Published in Biophys J on December 01, 2000
Cellular magnesium homeostasis. Arch Biochem Biophys (2011) 1.46
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential. Pharmacol Rev (2015) 1.38
Inhibition of T-type Ca²⁺ channels by endostatin attenuates human glioblastoma cell proliferation and migration. Br J Pharmacol (2012) 1.11
Mg2+ deprivation elicits rapid Ca2+ uptake and activates Ca2+/calcineurin signaling in Saccharomyces cerevisiae. Eukaryot Cell (2007) 1.06
Availability of low-threshold Ca2+ current in retinal ganglion cells. J Neurophysiol (2003) 1.03
Pore structure influences gating properties of the T-type Ca2+ channel alpha1G. J Gen Physiol (2003) 1.01
Gating kinetics of the alpha1I T-type calcium channel. J Gen Physiol (2001) 1.00
Y3+ block demonstrates an intracellular activation gate for the alpha1G T-type Ca2+ channel. J Gen Physiol (2004) 0.98
Permeation and gating in CaV3.1 (alpha1G) T-type calcium channels effects of Ca2+, Ba2+, Mg2+, and Na+. J Gen Physiol (2008) 0.88
Zn2+ sensitivity of high- and low-voltage activated calcium channels. Biophys J (2007) 0.87
Molecular determinant for specific Ca/Ba selectivity profiles of low and high threshold Ca2+ channels. J Gen Physiol (2007) 0.87
Extracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ channel alpha1G (CaV3.1). J Gen Physiol (2003) 0.86
Ni2+ block of CaV3.1 (alpha1G) T-type calcium channels. J Gen Physiol (2008) 0.85
Contrasting effects of Cd2+ and Co2+ on the blocking/unblocking of human Cav3 channels. J Membr Biol (2005) 0.80
The relationship between single-channel and whole-cell conductance in the T-type Ca2+ channel CaV3.1. Biophys J (2008) 0.79
Fe²⁺ block and permeation of CaV3.1 (α1G) T-type calcium channels: candidate mechanism for non-transferrin-mediated Fe²⁺ influx. Mol Pharmacol (2012) 0.77
T-type Ca2+ channels in absence epilepsy. Pflugers Arch (2014) 0.77
Ion trafficking through T-type Ca2+ channels: a way to look at channel gating position. J Gen Physiol (2004) 0.75
Models of calcium permeation through T-type channels. Pflugers Arch (2014) 0.75
The components of membrane conductance in the giant axon of Loligo. J Physiol (1952) 82.70
Ionic blockage of sodium channels in nerve. J Gen Physiol (1973) 20.47
Mechanism of ion permeation through calcium channels. Nature (1984) 9.82
Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore. J Physiol (1984) 8.20
Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. J Gen Physiol (1986) 6.76
Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore. J Gen Physiol (1986) 5.38
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature (1993) 5.31
Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology. J Gen Physiol (1985) 5.16
Membrane currents carried by Ca, Sr, and Ba in barnacle muscle fiber during voltage clamp. J Gen Physiol (1974) 3.94
Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature (1998) 3.77
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci (1999) 3.73
Currents carried by monovalent cations through calcium channels in mouse neoplastic B lymphocytes. J Physiol (1985) 3.69
Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol (1996) 3.20
Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H. Biophys J (1999) 2.91
Kinetics and selectivity of a low-voltage-activated calcium current in chick and rat sensory neurones. J Physiol (1987) 2.83
Bound and determined: a computer program for making buffers of defined ion concentrations. Anal Biochem (1992) 2.65
A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus. J Neurosci (1992) 2.57
The Ca channel in skeletal muscle is a large pore. Proc Natl Acad Sci U S A (1985) 2.49
Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circ Res (1998) 2.49
Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci (1999) 2.30
Permeation in the dihydropyridine-sensitive calcium channel. Multi-ion occupancy but no anomalous mole-fraction effect between Ba2+ and Ca2+. J Gen Physiol (1990) 2.06
Ion permeation and glutamate residues linked by Poisson-Nernst-Planck theory in L-type calcium channels. Biophys J (1998) 2.04
Ion channel selectivity through stepwise changes in binding affinity. J Gen Physiol (1998) 1.89
Interaction between calcium ions and surface charge as it relates to calcium currents. J Membr Biol (1983) 1.76
