Published in Science on October 17, 1997
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev (1998) 8.51
The transcriptional network for mesenchymal transformation of brain tumours. Nature (2009) 8.44
Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells (2005) 6.72
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell (2008) 3.87
Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A (2004) 3.60
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci (2008) 3.44
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev (2008) 2.61
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A (2004) 2.57
The stem cell potential of glia: lessons from reactive gliosis. Nat Rev Neurosci (2011) 2.49
STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells (2009) 2.46
Developmental genetics of vertebrate glial-cell specification. Nature (2010) 2.44
A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci (2005) 2.30
Astrocytes and disease: a neurodevelopmental perspective. Genes Dev (2012) 2.28
Gliogenesis and glial pathology in depression. CNS Neurol Disord Drug Targets (2007) 2.26
Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci (2008) 1.84
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem Biol (2007) 1.78
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med (2005) 1.72
MEK Is a Key Regulator of Gliogenesis in the Developing Brain. Neuron (2012) 1.68
BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells. J Cell Biol (2003) 1.59
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc Natl Acad Sci U S A (1998) 1.56
Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci U S A (2003) 1.55
Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci (2013) 1.52
Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics. Sci Rep (2013) 1.51
Temporal fate specification and neural progenitor competence during development. Nat Rev Neurosci (2013) 1.48
Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol (2007) 1.48
Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Neuron (2007) 1.47
Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor. Proc Natl Acad Sci U S A (1998) 1.45
Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells. Mol Cell Biol (2007) 1.41
Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. EMBO J (2000) 1.41
Differential regulation of STAT family members by glycogen synthase kinase-3. J Biol Chem (2008) 1.41
PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes. Mol Brain (2016) 1.39
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J Neurosci (2008) 1.36
Müller glia: Stem cells for generation and regeneration of retinal neurons in teleost fish. Prog Retin Eye Res (2014) 1.30
Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development. Breast Cancer Res (2000) 1.30
Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain. J Neuroinflammation (2009) 1.29
Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling. Genes Dev (1999) 1.29
A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc Natl Acad Sci U S A (2000) 1.28
Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration. Rev Neurosci (2008) 1.28
Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation. J Cell Biol (2004) 1.25
Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment. Clin Dev Immunol (2011) 1.24
Cross talk between notch and growth factor/cytokine signaling pathways in neural stem cells. Mol Cell Biol (2007) 1.21
Specification of CNS glia from neural stem cells in the embryonic neuroepithelium. Philos Trans R Soc Lond B Biol Sci (2008) 1.21
mTOR signaling and its roles in normal and abnormal brain development. Front Mol Neurosci (2014) 1.19
STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. Am J Pathol (2002) 1.16
Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. EMBO J (2004) 1.14
Epigenetic mechanisms regulating fate specification of neural stem cells. Philos Trans R Soc Lond B Biol Sci (2008) 1.13
STAT3 regulation of glioblastoma pathogenesis. Curr Mol Med (2009) 1.13
The role of JAK-STAT signaling within the CNS. JAKSTAT (2013) 1.12
Glial development: the crossroads of regeneration and repair in the CNS. Neuron (2014) 1.12
Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets. Cancer Invest (2012) 1.12
STAT signaling in the pathogenesis and treatment of cancer. Mol Med (1999) 1.11
Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex. Proc Natl Acad Sci U S A (2004) 1.10
Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway. PLoS One (2008) 1.10
The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation. Dev Neurobiol (2012) 1.10
Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling. PLoS One (2008) 1.10
Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Proc Natl Acad Sci U S A (2008) 1.06
BMP-induced REST regulates the establishment and maintenance of astrocytic identity. J Cell Biol (2010) 1.05
Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation. Nat Commun (2012) 1.03
Interleukin-6 and neural stem cells: more than gliogenesis. Mol Biol Cell (2008) 1.01
Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells. Mol Biol Cell (2011) 0.99
ASK1 inhibits astroglial development via p38 mitogen-activated protein kinase and promotes neuronal differentiation in adult hippocampus-derived progenitor cells. Mol Cell Biol (2004) 0.98
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem (2009) 0.96
Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J Mol Neurosci (2008) 0.96
The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors. Cereb Cortex (2011) 0.96
Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice. Brain (2012) 0.95
Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis. EMBO J (2015) 0.95
Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Nat Neurosci (2016) 0.95
Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome. Cell Death Differ (2009) 0.94
Role of Kruppel-like factor 4 in neurogenesis and radial neuronal migration in the developing cerebral cortex. Mol Cell Biol (2012) 0.92
Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells. Mol Cell Biol (2007) 0.92
SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway. Cancer Res (2011) 0.91
Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1. Neuron Glia Biol (2007) 0.91
Dynamic signaling for neural stem cell fate determination. Cell Adh Migr (2009) 0.91
The Role of Glial Cells in Drug Abuse. Curr Drug Abuse Rev (2009) 0.90
The repair of complex neuronal circuitry by transplanted and endogenous precursors. NeuroRx (2004) 0.90
Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation. PLoS One (2008) 0.90
iNOS: a potential therapeutic target for malignant glioma. Curr Mol Med (2013) 0.89
HIV-1-infected and immune-activated macrophages induce astrocytic differentiation of human cortical neural progenitor cells via the STAT3 pathway. PLoS One (2011) 0.89
MCP-1 involvement in glial differentiation of neuroprogenitor cells through APP signaling. Brain Res Bull (2009) 0.89
Notch exhibits ligand bias and maneuvers stage-specific steering of neural differentiation in embryonic stem cells. Mol Cell Biol (2010) 0.89
Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation. Stem Cells (2015) 0.88
VGluT1+ neuronal glutamatergic signaling regulates postnatal developmental maturation of cortical protoplasmic astroglia. J Neurosci (2014) 0.88
STAT3 but not STAT1 is required for astrocyte differentiation. PLoS One (2014) 0.88
STAT3 regulation of and by microRNAs in development and disease. JAKSTAT (2012) 0.88
