Published in Nature on August 24, 2000
High accuracy 3D quantum dot tracking with multifocal plane microscopy for the study of fast intracellular dynamics in live cells. Biophys J (2008) 3.90
Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release. J Cell Biol (2003) 3.26
Organelles and trafficking machinery for postsynaptic plasticity. Annu Rev Neurosci (2006) 2.82
Evidence for ectopic neurotransmission at a neuronal synapse. Science (2005) 2.81
Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy. Proc Natl Acad Sci U S A (2007) 2.56
Reconstituted syntaxin1a/SNAP25 interacts with negatively charged lipids as measured by lateral diffusion in planar supported bilayers. Biophys J (2001) 2.22
Neuronal SNAREs do not trigger fusion between synthetic membranes but do promote PEG-mediated membrane fusion. Biophys J (2005) 2.18
Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Proc Natl Acad Sci U S A (2004) 2.09
Single-molecule biophysics: at the interface of biology, physics and chemistry. J R Soc Interface (2008) 2.06
"Kiss and run" exocytosis at hippocampal synapses. Proc Natl Acad Sci U S A (2000) 2.01
Synaptic transmission at retinal ribbon synapses. Prog Retin Eye Res (2005) 1.85
RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels. Neuron (2002) 1.81
Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size. Proc Natl Acad Sci U S A (2002) 1.78
Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctions. Elife (2013) 1.74
Structure and function of the hair cell ribbon synapse. J Membr Biol (2006) 1.73
Restriction of secretory granule motion near the plasma membrane of chromaffin cells. J Cell Biol (2001) 1.73
Dissecting docking and tethering of secretory vesicles at the target membrane. EMBO J (2006) 1.70
A fast, single-vesicle fusion assay mimics physiological SNARE requirements. Proc Natl Acad Sci U S A (2010) 1.68
Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis. J Cell Biol (2007) 1.67
Endocytosis at the synaptic terminal. J Physiol (2003) 1.67
Protein scaffolds in the coupling of synaptic exocytosis and endocytosis. Nat Rev Neurosci (2011) 1.61
Recapture after exocytosis causes differential retention of protein in granules of bovine chromaffin cells. J Physiol (2004) 1.60
Calcium influx selects the fast mode of endocytosis in the synaptic terminal of retinal bipolar cells. Proc Natl Acad Sci U S A (2001) 1.58
Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites. J Cell Biol (2006) 1.49
Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography. J Cell Biol (2010) 1.48
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. Nat Neurosci (2010) 1.48
Evidence that vesicles undergo compound fusion on the synaptic ribbon. J Neurosci (2008) 1.45
Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming. Nat Neurosci (2011) 1.44
Vesicle association and exocytosis at ribbon and extraribbon sites in retinal bipolar cell presynaptic terminals. Proc Natl Acad Sci U S A (2008) 1.41
Single molecule mechanical probing of the SNARE protein interactions. Biophys J (2006) 1.35
A comparison between exocytic control mechanisms in adrenal chromaffin cells and a glutamatergic synapse. Pflugers Arch (2006) 1.33
Calcium-dependent synaptic vesicle trafficking underlies indefatigable release at the hair cell afferent fiber synapse. Neuron (2011) 1.33
Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses. J Neurosci (2011) 1.33
Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles. Proc Natl Acad Sci U S A (2007) 1.30
Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells. J Physiol (2004) 1.29
CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons. J Cell Biol (2008) 1.25
Heterogeneous presynaptic release probabilities: functional relevance for short-term plasticity. Biophys J (2003) 1.25
Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. EMBO J (2006) 1.22
Expansion of calcium microdomains regulates fast exocytosis at a ribbon synapse. Proc Natl Acad Sci U S A (2005) 1.19