Progress and prospects in permeation. J Gen Physiol (1999) 1.53
Calcium channel permeation: A field in flux. J Gen Physiol (1999) 1.51
Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels. J Biol Chem (2000) 1.51
State-dependent inactivation of the alpha1G T-type calcium channel. J Gen Physiol (1999) 1.45
Na+ currents through low-voltage-activated Ca2+ channels of chick sensory neurones: block by external Ca2+ and Mg2+. J Physiol (1990) 1.33
Surface charge and calcium channel saturation in bullfrog sympathetic neurons. J Gen Physiol (1995) 1.31
Graphic representation of the results of kinetic analyses. J Gen Physiol (1999) 1.30
Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaeochromocytoma cells. J Physiol (1993) 1.26
The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels. J Neurosci (1996) 1.24
Ca2+ and Na+ permeability of high-threshold Ca2+ channels and their voltage-dependent block by Mg2+ ions in chick sensory neurones. J Physiol (1997) 1.17
A T-type calcium channel from mouse brain. Pflugers Arch (1999) 1.16
Effects of magnesium on inactivation of the voltage-gated calcium current in cardiac myocytes. J Gen Physiol (1989) 1.08
Ion transfer characteristics of the calcium current in bull-frog atrial myocytes. J Physiol (1988) 1.06
Apparent change in ion selectivity caused by changes in intracellular K(+) during whole-cell recording. Biophys J (2000) 1.02
Regulation of the calcium channel alpha(1G) subunit by divalent cations and organic blockers. Neuropharmacology (2000) 1.01
Intra and extracellular surface charges near Ca2+ channels in neurons and neuroblastoma cells. Biophys J (1992) 0.98
Magnesium affects excitation, conduction, and contraction of isolated mammalian cardiac muscle. Am J Physiol (1992) 0.96
Inhibition by magnesium of calcium inward current in heart ventricular muscle. Eur J Pharmacol (1991) 0.92
Dual effects of external magnesium on action potential duration in guinea pig ventricular myocytes. Am J Physiol (1995) 0.78
Effects of extracellular Mg2+ on T- and L-type Ca2+ currents in single atrial myocytes. Am J Physiol (1990) 0.77
On the antiarrhythmic actions of magnesium in single guinea-pig ventricular myocytes. Clin Exp Pharmacol Physiol (1996) 0.77
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci (1999) 3.73
Nomenclature of voltage-gated calcium channels. Neuron (2000) 3.09
Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H. Biophys J (1999) 2.91
LHRH and GTP-gamma-S modify calcium current activation in bullfrog sympathetic neurons. Neuron (1990) 2.64
Heterologous regulation of the cardiac Ca2+ channel alpha 1 subunit by skeletal muscle beta and gamma subunits. Implications for the structure of cardiac L-type Ca2+ channels. J Biol Chem (1991) 2.55
Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circ Res (1998) 2.49
Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels. Science (1995) 2.30
Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci (1999) 2.30
Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. Nature (1991) 2.09
Inactivation of Kv2.1 potassium channels. Biophys J (1998) 2.02
Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for calcium channel activation and dihydropyridine agonist action. J Gen Physiol (1992) 1.99
Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol (1989) 1.96
Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit. J Biol Chem (1994) 1.85
Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J Neurosci (2001) 1.77
Cloning and expression of a third calcium channel beta subunit. J Biol Chem (1993) 1.77
Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron (2001) 1.70
Cloning and expression of a neuronal calcium channel beta subunit. J Biol Chem (1993) 1.54
Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther (2000) 1.52
Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release. Cardiovasc Res (1999) 1.47
State-dependent inactivation of the alpha1G T-type calcium channel. J Gen Physiol (1999) 1.45
Comparison of the Ca2 + currents induced by expression of three cloned alpha1 subunits, alpha1G, alpha1H and alpha1I, of low-voltage-activated T-type Ca2 + channels. Eur J Neurosci (1999) 1.42
Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. Nat Neurosci (1998) 1.38
Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit. Receptors Channels (1994) 1.37
Muscarinic and peptidergic excitation of bull-frog sympathetic neurones. J Physiol (1985) 1.37
Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels. FEBS Lett (1999) 1.36
Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2). J Biol Chem (2000) 1.36
Identification of mitogen-responsive ribosomal protein S6 kinase pp90rsk, a homolog of Xenopus S6 kinase II, in chicken embryo fibroblasts. Mol Cell Biol (1990) 1.35
Surface charge and calcium channel saturation in bullfrog sympathetic neurons. J Gen Physiol (1995) 1.31
Distinct kinetics of cloned T-type Ca2 + channels lead to differential Ca2 + entry and frequency-dependence during mock action potentials. Eur J Neurosci (1999) 1.29
Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. EMBO J (2001) 1.29
Slow synaptic transmission in frog sympathetic ganglia. J Exp Biol (1986) 1.26
Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants. Mol Pharmacol (2000) 1.25
U-type inactivation of Kv3.1 and Shaker potassium channels. Biophys J (2001) 1.25
Differential regulation of skeletal muscle L-type Ca2+ current and excitation-contraction coupling by the dihydropyridine receptor beta subunit. Biophys J (1999) 1.25
A synthetic peptide that is a bombesin receptor antagonist. Nature (1984) 1.24
Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit. J Biol Chem (1998) 1.24
T-type and N-type calcium channels of Xenopus oocytes: evidence for specific interactions with beta subunits. Biophys J (1994) 1.22
The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes. Mol Pharmacol (1980) 1.21
Cadmium block of calcium current in frog sympathetic neurons. Biophys J (1992) 1.19
Substance P inhibits the M-current in bullfrog sympathetic neurones. Br J Pharmacol (1983) 1.19
The effect of alpha2-delta and other accessory subunits on expression and properties of the calcium channel alpha1G. J Physiol (1999) 1.16
Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat. Brain Res Mol Brain Res (2000) 1.15
Reevaluation of Ca2+ channel types and their modulation in bullfrog sympathetic neurons. Neuron (1994) 1.14
Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs. Biochim Biophys Acta (1980) 1.12
The role of T-type calcium channels in epilepsy and pain. Curr Pharm Des (2006) 1.11
Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol Pharmacol (2001) 1.10
Overexpression of T-type calcium channels in HEK-293 cells increases intracellular calcium without affecting cellular proliferation. FEBS Lett (2000) 1.07
Concentration dependence of neurotransmitter effects on calcium current kinetics in frog sympathetic neurones. J Physiol (1994) 1.06
Calcium currents in the A7r5 smooth muscle-derived cell line. Calcium-dependent and voltage-dependent inactivation. J Gen Physiol (1991) 1.05
Low-voltage-activated Ca2+ currents are generated by members of the CavT subunit family (alpha1G/H) in rat primary sensory neurons. J Neurosci (1998) 1.03
The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity. Int J Oncol (2000) 1.03
Inactivation determinants in segment IIIS6 of Ca(v)3.1. J Physiol (2001) 1.02
Ion permeation and block of M-type and delayed rectifier potassium channels. Whole-cell recordings from bullfrog sympathetic neurons. J Gen Physiol (1996) 1.02
Calcium current modulation in frog sympathetic neurones: L-current is relatively insensitive to neurotransmitters. J Physiol (1992) 1.02
Apparent change in ion selectivity caused by changes in intracellular K(+) during whole-cell recording. Biophys J (2000) 1.02
T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates. J Physiol (2006) 1.01
Molecular analyses of gene products associated with the response of cells to mitogenic stimulation. Cold Spring Harb Symp Quant Biol (1988) 1.01
The effects of external pH on calcium channel currents in bullfrog sympathetic neurons. Biophys J (1996) 1.01
Gating kinetics of the alpha1I T-type calcium channel. J Gen Physiol (2001) 1.00
alpha1H T-type Ca2+ channel is the predominant subtype expressed in bovine and rat zona glomerulosa. Am J Physiol Cell Physiol (2001) 1.00
