Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.

PubWeight™: 3.27‹?› | Rank: Top 1%

🔗 View Article (PMC 86503)

Published in Mol Cell Biol on December 01, 2000

Authors

M N Boddy1, A Lopez-Girona, P Shanahan, H Interthal, W D Heyer, P Russell

Author Affiliations

1: Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Articles citing this

(truncated to the top 100)

Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev (2002) 8.50

Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev (2001) 3.99

Homologous recombination in DNA repair and DNA damage tolerance. Cell Res (2008) 3.86

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication. Proc Natl Acad Sci U S A (2002) 3.70

A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46

The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast. Genetics (2003) 3.22

Single Holliday junctions are intermediates of meiotic recombination. Cell (2006) 3.15

The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions. Genes Dev (2004) 2.89

SUMO-targeted ubiquitin ligases in genome stability. EMBO J (2007) 2.77

The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol (2003) 2.59

Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol (2004) 2.55

Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin. Mol Cell (2009) 2.49

Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast. Mol Cell (2010) 2.49

Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol Cell Biol (2003) 2.33

Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol Cell Biol (2003) 2.19

Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage. Cell Cycle (2010) 2.12

Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. EMBO J (2002) 2.09

Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol (2005) 2.00

Slx1-Slx4 are subunits of a structure-specific endonuclease that maintains ribosomal DNA in fission yeast. Mol Biol Cell (2003) 1.96

Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma (2011) 1.78

MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis. PLoS Genet (2008) 1.76

Fission yeast Mus81.Eme1 Holliday junction resolvase is required for meiotic crossing over but not for gene conversion. Genetics (2003) 1.72

Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex. Mol Cell Biol (2006) 1.65

Mus81 is essential for sister chromatid recombination at broken replication forks. EMBO J (2008) 1.63

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. Proc Natl Acad Sci U S A (2008) 1.62

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev (2005) 1.60

The role of AtMUS81 in interference-insensitive crossovers in A. thaliana. PLoS Genet (2007) 1.57

Temporal separation of replication and recombination requires the intra-S checkpoint. J Cell Biol (2005) 1.54

Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis. Mol Biol Cell (2004) 1.52

Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol (2003) 1.50

The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint. Mol Cell Biol (2003) 1.45

GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution. Genes Dev (2010) 1.44

Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease. Nucleic Acids Res (2008) 1.44

Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates? EMBO J (2007) 1.42

The involvement of Srs2 in post-replication repair and homologous recombination in fission yeast. Nucleic Acids Res (2004) 1.41

Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res (2012) 1.40

MUS81 promotes common fragile site expression. Nat Cell Biol (2013) 1.40

DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51. Nucleic Acids Res (2004) 1.38

Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase. Mol Cell Biol (2003) 1.37

The role of DNA-PKcs and artemis in opening viral DNA hairpin termini in various tissues in mice. J Virol (2007) 1.35

Replication fork blockage by RTS1 at an ectopic site promotes recombination in fission yeast. EMBO J (2005) 1.32

Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. Mol Cell Biol (2004) 1.31

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway. J Cell Biol (2008) 1.31

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast. Mol Cell Biol (2004) 1.30

Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast. EMBO J (2007) 1.30

The role of AtMUS81 in DNA repair and its genetic interaction with the helicase AtRecQ4A. Nucleic Acids Res (2006) 1.28

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint. Mol Biol Cell (2007) 1.28

Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks. Mol Cell Biol (2006) 1.27

Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2007) 1.27

Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Nucleic Acids Res (2006) 1.26

mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation. Eukaryot Cell (2002) 1.22

Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell (2009) 1.22

A novel recombination pathway initiated by the Mre11/Rad50/Nbs1 complex eliminates palindromes during meiosis in Schizosaccharomyces pombe. Genetics (2005) 1.21

Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast. Mol Cell Biol (2003) 1.20

Multiple-pathway analysis of double-strand break repair mutations in Drosophila. PLoS Genet (2007) 1.20

RecQ helicases: lessons from model organisms. Nucleic Acids Res (2006) 1.19

Brc1-mediated DNA repair and damage tolerance. Genetics (2005) 1.18

Rad54, the motor of homologous recombination. DNA Repair (Amst) (2010) 1.18

Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells. Mol Biol Cell (2003) 1.17

RNA interference inhibition of Mus81 reduces mitotic recombination in human cells. Mol Biol Cell (2003) 1.17

Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis. Genetics (2007) 1.16

Checkpoints: it takes more than time to heal some wounds. Curr Biol (2001) 1.16

Molecular mimicry of SUMO promotes DNA repair. Nat Struct Mol Biol (2009) 1.14

Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair. Mol Cell Biol (2012) 1.13

Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae. Genetics (2005) 1.08

Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants. Proc Natl Acad Sci U S A (2006) 1.06

Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis. PLoS Genet (2013) 1.06

Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. Mol Biol Cell (2008) 1.05

Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease. Mol Biol Cell (2006) 1.05

Crystal structure of the Mus81-Eme1 complex. Genes Dev (2008) 1.04

The dissolution of double Holliday junctions. Cold Spring Harb Perspect Biol (2014) 1.03

SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability. PLoS Genet (2011) 1.02

Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe. Genetics (2006) 1.02

Regulation of DNA replication machinery by Mrc1 in fission yeast. Genetics (2006) 1.01

Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates. J Biol Chem (2009) 1.01

DNA double-strand break repair in Caenorhabditis elegans. Chromosoma (2010) 1.00

RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana. Plant Cell (2010) 0.99

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks. EMBO J (2012) 0.99

Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe. Genetics (2007) 0.98

Hitting the bull's eye: novel directed cancer therapy through helicase-targeted synthetic lethality. J Cell Biochem (2009) 0.97

The fission yeast BLM homolog Rqh1 promotes meiotic recombination. Genetics (2008) 0.95

Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes. Chromosoma (2013) 0.95

Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint. Mol Biol Cell (2008) 0.95

Holliday junction resolvases. Cold Spring Harb Perspect Biol (2014) 0.94

Genetic and functional interactions between Mus81-Mms4 and Rad27. Nucleic Acids Res (2010) 0.92

Continued DNA synthesis in replication checkpoint mutants leads to fork collapse. Mol Cell Biol (2012) 0.92

Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage. Nucleic Acids Res (2013) 0.91

Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex. Nucleic Acids Res (2012) 0.91

Biochemistry of eukaryotic homologous recombination. Top Curr Genet (2007) 0.91

Human Rad54 protein stimulates human Mus81-Eme1 endonuclease. Proc Natl Acad Sci U S A (2008) 0.91

The DNA damage checkpoint pathways exert multiple controls on the efficiency and outcome of the repair of a double-stranded DNA gap. Nucleic Acids Res (2004) 0.90

Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant. Mol Cell Biol (2012) 0.89

Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage. Nat Struct Mol Biol (2013) 0.89

Mus81-Eme1-dependent and -independent crossovers form in mitotic cells during double-strand break repair in Schizosaccharomyces pombe. Mol Cell Biol (2007) 0.89

Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair. Curr Genet (2008) 0.88

Two distinct MUS81-EME1 complexes from Arabidopsis process Holliday junctions. Plant Physiol (2009) 0.87

Role of Blm and collaborating factors in recombination and survival following replication stress in Ustilago maydis. DNA Repair (Amst) (2009) 0.87

The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast. Mol Cell Biol (2011) 0.87

Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast. PLoS Genet (2010) 0.86

Articles cited by this

Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast (1998) 18.47

Cell cycle checkpoints: preventing an identity crisis. Science (1996) 13.74

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (1998) 8.74

DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature (1998) 6.47

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell (1995) 6.00

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature (1993) 5.70

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell (1998) 5.37

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science (1999) 5.09

Conserved domains in DNA repair proteins and evolution of repair systems. Nucleic Acids Res (1999) 4.80

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J (1999) 4.64

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes Dev (1998) 4.63

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science (1998) 4.59

Regulation of DNA-replication origins during cell-cycle progression. Nature (1998) 4.52

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J (1997) 4.31

Replication checkpoint enforced by kinases Cds1 and Chk1. Science (1998) 4.22

Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell (1997) 3.83

A kinase from fission yeast responsible for blocking mitosis in S phase. Nature (1995) 3.83

Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Cell (1996) 3.81

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature (2000) 3.65

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature (1998) 3.36

DNA recombination: the replication connection. Trends Biochem Sci (1999) 3.32

The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA. Nucleic Acids Res (1996) 3.20

The FHA domain is a modular phosphopeptide recognition motif. Mol Cell (1999) 3.16

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J (1999) 3.03

Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance. Mol Cell Biol (1997) 2.76