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion. J Cell Biol (2011) 1.19
Vesicle release probability and pre-primed pool at glutamatergic synapses in area CA1 of the rat neonatal hippocampus. J Physiol (2001) 1.18
Stimulated exocytosis of endosomes in goldfish retinal bipolar neurons. J Physiol (2007) 1.15
What is Rate-Limiting during Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites. Front Synaptic Neurosci (2010) 1.13
Mobility and turnover of vesicles at the synaptic ribbon. J Neurosci (2008) 1.11
Kinetics of synaptic transmission at ribbon synapses of rods and cones. Mol Neurobiol (2007) 1.10
Visualization of synaptic vesicle movement in intact synaptic boutons using fluorescence fluctuation spectroscopy. Biophys J (2005) 1.09
Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane. Mol Biol Cell (2010) 1.09
Correlation between vesicle quantal size and fusion pore release in chromaffin cell exocytosis. Biophys J (2005) 1.08
Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution. J Physiol (2011) 1.07
Quantification of nano-scale intermembrane contact areas by using fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2009) 1.06
The septin Sept5/CDCrel-1 competes with alpha-SNAP for binding to the SNARE complex. Biochem J (2005) 1.05
Leaky synapses: regulation of spontaneous neurotransmission in central synapses. Neuroscience (2008) 1.05
Interactive, computer-assisted tracking of speckle trajectories in fluorescence microscopy: application to actin polymerization and membrane fusion. Biophys J (2011) 1.04
Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes. J Neurosci (2008) 1.04
Exocytosis and endocytosis of small vesicles in PC12 cells studied with TEPIQ (two-photon extracellular polar-tracer imaging-based quantification) analysis. J Physiol (2005) 1.04
Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis. EMBO J (2014) 1.03
Lateral mobility of presynaptic L-type calcium channels at photoreceptor ribbon synapses. J Neurosci (2011) 1.02
Evidence that exocytosis is driven by calcium entry through multiple calcium channels in goldfish retinal bipolar cells. J Neurophysiol (2009) 1.00
Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants. Proc Natl Acad Sci U S A (2009) 0.99
Computational image analysis of cellular dynamics: a case study based on particle tracking. Cold Spring Harb Protoc (2009) 0.98
Sustaining rapid vesicular release at active zones: potential roles for vesicle tethering. Trends Neurosci (2012) 0.98
Spatial control of exocytosis. Curr Opin Cell Biol (2003) 0.97
Quantifying exocytosis by combination of membrane capacitance measurements and total internal reflection fluorescence microscopy in chromaffin cells. PLoS One (2007) 0.96
Physical mobilization of secretory vesicles facilitates neuropeptide release by nerve growth factor-differentiated PC12 cells. J Physiol (2002) 0.96
Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. Elife (2015) 0.96
Properties of exocytotic response in vertebrate photoreceptors. J Neurophysiol (2003) 0.95
Calcium regulates vesicle replenishment at the cone ribbon synapse. J Neurosci (2010) 0.95
Conical tomography of a ribbon synapse: structural evidence for vesicle fusion. PLoS One (2011) 0.93
Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release. Proc Natl Acad Sci U S A (2008) 0.92
The actions of barium and strontium on exocytosis and endocytosis in the synaptic terminal of goldfish bipolar cells. J Physiol (2001) 0.92
Distinct modes of perimembrane TRP channel turnover revealed by TIR-FRAP. Sci Rep (2014) 0.91
Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events. J Cell Sci (2008) 0.91
Release monitoring of single cells on a microfluidic device coupled with fluorescence microscopy and electrochemistry. Biomicrofluidics (2010) 0.90
A 20-nm step toward the cell membrane preceding exocytosis may correspond to docking of tethered granules. Biophys J (2008) 0.90
