Published in Cell Regul on November 01, 1991
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol (1996) 11.04
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A (1992) 8.46
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J Cell Biol (1992) 7.97
Signal transduction from the extracellular matrix. J Cell Biol (1993) 7.64
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol (1994) 7.53
The extracellular matrix as a cell survival factor. Mol Biol Cell (1993) 6.32
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol (1995) 5.36
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci U S A (1992) 5.06
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol (1995) 4.26
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol (1996) 4.21
Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol (1994) 4.11
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J Cell Biol (1992) 4.06
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol Cell Biol (1995) 3.85
Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions. J Cell Biol (1993) 3.64
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol Biol Cell (1996) 3.60
Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol (1998) 3.46
Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol (1992) 3.20
Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1994) 3.14
Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc Natl Acad Sci U S A (1994) 3.09
Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol (1998) 2.97
Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell (1995) 2.79
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell (1994) 2.78
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Mol Cell Biol (1993) 2.75
Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol Biol Cell (1995) 2.68
Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol Biol Cell (1995) 2.57
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol (1998) 2.52
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci (2004) 2.41
Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. J Cell Biol (1996) 2.38
Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol (1993) 2.38
Regulation of the cell cycle by focal adhesion kinase. J Cell Biol (1998) 2.32
Extracellular matrix and integrin signalling: the shape of things to come. Biochem J (1999) 2.28
Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly. J Cell Biol (1994) 2.27
The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. EMBO J (1995) 2.22
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv Drug Deliv Rev (2010) 2.21
Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK. J Exp Med (1995) 2.17
Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J Cell Biol (1993) 2.08
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol (2006) 2.08
Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci U S A (1994) 2.02
Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol Cell Biol (1993) 1.94
Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density. EMBO J (1993) 1.85
Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. J Cell Biol (1995) 1.82
Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. J Cell Biol (1997) 1.78
A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397. Mol Biol Cell (2003) 1.72
Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell (1994) 1.67
Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts. J Clin Invest (1998) 1.64
Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Mol Biol Cell (1999) 1.64
Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Mol Biol Cell (1994) 1.61
Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK. Mol Cell Biol (1995) 1.60
Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett (2009) 1.59
Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells. J Cell Biol (1996) 1.57
Activation of phosphotyrosine phosphatase activity by reduction of cell-substrate adhesion. Proc Natl Acad Sci U S A (1993) 1.53
Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Mol Cell Biol (2003) 1.51
Structural requirements for biological activity of the ninth and tenth FIII domains of human fibronectin. J Biol Chem (1997) 1.51
Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol (1993) 1.50
Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells. Mol Biol Cell (1992) 1.47
Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton. J Cell Biol (1999) 1.46
Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J Cell Biol (1993) 1.45
Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein. J Cell Biol (1996) 1.42
Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells. J Cell Biol (1992) 1.39
Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal. J Cell Biol (1999) 1.38
Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation. Proc Natl Acad Sci U S A (1993) 1.37
Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants. Mol Biol Cell (1995) 1.36
Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels. J Cell Biol (1993) 1.36
Integrin-mediated signaling events in human endothelial cells. Mol Biol Cell (1998) 1.35
Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase. J Clin Invest (1996) 1.35
Vascular smooth muscle cell motility: From migration to invasion. Exp Clin Cardiol (2010) 1.33
Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity. J Cell Biol (1994) 1.33
FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer (2003) 1.32
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit. J Cell Biol (1993) 1.32
The Walter Herbert Lecture. Control of cell motility and tumour invasion by extracellular matrix interactions. Br J Cancer (1992) 1.27
Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. J Clin Invest (1997) 1.26
Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Proc Natl Acad Sci U S A (1996) 1.25
Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin. J Cell Biol (1992) 1.25
Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility. J Cell Biol (1994) 1.24
The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes. J Cell Biol (1994) 1.23
Decreased level of PDGF-stimulated receptor autophosphorylation by fibroblasts in mechanically relaxed collagen matrices. J Cell Biol (1993) 1.21
Activation of distinct alpha5beta1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domains. J Cell Biol (1998) 1.18
Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration. J Cell Biol (1994) 1.18
A cell cycle and mutational analysis of anchorage-independent growth: cell adhesion and TGF-beta 1 control G1/S transit specifically. J Cell Biol (1993) 1.16
Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variants. EMBO J (1993) 1.13
Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life (2010) 1.12
