LcrV, a substrate for Yersinia enterocolitica type III secretion, is required for toxin targeting into the cytosol of HeLa cells.

PubWeight™: 1.75‹?› | Rank: Top 3%

🔗 View Article (PMID 10930402)

Published in J Biol Chem on November 24, 2000

Authors

V T Lee1, C Tam, O Schneewind

Author Affiliations

1: Department of Microbiology and Immunology, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA.

Articles citing this

Plague bacteria target immune cells during infection. Science (2005) 3.32

Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J Exp Med (2002) 2.41

The V antigen of Pseudomonas aeruginosa is required for assembly of the functional PopB/PopD translocation pore in host cell membranes. Infect Immun (2004) 1.70

LcrV plague vaccine with altered immunomodulatory properties. Infect Immun (2005) 1.57

YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA. J Bacteriol (2002) 1.44

Subversion of host recognition and defense systems by Francisella spp. Microbiol Mol Biol Rev (2012) 1.40

LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis. J Bacteriol (2001) 1.36

A program of Yersinia enterocolitica type III secretion reactions is activated by specific signals. J Bacteriol (2001) 1.34

Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica. J Bacteriol (2001) 1.32

Regulated secretion of YopN by the type III machinery of Yersinia enterocolitica. J Bacteriol (2001) 1.32

Translocation of ExsE into Chinese hamster ovary cells is required for transcriptional induction of the Pseudomonas aeruginosa type III secretion system. Infect Immun (2007) 1.26

The ADP-ribosylating toxin, AexT, from Aeromonas salmonicida subsp. salmonicida is translocated via a type III secretion pathway. J Bacteriol (2003) 1.25

Secretion signal recognition by YscN, the Yersinia type III secretion ATPase. Proc Natl Acad Sci U S A (2006) 1.23

The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate. Protein Sci (2011) 1.23

Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. Infect Immun (2006) 1.21

Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV. Mol Microbiol (2010) 1.17

Yersinia enterocolitica type III secretion: yscM1 and yscM2 regulate yop gene expression by a posttranscriptional mechanism that targets the 5' untranslated region of yop mRNA. J Bacteriol (2002) 1.16

Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells. J Bacteriol (2006) 1.16

Yersinia enterocolitica type III secretion: mutational analysis of the yopQ secretion signal. J Bacteriol (2002) 1.14

YopB of Yersinia enterocolitica is essential for YopE translocation. Infect Immun (2001) 1.14

YopK regulates the Yersinia pestis type III secretion system from within host cells. Mol Microbiol (2011) 1.11

Role of predicted transmembrane domains for type III translocation, pore formation, and signaling by the Yersinia pseudotuberculosis YopB protein. Infect Immun (2005) 1.09

YscU cleavage and the assembly of Yersinia type III secretion machine complexes. Mol Microbiol (2008) 1.07

Multi-Functional Characteristics of the Pseudomonas aeruginosa Type III Needle-Tip Protein, PcrV; Comparison to Orthologs in other Gram-negative Bacteria. Front Microbiol (2011) 1.03

Rejection of impassable substrates by Yersinia type III secretion machines. J Bacteriol (2005) 1.03

Binding of SycH chaperone to YscM1 and YscM2 activates effector yop expression in Yersinia enterocolitica. J Bacteriol (2004) 1.03

Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines. Vaccine (2011) 1.02

Impassable YscP substrates and their impact on the Yersinia enterocolitica type III secretion pathway. J Bacteriol (2008) 1.01

Yersinia pestis IS1541 transposition provides for escape from plague immunity. Infect Immun (2009) 0.98

Vp1659 is a Vibrio parahaemolyticus type III secretion system 1 protein that contributes to translocation of effector proteins needed to induce cytolysis, autophagy, and disruption of actin structure in HeLa cells. J Bacteriol (2010) 0.95

Oligomerization of PcrV and LcrV, protective antigens of Pseudomonas aeruginosa and Yersinia pestis. J Biol Chem (2008) 0.95

Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM. Infect Immun (2012) 0.94

The ttsA gene is required for low-calcium-induced type III secretion of Yop proteins and virulence of Yersinia enterocolitica W22703. J Bacteriol (2003) 0.93

Amino acid residues 196-225 of LcrV represent a plague protective epitope. Vaccine (2009) 0.93

Amino acid and structural variability of Yersinia pestis LcrV protein. Infect Genet Evol (2009) 0.90

Identification of novel type III secretion chaperone-substrate complexes of Chlamydia trachomatis. PLoS One (2013) 0.90

