Published in J Exp Med on September 01, 1983
Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J Exp Med (1985) 5.62
Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J Exp Med (1984) 5.26
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc Natl Acad Sci U S A (1987) 3.33
Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer. Proc Natl Acad Sci U S A (1986) 2.73
Perturbation of the T4 molecule transmits a negative signal to T cells. J Exp Med (1985) 2.66
T lymphocytes respond to solid-phase antigen: a novel approach to the molecular analysis of cellular immunity. Immunology (1986) 2.45
Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol Cell Biol (1993) 2.37
Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes. Proc Natl Acad Sci U S A (1985) 2.10
Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J Exp Med (1988) 2.08
Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex. J Exp Med (1985) 1.92
Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation. Mol Cell Biol (1988) 1.90
Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation. J Exp Med (1987) 1.80
The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells. Proc Natl Acad Sci U S A (1986) 1.55
Possible orientational constraints determine secretory signals induced by aggregation of IgE receptors on mast cells. EMBO J (1988) 1.50
Delineation of an immunoregulatory amplifier population recognizing autologous Ia molecules. Analysis with human T cell clones. J Exp Med (1984) 1.49
Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes. EMBO J (1988) 1.47
Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones. Proc Natl Acad Sci U S A (1987) 1.45
Functional characterization of an antigen involved in an early step of T-cell activation. Proc Natl Acad Sci U S A (1987) 1.41
Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity. Proc Natl Acad Sci U S A (1986) 1.40
Signaling clusters in the cell membrane. Curr Opin Cell Biol (2011) 1.39
Involvement of Lyt-2 and L3T4 in activation of hapten-specific Lyt-2+ L3T4+ T-cell clones. Proc Natl Acad Sci U S A (1986) 1.35
Clonal heterogeneity in the requirement for T3, T4, and T8 molecules in human cytolytic T lymphocyte function. J Exp Med (1984) 1.29
Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis. Proc Natl Acad Sci U S A (1989) 1.25
Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway. J Virol (1993) 1.24
Human T lymphocyte subsets. Functional heterogeneity and surface recognition structures. J Clin Invest (1984) 1.23
Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation. Mol Cell Biol (1989) 1.20
Antibody-induced modulation of the CD3/T cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation. J Exp Med (1987) 1.19
Regulation of inositol 1,4,5-trisphosphate kinase activity after stimulation of human T cell antigen receptor. J Clin Invest (1987) 1.18
The quantal theory of how the immune system discriminates between "self and non-self" Med Immunol (2004) 1.13
A synaptic basis for T-lymphocyte activation. Ann Immunol (Paris) (1985) 1.11
Medical immunology: a new journal for a new subspecialty. Med Immunol (2002) 1.10
Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones. J Exp Med (1987) 1.06
Predominant expression of circulating CD3+ lymphocytes bearing gamma T cell receptor in a prolonged immunodeficiency after allogeneic bone marrow transplantation. J Clin Invest (1988) 1.06
Perturbation of the human T-cell antigen receptor-T3 complex leads to the production of inositol tetrakisphosphate: evidence for conversion from inositol trisphosphate. Proc Natl Acad Sci U S A (1986) 1.05
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J Exp Med (1999) 1.03
Bacterial toxins affect early events of T lymphocyte activation. J Clin Invest (1989) 1.02
Selective suppressive effects of Trypanosoma cruzi on activated human lymphocytes. Infect Immun (1989) 1.01
A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3. J Exp Med (1986) 1.00
Phaseolus vulgaris phytohaemagglutinin (PHA) binds to the human T lymphocyte antigen receptor. EMBO J (1984) 1.00
Production of granulocyte/macrophage-colony-stimulating factor by human natural killer cells. Modulation by the p75 subunit of the interleukin 2 receptor and by the CD2 receptor. J Clin Invest (1991) 0.98
T cell antiidiotypic antibodies reveal differences between two human leukemias. J Exp Med (1984) 0.97
The role of class I histocompatibility antigens in the regulation of T-cell activation. Proc Natl Acad Sci U S A (1987) 0.96
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation. PLoS One (2008) 0.93
The effects of pertussis toxin on human T lymphocytes. Immunology (1988) 0.93
Direct interactions between B and T lymphocytes bearing complementary receptors. J Exp Med (1986) 0.93
Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants. J Exp Med (1988) 0.92
Anergy induction by dimeric TCR ligands. J Immunol (2001) 0.91