Cell adhesion to extracellular matrix regulates the life cycle of integrins. Mol Biol Cell (1995) 1.11
Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study. J Korean Med Sci (2004) 1.09
Role of CD44 in the reaction of vascular smooth muscle cells to arterial wall injury. J Clin Invest (1996) 1.08
Integrin alpha 6A beta 1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate. Mol Biol Cell (1997) 1.08
Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. Am J Pathol (2005) 1.07
Down-regulation of beta 1C integrin, an inhibitor of cell proliferation, in prostate carcinoma. Am J Pathol (1996) 1.06
Focal adhesion kinase and endothelial cell apoptosis. Microvasc Res (2011) 1.05
beta1-integrin cytoplasmic subdomains involved in dominant negative function. Mol Biol Cell (1998) 1.05
Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate. Proc Natl Acad Sci U S A (1994) 1.04
Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol (2009) 1.03
T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells. J Exp Med (1995) 1.00
Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology. J Clin Invest (1997) 1.00
Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. Proc Natl Acad Sci U S A (1994) 1.00
Dominant negative mutation in cell surface beta 1,4-galactosyltransferase inhibits cell-cell and cell-matrix interactions. J Cell Biol (1993) 0.99
Mechanisms of integrin-mediated calcium signaling in MDCK cells: regulation of adhesion by IP3- and store-independent calcium influx. Mol Biol Cell (1996) 0.99
DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Oncogene (2010) 0.99
Different adhesion properties of highly and poorly metastatic HT-29 colon carcinoma cells with extracellular matrix components: role of integrin expression and cytoskeletal components. Br J Cancer (1999) 0.99
Modulation of integrin activity is vital for morphogenesis. J Cell Biol (1998) 0.97
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
Adhesion receptors of the immune system. Nature (1990) 28.86
Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 22.72
Integrins: a family of cell surface receptors. Cell (1987) 21.14
New perspectives in cell adhesion: RGD and integrins. Science (1987) 18.41
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol (1988) 14.18
Role of cell shape in growth control. Nature (1978) 12.46
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell (1988) 10.47
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell (1991) 8.99
Growth factor receptor tyrosine kinases. Annu Rev Biochem (1988) 8.67
Protein serine/threonine kinases. Annu Rev Biochem (1987) 8.42
Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature (1986) 8.06
VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol (1990) 7.62
A thousand and one protein kinases. Cell (1987) 7.61
Fibronectin and its receptors. Annu Rev Biochem (1988) 7.06
Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J Cell Biol (1989) 5.69
Cell surface receptors for extracellular matrix molecules. Annu Rev Cell Biol (1987) 5.69
An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. J Cell Biol (1990) 5.66
Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell (1986) 5.29
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci U S A (1990) 5.25
Proteoglycans as modulators of growth factor activities. Cell (1991) 4.45
Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol Cell Biol (1989) 4.08
Signal transduction by the platelet-derived growth factor receptor. Science (1989) 3.94
Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science (1991) 3.86
Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinases. Proc Natl Acad Sci U S A (1986) 3.84
Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proc Natl Acad Sci U S A (1985) 3.76
Regulation of transmembrane signaling by receptor phosphorylation. Cell (1987) 3.74
Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi. J Cell Biol (1988) 3.35
A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices. J Cell Biol (1982) 3.23
Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts. Oncogene (1989) 2.77
Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells. J Cell Biol (1988) 2.64
Monoclonal antibodies to phosphotyrosine. J Immunol Methods (1988) 2.47
Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Proc Natl Acad Sci U S A (1989) 2.35
Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation. J Cell Biol (1988) 2.26
Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1. J Biol Chem (1990) 2.08
Expression of normal and mutant avian integrin subunits in rodent cells. J Cell Biol (1989) 2.03
Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins. J Cell Biol (1990) 1.99
Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regul (1990) 1.94
Tyrosine phosphorylated proteins in different tissues during chick embryo development. J Cell Biol (1988) 1.76
Progressive loss of shape-responsive metabolic controls in cells with increasingly transformed phenotype. Cell (1981) 1.59
Adhesion of glycosaminoglycan-deficient chinese hamster ovary cell mutants to fibronectin substrata. J Cell Biol (1988) 1.55
An endogenous substrate for the insulin receptor-associated tyrosine kinase. J Biol Chem (1985) 1.42
Nonmyristoylated p60v-src fails to phosphorylate proteins of 115-120 kDa in chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1988) 1.42
Interaction of serum and cell spreading affects the growth of neoplastic and non-neoplastic fibroblasts. J Supramol Struct Cell Biochem (1981) 1.20
Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase. Biochem J (1985) 1.15
Comparative study of the tyrosine phosphorylation of proteins in Swiss 3T3 fibroblasts stimulated by a variety of mitogenic agents. J Cell Physiol (1988) 1.11
Fibronectin fibril formation involves cell interactions with two fibronectin domains. Exp Cell Res (1988) 1.11
Comparative genomics of the eukaryotes. Science (2000) 26.62
Integrins: a family of cell surface receptors. Cell (1987) 21.14
Genomic analysis of metastasis reveals an essential role for RhoC. Nature (2000) 10.11
Fibronectins: multifunctional modular glycoproteins. J Cell Biol (1982) 8.05
Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc Natl Acad Sci U S A (1973) 6.98
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development (1993) 6.56
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature (1999) 6.50
Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell (1998) 6.44
Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell (1983) 6.27
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell (1993) 6.05
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest (1999) 5.65
Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell (1986) 5.29
