Published in Nat Neurosci on June 20, 2010
The diverse roles of ribbon synapses in sensory neurotransmission. Nat Rev Neurosci (2010) 1.83
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. J Neurosci (2010) 1.72
Bassoon speeds vesicle reloading at a central excitatory synapse. Neuron (2010) 1.67
Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses. J Neurosci (2011) 1.33
Mice do not require auditory input for the normal development of their ultrasonic vocalizations. BMC Neurosci (2012) 1.26
Recovery from short-term depression and facilitation is ultrafast and Ca2+ dependent at auditory hair cell synapses. J Neurosci (2011) 1.17
Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy. J Assoc Res Otolaryngol (2013) 1.15
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis. J Neurosci (2011) 1.11
Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis. EMBO J (2014) 1.03
Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies. J Neurosci (2012) 1.00
A new probe for super-resolution imaging of membranes elucidates trafficking pathways. J Cell Biol (2014) 0.99
Sustaining rapid vesicular release at active zones: potential roles for vesicle tethering. Trends Neurosci (2012) 0.98
EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells. Proc Natl Acad Sci U S A (2015) 0.96
Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity. Proc Natl Acad Sci U S A (2013) 0.95
Optogenetic stimulation of the auditory pathway. J Clin Invest (2014) 0.93
The SNARE complex in neuronal and sensory cells. Mol Cell Neurosci (2012) 0.92
Functional assembly of mammalian cochlear hair cells. Exp Physiol (2011) 0.90
Short-term facilitation modulates size and timing of the synaptic response at the inner hair cell ribbon synapse. J Neurosci (2011) 0.89
Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J Neurosci (2013) 0.89
The C2 domains of otoferlin, dysferlin, and myoferlin alter the packing of lipid bilayers. Biochemistry (2013) 0.89
Auditory neuropathy - neural and synaptic mechanisms. Nat Rev Neurol (2016) 0.89
Membrane Repair: Mechanisms and Pathophysiology. Physiol Rev (2015) 0.88
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene. J Neurosci (2012) 0.87
Characterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains. Biochemistry (2014) 0.87
Information from cochlear potentials and genetic mutations helps localize the lesion site in auditory neuropathy. Genome Med (2010) 0.86
Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair. Mol Biol Cell (2014) 0.85
Cochlear hair cells: The sound-sensing machines. FEBS Lett (2015) 0.84
Relating structure and function of inner hair cell ribbon synapses. Cell Tissue Res (2015) 0.84
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells. J Neurosci (2014) 0.83
Mice lacking the cerebral cortex develop normal song: insights into the foundations of vocal learning. Sci Rep (2015) 0.83
Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing. EMBO J (2015) 0.83
Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses. Open Biol (2013) 0.82
Calcium signaling in the cochlea - Molecular mechanisms and physiopathological implications. Cell Commun Signal (2012) 0.82
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. EMBO J (2016) 0.82
Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis. J Biol Chem (2014) 0.81
Ca(2+) influx and neurotransmitter release at ribbon synapses. Cell Calcium (2012) 0.80
Loudness adaptation accompanying ribbon synapse and auditory nerve disorders. Brain (2013) 0.80
Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants. EMBO J (2016) 0.79
New insights into cochlear sound encoding. F1000Res (2016) 0.79
A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis. PLoS One (2013) 0.78
Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses. Front Cell Neurosci (2015) 0.78
Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin. J Neurophysiol (2014) 0.78
Developmental acquisition of a rapid calcium-regulated vesicle supply allows sustained high rates of exocytosis in auditory hair cells. PLoS One (2011) 0.78
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse. EMBO J (2014) 0.78
Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder. Hear Res (2015) 0.78
The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors. J Physiol (2015) 0.77
Perinatal thiamine deficiency causes cochlear innervation abnormalities in mice. Hear Res (2016) 0.76
Modeling the influence of short term depression in vesicle release and stochastic calcium channel gating on auditory nerve spontaneous firing statistics. Front Comput Neurosci (2014) 0.76
FM dye photo-oxidation as a tool for monitoring membrane recycling in inner hair cells. PLoS One (2014) 0.76
Otoferlin deficiency in zebrafish results in defects in balance and hearing: rescue of the balance and hearing phenotype with full-length and truncated forms of mouse otoferlin. Mol Cell Biol (2015) 0.76
Identification of a novel pathogenic OTOF variant causative of nonsyndromic hearing loss with high frequency in the Ashkenazi Jewish population. Appl Clin Genet (2016) 0.75
Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels. Proc Natl Acad Sci U S A (2017) 0.75
Transmitter release at the hair cell ribbon synapse. Nat Neurosci (2002) 4.08
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell (2006) 3.71
Transport, capture and exocytosis of single synaptic vesicles at active zones. Nature (2000) 3.58
Hair cell synaptic ribbons are essential for synchronous auditory signalling. Nature (2005) 3.54
