Published in Clin Exp Allergy on November 01, 2002
T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med (2009) 7.11
Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med (2012) 4.85
Diminished lipoxin biosynthesis in severe asthma. Am J Respir Crit Care Med (2005) 1.87
Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr Mol Med (2008) 1.64
Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma. Am J Pathol (2004) 1.58
Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med (2007) 1.46
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med (2008) 1.45
Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol (2010) 1.32
Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev (2011) 1.29
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc Natl Acad Sci U S A (2011) 1.23
An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol (2014) 1.09
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med (2009) 1.07
PPARs and lipid ligands in inflammation and metabolism. Chem Rev (2011) 1.06
12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. J Allergy Clin Immunol (2008) 1.05
Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells. Am J Respir Crit Care Med (2009) 1.05
IgE expression pattern in lung: relation to systemic IgE and asthma phenotypes. J Allergy Clin Immunol (2007) 1.01
Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. Proc Natl Acad Sci U S A (2008) 1.00
A novel function of MUC18: amplification of lung inflammation during bacterial infection. Am J Pathol (2012) 0.95
MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One (2012) 0.93
Gene expression profiling in human asthma. Proc Am Thorac Soc (2007) 0.92
Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure. PLoS One (2011) 0.91
Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia. Neoplasia (2005) 0.91
Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PLoS One (2012) 0.91
Re-defining the unique roles for eosinophils in allergic respiratory inflammation. Clin Exp Allergy (2014) 0.91
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase. J Lipid Res (2015) 0.89
12/15-lipoxygenase is an interleukin-13 and interferon-γ counterregulated-mediator of allergic airway inflammation. Mediators Inflamm (2010) 0.86
Emerging molecular phenotypes of asthma. Am J Physiol Lung Cell Mol Physiol (2014) 0.85
Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids. Chem Phys Lipids (2014) 0.84
Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection. Bioorg Med Chem (2013) 0.81
Role of lipoxygenase metabolites of arachidonic acid in enhanced pulmonary artery contractions of female rabbits. Hypertension (2011) 0.80
Steroid response in refractory asthmatics. Korean J Intern Med (2012) 0.80
Chemical mediators and the resolution of airway inflammation. Allergol Int (2008) 0.80
Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model. Am J Pathol (2011) 0.80
Epithelial regulation of eicosanoid production in asthma. Pulm Pharmacol Ther (2012) 0.79
Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells. PLoS One (2014) 0.78
IgE-mediated 15-hydroxyeicosatetraenoic acid (15-HETE) generation by peripheral blood leukocytes: its association with basophil activation. Postepy Dermatol Alergol (2015) 0.78
Products of 15-lipoxygenase: are they important in asthma? Clin Exp Allergy (2002) 0.77
Interactions of RKIP with inflammatory signaling pathways. Crit Rev Oncog (2014) 0.77
Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency. J Cyst Fibros (2012) 0.75
Lipidomic characterization and localization of phospholipids in the human lung. J Lipid Res (2017) 0.75
15-Lipoxygenases regulate the production of chemokines in human lung macrophages. Br J Pharmacol (2015) 0.75
Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. Eur J Med Chem (2016) 0.75
1,6-O,O-Diacetylbritannilactone Inhibits Eotaxin-1 and ALOX15 Expression Through Inactivation of STAT6 in A549 Cells. Inflammation (2017) 0.75
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell (1996) 17.13
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest (1998) 13.05
Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J (2008) 10.08
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science (1998) 8.36
Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med (1998) 7.48
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates. J Virol (1995) 5.01
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med (1999) 4.75
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science (1997) 4.26
Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature (1998) 4.14
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A (2000) 3.95
Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol (2001) 3.92
Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol (1994) 3.79
CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization. J Virol (1998) 3.60
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature (1997) 3.54
Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev (1998) 3.24
A new perspective on concepts of asthma severity and control. Eur Respir J (2008) 3.16
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci U S A (1997) 2.97
Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J Biol Chem (1997) 2.95
Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology (2009) 2.76
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci (2001) 2.75
Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J Exp Med (1997) 2.75
High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth (2012) 2.71
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J Clin Invest (1998) 2.64
HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5. J Biol Chem (1997) 2.55
Regulation of the proinflammatory effects of Fas ligand (CD95L). Science (1998) 2.43
Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J (2002) 2.33
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A (1996) 2.32
Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies. J Virol (1998) 2.28
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5. J Virol (1998) 2.28
Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development (1995) 2.25
