Published in Toxicology on October 28, 1996
Ovarian follicle counts--not as simple as 1, 2, 3. Reprod Biol Endocrinol (2003) 1.36
Tobacco smoke-related health effects induced by 1,3-butadiene and strategies for risk reduction. Toxicol Sci (2013) 0.99
Xenobiotic effects on ovarian preantral follicles. Biol Reprod (2011) 0.91
The 5'-GNC site for DNA interstrand cross-linking is conserved for diepoxybutane stereoisomers. Chem Res Toxicol (2006) 0.81
Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries. Toxicol Sci (2001) 2.51
Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats. Toxicol Appl Pharmacol (1996) 1.39
Destruction of preantral follicles in adult rats by 4-vinyl-1-cyclohexene diepoxide. Reprod Toxicol (1995) 1.36
Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades. Biol Reprod (2001) 1.28
Expression and redistribution of cellular Bad, Bax, and Bcl-X(L) protein is associated with VCD-induced ovotoxicity in rats. Biol Reprod (2001) 1.26
Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index. Toxicol Appl Pharmacol (2000) 1.21
Early effects of ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats and mice. Reprod Toxicol (1999) 1.18
The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity. Toxicol Appl Pharmacol (1990) 1.18
Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl by human hepatic microsomes. Biochem Pharmacol (1983) 1.16
Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat. Toxicol Appl Pharmacol (1996) 1.15
Evaluation of certain food additives and contaminants. World Health Organ Tech Rep Ser (2007) 1.06
An animal model of hepatotoxicity associated with halothane anesthesia. Anesthesiology (1976) 1.06
Assessment of follicle destruction in chemical-induced ovarian toxicity. Annu Rev Pharmacol Toxicol (1996) 1.06
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. Anesthesiology (1979) 1.02
Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species. Toxicol Appl Pharmacol (1993) 1.02
In vitro solubility and in vivo toxicity of gallium arsenide. Toxicol Appl Pharmacol (1984) 1.01
Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules. Exp Mol Pathol (1973) 1.01
Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans. Drug Metab Dispos (2002) 1.01
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. Food Chem Toxicol (2002) 1.00
Dermal absorption of phthalate diesters in rats. Fundam Appl Toxicol (1989) 1.00
Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: role of cytochrome P-450. Life Sci (1977) 1.00
Cytotoxicity and genotoxicity of methyleugenol and related congeners-- a mechanism of activation for methyleugenol. Mutat Res (2000) 0.99
Bioactivation and covalent binding of halothane in vitro: studies with [3H]- and [14C]halothane. J Pharmacol Exp Ther (1980) 0.98
Ovarian toxicity of 4-vinylcyclohexene diepoxide: a mechanistic model. Toxicol Pathol (2001) 0.97
The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol. Toxicol Appl Pharmacol (1996) 0.97
A single dose of the ovotoxicant 4-vinylcyclohexene diepoxide is protective in rat primary ovarian follicles. Toxicol Appl Pharmacol (1999) 0.96
Circadian alterations in prolactin, corticosterone, and thyroid hormone levels and down-regulation of prolactin receptor activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol (1987) 0.94
Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin. Drug Metab Dispos (1984) 0.94
Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model. Drug Metab Dispos (1985) 0.94
Preparation and composition of alveolar extracellular matrix and incorporated basement membrane. Lung (1981) 0.93
Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane. J Pharmacol Exp Ther (1980) 0.93
Pharmacokinetics of acrylamide in Fisher-344 rats. Toxicol Appl Pharmacol (1982) 0.92
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione. Anesthesiology (1974) 0.92
Characterization of the hepatic DNA damage caused by 1,2-dibromoethane using the alkaline elution technique. Carcinogenesis (1981) 0.91
Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F1 mice: role of diepoxides. Chem Res Toxicol (1996) 0.91
Risk assessment of chemical mixtures: biologic and toxicologic issues. Fundam Appl Toxicol (1993) 0.91
2,4,5,2',4',5'-Hexachlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey. Toxicol Appl Pharmacol (1982) 0.91
Sensitive gas chromatographic determination of trifluoperazine in human plasma. J Chromatogr (1981) 0.90
In vitro degradation of L-phenylalanine mustard (L-PAM). Cancer Chemother Pharmacol (1982) 0.90
Biotransformation and hepatotoxicity of halothane. Biochem Pharmacol (1977) 0.90
Toxicokinetics of sulfasalazine (salicylazosulfapyridine) and its metabolites in B6C3F1 mice. Drug Metab Dispos (1994) 0.89
Reactions of peroxynitrite with gamma-tocopherol. Chem Res Toxicol (1997) 0.88
A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients. Food Chem Toxicol (2003) 0.88
Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2. Drug Metab Dispos (2009) 0.88
The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain-specific differential toxicity. Toxicol Appl Pharmacol (1991) 0.88
Some cardiovascular and autonomic effects of fenfluramine hydrochloride. J Pharmacol Exp Ther (1971) 0.87
Central nervous system effects of fenfluramine hydrochloride. J Pharmacol Exp Ther (1972) 0.87
Factors influencing halothane hepatotoxicity in the rat hypoxic model. Toxicol Appl Pharmacol (1980) 0.87
Reduced ability of rat preantral ovarian follicles to metabolize 4-vinyl-1-cyclohexene diepoxide in vitro. Toxicol Appl Pharmacol (1994) 0.86
Regulation of substance P by nerve growth factor: disruption by capsaicin. Brain Res (1982) 0.86
Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. Arch Biochem Biophys (1987) 0.86
Follicular mechanisms associated with 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats. Reprod Toxicol (1996) 0.85