Response properties of single auditory nerve fibers in the mouse. J Neurophysiol (2004) 3.27
Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse. Proc Natl Acad Sci U S A (2000) 3.07
Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron (2008) 2.96
Few CaV1.3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse. J Neurosci (2005) 2.85
Calcium dependence of exo- and endocytotic coupling at a glutamatergic synapse. Neuron (2009) 2.79
Structure and function of ribbon synapses. Trends Neurosci (2005) 2.45
Calcium dependence of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse. Neuron (2001) 2.43
The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release. Neuron (2007) 2.39
Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. J Neurosci (2008) 2.36
Transfer characteristics of the hair cell's afferent synapse. Proc Natl Acad Sci U S A (2006) 2.33
Calcium-triggered exocytosis and endocytosis in an isolated presynaptic cell: capacitance measurements in saccular hair cells. Neuron (1994) 2.29
Tuning of synapse number, structure and function in the cochlea. Nat Neurosci (2009) 2.29
A highly Ca2+-sensitive pool of vesicles contributes to linearity at the rod photoreceptor ribbon synapse. Neuron (2004) 2.14
Time course and calcium dependence of transmitter release at a single ribbon synapse. Proc Natl Acad Sci U S A (2007) 2.11
Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell (2009) 2.06
The unitary event underlying multiquantal EPSCs at a hair cell's ribbon synapse. J Neurosci (2009) 1.93
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci (2007) 1.90
Vesicle depletion and synaptic depression at a mammalian ribbon synapse. J Neurophysiol (2006) 1.89
Pressure polishing: a method for re-shaping patch pipettes during fire polishing. J Neurosci Methods (2000) 1.89
Depletion and replenishment of vesicle pools at a ribbon-type synaptic terminal. J Neurosci (1997) 1.84
Synaptic ribbon enables temporal precision of hair cell afferent synapse by increasing the number of readily releasable vesicles: a modeling study. J Neurophysiol (2008) 1.83
Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells. J Physiol (2004) 1.82
Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse. Nature (2006) 1.79
Auditory hair cell-afferent fiber synapses are specialized to operate at their best frequencies. Neuron (2005) 1.79
Fast vesicle replenishment allows indefatigable signalling at the first auditory synapse. Nature (2005) 1.67
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. Am J Hum Genet (2008) 1.65
Acoustically responsive fibers in the vestibular nerve of the cat. J Neurosci (1994) 1.58
Role of the synaptic ribbon in transmitting the cone light response. Nat Neurosci (2009) 1.58
A mechanism intrinsic to the vesicle fusion machinery determines fast and slow transmitter release at a large CNS synapse. J Neurosci (2007) 1.51
Two actions of calcium regulate the supply of releasable vesicles at the ribbon synapse of retinal bipolar cells. J Neurosci (1999) 1.50
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells. Proc Natl Acad Sci U S A (2009) 1.49
Kinetics of exocytosis is faster in cones than in rods. J Neurosci (2005) 1.49
Mechanisms underlying the temporal precision of sound coding at the inner hair cell ribbon synapse. J Physiol (2006) 1.46
Two modes of release shape the postsynaptic response at the inner hair cell ribbon synapse. J Neurosci (2010) 1.45
Quantitative analysis of calcium-dependent vesicle recruitment and its functional role at the calyx of Held synapse. J Neurosci (2007) 1.45
Evidence that rapid vesicle replenishment of the synaptic ribbon mediates recovery from short-term adaptation at the hair cell afferent synapse. J Assoc Res Otolaryngol (2004) 1.38
Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses. J Neurosci (2009) 1.37
Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse. J Neurosci (2009) 1.36
Probing the mechanism of exocytosis at the hair cell ribbon synapse. J Neurosci (2007) 1.33
Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell. Hum Mol Genet (2009) 1.21
The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing. J Neurosci (2009) 1.14
Large releasable pool of synaptic vesicles in chick cochlear hair cells. J Neurophysiol (2004) 1.12
Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses. Hum Mol Genet (2009) 1.11
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83
Neuroligins determine synapse maturation and function. Neuron (2006) 5.70
Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells. Nature (2007) 4.87
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
The development of executive function in early childhood. Monogr Soc Res Child Dev (2003) 4.01
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci U S A (2008) 3.74
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell (2006) 3.71
Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature (2004) 3.69
Hair cell synaptic ribbons are essential for synchronous auditory signalling. Nature (2005) 3.54
Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc Natl Acad Sci U S A (2005) 3.37
Neuroligin 2 is exclusively localized to inhibitory synapses. Eur J Cell Biol (2004) 3.15
Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells. Nature (2004) 3.02
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat Genet (2011) 2.97
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A (2002) 2.91
Few CaV1.3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse. J Neurosci (2005) 2.85
