Published in Blood on November 15, 2000
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell (2003) 4.55
Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest (2006) 3.38
von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Blood (2010) 2.82
A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med (2002) 2.75
Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest (2005) 2.50
Systemic antithrombotic effects of ADAMTS13. J Exp Med (2006) 2.21
The vessel wall and its interactions. Blood (2008) 2.17
Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol (2003) 2.12
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A (2006) 2.09
Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress. Blood (2008) 2.04
Rolling cell adhesion. Annu Rev Cell Dev Biol (2010) 1.97
P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest (2003) 1.90
A novel class of fusion polypeptides inhibits exocytosis. Mol Pharmacol (2004) 1.78
Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13. Blood (2009) 1.70
Emerging roles for platelets as immune and inflammatory cells. Blood (2014) 1.56
Critical review of mouse models of venous thrombosis. Arterioscler Thromb Vasc Biol (2012) 1.46
von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins. Blood (2006) 1.44
Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med (2009) 1.41
Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling. Proc Natl Acad Sci U S A (2003) 1.36
Rate, extent and concentration dependence of histamine-evoked Weibel-Palade body exocytosis determined from individual fusion events in human endothelial cells. J Physiol (2007) 1.36
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13. Blood (2005) 1.35
Platelet adhesion under flow. Microcirculation (2009) 1.31
An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood (2009) 1.27
Antithrombotic activity of TNF-alpha. J Clin Invest (2003) 1.25
Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice. Proc Natl Acad Sci U S A (2001) 1.25
Real-time analysis of platelet aggregation and procoagulant activity during thrombus formation in vivo. Pflugers Arch (2008) 1.08
Microfluidic technology in vascular research. J Biomed Biotechnol (2009) 1.06
Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice. Arterioscler Thromb Vasc Biol (2012) 1.01
Matrix protein microarrays for spatially and compositionally controlled microspot thrombosis under laminar flow. Biophys J (2006) 0.99
Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor. J Cell Biol (2005) 0.95
Differential modulation of adhesion molecule expression by hydroxycarbamide in human endothelial cells from the micro- and macrocirculation: potential implications in sickle cell disease vasoocclusive events. Haematologica (2011) 0.95
Of von Willebrand factor and platelets. Cell Mol Life Sci (2014) 0.93
ITF1697, a stable Lys-Pro-containing peptide, inhibits weibel-palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med (2007) 0.89
Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality. Arterioscler Thromb Vasc Biol (2013) 0.89
Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice. Arterioscler Thromb Vasc Biol (2013) 0.89
Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells. Acta Pharmacol Sin (2009) 0.87
The role of platelets in the recruitment of leukocytes during vascular disease. Platelets (2015) 0.87
Differential exocytosis from human endothelial cells evoked by high intracellular Ca(2+) concentration. J Physiol (2002) 0.86
A phenomenological particle-based platelet model for simulating filopodia formation during early activation. Int J Numer Method Biomed Eng (2015) 0.83
Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients. Basic Res Cardiol (2011) 0.83
Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne), in the CAM model. Angiogenesis (2008) 0.83
Terminal platelet production is regulated by von Willebrand factor. PLoS One (2013) 0.81
Synergistic Effect of AJW200, a von Willebrand Factor Neutralizing Antibody with Low Dose (0.9 mg/mg) Thrombolytic Therapy Following Embolic Stroke in Rabbits. J Neurol Neurophysiol (2013) 0.80
Platelets Guide Leukocytes to Their Sites of Extravasation. PLoS Biol (2016) 0.79
Contributing role of extracellular vesicles on vascular endothelium haemostatic balance in cancer. J Extracell Vesicles (2014) 0.78
A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation. Sci Rep (2016) 0.77
A vascular injury model using focal heat-induced activation of endothelial cells. Integr Biol (Camb) (2015) 0.76
Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis. J Biomed Res (2015) 0.75
Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings. J Biol Chem (2014) 0.75
Platelets and von Willebrand factor in atherogenesis. Blood (2017) 0.75
Early recovery of microvascular perfusion induced by t-PA in combination with abciximab or eptifibatide during postischemic reperfusion. BMC Cardiovasc Disord (2002) 0.75
Functional assessment of von Willebrand factor expression by cancer cells of non-endothelial origin. Oncotarget (2016) 0.75
Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction. Biomed Res Int (2016) 0.75
Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis. Blood (2017) 0.75
Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor. PLoS One (2017) 0.75
von Willebrand factor contributes to poor outcome in a mouse model of intracerebral haemorrhage. Sci Rep (2016) 0.75
Comparative genomics of the eukaryotes. Science (2000) 26.62
Integrins: a family of cell surface receptors. Cell (1987) 21.14
The functioning and well-being of depressed patients. Results from the Medical Outcomes Study. JAMA (1989) 12.07
Genomic analysis of metastasis reveals an essential role for RhoC. Nature (2000) 10.11
Fibronectins: multifunctional modular glycoproteins. J Cell Biol (1982) 8.05
Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc Natl Acad Sci U S A (1973) 6.98
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development (1993) 6.56
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature (1999) 6.50
Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell (1998) 6.44
Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell (1983) 6.27
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell (1993) 6.05
Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul (1991) 5.80
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest (1999) 5.65
Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell (1986) 5.29
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell (1996) 5.12
The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem (1999) 4.92
10 nm filaments in normal and transformed cells. Cell (1978) 4.77
Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor. J Thromb Haemost (2006) 4.58
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest (2000) 4.54
Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell (1996) 4.52
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med (1999) 4.44
Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development (1995) 4.44
Cell surface proteins and malignant transformation. Biochim Biophys Acta (1976) 4.33
Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development (1993) 4.22
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell (1998) 4.20
Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell (1998) 4.18
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol (1986) 4.16
Relationships between fibronectin (LETS protein) and actin. Cell (1978) 4.12
Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J Cell Biol (1982) 4.08
Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell (1986) 4.01
Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest (1998) 4.00
PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell (1989) 3.95
The isolation of antibiotic-resistant salmonella from retail ground meats. N Engl J Med (2001) 3.55
A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci U S A (1998) 3.54
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell (1990) 3.46
Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol (1998) 3.46
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. J Cell Biol (1989) 3.44
Developmental defects in mouse embryos lacking N-cadherin. Dev Biol (1997) 3.39
Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell (1977) 3.36
Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi. J Cell Biol (1988) 3.35
Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med (1998) 3.26
Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes Dev (1994) 3.20
Changes in integrin receptors on oncogenically transformed cells. Cell (1989) 3.09
Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A (2001) 3.07
Sequence and domain structure of talin. Nature (1990) 2.98
Platelets have more than one binding site for von Willebrand factor. J Clin Invest (1983) 2.89
Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and platelets. J Clin Invest (1980) 2.88
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood (1989) 2.86
Inducible secretion of large, biologically potent von Willebrand factor multimers. Cell (1986) 2.85
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A (2001) 2.82
The complex multimeric composition of factor VIII/von Willebrand factor. Blood (1981) 2.76
Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol (1988) 2.72
Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest (2000) 2.68
The combined role of P- and E-selectins in atherosclerosis. J Clin Invest (1998) 2.53
Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. Proc Natl Acad Sci U S A (1999) 2.47
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol (1997) 2.46
Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed cells. J Cell Biol (1977) 2.40
Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials (1995) 2.40
Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells. J Virol (1996) 2.38
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci U S A (1995) 2.37
Extensive disulfide bonding at the mammalian cell surface. Proc Natl Acad Sci U S A (1977) 2.32
Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells. Science (1983) 2.31
Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul (1990) 2.29
Cross-linking of fibronectin to sulfated proteoglycans at the cell surface. Cell (1979) 2.28
Plasma fibronectin is synthesized and secreted by hepatocytes. J Biol Chem (1983) 2.25
Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor. Proc Natl Acad Sci U S A (1990) 2.23
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol (2001) 2.16
Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood (1997) 2.15
Usefulness of cardiovascular family history data for population-based preventive medicine and medical research (the Health Family Tree Study and the NHLBI Family Heart Study). Am J Cardiol (2001) 2.14
Density and cell cycle dependence of cell surface proteins in hamster fibroblasts. Cell (1974) 2.13
Hemostasis in the mouse (Mus musculus): a review. Thromb Haemost (1999) 2.13
Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization. J Cell Biol (1984) 2.13
A large glycoprotein lost from the surfaces of transformed cells. Ann N Y Acad Sci (1978) 2.11
Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol (1997) 2.10
Cell-type-specific fibronectin subunits generated by alternative splicing. J Biol Chem (1986) 2.09
Induction of specific storage organelles by von Willebrand factor propolypeptide. Cell (1991) 2.09
Auranofin therapy and quality of life in patients with rheumatoid arthritis. Results of a multicenter trial. Am J Med (1986) 2.08
Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's disease. N Engl J Med (1980) 2.07
Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci U S A (1998) 2.06
1-Deamino-8-d-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrands' diseases. Lancet (1977) 2.06
An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin. Blood (1989) 2.05
Echocardiographic measurements in normal subjects. Growth-related changes that occur between infancy and early adulthood. Circulation (1978) 2.05
Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J (1987) 2.03
Expression of normal and mutant avian integrin subunits in rodent cells. J Cell Biol (1989) 2.03
Glanzmann thrombasthenia: deficient binding of von Willebrand factor to thrombin-stimulated platelets. Proc Natl Acad Sci U S A (1982) 2.02
Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell (1996) 2.01
A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proc Natl Acad Sci U S A (1984) 2.00
PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Cell (1990) 1.96
Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell (1982) 1.96
Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. J Cell Sci (1996) 1.95