Modified needle-tip PcrV proteins reveal distinct phenotypes relevant to the control of type III secretion and intoxication by Pseudomonas aeruginosa. PLoS One (2011) 0.89

Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence. J Bacteriol (2007) 0.89

Translational regulation of Yersinia enterocolitica mRNA encoding a type III secretion substrate. J Biol Chem (2013) 0.85

YopR impacts type III needle polymerization in Yersinia species. Mol Microbiol (2009) 0.83

A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cell contact. J Bacteriol (2013) 0.82

A plague on host defense. J Exp Med (2002) 0.81

Polymorphisms in the lcrV gene of Yersinia enterocolitica and their effect on plague protective immunity. Infect Immun (2012) 0.81

LcrV mutants that abolish Yersinia type III injectisome function. J Bacteriol (2012) 0.80

Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis. MBio (2017) 0.75

Articles by these authors

Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol Mol Biol Rev (1999) 7.76

Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med (1999) 6.09

Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science (1999) 5.98

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci U S A (1998) 5.94

Conservation of a hexapeptide sequence in the anchor region of surface proteins from gram-positive cocci. Mol Microbiol (1990) 4.50

A dual thrombin receptor system for platelet activation. Nature (1998) 3.96

Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif. Proc Natl Acad Sci U S A (1999) 3.90

Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature (2000) 3.81

A mRNA signal for the type III secretion of Yop proteins by Yersinia enterocolitica. Science (1997) 3.68

Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in gram-positive bacteria. Mol Microbiol (1994) 3.57

Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections. Proc Natl Acad Sci U S A (2000) 3.46

Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus. Mol Microbiol (2001) 3.39

Her-2-neu expression and progression toward androgen independence in human prostate cancer. J Natl Cancer Inst (2000) 2.87

Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides. Science (1991) 2.56

Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH(2)-Gly(3) substrates. J Biol Chem (2000) 2.52

Two independent type III secretion mechanisms for YopE in Yersinia enterocolitica. Mol Microbiol (1997) 2.34

Protein secretion and the pathogenesis of bacterial infections. Genes Dev (2001) 2.13

Targeting of Yersinia Yop proteins into the cytosol of HeLa cells: one-step translocation of YopE across bacterial and eukaryotic membranes is dependent on SycE chaperone. Mol Microbiol (1998) 2.09

Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity (1996) 2.07

Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi11. Identification of a D-alanyl-glycine endopeptidase activity. J Biol Chem (1999) 2.05

Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus. Proc Natl Acad Sci U S A (2001) 2.03

Anchor structure of staphylococcal surface proteins. IV. Inhibitors of the cell wall sorting reaction. J Biol Chem (1999) 2.01

Target cell specificity of a bacteriocin molecule: a C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus. EMBO J (1996) 1.82

Anchor structure of staphylococcal surface proteins. A branched peptide that links the carboxyl terminus of proteins to the cell wall. J Biol Chem (1997) 1.68

Yersinia enterocolitica type III secretion: an mRNA signal that couples translation and secretion of YopQ. Mol Microbiol (1999) 1.67

Pseudomonas syringae Hrp type III secretion system and effector proteins. Proc Natl Acad Sci U S A (2000) 1.66

Targeting of muralytic enzymes to the cell division site of Gram-positive bacteria: repeat domains direct autolysin to the equatorial surface ring of Staphylococcus aureus. EMBO J (1998) 1.64

Reciprocal secretion of proteins by the bacterial type III machines of plant and animal pathogens suggests universal recognition of mRNA targeting signals. Proc Natl Acad Sci U S A (1999) 1.64

Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines. J Lab Clin Med (1992) 1.58

Type III machines of pathogenic yersiniae secrete virulence factors into the extracellular milieu. Mol Microbiol (1999) 1.55

Instruments of microbial warfare: bacteriocin synthesis, toxicity and immunity. Trends Microbiol (1998) 1.44

Yersinia enterocolitica TyeA, an intracellular regulator of the type III machinery, is required for specific targeting of YopE, YopH, YopM, and YopN into the cytosol of eukaryotic cells. J Bacteriol (2000) 1.41

LcrQ/YscM1, regulators of the Yersinia yop virulon, are injected into host cells by a chaperone-dependent mechanism. Mol Microbiol (2000) 1.36

A program of Yersinia enterocolitica type III secretion reactions is activated by specific signals. J Bacteriol (2001) 1.34

Type III machines of Gram-negative bacteria: delivering the goods. Trends Microbiol (2000) 1.32