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids. Nat Struct Mol Biol (2007) 2.63
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron (2002) 2.52
Mechanotransduction by hair cells: models, molecules, and mechanisms. Cell (2009) 2.46
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron (2009) 2.44
Neurochemical modulation of response inhibition and probabilistic learning in humans. Science (2006) 2.41
BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Science (2006) 2.40
The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. Proc Natl Acad Sci U S A (2002) 2.34
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell (2005) 2.30
Review series: The cell biology of hearing. J Cell Biol (2010) 2.29
Tuning of synapse number, structure and function in the cochlea. Nat Neurosci (2009) 2.29
Determinants of liposome fusion mediated by synaptic SNARE proteins. Proc Natl Acad Sci U S A (2004) 2.28
Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23. Cell (2003) 2.25
A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron (2006) 2.25
Characterization of the Drosophila lipid droplet subproteome. Mol Cell Proteomics (2006) 2.23
Beta1 integrins regulate myoblast fusion and sarcomere assembly. Dev Cell (2003) 2.21
Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. Cell Rep (2011) 2.17
One SNARE complex is sufficient for membrane fusion. Nat Struct Mol Biol (2010) 2.14
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin. Neuropharmacology (2004) 2.13
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science (2010) 2.12
CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells. J Neurosci (2003) 2.12
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol Cell (2005) 2.09
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J (2009) 2.09
Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes. Nat Genet (2006) 2.09
Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell (2009) 2.06
Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence. Am J Psychiatry (2012) 2.05
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25. Neuron (2004) 2.04
Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex. Neuron (2011) 2.02
Atomic model of the type III secretion system needle. Nature (2012) 2.02
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling. Neuron (2010) 1.95
CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron (2005) 1.94
Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol (2005) 1.93
A common molecular basis for membrane docking and functional priming of synaptic vesicles. Eur J Neurosci (2009) 1.91
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci (2007) 1.90
Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study. Biol Psychiatry (2008) 1.89
Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matter. Neuron (2007) 1.89
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. EMBO J (2006) 1.88
Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Mol Biol Cell (2004) 1.85
Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity. J Allergy Clin Immunol (2009) 1.84
Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder. Biol Psychiatry (2007) 1.82
Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity. Cell (2004) 1.80
Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling. Neuron (2013) 1.79
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A (2008) 1.78
Fate-restricted neural progenitors in the mammalian cerebral cortex. Science (2012) 1.77
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J Neurosci (2006) 1.75
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice. J Neurosci (2011) 1.73
Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet (2004) 1.72
Membrane fusion intermediates via directional and full assembly of the SNARE complex. Science (2012) 1.71
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci U S A (2008) 1.68
In vitro and in vivo evaluation of [18F]ciprofloxacin for the imaging of bacterial infections with PET. Eur J Nucl Med Mol Imaging (2004) 1.67
Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J (2002) 1.66
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. Am J Hum Genet (2008) 1.65
The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila. Dev Cell (2003) 1.64
Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron (2009) 1.63
CaMKII binding to GluN2B is critical during memory consolidation. EMBO J (2012) 1.62
The dynamic range of the human metabolome revealed by challenges. FASEB J (2012) 1.61
Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus. J Physiol (2006) 1.61
Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A (2009) 1.60
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell (2007) 1.60
Equalization of odor representations by a network of electrically coupled inhibitory interneurons. Nat Neurosci (2013) 1.59
The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses. Curr Opin Neurobiol (2012) 1.58
TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells. Cell (2012) 1.58
Industrial applications of metal-organic frameworks. Chem Soc Rev (2009) 1.58
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol (2010) 1.58
Risk assessment in anaphylaxis: current and future approaches. J Allergy Clin Immunol (2007) 1.57
Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons. J Neurosci (2010) 1.57
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron (2010) 1.57
Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis. Genetics (2010) 1.56
Dissociation of amyloid fibrils of alpha-synuclein in supercooled water. Angew Chem Int Ed Engl (2008) 1.51