Comparison of random and serial sections in assessment of ovarian toxicity. Reprod Toxicol (1991) 0.85
Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration. Toxicol Appl Pharmacol (1983) 0.85
Long-term ovarian and gonadotropin changes in mice exposed to 4-vinylcyclohexene. Reprod Toxicol (1994) 0.85
Enhanced hepatic microsomal activity by pretreatment of rats with acetone or isopropanol. Proc Soc Exp Biol Med (1973) 0.84
Comparison of the disposition and in vitro metabolism of 4-vinylcyclohexene in the female mouse and rat. Toxicol Appl Pharmacol (1990) 0.84
Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine). Biochem Pharmacol (1974) 0.83
Effects of dose and route on the disposition and kinetics of 1-butyl-1-methylpyrrolidinium chloride in male F-344 rats. Drug Metab Dispos (2009) 0.83
Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat. Toxicology (1997) 0.83
The disposition of acrylic acid in the male Sprague-Dawley rat following oral or topical administration. Food Chem Toxicol (1993) 0.83
Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. Toxicol Appl Pharmacol (1993) 0.83
A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. Food Chem Toxicol (2010) 0.83
Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat-hepatocyte cultures. Xenobiotica (1984) 0.83
Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity. Toxicology (1997) 0.83
Enhanced hepatotoxicity of carbon tetrachloride, thioacetamide, and dimethylnitrosamine by pretreatment of rats with ethanol and some comparisons with potentiation by isopropanol. Toxicol Appl Pharmacol (1975) 0.83
A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients. Food Chem Toxicol (2005) 0.82
Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents. Environ Health Perspect (1994) 0.82
2,3,6,2',3',6'-hexachlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey. Toxicol Appl Pharmacol (1982) 0.82
Prediction of metabolic clearance of bisphenol A (4,4 '-dihydroxy-2,2-diphenylpropane) using cryopreserved human hepatocytes. Drug Metab Dispos (2007) 0.82
Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fischer-344 and human liver slices. Hum Exp Toxicol (1995) 0.82
Tissue distribution and elimination of indium in male Fischer 344 rats following oral and intratracheal administration of indium phosphide. J Toxicol Environ Health (1994) 0.82
Activation of 3':5'-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed-function oxygenases. Proc Natl Acad Sci U S A (1976) 0.81
Absorption, distribution, metabolism and excretion of intravenously and orally administered tetrabromobisphenol A [2,3-dibromopropyl ether] in male Fischer-344 rats. Toxicology (2007) 0.81
Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicol Appl Pharmacol (1985) 0.81
Evidence for the metabolism of bumetanide in man. Life Sci (1975) 0.81
Inhibition of ornithine decarboxylase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem Pharmacol (1982) 0.81
Deuterium isotope effect on the metabolism and toxicity of 1,2-dibromoethane. Toxicol Appl Pharmacol (1983) 0.81
Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene. Drug Metab Dispos (2001) 0.81
Inhibition of NADPH oxidation and related drug oxidation in liver microsomes by zinc. Biochem Pharmacol (1976) 0.81
The bioactivation of 1,2-dibromoethane in rat hepatocytes: covalent binding to nucleic acids. Carcinogenesis (1982) 0.80
Evaluation of hepatic cytochrome P4502E1 in the species-dependent bioactivation of 4-vinylcyclohexene. Life Sci (2001) 0.80
Characterization of hepatic DNA damage induced in rats by the pyrrolizidine alkaloid monocrotaline. Cancer Res (1984) 0.80
A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients. Food Chem Toxicol (2011) 0.80
Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat. J Toxicol Environ Health (1986) 0.80
Altered retrograde axonal transport of nerve growth factor after single and repeated doses of acrylamide in the rat. Toxicol Appl Pharmacol (1983) 0.80
The biochemical basis for the species difference in hepatic microsomal 4-vinylcyclohexene epoxidation between female mice and rats. Carcinogenesis (1990) 0.80
Gas-chromatographic method for the halothane metabolites, trifluoroacetic acid and bromide, in biological fluids. J Anal Toxicol (1981) 0.80
The hydroxylation, dechlorination, and glucuronidation of 4,4'-dichlorobiphenyl (4-DCB) by human hepatic microsomes. Biochem Pharmacol (1984) 0.80
Cystamine modulation of galactosamine-induced hepatotoxicity. Toxicol Appl Pharmacol (1984) 0.80
Functional and numerical alterations induced by ethanol in the cellular immune system. Immunopharmacology (1988) 0.80
Quantitative analysis of volatile halothane metabolites in biological tissues by gas chromatography. J Chromatogr (1979) 0.80
Time course of hepatic injury and recovery following coadministration of carbon tetrachloride and trichloroethylene in Fischer-344 rats. Toxicol Pathol (1993) 0.79
A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients. RIFM Expert Panel. Food Chem Toxicol (2013) 0.79
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats. Drug Metab Dispos (1999) 0.79
Adenosine cyclic 3',5'-monophosphate-dependent protein kinase and ornithine decarboxylase involvement in the induction of cytochrome P-450 and hepatic hypertrophy. Mol Pharmacol (1976) 0.79
Interaction of capsaicinoids with drug-metabolizing systems. Relationship to toxicity. Biochem Pharmacol (1983) 0.78
Mechanisms of ovotoxicity induced by environmental chemicals: 4-vinylcyclohexene diepoxide as a model chemical. Adv Exp Med Biol (2001) 0.78
Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F1 mice. Drug Metab Dispos (1999) 0.78
1,2-Dichlorobenzene-mediated hepatocellular oxidative stress in Fischer-344 and Sprague-Dawley rats. Toxicol Appl Pharmacol (2000) 0.78