The two sides of cytokine signaling and glaucomatous optic neuropathy. J Ocul Biol Dis Infor (2009) 0.88
Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eye. Dev Dyn (2010) 0.88
Chromatin-based epigenetics of adult subventricular zone neural stem cells. Front Genet (2013) 0.88
Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders. J Neurodev Disord (2013) 0.87
STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation. J Neurosci (2012) 0.87
MicroRNAs in hematopoietic development. BMC Immunol (2014) 0.87
The genetic and epigenetic journey of embryonic stem cells into mature neural cells. Front Genet (2012) 0.87
Long-term effects of ionising radiation on the brain: cause for concern? Radiat Environ Biophys (2012) 0.86
Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells. Proc Natl Acad Sci U S A (2006) 0.86
Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome. J Physiol (2014) 0.86
The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome. J Biol Chem (2013) 0.85
Neural stem cells: brain building blocks and beyond. Ups J Med Sci (2012) 0.85
Temporal and epigenetic regulation of neurodevelopmental plasticity. Philos Trans R Soc Lond B Biol Sci (2008) 0.85
Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch. Neuro Oncol (2012) 0.84
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell (1997) 21.42
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (1995) 17.76
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell (1996) 17.13
Cellular survival: a play in three Akts. Genes Dev (1999) 17.05
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science (1997) 15.48
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell (1996) 13.95
Identification of ubiquitin ligases required for skeletal muscle atrophy. Science (2001) 12.98
Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (1997) 11.48
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol (2001) 10.85
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science (1999) 9.18
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell (1996) 9.10
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science (1998) 8.36
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev (1991) 7.51
Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med (1998) 7.48
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science (1999) 7.37
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell (1998) 7.13
The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev (1989) 7.03
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science (1999) 6.96
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol (2001) 6.71
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell (1988) 6.24
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell (1985) 6.21
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol (2001) 5.78
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58
E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26
The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron (1990) 5.19
Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription. Mol Cell Biol (1986) 5.07
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates. J Virol (1995) 5.01
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science (1996) 4.96
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (1995) 4.90
Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem (1985) 4.87
Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science (2001) 4.81
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol Cell Biol (1995) 4.76
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science (1990) 4.63
A cytoplasmic inhibitor of the JNK signal transduction pathway. Science (1997) 4.56
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science (1991) 4.53
Effects of maternal marijuana and cocaine use on fetal growth. N Engl J Med (1989) 4.47
Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol (2001) 4.43
The E2F1-3 transcription factors are essential for cellular proliferation. Nature (2001) 4.37
EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell (2000) 4.34
Calcium regulation of neuronal gene expression. Proc Natl Acad Sci U S A (2001) 4.31
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A (2007) 4.27
Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science (1995) 4.25
Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J Neurosci (1996) 4.21
Development of the primary antibody repertoire. Science (1987) 4.19
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature (1984) 4.18
Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature (1998) 4.14
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science (1999) 4.10
Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol (1986) 4.09
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell (2000) 4.05
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A (2000) 3.95
Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol (2001) 3.92
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell (1996) 3.81
Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol (1994) 3.79
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res (1998) 3.79
Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (1987) 3.74
Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science (1993) 3.71
Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron (1990) 3.70
Ecosystem-level patterns of primary productivity and herbivory in terrestrial habitats. Nature (1989) 3.68
Increased vascularization in mice overexpressing angiopoietin-1. Science (1998) 3.67
Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev (1986) 3.65
CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization. J Virol (1998) 3.60
Differential expression of myc family genes during murine development. Nature (1986) 3.57
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature (1997) 3.54
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science (1994) 3.53
Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro. Mol Cell Biol (1987) 3.53
Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell (1986) 3.51
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J Cell Biol (1990) 3.46
Neural induction by the secreted polypeptide noggin. Science (1993) 3.45
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene (1999) 3.45
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev (1999) 3.35
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc Natl Acad Sci U S A (1991) 3.31
Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell (1994) 3.30
Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev (1998) 3.24
EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell (2001) 3.20
Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science (1999) 3.19
Multiple sexual partners among U.S. adolescents and young adults. Fam Plann Perspect (1999) 3.13
NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron (1990) 3.12
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron (1998) 3.09
VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci (2001) 3.08
CREB: a major mediator of neuronal neurotrophin responses. Neuron (1997) 3.04
Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science (1993) 3.03
Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci (1996) 2.98
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci U S A (1997) 2.97
Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J Biol Chem (1997) 2.95
Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell (2001) 2.93
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science (1993) 2.93