Imaging synaptosomal calcium concentration microdomains and vesicle fusion by using total internal reflection fluorescent microscopy. Proc Natl Acad Sci U S A (2007) 0.89
The voltage-gated Ca2+ channel is the Ca2+ sensor of fast neurotransmitter release. Cell Mol Neurobiol (2001) 0.89
Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons. J Biol Chem (2011) 0.89
Syntaxin 3B is essential for the exocytosis of synaptic vesicles in ribbon synapses of the retina. Neuroscience (2010) 0.89
Modulating vesicle priming reveals that vesicle immobilization is necessary but not sufficient for fusion-competence. PLoS One (2008) 0.88
New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system. J Neurosci (2013) 0.88
Bilateral effects of unilateral cochlear implantation in congenitally deaf cats. J Comp Neurol (2010) 0.88
The spatial pattern of exocytosis and post-exocytic mobility of synaptopHluorin in mouse motor nerve terminals. J Physiol (2009) 0.87
A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals. J Gen Physiol (2015) 0.87
Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles. J Neurosci (2013) 0.87
Imaging exocytosis in retinal bipolar cells with TIRF microscopy. J Vis Exp (2009) 0.87
High refractive index substrates for fluorescence microscopy of biological interfaces with high z contrast. Proc Natl Acad Sci U S A (2001) 0.87
Gαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes (2010) 0.86
Synaptic vesicle dynamics in mouse rod bipolar cells. Vis Neurosci (2008) 0.85
Synaptic release at mammalian bipolar cell terminals. Vis Neurosci (2011) 0.85
Synaptic vesicles are "primed" for fast clathrin-mediated endocytosis at the ribbon synapse. Front Mol Neurosci (2014) 0.84
Okadaic acid disrupts synaptic vesicle trafficking in a ribbon-type synapse. J Neurochem (2002) 0.84
The dynamics of somatic exocytosis in monoaminergic neurons. Front Physiol (2012) 0.84
Relating structure and function of inner hair cell ribbon synapses. Cell Tissue Res (2015) 0.84
Presynaptic membrane retrieval and endosome biology: defining molecularly heterogeneous synaptic vesicles. Cold Spring Harb Perspect Biol (2013) 0.83
EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals. Front Mol Neurosci (2012) 0.82
The ubiquitous nature of multivesicular release. Trends Neurosci (2015) 0.82
Passive diffusion as a mechanism underlying ribbon synapse vesicle release and resupply. J Neurosci (2014) 0.81
Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma. J Neurosci (2012) 0.80
Exocytosis through the Lens. Front Endocrinol (Lausanne) (2013) 0.80
Structure parameters of synaptic vesicles quantified by small-angle x-ray scattering. Biophys J (2010) 0.80
Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore. J Physiol (1984) 8.20
Gating currents and charge movements in excitable membranes. Rev Physiol Biochem Pharmacol (1978) 5.67
Potassium conductance changes in skeletal muscle and the potassium concentration in the transverse tubules. J Physiol (1972) 4.24
A non-selective cation conductance in frog muscle membrane blocked by micromolar external calcium ions. J Physiol (1984) 4.06
A real-time view of life within 100 nm of the plasma membrane. Nat Rev Mol Cell Biol (2001) 4.01
Currents through the fusion pore that forms during exocytosis of a secretory vesicle. Nature (1987) 3.97
The Ca signal from fura-2 loaded mast cells depends strongly on the method of dye-loading. FEBS Lett (1985) 3.95
Charge movement in the membrane of striated muscle. J Physiol (1976) 3.94
Transport, docking and exocytosis of single secretory granules in live chromaffin cells. Nature (1997) 3.81
Membrane capacity measurements on frog skeletal muscle in media of low ion content. J Physiol (1974) 3.80
The exocytotic event in chromaffin cells revealed by patch amperometry. Nature (1997) 3.69
Slow calcium and potassium currents across frog muscle membrane: measurements with a vaseline-gap technique. J Physiol (1981) 3.42
