Published in J Exp Med on September 18, 2000
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Natl Acad Sci U S A (2002) 2.35
T cell metabolism drives immunity. J Exp Med (2015) 2.06
Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol (2007) 1.76
Immunoregulation in the gut: success and failures in human disease. Gut (2002) 1.25
The rate of interleukin-1beta secretion in different myeloid cells varies with the extent of redox response to Toll-like receptor triggering. J Biol Chem (2011) 1.09
Redox remodeling as an immunoregulatory strategy. Biochemistry (2010) 1.08
Role of glutathione in immunity and inflammation in the lung. Int J Gen Med (2011) 1.06
Increased level of arginase activity correlates with disease severity in HIV-seropositive patients. J Infect Dis (2010) 1.05
Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells. J Biol Chem (2010) 1.01
The cystine/glutamate antiporter regulates dendritic cell differentiation and antigen presentation. J Immunol (2010) 0.97
Redox biology of the intestine. Free Radic Res (2011) 0.92
Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration. Immunol Rev (2013) 0.84
Obesity, longevity, quality of life: alteration by dietary 2-mercaptoethanol. Virulence (2010) 0.81
Up-regulation of the phosphoinositide 3-kinase pathway in human lamina propria T lymphocytes. Clin Exp Immunol (2008) 0.80
Initiation of an inflammatory response in resident intestinal lamina propria cells -use of a human organ culture model. PLoS One (2014) 0.77
Functional and molecular aspects of transient T cell unresponsiveness: role of selective interleukin-2 deficiency. Clin Exp Immunol (2003) 0.76
Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex®. Immun Inflamm Dis (2014) 0.76
LPS alters pattern of sickness behavior but does not affect glutathione level in aged male rats. Biogerontology (2016) 0.75
Human monocytes downregulate innate response receptors following exposure to the microbial metabolite n-butyrate. Immun Inflamm Dis (2017) 0.75
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem (1979) 7.16
Isolation and functional characterization of human intestinal mucosal lymphoid cells. J Clin Invest (1977) 5.09
Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease. Gut (1989) 4.59
Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes. Gut (1994) 1.87
Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J Immunol (1995) 1.62
Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx. Proc Natl Acad Sci U S A (1994) 1.55
Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma. Anal Biochem (1992) 1.53
Role of membrane transport in metabolism and function of glutathione in mammals. J Membr Biol (1986) 1.51
Severe generalized glutathione reductase deficiency after antitumor chemotherapy with BCNU" [1,3-bis(chloroethyl)-1-nitrosourea]. J Lab Clin Med (1977) 1.48
Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase. J Immunol (1989) 1.38
Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease. Gastroenterology (1995) 1.33
In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease. Am J Pathol (1998) 1.28
Activation and signaling status of human lamina propria T lymphocytes. Gastroenterology (1991) 1.25
Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes. Eur J Immunol (1993) 1.22
Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine. J Biol Chem (1981) 1.19
Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine. Cell Immunol (1990) 1.18
Regulation of glutathione levels in mouse spleen lymphocytes by transport of cysteine. J Cell Physiol (1987) 1.18
Induction of cystine transport activity in mouse peritoneal macrophages. J Exp Med (1987) 1.13
Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones. Eur J Biochem (1991) 1.05
Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn's disease. Virchows Arch (1995) 1.00
Human intestinal mucosa alters T-cell reactivities. Gastroenterology (1993) 0.98
Differential regulation of human T cell responsiveness by mucosal versus blood monocytes. Eur J Immunol (1996) 0.91
Glutathione reverses the inhibition of T cell responses by superoptimal numbers of "nonprofessional" antigen presenting cells. Cell Immunol (1994) 0.79
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 9.23
An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell (1984) 7.56
Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A (1982) 5.85
Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. Nature (1983) 4.96
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene (2002) 4.15
Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med (1983) 4.10
The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors. Cell (1983) 3.07
Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. Proc Natl Acad Sci U S A (1983) 2.93
Surface structures involved in target recognition by human cytotoxic T lymphocytes. Science (1982) 2.52
Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand. Nature (1987) 2.28
The human T-cell receptor. Annu Rev Immunol (1984) 2.23
Pancreatic ischaemia in experimental acute pancreatitis: mechanism, significance and therapy. Br J Surg (1990) 2.21
