Published in J Pharmacol Exp Ther on December 01, 1999
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How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology (2008) 1.56
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A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology (Berl) (2007) 0.94
Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD. Neurosci Biobehav Rev (2008) 0.94
Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells. Transl Psychiatry (2012) 0.93
Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology (Berl) (2008) 0.93
Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers. Biol Psychol (2009) 0.92
Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior. ACS Chem Neurosci (2012) 0.90
Living in a dangerous world: the shaping of behavioral profile by early environment and 5-HTT genotype. Front Behav Neurosci (2009) 0.90
Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques. Neuroscience (2011) 0.89
Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice. Psychoneuroendocrinology (2008) 0.88
Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT). Br J Pharmacol (2010) 0.87
Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. Alcohol (2010) 0.87
Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat. BMC Neurosci (2012) 0.85
Early life adversity and serotonin transporter gene variation interact at the level of the adrenal gland to affect the adult hypothalamo-pituitary-adrenal axis. Transl Psychiatry (2014) 0.81
Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice. Pharmacol Biochem Behav (2007) 0.81
Consequences of serotonin transporter genotype and early adversity on behavioral profile - pathology or adaptation? Front Neurosci (2010) 0.80
Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology (2014) 0.78
Perinatal vs genetic programming of serotonin states associated with anxiety. Neuropsychopharmacology (2014) 0.78
Reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degeneration. Exp Neurol (2015) 0.77
5-HT2A receptors are concentrated in regions of the human infant medulla involved in respiratory and autonomic control. Auton Neurosci (2009) 0.77
5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze. PLoS One (2013) 0.77
Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. Int J Neuropsychopharmacol (2009) 0.77
Neurosteroids as neuromodulators in the treatment of anxiety disorders. Front Endocrinol (Lausanne) (2011) 0.76
Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter. Neuropharmacology (2014) 0.76
Neurogenetics of emotional reactivity to stress in animals. Dialogues Clin Neurosci (2002) 0.75
Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults. Psychiatry Res (2016) 0.75
The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by 5-HTTLPR genotype. Neurobiol Stress (2017) 0.75
The Serotonin Transporter and Early Life Stress: Translational Perspectives. Front Cell Neurosci (2017) 0.75
Studying longitudinal trajectories in animal models of psychiatric illness and their translation to the human condition. Neurosci Res (2015) 0.75
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Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease. Lancet (1989) 3.69
Pharmacogenetic prediction of clozapine response. Lancet (2000) 3.10
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Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol (1998) 2.94
Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry (2002) 2.85
Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Mol Psychiatry (2002) 2.65
A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry (1996) 2.60
Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci (2007) 2.33
A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree. Mol Psychiatry (2001) 2.27
Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci U S A (1998) 2.22
Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci (2001) 2.19
Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci U S A (2001) 2.19
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet (1996) 2.18
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet (1999) 2.16
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry (2003) 2.12
Exclusion of the neuronal nicotinic acetylcholine receptor alpha7 subunit gene as a candidate for catatonic schizophrenia in a large family supporting the chromosome 15q13-22 locus. Mol Psychiatry (2002) 2.01
Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet (1999) 1.98
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Social approach in genetically engineered mouse lines relevant to autism. Genes Brain Behav (2008) 1.94
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A novel SCN1A mutation associated with generalized epilepsy with febrile seizures plus--and prevalence of variants in patients with epilepsy. Am J Hum Genet (2001) 1.91
The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav (2003) 1.91
Platelet 5-HT uptake and release stopped rapidly by formaldehyde. Nature (1975) 1.84
Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest (2000) 1.80
A genetic association for cigarette smoking behavior. Health Psychol (1999) 1.69
Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immun (1998) 1.69
The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. Rapid communication. J Neural Transm (Vienna) (1997) 1.65
A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Gut (1999) 1.58
Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry (2012) 1.57
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Exploring the genetic link between RLS and ADHD. J Psychiatr Res (2009) 1.55
Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav (2003) 1.54
Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences. J Neurosci (2000) 1.46
Controlled comparisons of clomipramine and fluoxetine in the treatment of obsessive-compulsive disorder. Behavioral and biological results. Arch Gen Psychiatry (1990) 1.46
A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP. Biol Psychiatry (1993) 1.44
What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behav Brain Res (2007) 1.41
The human serotonin transporter gene polymorphism--basic research and clinical implications. J Neural Transm (Vienna) (1997) 1.39
Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Mol Psychiatry (2009) 1.37
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Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci (2001) 1.34
Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice. J Neurosci (2001) 1.33
Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior. Mol Psychiatry (2000) 1.29
Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur J Neurosci (2000) 1.29
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Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience (2002) 1.26
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Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry (2006) 1.24
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Hallucinations: psychopathology meets functional genomics. Mol Psychiatry (1998) 1.09
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