The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem (1999) 4.92
10 nm filaments in normal and transformed cells. Cell (1978) 4.77
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest (2000) 4.54
Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell (1996) 4.52
Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development (1995) 4.44
Cell surface proteins and malignant transformation. Biochim Biophys Acta (1976) 4.33
Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development (1993) 4.22
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell (1998) 4.20
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol (1986) 4.16
Relationships between fibronectin (LETS protein) and actin. Cell (1978) 4.12
Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell (1986) 4.01
Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest (1998) 4.00
A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci U S A (1998) 3.54
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell (1990) 3.46
Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol (1998) 3.46
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. J Cell Biol (1989) 3.44
Developmental defects in mouse embryos lacking N-cadherin. Dev Biol (1997) 3.39
Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell (1977) 3.36
Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi. J Cell Biol (1988) 3.35
Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med (1998) 3.26
Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes Dev (1994) 3.20
Changes in integrin receptors on oncogenically transformed cells. Cell (1989) 3.09
Sequence and domain structure of talin. Nature (1990) 2.98
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A (2001) 2.82
Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol (1988) 2.72
Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest (2000) 2.68
The combined role of P- and E-selectins in atherosclerosis. J Clin Invest (1998) 2.53
Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. Proc Natl Acad Sci U S A (1999) 2.47
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol (1997) 2.46
Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed cells. J Cell Biol (1977) 2.40
Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials (1995) 2.40
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci U S A (1995) 2.37
Extensive disulfide bonding at the mammalian cell surface. Proc Natl Acad Sci U S A (1977) 2.32
Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells. Science (1983) 2.31
Cross-linking of fibronectin to sulfated proteoglycans at the cell surface. Cell (1979) 2.28
Plasma fibronectin is synthesized and secreted by hepatocytes. J Biol Chem (1983) 2.25
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol (2001) 2.16
Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood (1997) 2.15
Density and cell cycle dependence of cell surface proteins in hamster fibroblasts. Cell (1974) 2.13
Hemostasis in the mouse (Mus musculus): a review. Thromb Haemost (1999) 2.13
A large glycoprotein lost from the surfaces of transformed cells. Ann N Y Acad Sci (1978) 2.11
Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol (1997) 2.10
Cell-type-specific fibronectin subunits generated by alternative splicing. J Biol Chem (1986) 2.09
Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood (2000) 2.05
An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin. Blood (1989) 2.05
Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J (1987) 2.03
Expression of normal and mutant avian integrin subunits in rodent cells. J Cell Biol (1989) 2.03
Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell (1996) 2.01
A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proc Natl Acad Sci U S A (1984) 2.00
Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell (1982) 1.96
Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. J Cell Sci (1996) 1.95
Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regul (1990) 1.94
Interaction of fibronectin with its receptor on platelets. Cell (1985) 1.92
alpha 3A beta 1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins. J Cell Sci (1995) 1.88
The location of proteins labeled by the 125I-lactoperoxidase system in the NIL 8 hamster fibroblast. Cell (1975) 1.84
Control of alternative pre-mRNA splicing by distributed pentameric repeats. Proc Natl Acad Sci U S A (1997) 1.82
Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J Clin Invest (1996) 1.81
Fibronectin localization in the rat glomerulus. J Cell Biol (1980) 1.80
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development (1997) 1.75
Effects of LETS glycoprotein on cell motility. Cell (1978) 1.69
Novel roles for alpha3beta1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes. J Cell Biol (1998) 1.69
Alternative splicing of fibronectin is temporally and spatially regulated in the chicken embryo. Development (1989) 1.69
Biosynthesis and processing of fibronectin in NIL.8 hamster cells. J Biol Chem (1979) 1.66
Defects in hemostasis in P-selectin-deficient mice. Blood (1996) 1.64
Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Mol Biol Cell (1999) 1.64
Absence of P-selectin delays fatty streak formation in mice. J Clin Invest (1997) 1.63
Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J Biol Chem (1996) 1.62
A difference between plasma and cellular fibronectins located with monoclonal antibodies. Cell (1981) 1.62
Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell (1979) 1.62
Effects of cytochalasin B and colchicine on attachment of a major surface protein of fibroblasts. Biochim Biophys Acta (1977) 1.61
Fibronectins. Sci Am (1986) 1.61
A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Development (1997) 1.60
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nat Med (2005) 1.58
Xenopus laevis integrins. Structural conservation and evolutionary divergence of integrin beta subunits. J Biol Chem (1988) 1.57
Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance. J Exp Med (1999) 1.55
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proc Natl Acad Sci U S A (1999) 1.55
Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn (1996) 1.55
Elements regulating an alternatively spliced exon of the rat fibronectin gene. Mol Cell Biol (1993) 1.54
Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity (1999) 1.51
Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. Dev Biol (1999) 1.51
On the origin of species of fibronectin. Proc Natl Acad Sci U S A (1985) 1.51
Alternative splicing of chicken fibronectin in embryos and in normal and transformed cells. Mol Cell Biol (1987) 1.51
Role of endothelial selectins in wound repair. Am J Pathol (1997) 1.50
Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa. Dev Biol (1981) 1.48