Impact of diagnostic laparoscopy on the management of gastric cancer: prospective study of 120 consecutive patients with primary gastric adenocarcinoma. Br J Surg (2002) 2.21
Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes. Science (1983) 2.21
Resection of liver metastases in colorectal cancer--competitive analysis of treatment results in synchronous versus metachronous metastases. Eur J Surg Oncol (1990) 2.07
Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis. Gastroenterology (2001) 1.97
Cellular origin of interleukin 2 (IL 2) in man: evidence for stimulus-restricted IL 2 production by T4+ and T8+ T lymphocytes. J Immunol (1982) 1.87
The human T cell receptor: analysis with cytotoxic T cell clones. Immunol Rev (1983) 1.84
Dissemination of tumor cells in patients undergoing surgery for colorectal cancer. Clin Cancer Res (1998) 1.68
Effect of training on the incidence of nerve damage in thyroid surgery. Br J Surg (1999) 1.64
Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis. Ann Surg (1998) 1.61
General stress response to conventional and laparoscopic cholecystectomy. Ann Surg (1995) 1.61
Interleukin 10 and immune restoration in common variable immunodeficiency. Lancet (1993) 1.60
Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology (1993) 1.58
Isovolemic hemodilution with dextran prevents contrast medium induced impairment of pancreatic microcirculation in necrotizing pancreatitis of the rat. Am J Surg (1995) 1.54
Granulocyte/macrophage colony-stimulating factor induces interleukin 1 production by human polymorphonuclear neutrophils. J Immunol (1988) 1.51
The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes. Eur J Immunol (2000) 1.51
T cell receptor triggering induces responsiveness to interleukin 1 and interleukin 2 but does not lead to T cell proliferation. J Immunol (1986) 1.50
Delineation of an immunoregulatory amplifier population recognizing autologous Ia molecules. Analysis with human T cell clones. J Exp Med (1984) 1.49
Outcome after emergency surgery for cancer of the large intestine. Br J Surg (1991) 1.48
The impact of 3-dimensional reconstructions on operation planning in liver surgery. Arch Surg (2000) 1.47
Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease. Ann N Y Acad Sci (1998) 1.46
Increased autologous blood donation in rectal cancer by recombinant human erythropoietin (rhEPO) Eur J Cancer (1998) 1.45
Expression of different CD8 isoforms on distinct human lymphocyte subpopulations. Eur J Immunol (1991) 1.44
Desmopressin impairs microcirculation in donor pancreas and early graft function after experimental pancreas transplantation. Transplantation (2001) 1.44
[Results of isolated hyperthermic extremity perfusion in soft tissue sarcomas within the scope of a multimodality treatment concept]. Chirurg (1996) 1.43
[Surgical procedure in Crohn disease]. Chirurg (1992) 1.38
Recognition of distress and psychiatric morbidity in cancer patients: a multi-method approach. Ann Oncol (2004) 1.34
Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. J Biol Chem (1997) 1.34
Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen. J Exp Med (1983) 1.33
Two-stage radical gastrectomy for perforated gastric cancer. Eur J Surg Oncol (2000) 1.30
Clinical value of [18-F]] fluorodeoxyglucose positron emission tomography imaging in soft tissue sarcomas. Ann Surg (2000) 1.29
In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease. Am J Pathol (1998) 1.28
Differential responsiveness to CD3-Ti vs. CD2-dependent activation of human intestinal T lymphocytes. Eur J Immunol (1990) 1.25
Activation and signaling status of human lamina propria T lymphocytes. Gastroenterology (1991) 1.25
Clonotypic surface structure on human T lymphocytes: functional and biochemical analysis of the antigen receptor complex. Immunol Rev (1984) 1.24
Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut (1998) 1.24
Dephosphorylation of serine 3 regulates nuclear translocation of cofilin. J Biol Chem (1996) 1.23
Are nitrite and N-nitroso compounds in gastric juice risk factors for carcinoma in the operated stomach? Lancet (1980) 1.21
Surgery for benign insulinoma: an international review. World J Surg (1990) 1.21
Prognostic value of codon 918 (ATG-->ACG) RET proto-oncogene mutations in sporadic medullary thyroid carcinoma. Int J Cancer (2001) 1.20
Risks of intestinal anastomoses in Crohn's disease. Ann Surg (1991) 1.20
Association of CD2 and CD45 on human T lymphocytes. Nature (1990) 1.18
Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis. Cancer Res (1999) 1.18
Detection of hematogenic tumor cell dissemination in patients undergoing resection of liver metastases of colorectal cancer. Ann Surg (2000) 1.18
Human cytotoxic T cell clones directed at autologous virus-transformed targets: further evidence for linkage of genetic restriction to T4 and T8 surface glycoproteins. J Immunol (1983) 1.18
Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register. Int J Colorectal Dis (2001) 1.17
Adenocarcinoma in the ileal pouch: late risk of cancer after restorative proctocolectomy. Int J Colorectal Dis (2001) 1.16
