy against simple mastectomy with radiotherapy in breast cancer. Cancer Treat Rep (1987) 0.99
The protein component of human brain thromboplastin. Biochem Biophys Res Commun (1973) 0.99
Evaluation of the exon predictions of the GRAIL software. Genomics (1994) 0.99
The detection of transmissible gastroenteritis viral antigens by immunodiffusion. Can J Comp Med (1975) 0.99
The effect of antithrombin III on the activity of the coagulation factors VII, IX and X. Thromb Haemost (1976) 0.98
Hammerhead ribozyme design and application. Cell Mol Life Sci (1998) 0.98
Experimental immunization of sows with inactivated transmissible gastroenteritis (TGE) virus. Can J Comp Med (1971) 0.98
Commonly used reference genes are actively regulated in in vitro stimulated lymphocytes. Scand J Immunol (2007) 0.98
A tight cluster of five unrelated human genes on chromosome 16q22.1. Hum Mol Genet (1993) 0.98
CpG islands in mammalian gene promoters are inherently resistant to de novo methylation. Genet Anal Tech Appl (1992) 0.97
Neonatal characteristics as risk factors for preschool asthma. J Asthma (1996) 0.97
Thromboplastin as a marker for monocyte differentiation. Br J Haematol (1983) 0.97
Choice of enzymes for mapping based on CpG islands in the human genome. Genet Anal Tech Appl (1992) 0.97
Interferon regulatory factor 1 mediates the interferon-gamma induction of the human immunoproteasome subunit multicatalytic endopeptidase complex-like 1. J Biol Chem (1999) 0.97
Effect of cytosol on DNA synthesis in isolated HeLa cell nuclei. Biochem Biophys Res Commun (1977) 0.96
Virus isolations from mosquitoes in southern Ontario, 1976 and 1977. Can J Microbiol (1980) 0.96