Published in Neoplasia on June 01, 1999
Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res (2004) 3.16
A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur J Nucl Med Mol Imaging (2004) 3.07
Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia (2000) 2.84
Multimodality imaging probes: design and challenges. Chem Rev (2010) 2.61
Noninvasive assessment of tumor cell proliferation in animal models. Neoplasia (1999) 2.16
Noninvasive real-time imaging of apoptosis. Proc Natl Acad Sci U S A (2002) 1.93
Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci U S A (2002) 1.81
Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy. Blood (2005) 1.57
Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo. Neoplasia (2002) 1.36
Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (1999) 1.26
A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase. Neoplasia (1999) 1.25
Minimally invasive localization of oncolytic herpes simplex viral therapy of metastatic pleural cancer. Cancer Gene Ther (2006) 1.23
Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc Natl Acad Sci U S A (2001) 1.22
Positron emission tomography reporter genes and reporter probes: gene and cell therapy applications. Theranostics (2012) 1.19
Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab (2012) 1.19
Potential applications of flat-panel volumetric CT in morphologic and functional small animal imaging. Neoplasia (2005) 1.06
Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging. Neoplasia (2003) 0.99
PET-based molecular imaging in neuroscience. Eur J Nucl Med Mol Imaging (2003) 0.95
Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein. Acta Oncol (2008) 0.91
Novel infectivity-enhanced oncolytic adenovirus with a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancer. Mol Imaging (2009) 0.90
Switching on the lights for gene therapy. PLoS One (2007) 0.84
Gene expression and gene therapy imaging. Eur Radiol (2006) 0.81
Reporter gene imaging identifies intratumoral infection voids as a critical barrier to systemic oncolytic virus efficacy. Mol Ther Oncolytics (2014) 0.80
Human gene therapy and imaging in neurological diseases. Eur J Nucl Med Mol Imaging (2005) 0.77
Rational design of a triple reporter gene for multimodality molecular imaging. Biomed Res Int (2014) 0.75
Is the future of nuclear medicine written in the genes? Eur J Nucl Med Mol Imaging (2004) 0.75
Green fluorescent protein as a marker for gene expression. Science (1994) 34.55
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (1988) 19.07
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A (1996) 8.53
Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell (1997) 7.15
Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo. J Virol (1989) 7.01
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (1996) 5.97
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (1992) 5.47
Tumor induction of VEGF promoter activity in stromal cells. Cell (1998) 5.20
Internal initiation of translation in eukaryotes: the picornavirus paradigm and beyond. RNA (1995) 4.58
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med (1997) 3.64
Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nat Med (1995) 3.37
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res (1986) 2.98
Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells. Proc Natl Acad Sci U S A (1995) 2.68
Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. J Nucl Med (1998) 2.58
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res (1998) 2.55
The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos. Mol Cell Biol (1991) 2.42
Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat Med (1997) 2.39
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res (1996) 2.22
Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction. Invest Ophthalmol Vis Sci (1997) 2.18
Imaging the expression of transfected genes in vivo. Cancer Res (1995) 2.05
Localization of iodine-125-mIP-Des-Met14-bombesin (7-13)NH2 in ovarian carcinoma induced to express the gastrin releasing peptide receptor by adenoviral vector-mediated gene transfer. J Nucl Med (1997) 2.05
Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Res (1997) 2.00
Labeling neural cells using adenoviral gene transfer of membrane-targeted GFP. Neuron (1996) 1.91
The jellyfish green fluorescent protein: a new tool for studying ion channel expression and function. Neuron (1995) 1.76
Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins. RNA (1998) 1.65
Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant. Cancer Res (1994) 1.41
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci U S A (1994) 1.34
Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1. Cancer Res (1995) 1.22
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol (1991) 1.22
The development of in vivo imaging systems to study gene expression. Trends Biotechnol (1998) 1.19
Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nat Med (1997) 1.19
Restricted beta-galactosidase expression of a hygromycin-lacZ gene targeted to the beta-actin locus and embryonic lethality of beta-actin mutant mice. Transgenic Res (1998) 1.17
