Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process.

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Published in J Virol on September 01, 2000

Authors

H Zhang1, R J Pomerantz, G Dornadula, Y Sun

Author Affiliations

1: Dorrance H. Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. hui.zhang@mail.tju.edu

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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science (1990) 35.96

Conserved structures and diversity of functions of RNA-binding proteins. Science (1994) 14.75

hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem (1993) 11.44

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell (1998) 10.14

The HIV 'A' (sor) gene product is essential for virus infectivity. Nature (1987) 7.51

Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu Rev Biochem (1996) 7.08

Tables for estimating sedimentation through linear concentration gradients of sucrose solution. Anal Biochem (1967) 6.48

RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J (1994) 6.17

The sor gene of HIV-1 is required for efficient virus transmission in vitro. Science (1987) 6.16

Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions. J Virol (1989) 6.11

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Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes. J Virol (1992) 5.85

RNA chaperones and the RNA folding problem. J Biol Chem (1995) 5.67

RNA packaging. Curr Top Microbiol Immunol (1996) 4.88

Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities. Mol Cell Biol (1988) 4.73

Structure and function of nuclear and cytoplasmic ribonucleoprotein particles. Annu Rev Cell Biol (1986) 4.33

Evidence for a newly discovered cellular anti-HIV-1 phenotype. Nat Med (1998) 3.84

First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses. J Mol Biol (1995) 3.63

RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1. J Virol (1995) 3.53

A study of the dimer formation of Rous sarcoma virus RNA and of its effect on viral protein synthesis in vitro. Nucleic Acids Res (1990) 3.50

A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphology. J Virol (1990) 3.33

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Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays. J Virol (1993) 3.15

Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1. J Virol (1993) 3.12

Identification of highly attenuated mutants of simian immunodeficiency virus. J Virol (1998) 2.94

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An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. J Virol (1998) 2.73

Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes. AIDS Res Hum Retroviruses (1994) 2.72

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Purification and visualization of native spliceosomes. Cell (1988) 2.57

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Sequence-specific binding of human immunodeficiency virus type 1 nucleocapsid protein to short oligonucleotides. J Virol (1998) 2.14

Role of vif during packing of the core of HIV-1. Virology (1994) 2.01

Binding sites of viral protein P19 onto Rous sarcoma virus RNA and possible controls of viral functions. J Mol Biol (1982) 2.00

Reverse transcription takes place within extracellular HIV-1 virions: potential biological significance. AIDS Res Hum Retroviruses (1993) 1.88

Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J Virol (1996) 1.80

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In vivo genetic variability of the HIV-1 vif gene. Virology (1994) 1.18

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Interaction and co-encapsidation of human immunodeficiency virus type 1 Gag and Vif recombinant proteins. J Gen Virol (1998) 1.12

Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants. J Virol (1995) 1.11

Interaction of mRNA with proteins in vesicular stomatitis virus-infected cells. J Virol (1986) 1.09

Conservation of an intact human immunodeficiency virus type 1 vif gene in vitro and in vivo. J Virol (1995) 1.06

gag, vif, and nef genes contribute to the homologous viral interference induced by a nonproducer human immunodeficiency virus type 1 (HIV-1) variant: identification of novel HIV-1-inhibiting viral protein mutants. J Virol (1998) 1.04

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Diversity of the vif gene of human immunodeficiency virus type 1 in Uganda. J Gen Virol (1997) 0.99

A quantitative reverse transcriptase-polymerase chain reaction for HIV-1-specific RNA species. J Virol Methods (1992) 0.94

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