Calcium depletion in frog muscle tubules: the decline of calcium current under maintained depolarization. J Physiol (1981) 3.18
Endocytic vesicles move at the tips of actin tails in cultured mast cells. Nat Cell Biol (1999) 3.17
Properties of the fusion pore that forms during exocytosis of a mast cell secretory vesicle. Neuron (1990) 3.07
The voltage dependence of membrane capacity. J Physiol (1976) 3.03
Final steps in exocytosis observed in a cell with giant secretory granules. Proc Natl Acad Sci U S A (1987) 3.01
The decline of potassium permeability during extreme hyperpolarization in frog skeletal muscle. J Physiol (1972) 2.99
Effects of tetracaine on displacement currents and contraction of frog skeletal muscle. J Physiol (1976) 2.99
Patch clamp studies of single cell-fusion events mediated by a viral fusion protein. Nature (1989) 2.83
Survival of K+ permeability and gating currents in squid axons perfused with K+-free media. J Gen Physiol (1980) 2.81
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin. Biophys J (1979) 2.77
Dihydropyridine receptors in muscle are voltage-dependent but most are not functional calcium channels. Nature (1985) 2.65
Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells. Neuron (1995) 2.60
Tetrodotoxin binding to normal depolarized frog muscle and the conductance of a single sodium channel. J Physiol (1975) 2.57
The Ca channel in skeletal muscle is a large pore. Proc Natl Acad Sci U S A (1985) 2.49
A low affinity Ca2+ receptor controls the final steps in peptide secretion from pituitary melanotrophs. Neuron (1993) 2.47
Differential effects of tetracaine on delayed potassium channels and displacement currents in frog skeletal muscle. J Physiol (1976) 2.35
Structure and function of fusion pores in exocytosis and ectoplasmic membrane fusion. Curr Opin Cell Biol (1995) 2.31
Block of sodium conductance and gating current in squid giant axons poisoned with quaternary strychnine. Biophys J (1979) 2.30
Ca2+-triggered peptide secretion in single cells imaged with green fluorescent protein and evanescent-wave microscopy. Neuron (1997) 2.30
Calcium-triggered exocytosis and endocytosis in an isolated presynaptic cell: capacitance measurements in saccular hair cells. Neuron (1994) 2.29
Microtubule-dependent transport of secretory vesicles visualized in real time with a GFP-tagged secretory protein. J Cell Sci (1997) 2.25
Fusion of constitutive membrane traffic with the cell surface observed by evanescent wave microscopy. J Cell Biol (2000) 2.24
Membrane flux through the pore formed by a fusogenic viral envelope protein during cell fusion. J Cell Biol (1993) 2.24
Lateral distribution of sodium and potassium channels in frog skeletal muscle: measurements with a patch-clamp technique. J Physiol (1983) 2.18
Tracking single secretory granules in live chromaffin cells by evanescent-field fluorescence microscopy. Biophys J (1999) 2.16
A triggered mechanism retrieves membrane in seconds after Ca(2+)-stimulated exocytosis in single pituitary cells. J Cell Biol (1994) 2.12
Cytosolic Ca2+, exocytosis, and endocytosis in single melanotrophs of the rat pituitary. Neuron (1990) 2.06
Role of actin cortex in the subplasmalemmal transport of secretory granules in PC-12 cells. Biophys J (2000) 2.05
Observations on intramembrane charge movements in skeletal muscle. Philos Trans R Soc Lond B Biol Sci (1975) 2.01
Fast calcium transients in rat peritoneal mast cells are not sufficient to trigger exocytosis. EMBO J (1986) 1.94
The first milliseconds of the pore formed by a fusogenic viral envelope protein during membrane fusion. Proc Natl Acad Sci U S A (1991) 1.94
Ca2+ triggers massive exocytosis in Chinese hamster ovary cells. EMBO J (1996) 1.80
Distribution of transport proteins over animal cell membranes. J Membr Biol (1984) 1.75