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron (1999) 2.25
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest (1999) 2.21
Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin Immunol (2001) 2.19
Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. Genomics (1998) 2.17
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum Mol Genet (2001) 2.13
Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms. J Mol Cell Cardiol (1994) 2.12
Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process. J Virol (2000) 2.11
Superparamagnetic gadonanotubes are high-performance MRI contrast agents. Chem Commun (Camb) (2005) 2.05
A hierarchical approach to color image segmentation using homogeneity. IEEE Trans Image Process (2000) 1.99
Persistent wheezing in very young children is associated with lower respiratory inflammation. Am J Respir Crit Care Med (2001) 1.94
Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol (2008) 1.92
KCNE1 mutations cause jervell and Lange-Nielsen syndrome. Nat Genet (1997) 1.90
Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A (1997) 1.89
Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J Biol Chem (1995) 1.86
Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Cancer Res (2001) 1.80
Pathophysiology of severe asthma. J Allergy Clin Immunol (2000) 1.80
Generation of mammalian cells stably expressing multiple genes at predetermined levels. Anal Biochem (2000) 1.79
Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int (2007) 1.79
Pneumococcal capsular polysaccharide preparations may contain non-C-polysaccharide contaminants that are immunogenic. Clin Diagn Lab Immunol (1999) 1.74
Transcriptional activation of the human glutathione peroxidase promoter by p53. J Biol Chem (1999) 1.73
Transduction of hepatocellular carcinoma (HCC) using recombinant adeno-associated virus (rAAV): in vitro and in vivo effects of genotoxic agents. J Hepatol (2000) 1.73
Ski/Sno and TGF-beta signaling. Cytokine Growth Factor Rev (2001) 1.71
Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev (1995) 1.70
Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes. J Biol Chem (2001) 1.68
The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells. J Biol Chem (1999) 1.68
Differential expression of tissue inhibitors of metalloproteinases in the failing human heart. Circulation (1998) 1.68
Characterization of the ileal microbiota in rejecting and nonrejecting recipients of small bowel transplants. Am J Transplant (2011) 1.67
beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J Biol Chem (2000) 1.67
Calmodulin regulation of Drosophila light-activated channels and receptor function mediates termination of the light response in vivo. Cell (1997) 1.64
The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1. J Virol (1998) 1.63
Elevated levels of leukotriene C4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis (1990) 1.62
Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. Genes Dev (2000) 1.61
High-throughput microRNAome analysis in human germ cell tumours. J Pathol (2007) 1.60
Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. J Clin Invest (1999) 1.59
CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev (1998) 1.59
Gq alpha protein function in vivo: genetic dissection of its role in photoreceptor cell physiology. Neuron (1995) 1.58
Stabilization of human immunodeficiency virus type 1 envelope glycoprotein trimers by disulfide bonds introduced into the gp41 glycoprotein ectodomain. J Virol (1998) 1.58
atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron (2000) 1.58
Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter. Mol Cell Biol (1997) 1.57
Envelope glycoprotein determinants of increased fusogenicity in a pathogenic simian-human immunodeficiency virus (SHIV-KB9) passaged in vivo. J Virol (2000) 1.55
p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389. J Biol Chem (1999) 1.55
PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Natl Acad Sci U S A (2000) 1.55
Post-translational modifications of water-soluble human lens crystallins from young adults. J Biol Chem (1994) 1.53
Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys. J Virol (1998) 1.49
Sequence analysis and expression of a cDNA clone encoding a 98-kDa allergen in Dermatophagoides farinae. Clin Exp Allergy (1999) 1.48
Nuclear isomers in superheavy elements as stepping stones towards the island of stability. Nature (2006) 1.48
Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. Am J Respir Crit Care Med (1998) 1.47
SCF E3 ubiquitin ligases as anticancer targets. Curr Cancer Drug Targets (2011) 1.46
Pb(II)-translocating P-type ATPases. J Biol Chem (1998) 1.46
p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res (1994) 1.46
Electric-field control of nonvolatile magnetization in Co40Fe40B20/Pb(Mg(1/3)Nb(2/3))(0.7)Ti(0.3)O3 structure at room temperature. Phys Rev Lett (2012) 1.44
Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid. J Biol Chem (2000) 1.43
Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med (1999) 1.43
Donepezil preserves cognition and global function in patients with severe Alzheimer disease. Neurology (2007) 1.43
Differential effects of cAMP in neurons and astrocytes. Role of B-raf. J Biol Chem (1999) 1.43
TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells. Cytokine (1997) 1.42
Great vessel management for endovascular exclusion of aortic arch aneurysms and dissections. Eur J Vasc Endovasc Surg (2006) 1.41
New perspectives on the biology of acute GVHD. Bone Marrow Transplant (2009) 1.40
4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB. Bioorg Med Chem Lett (2000) 1.38
Observation of an antimatter hypernucleus. Science (2010) 1.38
Survey of fungi and yeast in polymicrobial infections in chronic wounds. J Wound Care (2011) 1.38
Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J Cell Sci (1999) 1.38
Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study. J Rheumatol (1998) 1.37
Decision tree algorithm in deciding hospitalization for adult patients with dengue haemorrhagic fever in Singapore. Trop Med Int Health (2009) 1.36
IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells. Clin Exp Allergy (2008) 1.36