Published in Biochem Biophys Res Commun on September 24, 2000
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell (2011) 1.49
A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology. BMC Genomics (2010) 0.99
Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII). Biochem J (2001) 0.93
Molecular underpinnings of synaptic vesicle pool heterogeneity. Traffic (2015) 0.85
Structural elements that underlie Doc2β function during asynchronous synaptic transmission. Proc Natl Acad Sci U S A (2015) 0.79
The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I. Biochem J (2002) 0.79
The N-terminal cysteine cluster is essential for membrane targeting of B/K protein. Biochem J (2001) 0.79
Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission. Mol Biol Cell (2013) 0.78
Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science (2000) 5.04
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature (1989) 5.02
2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release. J Biochem (1997) 4.69
Functional expression of a mammalian odorant receptor. Science (1998) 4.09
Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature (1997) 3.22
The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol Cell Biol (2001) 2.87
Calcium stores regulate the polarity and input specificity of synaptic modification. Nature (2000) 2.84
The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron (1995) 2.82
'Ischemic tolerance' phenomenon found in the brain. Brain Res (1990) 2.73
Localization of inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae. J Cell Biol (1992) 2.72
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature (1996) 2.70
Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell. Dev Biol (1996) 2.68
Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes. Nature (1991) 2.67
A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature (1997) 2.61
Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proc Natl Acad Sci U S A (1999) 2.52
Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation (1995) 2.27
Structural and functional characterization of inositol 1,4,5-trisphosphate receptor channel from mouse cerebellum. J Biol Chem (1991) 2.23
Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J Neurosci (1997) 2.17
Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor. J Physiol (2000) 2.11
A cerebellar Purkinje cell marker P400 protein is an inositol 1,4,5-trisphosphate (InsP3) receptor protein. Purification and characterization of InsP3 receptor complex. EMBO J (1990) 2.01
Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. Science (1992) 1.99
The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner. Proc Natl Acad Sci U S A (1991) 1.96
Intracellular channels. Curr Opin Neurobiol (1994) 1.94
Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II. J Biol Chem (1994) 1.92
Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells. Neuron (1994) 1.89
Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits. J Biol Chem (1995) 1.79
The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev Biol (1997) 1.73
Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor. J Biol Chem (1996) 1.73
Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. EMBO J (2000) 1.70
The Xenopus IP3 receptor: structure, function, and localization in oocytes and eggs. Cell (1993) 1.68
Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain. J Biol Chem (1995) 1.63
A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem (1994) 1.62
Purification and characterization of P400 protein, a glycoprotein characteristic of Purkinje cell, from mouse cerebellum. J Neurochem (1988) 1.62
Mouse Zic1 is involved in cerebellar development. J Neurosci (1998) 1.60
Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor. Neuron (1999) 1.59
Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Res (1991) 1.59
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity. J Biol Chem (1996) 1.58
Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem (2000) 1.56
Structure-function relationships of the mouse inositol 1,4,5-trisphosphate receptor. Proc Natl Acad Sci U S A (1991) 1.55
Physical and functional interactions between Zic and Gli proteins. J Biol Chem (2001) 1.54
Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem (1999) 1.53
Monoclonal antibodies distinctively recognizing the subtypes of inositol 1,4,5-trisphosphate receptor: application to the studies on inflammatory cells. FEBS Lett (1994) 1.52
Trypsinized cerebellar inositol 1,4,5-trisphosphate receptor. Structural and functional coupling of cleaved ligand binding and channel domains. J Biol Chem (1999) 1.51
Differentiation of a teratocarcinoma line: preferential development of cholinergic neurons. J Cell Biol (1981) 1.51
Multiple types of ryanodine receptor/Ca2+ release channels are differentially expressed in rabbit brain. J Neurosci (1994) 1.46
Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum. Dev Biol (1989) 1.45
IP3 receptor blockade fails to prevent intracellular Ca2+ release by ET-1 and alpha-thrombin. Am J Physiol (1998) 1.42
Cyclic AMP-dependent phosphorylation of an immunoaffinity-purified homotetrameric inositol 1,4,5-trisphosphate receptor (type I) increases Ca2+ flux in reconstituted lipid vesicles. J Biol Chem (1994) 1.41
Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal. Proc Natl Acad Sci U S A (1995) 1.41
The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor. Biochem J (1995) 1.40
A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoforms. J Biol Chem (1999) 1.39
Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system. Receptors Channels (1993) 1.38
Ca2+ differentially regulates the ligand-affinity states of type 1 and type 3 inositol 1,4,5-trisphosphate receptors. Biochem J (1997) 1.38
Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. Cancer Res (1996) 1.36
Anatomical, physiological and biochemical studies of the cerebellum from Reeler mutant mouse. Philos Trans R Soc Lond B Biol Sci (1977) 1.35
Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci U S A (2000) 1.34
C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity. Biochemistry (2001) 1.33
Xenopus Zic3, a primary regulator both in neural and neural crest development. Proc Natl Acad Sci U S A (1997) 1.33
Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3. Neuron (1999) 1.32
Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner. J Biol Chem (1999) 1.30
Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron (1994) 1.30
Immunogold localization of inositol 1, 4, 5-trisphosphate (InsP3) receptor in mouse cerebellar Purkinje cells using three monoclonal antibodies. Cell Struct Funct (1990) 1.30
Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation. J Biol Chem (1994) 1.30
Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons. J Neurosci (1998) 1.29
Transmembrane topology and sites of N-glycosylation of inositol 1,4,5-trisphosphate receptor. J Biol Chem (1994) 1.29
Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science (1998) 1.28
The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired. J Biol Chem (1996) 1.28
Two types of ryanodine receptors in mouse brain: skeletal muscle type exclusively in Purkinje cells and cardiac muscle type in various neurons. Neuron (1992) 1.28
Expressed cerebellar-type inositol 1,4,5-trisphosphate receptor, P400, has calcium release activity in a fibroblast L cell line. Neuron (1990) 1.27
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain. J Neurochem (1995) 1.24
Disruption of hippocampal development in vivo by CR-50 mAb against reelin. Proc Natl Acad Sci U S A (1997) 1.24
Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos. Science (1997) 1.23
Inositol 1,4,5-trisphosphate receptors are strongly expressed in the nervous system, pharynx, intestine, gonad and excretory cell of Caenorhabditis elegans and are encoded by a single gene (itr-1). J Mol Biol (1999) 1.21
A truncated Reelin protein is produced but not secreted in the 'Orleans' reeler mutation (Reln[rl-Orl]). Brain Res Mol Brain Res (1997) 1.21
Endoplasmic reticulum is missing in dendritic spines of Purkinje cells of the ataxic mutant rat. Brain Res (1996) 1.21
The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: a squid giant synapse study. Proc Natl Acad Sci U S A (1994) 1.19
Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A (2001) 1.19
Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody. Proc Natl Acad Sci U S A (2000) 1.18
Core promoter of the mouse myelin basic protein gene governs brain-specific transcription in vitro. EMBO J (1990) 1.17
Fine structure of the central myelin sheath in the myelin deficient mutant Shiverer mouse, with special reference to the pattern of myelin formation by oligodendroglia. Brain Res (1981) 1.17
2-Aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptors. Receptors Channels (2001) 1.17
Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction. Science (2001) 1.13
Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice. J Comp Neurol (1996) 1.13
Isolation of complementary DNAs encoding a cerebellum-enriched nuclear factor I family that activates transcription from the mouse myelin basic protein promoter. J Biol Chem (1990) 1.13
Cell-specific expression of the mouse glial fibrillary acidic protein gene: identification of the cis- and trans-acting promoter elements for astrocyte-specific expression. J Neurochem (1990) 1.12
Motor discoordination in mutant mice heterozygous for the type 1 inositol 1,4,5-trisphosphate receptor. Behav Brain Res (2001) 1.12
Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage--immunohistochemical investigation of dendritic damage. Neuroscience (1989) 1.12
Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum. J Cell Biol (2000) 1.12
Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain. Biochem Biophys Res Commun (2001) 1.11
The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium. EMBO J (1997) 1.11
Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV. J Biol Chem (1996) 1.10
SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. J Biol Chem (2000) 1.10
Regulation of Purkinje cell alignment by reelin as revealed with CR-50 antibody. J Neurosci (1997) 1.10
Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster. J Biol Chem (1992) 1.09
Distinct self-oligomerization activities of synaptotagmin family. Unique calcium-dependent oligomerization properties of synaptotagmin VII. J Biol Chem (2000) 1.09
Synaptotagmin is an inositol polyphosphate binding protein: isolation and characterization as an Ins 1,3,4,5-P4 binding protein. Biochem Biophys Res Commun (1994) 1.09
Xenopus Zic family and its role in neural and neural crest development. Mech Dev (1998) 1.08
Mechanism of capacitative Ca2+ entry (CCE): interaction between IP3 receptor and TRP links the internal calcium storage compartment to plasma membrane CCE channels. Recent Prog Horm Res (2000) 1.08
Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Biochem Biophys Res Commun (2001) 1.07