Millisecond studies of secretion in single rat pituitary cells stimulated by flash photolysis of caged Ca2+. EMBO J (1993) 1.71
Some dielectric properties of muscle membrane and their possible importance for excitation-contraction coupling. Ann N Y Acad Sci (1975) 1.71
Fast steps in exocytosis and endocytosis studied by capacitance measurements in endocrine cells. Curr Opin Neurobiol (1996) 1.69
Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain. Science (1991) 1.62
Rhythmic exocytosis stimulated by GnRH-induced calcium oscillations in rat gonadotropes. Science (1993) 1.60
Annexin 2 has an essential role in actin-based macropinocytic rocketing. Curr Biol (2001) 1.60
Agonists that suppress M-current elicit phosphoinositide turnover and Ca2+ transients, but these events do not explain M-current suppression. Neuron (1988) 1.55
Photobleaching through glass micropipettes: sodium channels without lateral mobility in the sarcolemma of frog skeletal muscle. Proc Natl Acad Sci U S A (1982) 1.53
Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophs. Neuron (1997) 1.49
Slow changes in currents through sodium channels in frog muscle membrane. J Physiol (1983) 1.47
Voltage clamp of rat and human skeletal muscle: measurements with an improved loose-patch technique. J Physiol (1984) 1.46
Repulsion between tetraethylammonium ions in cloned voltage-gated potassium channels. Neuron (1992) 1.35
Targeting of green fluorescent protein to neuroendocrine secretory granules: a new tool for real time studies of regulated protein secretion. Eur J Cell Biol (1997) 1.31
Potassium concentration changes in the transverse tubules of vertebrate skeletal muscle. Fed Proc (1980) 1.16
Ethane-freezing/methanol-fixation of cell monolayers: a procedure for improved preservation of structure and antigenicity for light and electron microscopies. J Struct Biol (1998) 1.14
Measurement of membrane capacity in skeletal muscle. Nat New Biol (1973) 1.08
Local anesthetics and excitation-contraction coupling in skeletal muscle. Effects on a Ca++-channel [proceedings]. Biophys J (1977) 0.98
Two independently regulated secretory pathways in mast cells. J Physiol Paris (1993) 0.95
Patch voltage clamping with low-resistance seals: loose patch clamp. Methods Enzymol (1992) 0.93
Slow calcium and potassium currents in frog skeletal muscle: their relationship and pharmacologic properties. Pflugers Arch (1985) 0.92
Fusion needs more than SNAREs. Nature (2001) 0.91
Effect of glucocorticoid treatment on the excitability of rat skeletal muscle. Pflugers Arch (1982) 0.90
Synapses. How fast can you get? Nature (1994) 0.90
Mobility of voltage-dependent ion channels and lectin receptors in the sarcolemma of frog skeletal muscle. J Gen Physiol (1986) 0.90
Rhythmic opening and closing of vesicles during constitutive exo- and endocytosis in chromaffin cells. EMBO J (2000) 0.88
An improved loose patch voltage clamp method using concentric pipettes. Pflugers Arch (1984) 0.87
Calcium oscillations and exocytosis in pituitary gonadotropes. Ann N Y Acad Sci (1994) 0.82
The last seconds in the life of a secretory vesicle. Cold Spring Harb Symp Quant Biol (1995) 0.82
Membrane channel formation by the lymphocyte pore-forming protein: comparison between susceptible and resistant target cells. J Cell Biol (1990) 0.81
Millisecond studies of calcium-dependent exocytosis in pituitary melanotrophs: comparison of the photolabile calcium chelators nitrophenyl-EGTA and DM-nitrophen. Cell Calcium (1996) 0.81
Patch pipettes used for loading small cells with fluorescent indicator dyes. Adv Exp Med Biol (1986) 0.79
Quantal neurotransmitter release from early endosomes? Trends Cell Biol (1994) 0.77
Distribution and mobility of voltage-gated ion channels in skeletal muscle. Ann N Y Acad Sci (1986) 0.77
Exocytosis and its control at the synapse. Curr Opin Neurobiol (1992) 0.75
Different sites of polyadenylation in mRNAs encoding a rat metabotropic glutamate receptor. DNA Seq (1993) 0.75