Generation and characterization of monospecific and bispecific hexavalent trimerbodies. MAbs (2012) 0.91
T-cell clones and T-cell receptors. Microbiol Rev (1986) 0.90
Toward a molecular understanding of adaptive immunity: a chronology - part II. Front Immunol (2012) 0.87
Functional expression of the murine Thy-1.2 gene in transfected human T cells. J Exp Med (1986) 0.86
T-lymphocyte activation pathways in alcoholic liver disease. Immunology (1991) 0.85
Human T lymphocytes expressing a defined T-cell antigen receptor family specifically kill the hybridoma that makes the anti-receptor monoclonal antibody. Immunology (1986) 0.83
T suppressor cell growth factor and anti-CD3 antibodies stimulate reciprocal subsets of T lymphocytes. J Exp Med (1987) 0.81
Interferon-gamma secretion of peripheral blood CD8+ T lymphocytes in patients with bronchial asthma: in vitro stimulus determines cytokine production. Clin Exp Immunol (2001) 0.80
The T cell antigen receptor. Biochem J (1985) 0.80
Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells. EMBO J (1987) 0.80
Suppression by Trypanosoma cruzi of T-cell receptor expression by activated human lymphocytes. Immunology (1992) 0.80
Antibodies to the T3 antigen complex on human T cells render thymocytes unresponsive to mitogen. Immunology (1985) 0.79
A novel subset of CD2-, CD3/T cell receptor alpha/beta+ human peripheral blood T cells. Phenotypic and functional characterization of interleukin 2-dependent CD2-CD3+ T cell clones. J Exp Med (1989) 0.79
Does staphylococcal enterotoxin B bind directly to murine T cells? Immunology (1991) 0.79
Induction of interleukin 2 receptiveness and proliferation in resting peripheral T cells by monoclonal anti-CD3 (T3) antibodies does not require the presence of macrophages. Clin Exp Immunol (1987) 0.79
Rapid and preferential distribution of blood-borne alphaCD3epsilonAb to the liver is followed by local stimulation of T cells and natural killer T cells. Immunology (2006) 0.77
Revisiting the putative TCR Cα dimerization model through structural analysis. Front Immunol (2013) 0.77
Revisiting the Discovery of the αβ TCR Complex and Its Co-Receptors. Front Immunol (2014) 0.76
Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri. J Immunol Res (2015) 0.75
Activation of a murine T-cell hybridoma by cationized bacteria. Immunology (1989) 0.75
In vivo effects of monoclonal antibodies to distinct epitopes of Qa-2 antigens. J Exp Med (1990) 0.75
A monoclonal antibody (8H3) that binds to rat T lineage cells and augments in vitro proliferative responses. J Exp Med (1990) 0.75
In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth. Am J Reprod Immunol (2016) 0.75
Preparation of anti-T idiotype monoclonal antibody reacting with human T leukaemic cell lines and with a small percentage of peripheral T lymphocytes. Clin Exp Immunol (1990) 0.75
A role for self-recognizing T cells in the regulation of antibody-forming and cell-mediated cytotoxic responses in the mouse. Immunology (1985) 0.75
Abrogation of the requirement for feeder cell interaction and T cell receptor stimulation of lymphocytes infected with retroviral vectors. J Exp Med (1990) 0.75
Respective contribution of intracellular calcium release and extracellular calcium influx for interleukin-2 synthesis in activated T-cell hybrids. Immunology (1990) 0.75
Adaptive immune response to viral infections in the central nervous system. Handb Clin Neurol (2014) 0.75
Energy of adhesion of human T cells to adsorption layers of monoclonal antibodies measured by a film trapping technique. Biophys J (1998) 0.75
Subpopulations of CD4+ cells in lpr/lpr mice: differences in expression of T cell receptor/CD3 complex and proliferative responses. Clin Exp Immunol (1990) 0.75
Activation of resting human B cells by helper T-cell clone supernatant: characterization of a human B-cell-activating factor. Proc Natl Acad Sci U S A (1987) 0.75
In Vivo Activation of Invariant Natural Killer T Cells Induces Systemic and Local Alterations in T-Cell Subsets Prior to Preterm Birth. Clin Exp Immunol (2017) 0.75
T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol (1978) 28.92
Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. Immunochemistry (1978) 22.56
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 9.23
Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A (1982) 5.85
OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties. J Immunol (1980) 5.63
Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. Nature (1983) 4.96
Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell (1982) 4.86
A monoclonal antibody blocking human T cell function. Eur J Immunol (1980) 3.33
Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. Proc Natl Acad Sci U S A (1983) 2.93
Surface structures involved in target recognition by human cytotoxic T lymphocytes. Science (1982) 2.52
Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes. Nature (1981) 2.39
Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones. J Exp Med (1982) 2.14
Cellular origin of interleukin 2 (IL 2) in man: evidence for stimulus-restricted IL 2 production by T4+ and T8+ T lymphocytes. J Immunol (1982) 1.87
Two monoclonal anti-human T lymphocyte antibodies have similar biologic effects and recognize the same cell surface antigen. J Immunol (1982) 1.68
The differentiation and function of human T lymphocytes. Cell (1980) 11.88
Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A (1980) 11.23
Monoclonal antibodies defining distinctive human T cell surface antigens. Science (1979) 10.50
Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci U S A (1979) 10.28
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 9.23
An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell (1984) 7.56
A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol (1980) 6.96
The isolation and characterization of the human suppressor inducer T cell subset. J Immunol (1985) 6.69
Specific purification of lymphocyte populations on a digestible immunoabsorbent. J Immunol (1973) 6.64
A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol (1979) 6.08
A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol (1980) 6.05
Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A (1982) 5.85
Characterization of a human B lymphocyte-specific antigen. J Immunol (1980) 5.76
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci U S A (1988) 5.75
A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. Cell (1991) 5.65
Further characterization of the human inducer T cell subset defined by monoclonal antibody. J Immunol (1979) 5.63
Immunologic functions of isolated human lymphocyte subpopulations. I. Quantitative isolation of human T and B cells and response to mitogens. J Immunol (1974) 5.50
The isolation and characterization of the human helper inducer T cell subset. J Immunol (1985) 5.21
Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med (1979) 5.19
Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. Nature (1983) 4.96
Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell (1982) 4.86
Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med (1980) 4.80
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature (1990) 4.70
Antigens on human monocytes identified by monoclonal antibodies. J Immunol (1981) 4.67
Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens. J Exp Med (1978) 4.51
Two functionally distinct subpopulations of human T cells that collaborate in the generation of cytotoxic cells responsible for cell-mediated lympholysis. J Immunol (1978) 4.33
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature (1988) 4.15
Distribution of Ia-like molecules on the surface of normal and leukemic human cells. Proc Natl Acad Sci U S A (1976) 4.05
A monoclonal antibody to human acute lymphoblastic leukaemia antigen. Nature (1980) 3.90
Distribution of T cell subsets in human lymph nodes. J Exp Med (1981) 3.64
Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Science (1995) 3.62
The cellular basis for viral-induced immunodeficiency: analysis by monoclonal antibodies. J Immunol (1980) 3.49
Location of T cell and major histocompatibility complex antigens in the human thymus. J Exp Med (1980) 3.41
Studies on mediator production by highly purified human T and B lymphocytes. J Exp Med (1974) 3.38
A monoclonal antibody blocking human T cell function. Eur J Immunol (1980) 3.33
Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion. Cell (1988) 3.25
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest (1983) 3.23
Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens. J Exp Med (1987) 3.14
Aberrations of suppressor T cells in human graft-versus-host disease. N Engl J Med (1979) 3.10
B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol (1983) 3.09
The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors. Cell (1983) 3.07
Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison. J Exp Med (1980) 3.03
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science (1993) 2.93
Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. Proc Natl Acad Sci U S A (1983) 2.93
Structural analysis of differentiation antigens Mo1 and Mo2 on human monocytes. Hybridoma (1982) 2.92
Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science (1983) 2.91
Characterization of a human B cell-specific antigen (B2) distinct from B1. J Immunol (1981) 2.86
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci U S A (1989) 2.80
Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes. J Clin Invest (1985) 2.77
Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation. Blood (1984) 2.74
A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen. J Exp Med (1988) 2.74
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex. J Exp Med (1989) 2.69