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol (1999) 2.73

Defending genome integrity during DNA replication: a proposed role for RecQ family helicases. Bioessays (1999) 2.71

MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae. Mol Gen Genet (2000) 2.71

A plethora of lesion-replicating DNA polymerases. Genes Dev (1999) 2.68

Cloning the RAD51 homologue of Schizosaccharomyces pombe. Nucleic Acids Res (1993) 2.57

A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.51

Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1. Mol Biol Cell (1999) 2.14

Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase. EMBO J (2000) 2.08

Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Genes Dev (1997) 2.01

DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints. Mol Cell Biol (2000) 1.98

Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity. J Cell Sci (1996) 1.84

Characterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe. Nucleic Acids Res (1997) 1.58

Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc Natl Acad Sci U S A (1999) 1.47

Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis. Proc Natl Acad Sci U S A (2000) 1.46

The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage. Genetics (1998) 1.43

A new recombinational DNA repair gene from Schizosaccharomyces pombe with homology to Escherichia coli RecA. Genetics (1999) 1.37

Mutational effect of fission yeast polalpha on cell cycle events. Mol Biol Cell (1998) 1.26

Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint. Mol Biol Cell (2000) 1.25

A double-strand break repair component is essential for S phase completion in fission yeast cell cycling. Mol Biol Cell (1999) 1.17

Articles by these authors

Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science (1997) 9.30

cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell (1986) 8.82

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell (1987) 8.76

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature (1999) 5.38

Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell (2001) 5.37

A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J Cell Biol (1997) 4.93

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature (1991) 4.54

Replication checkpoint enforced by kinases Cds1 and Chk1. Science (1998) 4.22

Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature (1995) 4.17

Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. Nat Genet (1997) 4.16

Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase. Nature (1991) 3.86

The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. Cell (1987) 3.82

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev (1996) 3.81

p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. EMBO J (1991) 3.55

Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J (1993) 3.30

Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Mol Cell Biol (1996) 3.18

Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Mol Cell (2001) 3.18

DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe. Wild-type and mutant alleles including the recombination host spot allele ade6-M26. J Mol Biol (1988) 3.00

Recombinant ATM protein complements the cellular A-T phenotype. Oncogene (1997) 2.95

Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast. Nature (1990) 2.86

Mutations truncating the EP300 acetylase in human cancers. Nat Genet (2000) 2.84

The role of nonlymphoid accessory cells in the immune response to different antigens. J Exp Med (1970) 2.82

Replicating plasmids in Schizosaccharomyces pombe: improvement of symmetric segregation by a new genetic element. Mol Cell Biol (1986) 2.78

Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc Natl Acad Sci U S A (1990) 2.71

MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae. Mol Gen Genet (2000) 2.71

Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast. Genes Dev (1998) 2.68

Changing character of cervical cancer in young women. BMJ (1989) 2.66

Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Nat Cell Biol (2001) 2.62

Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Plasmid (1986) 2.58

Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev (1997) 2.57

Cell cycle regulation of human WEE1. EMBO J (1995) 2.56

Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division. EMBO J (1992) 2.41

Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. J Cell Sci (2000) 2.37

Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase. Nature (1993) 2.30

Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (1998) 2.19

A new improved sub-unit vaccine for plague: the basis of protection. FEMS Immunol Med Microbiol (1995) 2.16

Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast. EMBO J (1995) 2.14

Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1. Mol Biol Cell (1999) 2.14

The cdc25 M-phase inducer: an unconventional protein phosphatase. Cell (1992) 2.12

Mitotic DNA damage and replication checkpoints in yeast. Curr Opin Cell Biol (1998) 2.11

p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells. Proc Natl Acad Sci U S A (1991) 2.10

Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe. Mol Cell Biol (1997) 2.07

Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. J Biol Chem (1991) 2.07

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90. EMBO J (1994) 2.07

Schizosaccharomyces pombe and Saccharomyces cerevisiae: a look at yeasts divided. Cell (1986) 2.06

Characteristics of an established cell line of retinoblastoma. J Natl Cancer Inst (1974) 2.05

Active immunization with recombinant V antigen from Yersinia pestis protects mice against plague. Infect Immun (1995) 2.04

Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament. Mol Cell (2000) 1.98

DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints. Mol Cell Biol (2000) 1.98

Concerted evolution of tRNA genes: intergenic conversion among three unlinked serine tRNA genes in S. pombe. Cell (1985) 1.94

Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade. Mol Biol Cell (1997) 1.83

Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Genes Dev (1990) 1.83

Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases. Mol Cell Biol (1999) 1.83

Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature (1996) 1.82

Recombinational repair in yeast: functional interactions between Rad51 and Rad54 proteins. EMBO J (1997) 1.78

DNA replication checkpoint. Curr Biol (2001) 1.76

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. J Mol Biol (2001) 1.75

Passive protection against Burkholderia pseudomallei infection in mice by monoclonal antibodies against capsular polysaccharide, lipopolysaccharide or proteins. J Med Microbiol (2002) 1.74

A fission yeast B-type cyclin functioning early in the cell cycle. Cell (1991) 1.74

Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. Curr Biol (1996) 1.73

The fuss about Mus81. Cell (2001) 1.73

Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Proc Natl Acad Sci U S A (2001) 1.73

Rapid detection of regionally clustered germ-line BRCA1 mutations by multiplex heteroduplex analysis. UKCCCR Familial Ovarian Cancer Study Group. Am J Hum Genet (1996) 1.72

The separation of different cell classes from lymphoid organs. IV. The separation of lymphocytes from phagocytes on glass bead columns, and its effect on subpopulations of lymphocytes and antibody-forming cells. J Cell Biol (1971) 1.72

A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague. Vaccine (1997) 1.70

The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast. Mol Biol Cell (1998) 1.68

Rad54 protein stimulates heteroduplex DNA formation in the synaptic phase of DNA strand exchange via specific interactions with the presynaptic Rad51 nucleoprotein filament. J Mol Biol (2001) 1.66

Blepharophimosis plus ovarian failure: a likely candidate for a contiguous gene syndrome. J Med Genet (1989) 1.65

Induction of immunity and tolerance in vitro in the absence of phagocytic cells. Nature (1970) 1.64

Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe. Mol Cell Biol (1998) 1.64

Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia. Am J Hum Genet (1997) 1.62

Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. Curr Cancer Drug Targets (2010) 1.60

Influence of cellular DNA content on survival in advanced ovarian cancer. Cancer Res (1984) 1.58

Identification of a chicken RAD52 homologue suggests conservation of the RAD52 recombination pathway throughout the evolution of higher eukaryotes. Nucleic Acids Res (1993) 1.57

Placental abnormalities of congenital syphilis. A neglected aid to diagnosis. Am J Dis Child (1974) 1.57

Genotype-phenotype relationships in ataxia-telangiectasia and variants. Am J Hum Genet (1998) 1.55

Isolation and characterization of the DNA region encoding nodulation functions in Bradyrhizobium japonicum. J Bacteriol (1985) 1.55

Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle. Mol Cell Biol (1990) 1.54

Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol Cell Biol (1996) 1.52

Pyp3 PTPase acts as a mitotic inducer in fission yeast. EMBO J (1992) 1.50

Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism. Mol Biol Cell (1998) 1.48

Spectrum of histological changes reactive to prosthetic breast implants: a clinopathological study of 84 patients. Pathology (1996) 1.47

Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer. Cancer Res (1996) 1.47

DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1. Proc Natl Acad Sci U S A (2008) 1.46

Identification of a cdk-activating kinase in fission yeast. EMBO J (1995) 1.45

A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis. Infect Immun (2002) 1.45

The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes. Am J Hum Genet (1999) 1.45

Contribution of BRCA1 mutations to ovarian cancer. N Engl J Med (1997) 1.44

Expression of Crystallins, Pax6, Filensin, CP49, MIP, and MP20 in lens-derived cell lines. Invest Ophthalmol Vis Sci (1996) 1.44

Transitional (urothelial) cell metaplasia of the uterine cervix: morphological assessment of 31 cases. Int J Gynecol Pathol (1997) 1.44

Deletion mutation in an eye lens beta-crystallin. An animal model for inherited cataracts. J Biol Chem (1991) 1.43

The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage. Genetics (1998) 1.43

An upper limit on the stochastic gravitational-wave background of cosmological origin. Nature (2009) 1.42

Negative regulation of Cdc18 DNA replication protein by Cdc2. Mol Biol Cell (1998) 1.41

A role of Sep1 (= Kem1, Xrn1) as a microtubule-associated protein in Saccharomyces cerevisiae. EMBO J (1995) 1.40

Care for dying people in nursing homes. Nurs Older People (2001) 1.39

The tension wire method: a simple, effective means of mandibular fixation. Arch Otolaryngol Head Neck Surg (1998) 1.38