Published in J Biol Chem on December 11, 2000
CD81 is required for hepatitis C virus glycoprotein-mediated viral infection. J Virol (2004) 3.53
Tetraspanins: push and pull in suppressing and promoting metastasis. Nat Rev Cancer (2008) 3.04
Specific tetraspanin functions. J Cell Biol (2001) 2.35
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell (2008) 2.27
CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes. J Virol (2008) 2.09
Targeting of tetraspanin proteins--potential benefits and strategies. Nat Rev Drug Discov (2008) 1.91
Palmitoylation supports assembly and function of integrin-tetraspanin complexes. J Cell Biol (2004) 1.89
Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms. J Cell Biol (2008) 1.75
Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. Mol Biol Cell (2002) 1.69
Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. Mol Cancer (2013) 1.56
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J Cell Biol (2003) 1.51
A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5. Mol Biol Cell (2006) 1.47
Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. Mol Biol Cell (2004) 1.36
Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution. J Cell Biol (2006) 1.34
Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J (2009) 1.29
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol (2009) 1.25
EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. J Cell Biol (2003) 1.22
Structural organization and interactions of transmembrane domains in tetraspanin proteins. BMC Struct Biol (2005) 1.19
Complete predicted three-dimensional structure of the facilitator transmembrane protein and hepatitis C virus receptor CD81: conserved and variable structural domains in the tetraspanin superfamily. Biophys J (2006) 1.18
Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane. J Virol (2011) 1.18
Relationships between plasma membrane microdomains and HIV-1 assembly. Biol Cell (2010) 1.16
Tetraspanins in viral infections: a fundamental role in viral biology? J Virol (2005) 1.16
The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins. Mol Biol Cell (2004) 1.13
The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. Proc Natl Acad Sci U S A (2003) 1.11
Beta1 integrins show specific association with CD98 protein in low density membranes. BMC Biochem (2001) 1.09
Involvement of raft-like plasma membrane domains of Entamoeba histolytica in pinocytosis and adhesion. Infect Immun (2004) 1.06
Palmitoylation controls the catalytic activity and subcellular distribution of phosphatidylinositol 4-kinase II{alpha}. J Biol Chem (2009) 1.04
Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. J Biol Chem (2009) 1.03
Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability. Virology (2006) 1.01
Association of a photoreceptor-specific tetraspanin protein, ROM-1, with triton X-100-resistant membrane rafts from rod outer segment disk membranes. J Biol Chem (2002) 0.99
The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses. Mol Cell Biol (2002) 0.96
Gangliosides play an important role in the organization of CD82-enriched microdomains. Biochem J (2006) 0.96
Physiological and pathological roles of alpha3beta1 integrin. J Membr Biol (2004) 0.95
Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase. Blood (2011) 0.95
CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts. FASEB J (2009) 0.95
CD317/tetherin is an organiser of membrane microdomains. J Cell Sci (2013) 0.94
The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion. Asian J Androl (2010) 0.94
HIV-1 Gag associates with specific uropod-directed microdomains in a manner dependent on its MA highly basic region. J Virol (2013) 0.93
Sperm-egg fusion: a molecular enigma of mammalian reproduction. Int J Mol Sci (2014) 0.92
Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner. J Biol Chem (2012) 0.92
Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus. J Virol (2002) 0.91
Lipid rafts: keys to sperm maturation, fertilization, and early embryogenesis. J Lipids (2011) 0.89
Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. Prog Lipid Res (2013) 0.89
The tetraspanin web revisited by super-resolution microscopy. Sci Rep (2015) 0.89
The tetraspanin D6.1A and its molecular partners on rat carcinoma cells. Biochem J (2005) 0.88
Chondrocytes utilize a cholesterol-dependent lipid translocator to externalize phosphatidylserine. Biochemistry (2006) 0.87
Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction. Reprod Fertil Dev (2009) 0.87
Biochemical and biological characterization of exosomes containing prominin-1/CD133. Mol Cancer (2013) 0.87
TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Mol Psychiatry (2016) 0.86
Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circ Res (2014) 0.86
Isolation of membrane rafts and signaling complexes. Methods Mol Biol (2006) 0.85
Dynamic Association between HIV-1 Gag and Membrane Domains. Mol Biol Int (2012) 0.84
Understanding lipid rafts and other related membrane domains. F1000 Biol Rep (2010) 0.84
Novel function of CD81 in controlling hepatitis C virus replication. J Virol (2010) 0.84
Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance. PLoS One (2013) 0.83
CD81-receptor associations--impact for hepatitis C virus entry and antiviral therapies. Viruses (2014) 0.83
Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability. Am J Physiol Gastrointest Liver Physiol (2011) 0.82
Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen. Front Immunol (2015) 0.81
A glycosynapse in myelin? Glycoconj J (2004) 0.81
Tetraspanins as therapeutic targets in hematological malignancy: a concise review. Front Physiol (2015) 0.81
Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms. J Cell Biol (2008) 0.80
Toward atomic force microscopy and mass spectrometry to visualize and identify lipid rafts in plasmodesmata. Front Plant Sci (2014) 0.80
MHC class II association with lipid rafts on the antigen presenting cell surface. Biochim Biophys Acta (2014) 0.79
Glycosphingolipids govern gene expression. Glycoconj J (2004) 0.79
Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions. FASEB J (2010) 0.79
Tetraspanins and Transmembrane Adaptor Proteins As Plasma Membrane Organizers-Mast Cell Case. Front Cell Dev Biol (2016) 0.78
Oligomerization of the Tetraspanin CD81 via the Flexibility of Its δ-Loop. Biophys J (2016) 0.78
Molecular and cellular mechanisms of sperm-oocyte interactions opinions relative to in vitro fertilization (IVF). Int J Mol Sci (2014) 0.77
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence. Viruses (2016) 0.77
CUB domain containing protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells. BMC Cancer (2014) 0.76
Fluorosomes: fluorescent virus-like nanoparticles that represent a convenient tool to visualize receptor-ligand interactions. Sensors (Basel) (2013) 0.76
Pancreatic cancer stem cell markers and exosomes - the incentive push. World J Gastroenterol (2016) 0.76
Coronavirus and influenza virus proteolytic priming takes place in tetraspanin-enriched membrane microdomains. J Virol (2015) 0.75
Viruses and tetraspanins: lessons from single molecule approaches. Viruses (2014) 0.75
TETRASPANINs in Plants. Front Plant Sci (2017) 0.75
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell (1990) 8.87
The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. J Biol Chem (1987) 4.47
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol (1995) 3.88
Identification of the integrin VLA-2 as a receptor for echovirus 1. Science (1992) 3.28
Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J Immunol (1984) 3.26
Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers. J Cell Biochem (1988) 3.10
Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. J Immunol (1981) 3.02
Characterization of the cell surface heterodimer VLA-4 and related peptides. J Biol Chem (1987) 2.94
Adhesive protein receptors on hematopoietic cells. Immunol Today (1988) 2.85
Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem (1989) 2.71
Fibronectin receptor structures in the VLA family of heterodimers. Nature (1987) 2.54
Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell (1998) 2.39
Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res (2001) 2.33
Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell (1992) 2.33
The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc Natl Acad Sci U S A (1989) 2.31
Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations. J Cell Biol (1991) 2.27
Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem (1995) 2.21
Are changes in integrin affinity and conformation overemphasized? Trends Biochem Sci (1998) 2.17
Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes. J Biol Chem (1991) 2.17
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene (2012) 2.16
Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J Biol Chem (2001) 2.14
Characterization of a novel differentiation antigen complex recognize by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells. J Immunol (1983) 2.13
The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Proc Natl Acad Sci U S A (1987) 2.11
The pathophysiologic role of alpha 4 integrins in vivo. J Clin Invest (1994) 2.07
The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function. EMBO J (1989) 2.03
Cloning, primary structure and properties of a novel human integrin beta subunit. EMBO J (1990) 2.03
The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol (1989) 2.02
Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol Biol Cell (1996) 1.94
Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J Biol Chem (1993) 1.92
A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem (1997) 1.92
Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. J Biol Chem (1992) 1.91
Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2. J Immunol (1987) 1.90
Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J Cell Biol (1999) 1.89
Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem (1989) 1.88
In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science (1991) 1.85
Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans. Proc Natl Acad Sci U S A (1980) 1.81
Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells. J Biol Chem (1985) 1.80
Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem (1997) 1.78
EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem (2001) 1.72
Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J Biol Chem (2000) 1.69
Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. J Clin Invest (1992) 1.65
Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell (1991) 1.65
Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase. Biochem J (2000) 1.61