Molecular cloning and functional expression of Ca(v)3.1c, a T-type calcium channel from human brain. FEBS Lett (2000) 0.99
Molecular pharmacology of T-type Ca2+ channels. Jpn J Pharmacol (2001) 0.99
Characterization of the free radical formed in aerobic microsomal incubations containing carbon tetrachloride and NADPH. Biochem Biophys Res Commun (1979) 0.97
Distribution of the voltage-dependent calcium channel alpha1G subunit mRNA and protein throughout the mature rat brain. Eur J Neurosci (1999) 0.96
Absence of [125I] alpha-bungarotoxin binding to motor nerve terminals of frog, lizard and mouse muscle. J Neurosci (1983) 0.95
Phosphorylation enhances inactivation of N-type calcium channel current in bullfrog sympathetic neurons. Pflugers Arch (1993) 0.95
Calcium currents in the A7r5 smooth muscle-derived cell line. Increase in current and selective removal of voltage-dependent inactivation by intracellular trypsin. J Gen Physiol (1991) 0.95
Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide. Mol Pharmacol (2001) 0.94
Antipyrene clearance in Indian villagers. Br J Clin Pharmacol (1980) 0.92
Delayed rectifier current of bullfrog sympathetic neurons: ion-ion competition, asymmetrical block and effects of ions on gating. J Physiol (1997) 0.92
Calmodulin plays a dominant role in determining neurotransmitter regulation of neuronal adenylate cyclase. J Cell Biochem (1988) 0.91
Effects of temperature on calcium current of bullfrog sympathetic neurons. J Physiol (1993) 0.91
Calcium currents in the A7r5 smooth muscle-derived cell line. Pflugers Arch (1990) 0.90
Voltage-dependent inactivation in a cardiac-skeletal chimeric calcium channel. FEBS Lett (1995) 0.90
Structural features of various proglumide-related cholecystokinin receptor antagonists. Am J Physiol (1986) 0.90
Modulation of recombinant T-type Ca2+ channels by hypoxia and glutathione. Pflugers Arch (2000) 0.89
Activation kinetics of the delayed rectifier potassium current of bullfrog sympathetic neurons. J Neurophysiol (1998) 0.89
Teleost luteinizing hormone-releasing hormone: action on bullfrog sympathetic ganglia is consistent with role as neurotransmitter. J Neurosci (1984) 0.89
Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. J Biol Chem (1992) 0.87
Surface charge and lanthanum block of calcium current in bullfrog sympathetic neurons. Biophys J (1998) 0.87
Age-related differences in salt taste acuity. J Gerontol (1979) 0.87
[D-Phe12]bombesin analogues: a new class of bombesin receptor antagonists. Am J Physiol (1987) 0.87
Interaction of substance P antagonists with substance P receptors on dispersed pancreatic acini. Biochim Biophys Acta (1984) 0.87
Functional coupling between 'R-type' Ca2+ channels and insulin secretion in the insulinoma cell line INS-1. Eur J Biochem (2001) 0.85
Proglumide analogues: potent cholecystokinin receptor antagonists. Am J Physiol (1985) 0.85
Characterization of ability of various substance P antagonists to inhibit action of bombesin. Am J Physiol (1988) 0.84
Hydrodynamic properties of adenosine Ri receptors solubilized from rat cerebral-cortical membranes. Biochem J (1987) 0.84
Molecular diversity of Ca2+ channel beta subunits. Biochem Soc Trans (1994) 0.84
Facilitation of L-type calcium current in thalamic neurons. J Neurophysiol (1998) 0.84
A muscarine-resistant M-current in C cells of bullfrog sympathetic ganglia. Neurosci Lett (1987) 0.84
New isoform of the neuronal Ca2+ channel alpha1E subunit in islets of Langerhans and kidney--distribution of voltage-gated Ca2+ channel alpha1 subunits in cell lines and tissues. Eur J Biochem (1998) 0.84
Ion channels. Not an open-and-shut case. Nature (1991) 0.84
Beta2-adrenergic agonist-induced hypertrophy of the quadriceps skeletal muscle does not modulate disease severity in the rodent meniscectomy model of osteoarthritis. Osteoarthritis Cartilage (2009) 0.83
Cerebral herniation in bacterial meningitis. BMJ (1993) 0.83
Purification and characterization of a novel zinc-proteinase from cultures of Aeromonas hydrophila. J Biol Chem (1993) 0.83
Characterization of an oxytocin-induced rise in [Ca2+]i in single human myometrium smooth muscle cells. Cell Calcium (1996) 0.83
Inactivation of N-type Ca2+ channels: Ca2+ vs. voltage. J Physiol (1999) 0.83