In vivo imaging of oligonucleotides with positron emission tomography. Nat Med (1998) 1.15
Green fluorescent protein as a reporter for retrovirus and helper virus-free HSV-1 amplicon vector-mediated gene transfer into neural cells in culture and in vivo. Neuroreport (1997) 1.13
The 9L rat brain tumor: description and application of an animal model. J Neurol (1981) 1.11
Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats. J Neurooncol (1994) 1.09
HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells. Hum Gene Ther (1997) 1.08
Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. Gene Ther (1994) 1.02
Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Mol Med (1997) 1.00
Gene therapy for brain tumors. Brain Pathol (1995) 1.00
Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Hum Gene Ther (1994) 0.98
A fluorescence video-endoscopy technique for detection of gene transfer and expression. Gene Ther (1998) 0.97
Methods for the construction of retroviral vectors and the generation of high-titer producers. Methods Mol Med (1997) 0.96
RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma. Cancer Res (1995) 0.95
Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma. Cancer Gene Ther (1997) 0.89
Herpes simplex virus thymidine kinase-green fluorescent protein fusion gene: new tool for gene transfer studies and gene therapy. Biotechniques (1998) 0.84
Adenoviral-mediated delivery of gastrin-releasing peptide receptor results in specific tumor localization of a bombesin analogue in vivo. Clin Cancer Res (1997) 0.77
Suicide genes against brain tumors. Hum Gene Ther (1998) 0.77
Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci U S A (2000) 5.49
The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. Nat Genet (1997) 5.39
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science (1993) 5.05
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science (1994) 4.81
A randomised controlled trial of abdominal versus laparoscopic sacrocolpopexy for the treatment of post-hysterectomy vaginal vault prolapse: LAS study. Int Urogynecol J (2012) 3.36
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. Proc Natl Acad Sci U S A (2007) 3.07
Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin. Nature (2000) 2.84
Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer. Br J Cancer (2009) 2.76
A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy. Nat Genet (1993) 2.23
Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy. Ann Intern Med (1979) 2.22
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain. Neuroscience (2006) 2.19
Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. Hum Gene Ther (1998) 2.13
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo. J Natl Cancer Inst (1999) 2.10
Carbon monoxide re-breathing during low-flow anaesthesia in infants and children. Br J Anaesth (2010) 2.09
Imaging transgene expression with radionuclide imaging technologies. Neoplasia (2000) 2.03
A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons. Science (1988) 2.02
Localization of human monoamine oxidase-A gene to Xp11.23-11.4 by in situ hybridization: implications for Norrie disease. Genomics (1989) 1.93
FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc Natl Acad Sci U S A (2001) 1.90
Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells. Hum Mol Genet (2000) 1.90
Measurement of the rate of nu(e) + d --> p + p + e(-) interactions produced by (8)B solar neutrinos at the Sudbury Neutrino Observatory. Phys Rev Lett (2001) 1.88
Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells. J Virol (1996) 1.82
Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument. Proc Natl Acad Sci U S A (2000) 1.81
Identification of a highly polymorphic microsatellite VNTR within the argininosuccinate synthetase locus: exclusion of the dystonia gene on 9q32-34 as the cause of dopa-responsive dystonia in a large kindred. Am J Hum Genet (1991) 1.77
Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences. J Neurochem (1988) 1.77
Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen. Neoplasia (1999) 1.74
Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors. Hum Gene Ther (1999) 1.69
Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells. Nat Biotechnol (2000) 1.67
Temperature-sensitive divisionless mutant of Bacillus subtilis defective in the initiation of septation. J Bacteriol (1973) 1.66
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. J Natl Cancer Inst (1998) 1.60
The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites. J Virol (2000) 1.60
Development of a xenogeneic DNA vaccine program for canine malignant melanoma at the Animal Medical Center. Vaccine (2005) 1.59
Human monoamine oxidase A gene determines levels of enzyme activity. Am J Hum Genet (1991) 1.56
Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. Proc Natl Acad Sci U S A (1982) 1.53
Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome. Mol Ther (2001) 1.45
Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas. Mol Ther (2000) 1.45
Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum. J Neurosurg (1993) 1.44
Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons. J Virol (1999) 1.43
Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science (1988) 1.42
Parkin deletions in a family with adult-onset, tremor-dominant parkinsonism: expanding the phenotype. Ann Neurol (2000) 1.40
A unique folate hydrolase, prostate-specific membrane antigen (PSMA): a target for immunotherapy? Crit Rev Immunol (2001) 1.39
High prevalence of methicillin-resistant Staphylococcus aureus (MRSA) on doctors' neckties. Med J Malaysia (2009) 1.38
Localization of the gene for familial dysautonomia on chromosome 9 and definition of DNA markers for genetic diagnosis. Nat Genet (1993) 1.36
Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo. Neoplasia (2002) 1.36
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci U S A (1994) 1.34
Invasive Haemophilus influenzae disease in adults. Epidemiol Infect (2000) 1.32
Structural gene for beta-nerve growth factor not defective in familial dysautonomia. Proc Natl Acad Sci U S A (1984) 1.32
The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study. Clin Pharmacol Ther (1995) 1.31
Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes. J Exp Med (1998) 1.30
The DYT1 gene on 9q34 is responsible for most cases of early limb-onset idiopathic torsion dystonia in non-Jews. Am J Hum Genet (1994) 1.30
Biochemistry and genetics of monoamine oxidase. Pharmacol Ther (1990) 1.29
Molecular imaging of gene therapy for cancer. Gene Ther (2004) 1.28
Isolation and characterization of a candidate gene for Norrie disease. Nat Genet (1992) 1.27
Rapid-onset dystonia-parkinsonism. Neurology (1993) 1.26
Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (1999) 1.26
Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy. Hum Gene Ther (1997) 1.26
A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase. Neoplasia (1999) 1.25
Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc Natl Acad Sci U S A (2001) 1.22
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol (1991) 1.22
Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors. J Comp Neurol (1994) 1.21
Dinucleotide repeat polymorphism (D16S285) on human chromosome 16. Nucleic Acids Res (1991) 1.20
Clinical findings of a myoclonus-dystonia family with two distinct mutations. Neurology (2002) 1.20
Dystonia in Ashkenazi Jews: clinical characterization of a founder mutation. Ann Neurol (1994) 1.19
Multiplication of contaminant bacteria in urine and interpretation of delayed culture. J Clin Pathol (1977) 1.19
Novel mutation in the TOR1A (DYT1) gene in atypical early onset dystonia and polymorphisms in dystonia and early onset parkinsonism. Neurogenetics (2001) 1.18
Outbreak of Streptococcus pneumoniae serotype 1 pneumonia in a United Kingdom school. BMJ (2008) 1.18
Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic monophosphate levels in neuroblastoma cells. Proc Natl Acad Sci U S A (1978) 1.17
Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing. Semin Hematol (1998) 1.16
Tumor-specific transcriptional targeting of suicide gene therapy. Gene Ther (2002) 1.16
Trichosporon capitatum causing recurrent fungal endocarditis. Thorax (1981) 1.16
Expression of the early-onset torsion dystonia gene (DYT1) in human brain. Ann Neurol (1998) 1.16
Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors. Neuroscience (2004) 1.16
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res (1994) 1.15
Mutations in DYT1: extension of the phenotypic and mutational spectrum. Neurology (2004) 1.15
Prodrug activation enzymes in cancer gene therapy. J Gene Med (2000) 1.14
Green fluorescent protein as a reporter for retrovirus and helper virus-free HSV-1 amplicon vector-mediated gene transfer into neural cells in culture and in vivo. Neuroreport (1997) 1.13
Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol (1990) 1.13
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res (2001) 1.12
Distribution of the mRNAs encoding torsinA and torsinB in the normal adult human brain. Ann Neurol (1999) 1.12
Dopamine transmission in DYT1 dystonia: a biochemical and autoradiographical study. Neurology (2002) 1.12
Host and environmental factors associated with Hib in England, 1998-2002. Arch Dis Child (2007) 1.11
Electrophysiologic testing in patients with unexplained syncope: clinical and noninvasive predictors of outcome. J Am Coll Cardiol (1987) 1.10
Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J Neurosci Res (1990) 1.10
Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc Natl Acad Sci U S A (1994) 1.09
Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats. J Neurooncol (1994) 1.09
Absolute measurement of hadronic branching fractions of the Ds+ meson. Phys Rev Lett (2008) 1.09
Linkage disequilibrium between the juvenile neuronal ceroid lipofuscinosis gene and marker loci on chromosome 16p 12.1. Am J Hum Genet (1994) 1.08
Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood-brain barrier disruption. Proc Natl Acad Sci U S A (1995) 1.08
HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells. Hum Gene Ther (1997) 1.08
Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells. J Neurosci Res (1992) 1.08