The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregation. J Biol Chem (1993) 1.59
Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis. J Biol Chem (1980) 1.55
Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol (1996) 1.54
VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation. Eur J Immunol (1985) 1.53
Specialized functional properties of the integrin alpha 4 cytoplasmic domain. Mol Biol Cell (1995) 1.53
Specific association of CD63 with the VLA-3 and VLA-6 integrins. J Biol Chem (1995) 1.52
Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells. Proc Natl Acad Sci U S A (1984) 1.51
Prostaglandin biosynthesis can be triggered by lipid peroxides. Arch Biochem Biophys (1979) 1.47
FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. J Biol Chem (2000) 1.47
Very late activation antigens on rheumatoid synovial fluid T lymphocytes. Association with stages of T cell activation. J Clin Invest (1986) 1.43
Integrin-mediated collagen matrix reorganization by cultured human vascular smooth muscle cells. Circ Res (1995) 1.40
Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin. J Exp Med (1993) 1.40
Characterization of antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines. J Immunol (1982) 1.38
Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J Cell Biol (1991) 1.36
Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. J Exp Med (1997) 1.35
Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins. J Biol Chem (1998) 1.33
Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth. J Cell Sci (2000) 1.29
Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody. J Cell Biol (1993) 1.26
T lymphocytes compartmentalized on the epithelial surface of the lower respiratory tract express the very late activation antigen complex VLA-1. Clin Immunol Immunopathol (1988) 1.25
Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein. J Biol Chem (1999) 1.25
Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. J Immunol (1983) 1.24
Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry (1998) 1.23
The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. J Clin Invest (1993) 1.22
T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix. J Immunol (1991) 1.21
A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. J Cell Sci (1993) 1.21
Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. J Biol Chem (1992) 1.19
Development and characterization of allospecific long-term human cytolytic T-cell lines. Proc Natl Acad Sci U S A (1980) 1.18
Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration. J Cell Biol (1994) 1.18
The I domain is essential for echovirus 1 interaction with VLA-2. Cell Adhes Commun (1994) 1.17
Monoclonal antibodies reacting with immunogenic mycoplasma proteins present in human hematopoietic cell lines. J Immunol (1982) 1.16
A 55,000 Mr surface antigen on activated human T lymphocytes defined by a monoclonal antibody. Hum Immunol (1983) 1.14
Expression of the heparan sulfate proteoglycan glypican-1 in the developing rodent. Dev Dyn (1998) 1.13
Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion. J Biol Chem (1994) 1.12
Beta1 integrins show specific association with CD98 protein in low density membranes. BMC Biochem (2001) 1.09
NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. J Biol Chem (1997) 1.09
Molecular mapping of functional antibody binding sites of alpha 4 integrin. J Biol Chem (1995) 1.08
Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2. J Biol Chem (1993) 1.08
Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin. J Cell Biol (1993) 1.06
Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen. Somatic Cell Genet (1982) 1.04
Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth. J Cell Sci (1999) 1.04
Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation. Biochem J (1996) 1.02
Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group. Hum Immunol (1982) 1.00
Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding. Mol Biol Cell (1997) 0.99
Neuronal expression of glypican, a cell-surface glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan, in the adult rat nervous system. J Neurosci (1994) 0.99
Investigation of the role of beta 1 integrins in cell-cell adhesion. J Cell Sci (1995) 0.99
Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding. Glycobiology (1999) 0.99
Accelerative autoactivation of prostaglandin biosynthesis by PGG2. Biochem Biophys Res Commun (1978) 0.99
Bcr/Abl expression stimulates integrin function in hematopoietic cell lines. J Clin Invest (1996) 0.99
Cell matrix adhesion-related proteins VLA-1 and VLA-2: regulation of expression on T cells. J Immunol (1987) 0.99
Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule. J Cell Biol (1991) 0.98
Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement. Mol Biol Cell (2001) 0.98
Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions. Mol Biol Cell (1994) 0.98
Lipoxygenation activity of purified prostaglandin-forming cyclooxygenase. Biochemistry (1978) 0.97
Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol (1985) 0.95
Alpha 4/180, a novel form of the integrin alpha 4 subunit. J Biol Chem (1993) 0.94
Functional role of alpha 2/beta 1 and alpha 4/beta 1 integrins in leukocyte intercellular adhesion induced through the common beta 1 subunit. Eur J Immunol (1992) 0.94