Published in J Neurosci on November 01, 2000
Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behav Genet (2007) 1.84
Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology (2006) 1.83
A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci (2005) 1.77
Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A (2004) 1.71
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neurosci Biobehav Rev (2008) 1.65
Medullary serotonin neurons and central CO2 chemoreception. Respir Physiol Neurobiol (2009) 1.56
How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology (2008) 1.56
The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635. Eur J Nucl Med Mol Imaging (2008) 1.55
Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression. Proc Natl Acad Sci U S A (2003) 1.48
Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. J Psychiatr Res (2007) 1.40
Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. J Neurochem (2010) 1.24
Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion. Neuropsychopharmacology (2006) 1.12
The effect of polymorphism at the serotonin transporter gene on decision-making, memory and executive function in ecstasy users and controls. Psychopharmacology (Berl) (2006) 1.10
5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter. Psychopharmacology (Berl) (2005) 1.03
Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. Psychopharmacology (Berl) (2008) 1.02
Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia. J Physiol (2008) 1.02
Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PLoS One (2012) 1.02
Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans. Mol Pain (2009) 1.00
Psychedelics. Pharmacol Rev (2016) 1.00
A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology (Berl) (2007) 0.94
Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD. Neurosci Biobehav Rev (2008) 0.94
The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial. Nicotine Tob Res (2007) 0.92
Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior. ACS Chem Neurosci (2012) 0.90
Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. PLoS One (2011) 0.89
Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo. J Neurochem (2011) 0.89
Lack of serotonin reuptake during brain development alters rostral raphe-prefrontal network formation. Front Cell Neurosci (2013) 0.88
Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice. Psychoneuroendocrinology (2008) 0.88
Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT). Br J Pharmacol (2010) 0.87
Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain. Neuropsychopharmacology (2011) 0.86
Chronic fluoxetine treatment selectively uncouples raphe 5-HT(1A) receptors as measured by [(35)S]-GTP gamma S autoradiography. Br J Pharmacol (2002) 0.86
Anxiolytic effects of 5-HT₁A receptors and anxiogenic effects of 5-HT₂C receptors in the amygdala of mice. Neuropharmacology (2011) 0.85
Adult neurogenesis in serotonin transporter deficient mice. J Neural Transm (Vienna) (2007) 0.84
Is there a SERT-ain association with IBS? Gut (2004) 0.84
Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory. J Cogn Neurosci (2012) 0.84
Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.83
Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat. PLoS One (2012) 0.81
Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure. Curr Neuropharmacol (2011) 0.81
Diphtheria toxin treatment of Pet-1-Cre floxed diphtheria toxin receptor mice disrupts thermoregulation without affecting respiratory chemoreception. Neuroscience (2014) 0.81
Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice. Pharmacol Biochem Behav (2007) 0.81
Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology (2014) 0.78
Perinatal vs genetic programming of serotonin states associated with anxiety. Neuropsychopharmacology (2014) 0.78
Mice with compromised 5-HTT function lack phosphotyrosine-mediated inhibitory control over prefrontal 5-HT responses. J Neurosci (2014) 0.78
Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Front Synaptic Neurosci (2016) 0.78
Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. Neuroscience (2015) 0.77
Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. Int J Neuropsychopharmacol (2009) 0.77
Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice. Mol Brain (2016) 0.77
An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. Neuropharmacology (2016) 0.75
Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology (2015) 0.75
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04
Allelic variation of human serotonin transporter gene expression. J Neurochem (1996) 7.08
Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry (2006) 3.73
Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease. Lancet (1989) 3.69
Pharmacogenetic prediction of clozapine response. Lancet (2000) 3.10
Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase. Clin Chem (1986) 2.95
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol (1998) 2.94
Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry (2002) 2.85
Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Mol Psychiatry (2002) 2.65
A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry (1996) 2.60
Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci (2007) 2.33
A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree. Mol Psychiatry (2001) 2.27
Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci U S A (1998) 2.22
Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci (2001) 2.19
Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci U S A (2001) 2.19
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet (1996) 2.18
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet (1999) 2.16
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry (2003) 2.12
Exclusion of the neuronal nicotinic acetylcholine receptor alpha7 subunit gene as a candidate for catatonic schizophrenia in a large family supporting the chromosome 15q13-22 locus. Mol Psychiatry (2002) 2.01
Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet (1999) 1.98
Organization of the human serotonin transporter gene. J Neural Transm Gen Sect (1994) 1.97
Social approach in genetically engineered mouse lines relevant to autism. Genes Brain Behav (2008) 1.94
Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem (1993) 1.93
A novel SCN1A mutation associated with generalized epilepsy with febrile seizures plus--and prevalence of variants in patients with epilepsy. Am J Hum Genet (2001) 1.91
The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav (2003) 1.91
Platelet 5-HT uptake and release stopped rapidly by formaldehyde. Nature (1975) 1.84
Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest (2000) 1.80
A genetic association for cigarette smoking behavior. Health Psychol (1999) 1.69
Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immun (1998) 1.69
The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. Rapid communication. J Neural Transm (Vienna) (1997) 1.65
A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Gut (1999) 1.58
Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry (2012) 1.57
Biochemical changes during clomipramine treatment of childhood obsessive-compulsive disorder. Arch Gen Psychiatry (1987) 1.56
Exploring the genetic link between RLS and ADHD. J Psychiatr Res (2009) 1.55
Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav (2003) 1.54
Controlled comparisons of clomipramine and fluoxetine in the treatment of obsessive-compulsive disorder. Behavioral and biological results. Arch Gen Psychiatry (1990) 1.46
A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP. Biol Psychiatry (1993) 1.44
What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behav Brain Res (2007) 1.41
The human serotonin transporter gene polymorphism--basic research and clinical implications. J Neural Transm (Vienna) (1997) 1.39
Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Mol Psychiatry (2009) 1.37
Effort and cognition in depression. Arch Gen Psychiatry (1982) 1.37
Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci (2001) 1.34
Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice. J Neurosci (2001) 1.33
Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior. Mol Psychiatry (2000) 1.29
Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur J Neurosci (2000) 1.29
Leukocytosis during lithium treatment. Am J Psychiatry (1971) 1.27
Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience (2002) 1.26
Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. Psychol Med (2011) 1.25
Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment. Psychopharmacologia (1975) 1.24
Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry (2006) 1.24
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci U S A (1997) 1.24
Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm Gen Sect (1995) 1.23
Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder. Mol Psychiatry (2006) 1.23
High plasma norepinephrine levels in patients with major affective disorder. Am J Psychiatry (1982) 1.21
Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia. Science (1973) 1.21
Serotonin transporter (5-HTT) gene variants associated with autism? Hum Mol Genet (1997) 1.21
Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study. Am J Med Genet B Neuropsychiatr Genet (2009) 1.21
Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice. J Pharmacol Exp Ther (1999) 1.20
Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm (Vienna) (2005) 1.19
Hypercalcemia and gastric secretion in man. J Appl Physiol (1966) 1.19
Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12. Mol Psychiatry (2008) 1.18
Possible development of the serotonin syndrome in man. Am J Psychiatry (1982) 1.17
Substrate- and inhibitor-related characteristics of human platelet monoamine oxidase. Biochem Pharmacol (1977) 1.17
Splitting schizophrenia: periodic catatonia-susceptibility locus on chromosome 15q15. Am J Hum Genet (2000) 1.17
Clinical, biochemical, and neuropsychiatric evaluation of a patient with a contiguous gene syndrome due to a microdeletion Xp11.3 including the Norrie disease locus and monoamine oxidase (MAOA and MAOB) genes. Am J Med Genet (1992) 1.16
Increased norepinephrine levels and decreased dopamine-beta-hydroxylase activity in primary autism. Arch Gen Psychiatry (1977) 1.15
Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. Psychiatry Res (1999) 1.13
The biochemical high-risk paradigm: behavioral and familial correlates of low platelet monoamine oxidase activity. Science (1976) 1.13
Demonstration and evaluation of apparent cytoplasmic and vesicular serotonin compartments in human platelets. Biochem Pharmacol (1977) 1.13
Prediction of imipramine antidepressant response by a one-day dextro-amphetamine trial. Am J Psychiatry (1978) 1.13
Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice. Genes Brain Behav (2006) 1.13
Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice. Neuroscience (2006) 1.12
Stimulation by lithium of monoamine uptake in human platelets. Life Sci (1969) 1.11
Quantitative studies of norepinephrine uptake by synaptosomes. Biochem Pharmacol (1968) 1.11
Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study. Am J Psychiatry (1997) 1.11
Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. Epilepsy Res (2005) 1.10
Anticholinergic sensitivity in patients with dementia of the Alzheimer type and age-matched controls. A dose-response study. Arch Gen Psychiatry (1987) 1.10
Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cereb Cortex (2006) 1.10
Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes. J Clin Invest (1996) 1.09
Hallucinations: psychopathology meets functional genomics. Mol Psychiatry (1998) 1.09
Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol Psychiatry (2005) 1.09
Needle sharing and AIDS in minorities. JAMA (1987) 1.08