Anchor structure of staphylococcal surface proteins. III. Role of the FemA, FemB, and FemX factors in anchoring surface proteins to the bacterial cell wall. J Biol Chem (1998) 1.32

Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica. J Bacteriol (2001) 1.32

Regulated secretion of YopN by the type III machinery of Yersinia enterocolitica. J Bacteriol (2001) 1.32

Anchor structure of staphylococcal surface proteins. II. Cooh-terminal structure of muramidase and amidase-solubilized surface protein. J Biol Chem (1998) 1.32

Anchor structure of cell wall surface proteins in Listeria monocytogenes. Biochemistry (2000) 1.27

Yersinia enterocolitica type III secretion. On the role of SycE in targeting YopE into HeLa cells. J Biol Chem (1999) 1.26

Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects. AIDS (1998) 1.23

Expression of Periostin, homologous with an insect cell adhesion molecule, as a prognostic marker in non-small cell lung cancers. Jpn J Cancer Res (2001) 1.23

Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins. Circulation (1998) 1.14

Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. J Lipid Res (1997) 1.12

Type III secretion machines and the pathogenesis of enteric infections caused by Yersinia and Salmonella spp. Immunol Rev (1999) 1.12

Type III machines of Gram-negative pathogens: injecting virulence factors into host cells and more. Curr Opin Microbiol (1999) 1.08

Response inhibition and ADHD traits: correlates and heritability in a community sample. J Abnorm Child Psychol (2013) 1.04

Recombinant human sickle hemoglobin expressed in yeast. Proc Natl Acad Sci U S A (1993) 1.03

Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood (1998) 1.03

Mineral homeostasis and bone mass at diagnosis in children with acute lymphoblastic leukemia. J Pediatr (1995) 1.00

Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine. J Biol Chem (1997) 0.99

Cell wall sorting of lipoproteins in Staphylococcus aureus. J Bacteriol (1996) 0.98

Genetic diversity among the T-protein genes of group A streptococci. Mol Microbiol (1991) 0.97

Prognostic interaction between thrombocytosis and JAK2 V617F mutation in the WHO subcategories of myelodysplastic/myeloproliferative disease-unclassifiable and refractory anemia with ringed sideroblasts and marked thrombocytosis. Leukemia (2007) 0.94

Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme. J Biol Chem (1992) 0.92

Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence. J Thromb Haemost (2011) 0.90

Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities. Proc Natl Acad Sci U S A (1991) 0.90

Determinants of severity of coronary artery disease in Australian men and women. Circulation (1994) 0.90

Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. Am J Clin Nutr (2001) 0.88

Protection against streptococcal pharyngeal colonization with vaccines composed of M protein conserved regions. Adv Exp Med Biol (1991) 0.86

Assembly and analysis of a functional vaccinia virus "amplicon" containing the C-repeat region from the M protein of Streptococcus pyogenes. Proc Natl Acad Sci U S A (1991) 0.83

Phophate-induced renal calcification in the rat. Can J Physiol Pharmacol (1979) 0.83

Investigating the link between the presence of enteroaggregative Escherichia coli and infectious intestinal disease in the United Kingdom, 1993 to 1996 and 2008 to 2009. Euro Surveill (2013) 0.83

Evaluation of erectile dysfunction and associated cardiovascular risk using structured questionnaires in Chinese type 2 diabetic men. Int J Androl (2010) 0.83

Three-year changes in bone mineral mass of postmenopausal osteoporotic patients based on neutron activation analysis of the central third of the skeleton. J Clin Endocrinol Metab (1981) 0.81

Purification and characterization of recombinant human sickle hemoglobin expressed in yeast. Methods Enzymol (1994) 0.81

Assignment of the 1H, 13C and 15N signals of Sortase. J Biomol NMR (2001) 0.79

Body fat of older adult subjects calculated from bioelectric impedance versus anthropometry correlated but did not agree. J Am Diet Assoc (2001) 0.77

Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. Diabetologia (2009) 0.77

Out of sight, out of mind: an audit of inferior vena cava filter insertion and clinical follow up in an Australian institution and literature review. Intern Med J (2013) 0.76

The relationship between fluoride effects on bone histology and on bone mass in patients with postmenopausal osteoporosis. Bone Miner (1986) 0.75

Reduced epinephrine-stimulated lipolytic activity in male golden-mantled ground squirrel during hibernation: an in situ microdialysis study. Comp Biochem Physiol B Biochem Mol Biol (1999) 0.75

Determinants of severity of left ventricular dysfunction in Australian men and women with coronary disease aged 65 years or less. Aust N Z J Med (1995) 0.75