Published in J Biol Chem on November 21, 2000
Specific tetraspanin functions. J Cell Biol (2001) 2.35
Targeting of tetraspanin proteins--potential benefits and strategies. Nat Rev Drug Discov (2008) 1.91
The CD81 partner EWI-2wint inhibits hepatitis C virus entry. PLoS One (2008) 1.86
Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J Lipid Res (2010) 1.82
Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. Mol Biol Cell (2002) 1.69
CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry. J Virol (2008) 1.62
Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis. Mol Biol Cell (2002) 1.61
An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology. J Cell Biol (2002) 1.61
EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. Biochem J (2003) 1.50
Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. Mol Biol Cell (2004) 1.36
Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J (2009) 1.29
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J (2009) 1.28
Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. J Cell Sci (2007) 1.24
EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. J Cell Biol (2003) 1.22
Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Mol Immunol (2007) 1.07
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. J Cell Biol (2012) 1.07
Hepatocyte permissiveness to Plasmodium infection is conveyed by a short and structurally conserved region of the CD81 large extracellular domain. PLoS Pathog (2008) 1.05
Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion. Mol Biol Cell (2003) 0.94
Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81. Nat Commun (2013) 0.93
Interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection. J Biol Chem (2011) 0.92
CD9 clustering and formation of microvilli zippers between contacting cells regulates virus-induced cell fusion. Traffic (2008) 0.90
Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo. Neoplasia (2009) 0.90
The tetraspanin D6.1A and its molecular partners on rat carcinoma cells. Biochem J (2005) 0.88
The tetraspanins CD9 and CD81 regulate CD9P1-induced effects on cell migration. PLoS One (2010) 0.88
Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction. Reprod Fertil Dev (2009) 0.87
CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte. Biol Open (2012) 0.86
Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. J Biol Chem (2014) 0.84
CD81 and hepatitis C virus (HCV) infection. Viruses (2014) 0.84
TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization. Cell Mol Life Sci (2015) 0.84
The Ig domain protein CD9P-1 down-regulates CD81 ability to support Plasmodium yoelii infection. J Biol Chem (2009) 0.83
A tetraspanin-family protein, T-cell acute lymphoblastic leukemia-associated antigen 1, is induced by the Ewing's sarcoma-Wilms' tumor 1 fusion protein of desmoplastic small round-cell tumor. Am J Pathol (2003) 0.83
Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a. J Biol Chem (2009) 0.83
The CD9/CD81 tetraspanin complex and tetraspanin CD151 regulate α3β1 integrin-dependent tumor cell behaviors by overlapping but distinct mechanisms. PLoS One (2013) 0.83
An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis. J Proteomics (2012) 0.82
EWI-2 negatively regulates TGF-β signaling leading to altered melanoma growth and metastasis. Cell Res (2015) 0.81
The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization. J Cell Sci (2011) 0.81
CD9P-1 expression correlates with the metastatic status of lung cancer, and a truncated form of CD9P-1, GS-168AT2, inhibits in vivo tumour growth. Br J Cancer (2011) 0.80
Tetraspanins: Small transmembrane proteins with big impact on membrane microdomain structures. Commun Integr Biol (2008) 0.80
Metastasis-associated cell surface oncoproteomics. Front Pharmacol (2012) 0.79
Novel CD9-targeted therapies in gastric cancer. World J Gastroenterol (2015) 0.79
Differential functions of phospholipid binding and palmitoylation of tumour suppressor EWI2/PGRL. Biochem J (2011) 0.77
Evolution and Structural Analyses of Glossina morsitans (Diptera; Glossinidae) Tetraspanins. Insects (2014) 0.76
Tetraspanins Function as Regulators of Cellular Signaling. Front Cell Dev Biol (2017) 0.75
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell (1990) 8.87
The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. J Biol Chem (1987) 4.47
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol (1995) 3.88
Identification of the integrin VLA-2 as a receptor for echovirus 1. Science (1992) 3.28
Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J Immunol (1984) 3.26
Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers. J Cell Biochem (1988) 3.10
Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. J Immunol (1981) 3.02
Characterization of the cell surface heterodimer VLA-4 and related peptides. J Biol Chem (1987) 2.94
Adhesive protein receptors on hematopoietic cells. Immunol Today (1988) 2.85
Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem (1989) 2.71
Fibronectin receptor structures in the VLA family of heterodimers. Nature (1987) 2.54
Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell (1998) 2.39
Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res (2001) 2.33
Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell (1992) 2.33
The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc Natl Acad Sci U S A (1989) 2.31
Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations. J Cell Biol (1991) 2.27
Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem (1995) 2.21
Are changes in integrin affinity and conformation overemphasized? Trends Biochem Sci (1998) 2.17
Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes. J Biol Chem (1991) 2.17
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene (2012) 2.16
Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J Biol Chem (2001) 2.14
Characterization of a novel differentiation antigen complex recognize by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells. J Immunol (1983) 2.13
The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Proc Natl Acad Sci U S A (1987) 2.11
The pathophysiologic role of alpha 4 integrins in vivo. J Clin Invest (1994) 2.07
The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function. EMBO J (1989) 2.03
Cloning, primary structure and properties of a novel human integrin beta subunit. EMBO J (1990) 2.03
The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol (1989) 2.02
Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol Biol Cell (1996) 1.94
Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J Biol Chem (1993) 1.92
A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem (1997) 1.92
Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. J Biol Chem (1992) 1.91
Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2. J Immunol (1987) 1.90
Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J Cell Biol (1999) 1.89
Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts. J Biol Chem (2000) 1.89
Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem (1989) 1.88
In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science (1991) 1.85
Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans. Proc Natl Acad Sci U S A (1980) 1.81
Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells. J Biol Chem (1985) 1.80
Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem (1997) 1.78
EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem (2001) 1.72
Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J Biol Chem (2000) 1.69
Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. J Clin Invest (1992) 1.65
Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell (1991) 1.65
Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase. Biochem J (2000) 1.61
The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregation. J Biol Chem (1993) 1.59
Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis. J Biol Chem (1980) 1.55
Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol (1996) 1.54
VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation. Eur J Immunol (1985) 1.53
Specialized functional properties of the integrin alpha 4 cytoplasmic domain. Mol Biol Cell (1995) 1.53
Specific association of CD63 with the VLA-3 and VLA-6 integrins. J Biol Chem (1995) 1.52
Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells. Proc Natl Acad Sci U S A (1984) 1.51
Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa. Hum Pathol (2001) 1.51
Prostaglandin biosynthesis can be triggered by lipid peroxides. Arch Biochem Biophys (1979) 1.47
Very late activation antigens on rheumatoid synovial fluid T lymphocytes. Association with stages of T cell activation. J Clin Invest (1986) 1.43
Integrin-mediated collagen matrix reorganization by cultured human vascular smooth muscle cells. Circ Res (1995) 1.40
Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin. J Exp Med (1993) 1.40
Characterization of antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines. J Immunol (1982) 1.38
Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J Cell Biol (1991) 1.36
Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. J Exp Med (1997) 1.35
Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins. J Biol Chem (1998) 1.33
Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth. J Cell Sci (2000) 1.29
Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody. J Cell Biol (1993) 1.26
T lymphocytes compartmentalized on the epithelial surface of the lower respiratory tract express the very late activation antigen complex VLA-1. Clin Immunol Immunopathol (1988) 1.25
Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein. J Biol Chem (1999) 1.25
Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. J Immunol (1983) 1.24
Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry (1998) 1.23
The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. J Clin Invest (1993) 1.22
T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix. J Immunol (1991) 1.21
A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. J Cell Sci (1993) 1.21
Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. J Biol Chem (1992) 1.19
Development and characterization of allospecific long-term human cytolytic T-cell lines. Proc Natl Acad Sci U S A (1980) 1.18
Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration. J Cell Biol (1994) 1.18
The I domain is essential for echovirus 1 interaction with VLA-2. Cell Adhes Commun (1994) 1.17
Monoclonal antibodies reacting with immunogenic mycoplasma proteins present in human hematopoietic cell lines. J Immunol (1982) 1.16
A 55,000 Mr surface antigen on activated human T lymphocytes defined by a monoclonal antibody. Hum Immunol (1983) 1.14
Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion. J Biol Chem (1994) 1.12
Beta1 integrins show specific association with CD98 protein in low density membranes. BMC Biochem (2001) 1.09
NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. J Biol Chem (1997) 1.09
Molecular mapping of functional antibody binding sites of alpha 4 integrin. J Biol Chem (1995) 1.08
Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2. J Biol Chem (1993) 1.08
Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin. J Cell Biol (1993) 1.06
Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen. Somatic Cell Genet (1982) 1.04
Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth. J Cell Sci (1999) 1.04
Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation. Biochem J (1996) 1.02
Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group. Hum Immunol (1982) 1.00
Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding. Mol Biol Cell (1997) 0.99
Investigation of the role of beta 1 integrins in cell-cell adhesion. J Cell Sci (1995) 0.99
Bcr/Abl expression stimulates integrin function in hematopoietic cell lines. J Clin Invest (1996) 0.99
Accelerative autoactivation of prostaglandin biosynthesis by PGG2. Biochem Biophys Res Commun (1978) 0.99
Cell matrix adhesion-related proteins VLA-1 and VLA-2: regulation of expression on T cells. J Immunol (1987) 0.99
Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule. J Cell Biol (1991) 0.98
Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions. Mol Biol Cell (1994) 0.98
Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement. Mol Biol Cell (2001) 0.98
Lipoxygenation activity of purified prostaglandin-forming cyclooxygenase. Biochemistry (1978) 0.97
Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol (1985) 0.95
Alpha 4/180, a novel form of the integrin alpha 4 subunit. J Biol Chem (1993) 0.94
Functional role of alpha 2/beta 1 and alpha 4/beta 1 integrins in leukocyte intercellular adhesion induced through the common beta 1 subunit. Eur J Immunol (1992) 0.94
Genetic and biochemical characterization of human lymphocyte cell surface antigens. The A-1A5 and A-3A4 determinants. J Exp Med (1984) 0.93
Proteolytic cleavage of the integrin beta 4 subunit. Exp Cell Res (1994) 0.92
Regulation of proteins in the VLA cell substrate adhesion family: influence of cell growth conditions on VLA-1, VLA-2, and VLA-3 expression. Exp Cell Res (1988) 0.92