Prehospital ultrasound imaging improves management of abdominal trauma. Br J Surg (2006) 1.15
Purified lymphocyte function-associated antigen-3 and T11 target structure are active in CD2-mediated T cell stimulation. Eur J Immunol (1987) 1.14
Immunoelectron microscopic observations on the inflammatory infiltrates and HLA antigens in hepatitis B and non-A, non-B. Hepatology (1988) 1.14
Immunoregulatory human T lymphocytes triggered as a consequence of viral infection: clonal analysis of helper, suppressor inducer and suppressor effector cell populations. J Immunol (1983) 1.14
Costimulatory signals for human T-cell activation induce nuclear translocation of pp19/cofilin. Proc Natl Acad Sci U S A (1994) 1.13
Triggering of the alternative pathway of human T cell activation involves members of the T 200 family of glycoproteins. Eur J Immunol (1989) 1.13
Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool. J Immunol (2000) 1.13
A monoclonal antibody that blocks class II histocompatibility-related immune interactions. Hum Immunol (1984) 1.12
Virtual planning of liver resections: image processing, visualization and volumetric evaluation. Int J Med Inform (1999) 1.12
Persistent reduction of complement receptor 3 alpha-chain expressing mononuclear blood cells and transient inhibitory serum factors in Whipple's disease. Clin Immunol Immunopathol (1994) 1.10
Selective blockade of the antigen-receptor-mediated pathway of T cell activation in patients with impaired primary immune responses. J Clin Invest (1987) 1.09
Tumor recurrence and options for further treatment after resection of liver metastases in patients with colorectal cancer. J Surg Oncol (1990) 1.08
Glutathione and immune function. Proc Nutr Soc (2000) 1.07
Therapeutic effect of isovolemic hemodilution with dextran 60 on the impairment of pancreatic microcirculation in acute biliary pancreatitis. Ann Surg (1990) 1.07
Outcome after septic complications in J pouch procedures. Br J Surg (2002) 1.05
Quality of life and functional results following different types of resection for gastric carcinoma. Eur J Surg Oncol (1990) 1.05
[First continuous nerve monitoring in thyroid gland surgery]. Chirurg (2000) 1.04
Impact of microcirculatory flow pattern changes on the development of acute edematous and necrotizing pancreatitis in rabbit pancreas. Dig Dis Sci (1994) 1.04
The impact of disease pattern, surgical management, and individual surgeons on the risk for relaparotomy for recurrent Crohn's disease. Ann Surg (1996) 1.04
Pouch-anal cancer after restorative proctocolectomy for familial adenomatous polyposis. Am J Surg Pathol (1996) 1.04
Influence of major histocompatibility complex class I and II antigens on survival in colorectal carcinoma. Cancer Res (1991) 1.03
T cell receptor gene rearrangements of T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis (PBC): oligoclonality of PBC-derived T cell clones. Eur J Immunol (1990) 1.03
Comparative analysis of tumor cell dissemination in mesenteric, central, and peripheral venous blood in patients with colorectal cancer. Arch Surg (2001) 1.03
Laparoscopically assisted colectomy and ileoanal pouch procedure with and without protective ileostomy. Surg Endosc (2003) 1.03
Deletion mapping defines different regions in 1p34.2-pter that may harbor genetic information related to human colorectal cancer. Oncogene (1995) 1.02
Detection of disseminated colorectal cancer cells in lymph nodes, blood and bone marrow. Clin Cancer Res (1999) 1.02
Improvement of impaired pancreatic microcirculation by isovolemic hemodilution protects pancreatic morphology in acute biliary pancreatitis. Surg Gynecol Obstet (1993) 1.02
[Computer-based training--a new method in surgical education and continuing education]. Chirurg (1997) 1.02
Negative predictive value of a population-based preschool vision screening program. Ophthalmology (1992) 1.02
Isovolemic hemodilution with dextran 60 as treatment of pancreatic ischemia in acute pancreatitis. Clinical practicability of an experimental concept. Ann Surg (1993) 1.01
Cofilin: a missing link between T cell co-stimulation and rearrangement of the actin cytoskeleton. Eur J Immunol (2000) 1.01
Inhibition of constitutive serine phosphatase activity in T lymphoma cells results in phosphorylation of pp19/cofilin and induces apoptosis. J Immunol (1996) 1.01
Indications for and results of surgical therapy for male gynecomastia. Am J Surg (1999) 1.00
Long-term follow-up after ileoanal pouch procedure: algorithm for diagnosis, classification, and management of pouchitis. Dis Colon Rectum (2001) 1.00
Cystine levels, cystine flux, and protein catabolism in cancer cachexia, HIV/SIV infection, and senescence. FASEB J (1997) 1.00
Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn's disease. Virchows Arch (1995) 1.00
Cigarette smoke enhances ethanol-induced pancreatic injury. Pancreas (2000) 0.99
Detection of isolated disseminated tumor cells in bone marrow and blood samples of patients with hepatocellular carcinoma. Arch Surg (2000) 0.99
A new way for surgical education--development and evaluation of a computer-based training module. Comput Biol Med (2000) 0.99